MYD88 - MYD88 innate immune signal transduction adaptor Gene

Also Known as IMD68; MYD88D

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4615

About MYD88

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:38,138,661-38,143,022 (from NCBI)

This gene has 16 transcripts (splice variants), 200 orthologues and is associated with 79 phenotypes. Ubiquitous expression in appendix (RPKM 32.5), bone marrow (RPKM 32.2) and 25 other tissues.

Summary

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like Receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic Bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

MYD88 Products (10)

mRNA	Protein	Name
NM_001172567.2	NP_001166038.2	myeloid differentiation primary response protein MyD88 isoform 1
NM_001172568.2	NP_001166039.2	myeloid differentiation primary response protein MyD88 isoform 3
NR_164663.1
NM_001374788.1
NM_001374787.1	NP_001361716.1	myeloid differentiation primary response protein MyD88 isoform 8
NM_001365877.1	NP_001352806.1	myeloid differentiation primary response protein MyD88 isoform 7
NM_002468.5	NP_002459.3	myeloid differentiation primary response protein MyD88 isoform 2
NM_001172569.3	NP_001166040.2	myeloid differentiation primary response protein MyD88 isoform 4
NM_001365876.1	NP_001352805.1	myeloid differentiation primary response protein MyD88 isoform 6
NM_001172566.2	NP_001166037.2	myeloid differentiation primary response protein MyD88 isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables TIR domain binding	IPI IPI: Inferred from physical interaction	19509286	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	11544529	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	9430229	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10880445	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	16751103	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 3'-UTR-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	15294994	GOA
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	22155231	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	20219467	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	33718825	GOA
involved in interleukin-1-mediated signaling pathway	IDA IDA: Inferred from direct assay	9430229	GOA
involved in interleukin-33-mediated signaling pathway	IDA IDA: Inferred from direct assay	18802081	GOA
involved in phagocytosis	IMP IMP: Inferred from mutant phenotype	30883606	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	22155231	GOA
involved in positive regulation of NLRP3 inflammasome complex assembly	IMP IMP: Inferred from mutant phenotype	33718825	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	12761501	GOA
involved in positive regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	20219467	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	33718825	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	20219467	GOA
involved in positive regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	23633945	GOA
involved in response to interleukin-1	IMP IMP: Inferred from mutant phenotype	19281832	GOA
involved in toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	16751103	GOA
involved in toll-like receptor 5 signaling pathway	IDA IDA: Inferred from direct assay	16751103	GOA
involved in toll-like receptor 8 signaling pathway	IDA IDA: Inferred from direct assay	33718825	GOA
involved in toll-like receptor TLR6:TLR2 signaling pathway	IDA IDA: Inferred from direct assay	36964784	GOA
involved in type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23633945	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cell surface	IDA IDA: Inferred from direct assay	22851693	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	9430229	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22155231	GOA
is active in extrinsic component of cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	16751103	GOA
is active in extrinsic component of plasma membrane	IDA IDA: Inferred from direct assay	9430229	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22155231	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	16751103	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYD88 Protein Structure

Death

TIR

0
100
200
309 a.a.

Protein Preferred Names	Protein Names
myeloid differentiation primary response protein MyD88	TLR adaptor MYD88 mutant myeloid differentiation primary response 88 myeloid differentiation primary response 88 myeloid differentiation primary response gene (88)

MYD88 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MYD88	Q99836	IRAK4	Homo sapiens	Q69FE3	Y2H Prey Pooling	25416956
Intra	MYD88	Q99836	IRAK4	Homo sapiens	Q69FE3	Validated Y2H	25416956
Intra	MYD88	Q99836	IRAK4	Homo sapiens	Q69FE3	Y2H Array	25416956
Intra	MYD88	Q99836	SARM1	Homo sapiens	Q6SZW1	MAPPIT	17258210
Intra	MYD88	Q99836	STAP2	Homo sapiens	Q9UGK3	Anti Tag CoIP	16365431
Intra	MYD88	Q99836	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	MYD88	Q99836	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	MYD88	Q99836	DOCK8	Homo sapiens	Q8NF50	Anti Bait CoIP	22581261
Intra	MYD88	Q99836	SPOPL	Homo sapiens	Q6IQ16	Y2H Prey Pooling	32296183
Intra	MYD88	Q99836	SPOPL	Homo sapiens	Q6IQ16	Y2H Array	32296183
Intra	MYD88	Q99836	HDAC6	Homo sapiens	Q9UBN7	Anti Bait CoIP	29281743
Intra	MYD88	Q99836	HDAC6	Homo sapiens	Q9UBN7	Anti Tag CoIP	29281743
Intra	MYD88	Q99836	USP7	Homo sapiens	Q93009	Y2H	21988832
Intra	MYD88	Q99836	USP7	Homo sapiens	Q93009	Confocal	21988832
Intra	MYD88	Q99836	USP7	Homo sapiens	Q93009	Anti Tag CoIP	21988832
Intra	MYD88	Q99836	IRAK1	Homo sapiens	P51617	Anti Tag CoIP	10383454
Intra	MYD88	Q99836	MYD88	Homo sapiens	Q99836	Y2H	21988832
Intra	MYD88	Q99836	MYD88	Homo sapiens	Q99836	MAPPIT	17258210
Intra	MYD88	Q99836	MYD88	Homo sapiens	Q99836	SLC	22155231
Intra	MYD88	Q99836	MYD88	Homo sapiens	Q99836	Y2H	11544529
Intra	MYD88	Q99836	MYD88	Homo sapiens	Q99836	Y2H Array	21988832
Intra	MYD88	Q99836	MYD88	Homo sapiens	Q99836	Y2H	21516116
Intra	MYD88	Q99836	IRAK4	Homo sapiens	Q9NWZ3	Y2H Array	25502805
Intra	MYD88	Q99836	IRAK4	Homo sapiens	Q9NWZ3	Y2H Array	25910212
Intra	MYD88	Q99836	IRAK4	Homo sapiens	Q9NWZ3	Y2H Prey Pooling	32296183
Intra	MYD88	Q99836	IRAK4	Homo sapiens	Q9NWZ3	Validated Y2H	32296183
Intra	MYD88	Q99836	IRAK4	Homo sapiens	Q9NWZ3	Y2H Array	32296183
Intra	MYD88	Q99836	IRAK4	Homo sapiens	Q9NWZ3	SLC	25910212
Intra	MYD88	Q99836	IRAK4	Homo sapiens	Q9NWZ3	Validated Y2H	25910212
Intra	MYD88	Q99836	IRAK4	Homo sapiens	Q9NWZ3	Y2H	12860405
Intra	MYD88	Q99836	IRAK4	Homo sapiens	Q9NWZ3	Y2H Array	31515488
Intra	MYD88	Q99836	IRAK4	Homo sapiens	Q9NWZ3	Y2H Bait-Prey Pool	25910212
Intra	MYD88	Q99836	FADD	Homo sapiens	Q13158	CoIP	10880445
Intra	MYD88	Q99836	TNFRSF13B	Homo sapiens	O14836	Pull Down	20676093
Intra	MYD88	Q99836	TNFRSF13B	Homo sapiens	O14836	Confocal	20676093
Intra	MYD88	Q99836	TNFRSF13B	Homo sapiens	O14836	CoIP	20676093
Intra	MYD88	Q99836	TIRAP	Homo sapiens	P58753	Y2H	11544529
Intra	MYD88	Q99836	TLR4	Homo sapiens	O00206	Anti Tag CoIP	15728506
Intra	MYD88	Q99836	TXN	Homo sapiens	P10599	Anti Tag CoIP	21988832
Intra	MYD88	Q99836	SPOP	Homo sapiens	O43791	Anti Tag CoIP	33961781
Intra	MYD88	Q99836	SPOP	Homo sapiens	O43791	Anti Tag CoIP	28514442
Intra	MYD88	Q99836	SPOP	Homo sapiens	O43791	Y2H Pooling	16189514
Intra	MYD88	Q99836	SPOP	Homo sapiens	O43791	Y2H Array	21988832
Intra	MYD88	Q99836	SIAH1	Homo sapiens	Q8IUQ4	Confocal	21988832
Intra	MYD88	Q99836	SIAH1	Homo sapiens	Q8IUQ4	Anti Tag CoIP	21988832
Intra	MYD88	Q99836	TLR2	Homo sapiens	O60603	TSA	29990310
Intra	MYD88	Q99836	TLR2	Homo sapiens	O60603	SPR	29990310
Intra	MYD88	Q99836	TLR2	Homo sapiens	O60603	Confocal	16293622
Cross	MYD88	Q99836	q8yf33_brume	Brucella melitensis biotype 1	Q8YF33	SLC	22155231
Cross	MYD88	Q99836	Q03463-PRO_0000278740	Hepatitis C virus	Q03463-PRO_0000278740	Anti Tag CoIP	17567694

Cross: Cross-species interaction Intra: Intraspecies interaction

MYD88 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80233	MyD88 Antibody (YA280)	WB, ICC/IF, IHC-P, FC	Human
HY-P80760	MyD88 Antibody	ICC/IF, WB, IHC-F, IHC-P, ELISA	Human, Mouse, Rat
HY-P85714	Myd88 Antibody (YA5406)	IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease
Superficial Basal Cell Carcinoma	Multifocal Superficial Basal Cell Carcinoma Multicentric Basal Cell Carcinoma Superficial Multicentric Basal-Cell Carcinoma
Paracoccidioidomycosis	Mucocutaneous-Lymphangitic Paracoccidioidomycosis Paracoccidioidal Mycosis Lobo Disease Lutz-Splendore-Almeida Disease Pcm Paracoccidioidal Granuloma South American Blastomycosis Lobomycosis Brazilian Blastomycosis Lutz Disease Brazilian Blastomycotic South American Blastomyces Infection Paracoccidioides Brasiliensis Infection Paracoccidioidomycosis Unspecified
Tularemia	Francisella Tularensis Infection Deerfly Fever Lemming Fever Ohara Disease Pahvant Valley Plague Rabbit Fever Yatobyo
Perinatal Necrotizing Enterocolitis	Necrotizing Enterocolitis Enterocolitis Necrotizing Enterocolitis, Necrotizing Necrotizing Enterocolitis In Fetus Or Newborn Perinatal Necrotising Enterocolitis Pseudomembranous Enterocolitis In Newborn Nec
Coccidiosis	Intestinal Coccidiosis Enteric Coccidiosis
Salmonellosis	Salmonella Infections Salmonella Infection
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Commensal Bacterial Infectious Disease
Lichen Sclerosus Et Atrophicus	Lichen Sclerosus LSA Lichen Sclerosis Lichen Sclerosis Et Atrophicus Ls Et A - [Lichen Sclerosus Et Atrophicus] Lichen Albus
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
X-Linked Immunodeficiency 74	Immunodeficiency 74, Covid-19-Related, X-Linked Imd74 Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection Tlr7 Deficiency X-Linked Immunodeficiency 74,Covid-19-Related
Listeriosis	Listeria Infection Infection By Listeria Monocytogenes Listeria Monocytogenes Infection Listeria Infections Listerial Foodborne Infection Circling Disease Infection Due To Listeria Monocytogenes Listerellosis
Autoimmune Disease Of Gastrointestinal Tract
Macroglobulinemia, Waldenstrom 1	Macroglobulinemia, Waldenstrom, Somatic WM1 Macroglobulinemia, Waldenstrom, Susceptibility To, 1 Macroglobulinemia, Waldenstrom, 1
Colonic Benign Neoplasm	Colon Neoplasm Colonic Mass Colonic Tumor Neoplasm Of Colon Neoplasm Of The Colon Colonic Neoplasms Colon Cancer Colon Carcinoma Nos Colonic Cancer Metastatic Colon Cancer Nos
Rosacea	Erythematotelangiectatic Rosacea Papulopustular Rosacea Phymatous Rosacea Acne Roscea Acne, Erythematosa Granulomatous Rosacea Ocular Rosacea Acne Rosacea Hypertrophic Rosacea
Toxoplasmosis	Disseminated Toxoplasmosis Multisystemic Disseminated Toxoplasmosis Acquired Toxoplasmosis Toxoplasmosis Disease Or Disorder Infection By Toxoplasma Gondii Toxoplasmal Toxoplasma
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Legionellosis	Legionella Infection Pontiac Fever Legionnaires' Disease Infection By Legionella Pneumophilia Legionella Pneumophila Infection
Macroglobulinemia	Primary Macroglobulinemia Waldenstrom Macroglobulinemia
Visceral Leishmaniasis	Kala-Azar Leishmaniasis, Visceral Infection By Visceral Leishmaniasis Leishmaniasis Visceral Sahib Disease Ponos Burdwan Fever Mard El Bicha Sirkari Disease Indian Visceral Leishmaniasis Dumdum Fever Visceral Leishmaniasis Due To Leishmania Donovani
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Eye Lymphoma	Malignant Lymphoma Of Eye Lymphoma Of Eye
Opportunistic Mycosis	Opportunistic Mycoses Opportunistic Systemic Mycoses
Intraocular Lymphoma	Primary Intraocular Lymphoma Piol Primary Intraocular Non-Hodgkin Lymphoma Primary Intraocular Non-Hodgkin Malignant Lymphoma
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
Testicular Lymphoma	Malignant Lymphoma Of Testis Lymphoma Of The Testis
Central Nervous System Lymphoma	Microglioma Primary Cns Lymphoma Cns Lymphoma Primary Central Nervous System Lymphoma
Fungal Infectious Disease	Mycoses Mycosis
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Bacterial Sepsis
Viral Infectious Disease	Arbovirus Infections Viral Disease Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Silo Filler'S Disease	Silo Filler Disease Silo-Fillers' Disease
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Peritonitis	Retractile Mesenteritis Sclerosing Mesenteritis Acute Generalized Peritonitis Primary Bacterial Peritonitis Idiopathic Sclerosing Mesenteritis Mesenteric Panniculitis Peritoneal Retractile Mesenteritis Liposclerotic Mesenteritis Mesenteric Fibromatosis Mesenteric Lipodystrophy Mesenteric Lipogranuloma Fibromatosis, Abdominal Peritoneum Inflammation Peritonitis Of Undetermined Cause Peritonitis Of Unspecified Cause Pelviperitonitis Pelvic Peritonitis, Nos Generalised Peritonitis Nos Abdominal Peritonitis Acute Idiopathic Peritonitis Acute Lesser Sac Peritonitis Acute Peritoneal Inflammation Diffuse Peritonitis Peritoneal Inflammation Acute Primary Peritonitis Pneumococcal Peritonitis
Retina Lymphoma	Lymphoma Of Retina Retinal Lymphoma
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Heavy Chain Disease	Hcd
Pneumonic Tularemia	Pulmonary Tularemia Bronchopneumonic Tularemia Pneumonic Tularaemia
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Plasma Protein Metabolism Disease
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculosis, Susceptibility To Tuberculoma Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Glanders	Farcy Pipes Infection Due To Pseudomonas Mallei Burkholderia Mallei Burkholderia Mallei Infection Equina Equine Glanders Farcy Farcy Buds Farcy Cords Infection Due To Actinobacillus Mallei Infection Due To Malleomyces Mallei Maliasmus Malleus Farce Actinobacillosis Actinobacillus Infection
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Q Fever	Infection Due To Coxiella Burnetii Quadrilateral Fever Query Fever Nine Mile Fever Coxiella Burnetii Fever Q Fever Pneumonia Coxiellosis Pneumonia In Q Fever Australian Q Fever Balkan Grippe
Primary Central Nervous System Lymphoma	Pcnsl Primary Cns Lymphoma Primary Brain Lymphoma Primary Lymphoma, Cns Primary Cerebral Lymphoma
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Disease, Susceptibility To Coronary Artery Anomaly Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Splenic Disease	Splenic Diseases Dyssplenism Spleen Disease Abnormality Of The Spleen Spleen Diseases
Schnitzler Syndrome	Chronic Urticaria With Gammopathy Chronic Urticaria With Macroglobulinemia Chronic Urticaria With Gammapathy
Zebrafish Allergy	Danio Rerio Allergy
Human Monocytic Ehrlichiosis	Ehrlichiosis Chafeensis Hme Human Ehrlichial Infection, Human Monocytic Type
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Monoclonal Gammopathy Of Uncertain Significance	Monoclonal Gammopathy Of Undetermined Significance Mgus Mgus - [Monoclonal Gammopathy Of Undetermined Significance] Monoclonal Gammopathy Nos Iga Gammopathy Monoclonal Gammoglobulinopathy
Lymphoplasmacytic Lymphoma	Waldenstrom Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic Waldenström Macroglobulinaemia Waldenström Macroglobulinaemia Without Mention Of Remission Idiopathic Macroglobulinaemia Primary Macroglobulinaemia
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Enteritis, Granulomatous Crohn'S Disease Of Colon Granulomatous Colitis Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Enteritis Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Lymphocytic Choriomeningitis	Lcm Lymphocytic Meningitis Lymphocytic Choriomeningitis Virus Encephalomyelitis Lymphocytic Meningoencephalitis Non-Arthropod Borne Lymphocytic Choriomeningitis Lcm - [Lymphocytic Choriomeningitis] Benign Lymphocytic Meningitis Meningitis Due To Lymphocytic Choriomeningitis Virus
Diabetes Mellitus	Diabetes
Primary Bacterial Infectious Disease
Bacterial Pneumonia	Gram-Negative Pneumonia Pneumonia Due To Other Gram-Negative Bacteria Pneumonia Bacterial Pneumonia, Bacterial Acute Bacillus Pneumonia Acute Bacterial Pneumonia Bacillus Double Pneumonia Bacillus Pneumonia Bacteria Pneumonia Bacterial Double Pneumonia Bacterial Lobar Pneumonia Bacterial Purulent Pneumonia Bronchopneumonia Due To Bacteria Other Than S. Pneumoniae And H. Influenzae
Legionnaire Disease	Legionnaires' Disease Legionnaires Disease Legionnaire Disease, Susceptibility To Legionella Legionella Pneumonia Infection By Legionella Pneumophilia Legionnaire'S Disease Legionellosis Legionaire Disease, Susceptibility To Legionnaires Pneumonia
Splenic Marginal Zone Lymphoma	Smzl Splenic Marginal Zone B-Cell Lymphoma
Plague	Yersiniosis Yersinia Infections Infection By Yersinia Pestis Pasteurella Pestis Infection Pestilential Fever Yersinia Pestis Infection
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Immunodeficiency 68	Myd88 Deficiency Pyogenic Bacterial Infections Due To Myd88 Deficiency IMD68 Myd88d Bacterial Susceptibility Due To Tlr Signaling Pathway Deficiency Pyogenic Bacterial Infections, Recurrent, Due To Myd88 Deficiency
Kawasaki Disease	Mucocutaneous Lymph Node Syndrome Acute Febrile Mucocutaneous Lymph Node Syndrome Kawasaki Syndrome Kd Infantile Polyarteritis Kawasaki Disease, Susceptibility To Acute Febrile Mcls Kawasaki'S Disease Mlns KWD
Marginal Zone B-Cell Lymphoma	Marginal Zone Lymphoma Mzl Mucosa-Associated Lymphoid Tissue Lymphoma
Waldenstroem'S Macroglobulinemia	Waldenstrom Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstrom'S Macroglobulinaemia Waldenstrom'S Syndrome Waldenström Macroglobulinemia Waldenstrom'S Macroglobulinemia Wm Waldenström'S Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic
Congenital Toxoplasmosis	Toxoplasmosis, Congenital Mother-To-Child Transmission Of Toxoplasmosis Toxoplasma Embryofetopathy Toxoplasma Embryopathy Toxoplasmosis - Congen. Toxoplasmosis Congenital
Bronchopneumonia	Lobular Pneumonia Bronchial Pneumonia Chest Infection - Bronchopneumonia
Central Nervous System Hematologic Cancer	Cns Hematopoietic Tumor Hematopoietic Neoplasm Of Central Nervous System Central Nervous System Hematopoietic Neoplasm
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Spleen Cancer	Spleen Neoplasm Splenic Neoplasm Splenic Neoplasms Malignant Splenic Tumor Malignant Tumour Of Spleen Tumor Of Spleen Malignant Neoplasm Of Spleen

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112137	Trehalose-6,6'-dibehenate		99.92%	Phase 3
HY-135317	Emavusertib	Inhibitor	99.97%	Phase 2
HY-135317B	Emavusertib hydrochloride	Inhibitor	/	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99555	Tomaralimab	Inhibitor	99.42%	Phase 2

Pre-clinical Phase

Bioactive Molecules (55)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139397	TJ-M2010-5	Inhibitor	99.94%	Unkown
HY-50937	ST 2825	Inhibitor	99.92%	Unkown
HY-110204	Heclin		98.00%	Unkown
HY-N0703	Schaftoside	Inhibitor	99.70%	Unkown
HY-Y1881B	Copper sulfate pentahydrate, for cell culture, 98%	Inhibitor	99.99%	Unkown
HY-160229	ssRNA40 sodium	Activator	98.34%	Unkown
HY-19744	T6167923	Inhibitor	99.40%	Unkown
HY-Y1881A	Copper sulfate pentahydrate, 99.9%	Inhibitor	99.90%	Unkown
HY-149992	MyD88-IN-1	Inhibitor	99.95%	Unkown
HY-110195	Smurf1-IN-A01		99.81%	Unkown
HY-N7088	Raffinose	Inhibitor	98.0%	Unkown
HY-Y0278	Chloranil	Inducer	98%	Unkown
HY-18976	UF010		99.83%	Unkown
HY-N0237	Atractyloside A	Inhibitor	98.11%	Unkown
HY-N4093	Astringin	Inhibitor	99.54%	Unkown
HY-129440	N-(p-Coumaroyl) Serotonin	Inhibitor	99.03%	Unkown
HY-P10719	Pepinh-MYD	Inhibitor	96.87%	Unkown
HY-W014223	2,4′-Dihydroxybenzophenone	Inhibitor	98.00%	Unkown
HY-P10719A	Pepinh-MYD TFA	Inhibitor	98.98%	Unkown
HY-W097625	6-Methoxyflavone	Inhibitor	99.73%	Unkown
HY-170446	MyD88-IN-2	Inhibitor	99.94%	Unkown
HY-173063	TLR8 antagonist-1	Inhibitor	99.95%	Unkown
HY-N2896	Arjunolic acid	Inhibitor	98.83%	Unkown
HY-N0320	Salvianolic acid D	Inhibitor	95.15%	Unkown
HY-178136	MyD88-IN-3	Inhibitor	99.33%	Unkown
HY-W011400	TLR1		99.43%	Unkown
HY-179474	TSI-13-57	Inhibitor	98.73%	Unkown
HY-RS08886	MYD88 Human Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-N3979	Grossamide	Inhibitor	98.0%	Unkown
HY-164670	D228	Inhibitor	99.77%	Unkown
HY-NP134	Flagellin from S. typhimurium	Activator	95%	Unkown
HY-163775	Anti-inflammatory agent 88	Agonist	/	Unkown
HY-178690	MyD88-IN-4	Inhibitor	/	Unkown
HY-179047	SMU-L11-R	Activator	/	Unkown
HY-RS08887	Myd88 Mouse Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-180580	SMU-C409	Activator	/	Unkown
HY-N19847	LYRM03	Inhibitor	/	Unkown
HY-155801	CRX 527	Activator	/	Unkown
HY-184654	MR-39	Inhibitor	/	Unkown
HY-P5762A	Phoenixin-14 TFA	Inhibitor	/	Unkown
HY-184470	MyD88 degrader-1	Degrader	/	Unkown
HY-P10178	Myristoylated ARF6 (2-13)	Inhibitor	/	Unkown
HY-180336	LM9	Inhibitor	/	Unkown
HY-173309	P53/TLR2 modulator-1	Inducer	/	Unkown
HY-107272	Chuanbeinone	Inhibitor	/	Unkown
HY-125447	Artemisinin B	Inhibitor	/	Unkown
HY-RS08888	Myd88 Rat Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-183400	BIM-46174	Inhibitor	/	Unkown
HY-135317C	Emavusertib tosylate	Inhibitor	/	Unkown
HY-N9164	Hecubine	Inhibitor	/	Unkown
HY-135317D	Emavusertib mesylate	Inhibitor	/	Unkown
HY-135317F	Emavusertib phosphate	Inhibitor	/	Unkown
HY-175637	COX-2-IN-57	Inhibitor	/	Unkown
HY-135317E	Emavusertib maleate	Inhibitor	/	Unkown
HY-Y0278R	Chloranil (Standard)	Inducer	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MYD88	RGD	RGD:735043
Canis familiaris	MYD88	VGNC	VGNC:43531
Bos taurus	MYD88	VGNC	VGNC:31789
Mus musculus	MYD88	MGD	MGI:108005
Macaca mulatta	MYD88	VGNC	VGNC:84149
Felis catus	MYD88	VGNC	VGNC:102779
Others	MYD88	NCBI