Geranial
Based on 1 Customer Validation
Geranial is an aromatic compound. It can be isolated from the fruits of Litsea cubeba Lour and the rhizomes of ginger (Zingiber officinale). Geranial inhibits LPS-induced phosphorylation of ERK1/2, JNK1/3 and IκB in macrophages. It suppresses the secretion of IL-1β, TNF-α and IL-6, as well as the expression of pro-IL-1β, iNOS and COX-2. Geranial increases ROS. It can be used in the research of inflammatory diseases.
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- Pureté: 99.51%
- CAS No.: 141-27-5
- Formule: C10H16O
- Masse moléculaire:152.23
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
|
IL-1β |
IL-6 |
COX-2 |
ERK1 |
ERK2 |
JNK2 |
JNK3 |
iNOS |
Geranial (6.6-66 μM; 24 h) exhibits no cytotoxicity toward J774A.1 murine macrophages, and promotes cell proliferation at 66 μM[1].
Geranial (6.6-66 μM; 30 min preincubation, 6 h LPS stimulation) inhibits LPS-induced TNF-α and IL-6 secretion in J774A.1 murine macrophages, with TNF-α inhibition rates ranging from 57 to 75%[1].
Geranial (6.6-66 μM; 30 min pretreatment, 6 h LPS stimulation) inhibits LPS-induced pro-IL-1β, iNOS, COX-2, and NLRP-3 expression in J774A.1 murine macrophages, with no dose dependency observed for COX-2 and NLRP-3 inhibition[1].
Geranial (6.6-66 μM; 30 min pretreatment, 5.5 h LPS stimulation, 30 min ATP treatment) inhibits NLRP-3 inflammasome activation in J774A.1 murine macrophages, as shown by reduced caspase-1 p10 production and IL-1β secretion after LPS/ATP stimulation[1].
Geranial (66 μM; 30 min pretreatment, 10, 20, 30, or 60 min LPS stimulation) inhibits LPS-induced phosphorylation of ERK1/2 and IκB, and slightly inhibits phosphorylation of JNK1/3 and p38, in J774A.1 murine macrophages[1].
Geranial (6.6-66 μM; 30 min pretreatment, 0-60 min LPS stimulation) increases intracellular ROS concentrations in LPS-stimulated J774A.1 murine macrophages, showing a dose-dependent enhancing effect rather than inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS-stimulated murine macrophage J774A.1 cells
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Concentration:6.6-66 μM
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Incubation Time:30 min preincubation; 6 h LPS stimulation
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Result:Inhibited LPS-induced TNF-α secretion with inhibition rates between 57 and 75% across the tested concentrations.
Inhibited LPS-induced IL-6 secretion, with lower efficacy than neral at 20 and 66 μM.
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Cell Line:LPS-stimulated murine macrophage J774A.1 cells
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Concentration:6.6-66 μM
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Incubation Time:30 min pretreatment; 6 h LPS stimulation
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Result:Inhibited LPS-induced pro-IL-1β expression significantly.
Inhibited iNOS, COX-2, and NLRP-3 expression, but showed no dose-dependent effect for COX-2 and NLRP-3 inhibition.
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Cell Line:LPS-stimulated murine macrophage J774A.1 cells
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Concentration:66 μM
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Incubation Time:30 min pretreatment; 10, 20, 30, or 60 min LPS stimulation
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Result:Inhibited LPS-induced phosphorylation of ERK1/2 and IκB significantly.
Inhibited LPS-induced phosphorylation of JNK1/3 and p38 slightly.
Chemical Information
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CAS No. 141-27-5
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Appearance Liquid (Density: 0.8888 g/cm3)
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Masse moléculaire 152.23
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Formule C10H16O
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Color Light yellow to brown
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SMILES
C/C(C)=C\CC/C(C)=C/C=O
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Synonyms
(E)-3,7-Dimethylocta-2,6-dienal
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureté et documentation
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Fiche technique (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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