BRD2 - bromodomain containing 2 Gene

Also Known as FSH; NAT; RNF3; FSRG1; RING3; D6S113E; O27.1.1; BRD2-IT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6046

About BRD2

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,968,594-32,981,505 (from NCBI)

This gene has 25 transcripts (splice variants), 1 gene allele, 298 orthologues and 11 paralogues. Ubiquitous expression in bone marrow (RPKM 74.5), thyroid (RPKM 55.5) and 25 other tissues.

Summary

This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during Mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]

BRD2 Products (8)

mRNA Protein Name
NM_001199456.2 NP_001186385.1 bromodomain-containing protein 2 isoform 3
NM_001199455.1 NP_001186384.1 bromodomain-containing protein 2 isoform 2
XM_047419222.1 XP_047275178.1 bromodomain-containing protein 2 isoform X1
NM_001291986.2 NP_001278915.1 bromodomain-containing protein 2 isoform 4
NM_001113182.3 NP_001106653.1 bromodomain-containing protein 2 isoform 1
XM_047419223.1 XP_047275179.1 bromodomain-containing protein 2 isoform X2
NR_037625.1
NM_005104.4 NP_005095.1 bromodomain-containing protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables acetylation-dependent protein binding IDA
IDA: Inferred from direct assay
28262505 GOA
enables chromatin binding IDA
IDA: Inferred from direct assay
18406326 GOA
enables lysine-acetylated histone binding IDA
IDA: Inferred from direct assay
17848202 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20709061 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
8595877 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in chromatin looping IDA
IDA: Inferred from direct assay
35410381 GOA
involved in nucleosome assembly IMP
IMP: Inferred from mutant phenotype
18406326 GOA
involved in positive regulation of T-helper 17 cell lineage commitment IDA
IDA: Inferred from direct assay
28262505 GOA
involved in protein localization to chromatin IDA
IDA: Inferred from direct assay
28262505 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18406326 GOA
Cellular Component GO Annotation Evidence Verweise Source
is active in chromatin IDA
IDA: Inferred from direct assay
17848202 GOA
located in nucleus IDA
IDA: Inferred from direct assay
8595877 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRD2 Protein Structure

Bromodomain

Bromodomain: Bromodomain (86 - 167)

Bromodomain

Bromodomain: Bromodomain (353 - 441)

  • 0
  • 200
  • 400
  • 600
  • 801 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 2

  • BRD2 intronic transcript 1

  • female sterile homeotic-related gene 1

  • really interesting new gene 3 protein

BRD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
BRD2 P25440 H4C16 Homo sapiens P62805
SPR
20709061
Intra
BRD2 P25440 H4C16 Homo sapiens P62805
X-Ray Diffraction
20709061
Intra
BRD2 P25440 RUNX3 Homo sapiens Q13761
IF
24229708
Intra
BRD2 P25440 RUNX3 Homo sapiens Q13761
Anti Tag CoIP
24229708
Intra
BRD2 P25440 RUNX3 Homo sapiens Q13761
Anti Bait CoIP
24229708
Cross: Cross-species interaction Intra: Intraspecies interaction

BRD2 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P80037 BRD2 Antibody (YA579) WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, FC Human
HY-P84213 BRD2 Antibody (YA3910) WB, FC, ELISA Human, Rat
HY-P84213A BRD2 Antibody (YA3910)(PBS only) WB, FC, ELISA Human, Rat

Related Diseases

Diseases Alias
Epilepsy, Idiopathic Generalized

  • Idiopathic Generalized Epilepsy

  • Generalised Epilepsy

  • Epilepsy, Generalized

  • EIG

  • Ige

  • Epilepsy, Idiopathic Generalized, Susceptibility To, 1

  • Epilepsy, Idiopathic Generalized 1

  • Epilepsy, Idiopathic Generalized, Susceptibility To

  • Epilepsy, Idiopathic, Generalized

  • Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1
Photosensitive Epilepsy

  • Pse

  • Photogenic Epilepsy

  • Photoparoxysmal Response

  • Reflex Epilepsy, Photosensitive

  • Photoparoxysmal Response 1
Epilepsy, Myoclonic Juvenile

  • Juvenile Myoclonic Epilepsy

  • Janz Syndrome

  • Jme

  • Myoclonic Epilepsy, Juvenile, Susceptibility To, 1

  • EJM

  • Myoclonic Epilepsy, Juvenile

  • Petit Mal, Impulsive

  • Myoclonic Epilepsy, Juvenile 1

  • Myoclonic Epilepsy, Juvenile, 1

  • Adolescent Myoclonic Epilepsy

  • Juvenile Myoclonus Epilepsy

  • Juvenile Myoclonic Epilepsy 1

  • EJM1

  • Petit Mal Impulsive

  • Susceptibility To Juvenile Myoclonic Epilepsy 1

  • Myoclonic Epilepsy Juvenile

  • Epilepsy, Myoclonic, Juvenile

  • Myoclonic Epilepsy Of Janz

  • Jme - [Juvenile Myoclonic Epilepsy]
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Leukemia, Myeloid, Acute

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Benign Epilepsy With Centrotemporal Spikes

  • Benign Rolandic Epilepsy

  • Rolandic Epilepsy

  • Epilepsy, Rolandic

  • Bcects

  • Benign Childhood Epilepsy With Centrotemporal Spike

  • Sylvan Seizures

  • Becrs

  • Bects

  • Bre

  • Benign Epilepsy Of Childhood With Centrotemporal Spikes

  • Benign Familial Epilepsy Of Childhood With Rolandic Spikes

  • Centrotemporal Epilepsy
Adolescence-Adult Electroclinical Syndrome
Nut Midline Carcinoma

  • Nuclear Protein In Testis Midline Carcinoma

  • Nmc
Epilepsy

  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-112090 ABBV-744 Inhibitor 99.97% Phase 1
HY-117286 (S)-JQ-35 Inhibitor 99.46% Phase 1

Pre-clinical Phase

Bioactive Molecules (53)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-100972 ARV-771 Degrader 99.87% Unkown
HY-78695 JQ-1 carboxylic acid Inhibitor 99.69% Unkown
HY-136570 GSK778 Inhibitor 99.14% Unkown
HY-162514 BBC0403 Inhibitor 98.78% Unkown
HY-136571 GSK046 Inhibitor 99.70% Unkown
HY-141438 SIM1 Degrader 99.47% Unkown
HY-160528 IBG3 Inhibitor 98.53% Unkown
HY-153385 TMX1 Degrader 99.57% Unkown
HY-153459 IBG1 Degrader 99.88% Unkown
HY-138563 GSK973 Inhibitor 99.97% Unkown
HY-101519 BETd-260 Inhibitor 99.68% Unkown
HY-112429 HJB97 Inhibitor 99.12% Unkown
HY-114504 RVX-297 Inhibitor 95.00% Unkown
HY-114416 GS-626510 Inhibitor 99.46% Unkown
HY-120000 MS402 Inhibitor 98.36% Unkown
HY-112610 CF53 Inhibitor 99.81% Unkown
HY-131061 BET bromodomain inhibitor 1 Inhibitor 99.67% Unkown
HY-146208 BRD4 Inhibitor-20 Inhibitor 99.24% Unkown
HY-115568 BETd-246 Inhibitor 98.34% Unkown
HY-145264 OARV-771 Inhibitor 98.77% Unkown
HY-110215 XD14 Inhibitor 95.02% Unkown
HY-142520 I-BET567 Inhibitor 99.49% Unkown
HY-130813 BET-IN-6 Inhibitor / Unkown
HY-126325 BY27 Inhibitor / Unkown
HY-169170 PARP1/BRD4-IN-3 Inhibitor / Unkown
HY-121738 TC AC 28 Inhibitor / Unkown
HY-181003 GSK785 Inhibitor / Unkown
HY-173062 BRD4 Inhibitor-40 Inhibitor / Unkown
HY-179588 PROTAC BET Degrader-14 Degrader / Unkown
HY-170900 SJ44236 Degrader / Unkown
HY-181729 PROTAC BET Degrader-15 Degrader / Unkown
HY-180831 BRD4 D1-IN-3 Inhibitor / Unkown
HY-143471 WNY0824 Inhibitor / Unkown
HY-182371 BRD4 ligand 15 Ligand / Unkown
HY-181867 PROTAC BET Degrader-16 Degrader / Unkown
HY-168634 SJ46421 Inhibitor / Unkown
HY-176535 KB-0118 Inhibitor / Unkown
HY-175679 BRD2 BD1 ligand-1 Ligand / Unkown
HY-181735 BET-IN-30 Inhibitor / Unkown
HY-184335 PROTAC BET Degrader-18 Degrader / Unkown
HY-179589 JQ-1 (carboxylic acid)-amine-PEG8-cyanogen Degrader / Unkown
HY-155680 BET BD2-IN-1 Inhibitor / Unkown
HY-151972 BRD4 Inhibitor-25 Inhibitor / Unkown
HY-149098 SJ1461 Inhibitor / Unkown
HY-180804 CZL-077 Inhibitor / Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-181495 RAJQ14 Degrader / Unkown
HY-182801 PROTAC BRD4 Degrader-46 Degrader / Unkown
HY-175678 PROTAC BRD2 BD1 Degrader-1 Degrader / Unkown
HY-130612 PROTAC BRD2/BRD4 degrader-1 Inhibitor / Unkown
HY-181869 PROTAC BET Degrader-17 Degrader / Unkown
HY-170390 AB3067 Degrader / Unkown
HY-136570A GSK778 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BRD2 VGNC VGNC:83422
Canis familiaris BRD2 VGNC VGNC:38519
Rattus norvegicus BRD2 RGD RGD:1303324
Mus musculus BRD2 MGD MGI:99495
Bos taurus BRD2 VGNC VGNC:26557
Others BRD2 NCBI