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Csf1r - colony stimulating factor 1 receptor Gene

Also Known as Fms; Fim2; CD115; Csfmr; Fim-2; CSF-1R; M-CSFR; M-CSF-R

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12978

About Csf1r

Chromosome 18: 61,233,670-61,265,221 forward strand.GRCm39:CM001011.3

This gene has 6 transcripts (splice variants), 273 orthologues, 53 paralogues and is associated with 73 phenotypes. Broad expression in spleen adult (RPKM 69.7), placenta adult (RPKM 34.8) and 23 other tissues.

Summary

Enables several functions, including macrophage colony-stimulating factor receptor activity; protein homodimerization activity; and protein Phosphatase binding activity. Involved in several processes, including nervous system development; positive regulation of protein phosphorylation; and protein phosphorylation. Located in cell surface and plasma membrane. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and limb. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Csf1r Products (1)

mRNA	Protein	Name
NM_001037859.2	NP_001032948.2	macrophage colony-stimulating factor 1 receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytokine binding	IDA IDA: Inferred from direct assay	8007983	MGI
enables cytokine binding	IPI IPI: Inferred from physical interaction	19017797	MGI
enables macrophage colony-stimulating factor receptor activity	IDA IDA: Inferred from direct assay	19100238	MGI
enables macrophage colony-stimulating factor receptor activity	IMP IMP: Inferred from mutant phenotype	8007983	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	2408759	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	19017797	MGI
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	16705167	MGI
enables transmembrane receptor protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	2408759	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in axon guidance	IMP IMP: Inferred from mutant phenotype	22542597	MGI
involved in cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: Inferred from direct assay	19100238	MGI
involved in cell surface receptor protein tyrosine kinase signaling pathway	IMP IMP: Inferred from mutant phenotype	8262059	MGI
involved in cellular response to cytokine stimulus	IMP IMP: Inferred from mutant phenotype	20504948	MGI
involved in cellular response to macrophage colony-stimulating factor stimulus	IMP IMP: Inferred from mutant phenotype	8007983	MGI
involved in forebrain neuron differentiation	IMP IMP: Inferred from mutant phenotype	22542597	MGI
involved in macrophage colony-stimulating factor signaling pathway	IDA IDA: Inferred from direct assay	19017797	MGI
involved in microglial cell proliferation	IGI IGI: Inferred from genetic interaction	23392676	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	22542597	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	22542597	MGI
involved in olfactory bulb development	IMP IMP: Inferred from mutant phenotype	22542597	MGI
involved in osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	17121910	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	8007983	MGI
involved in positive regulation by host of viral process	IGI IGI: Inferred from genetic interaction	20889566	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	8007983	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	8007983	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	21610095	MGI
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	8007983	MGI
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	8007983	MGI
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21610095	MGI
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	21610095	MGI
involved in regulation of macrophage migration	IMP IMP: Inferred from mutant phenotype	21610095	MGI
involved in response to ischemia	IDA IDA: Inferred from direct assay	8922060	MGI
involved in ruffle organization	IMP IMP: Inferred from mutant phenotype	21610095	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of CSF1-CSF1R complex	IDA IDA: Inferred from direct assay	19017797	MGI
located in cell surface	IDA IDA: Inferred from direct assay	8007983	MGI
located in membrane	IDA IDA: Inferred from direct assay	2408759	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15860730	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Csf1r Protein Structure

IG_like

Ig_3

PTKc_CSF-1R

0
200
400
600
800
977 a.a.

Protein Preferred Names	Protein Names
macrophage colony-stimulating factor 1 receptor	CSF-1 receptor CSF-1-R c-fms proto-oncogene c-Fms proto-oncogene fms

Recombinant Csf1r Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72951	CSF1R Protein, Mouse (HEK293, Fc)	P09581 (A20-S511)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72952	CSF1R Protein, Mouse (HEK293, His)	P09581/NP_001032948.2 (A20-S511)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72953	CSF1R Protein, Mouse (Biotinylated, HEK293, His)	P09581 (A20-S511)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78892	CSF1R Protein, Mouse (Biotinylated, HEK293, His-Avi)	P09581 (A20-S511)	≥ 95%, as determined by reducing SDS-PAGE.

Csf1r Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83460	M-CSF Receptor Antibody (YA3205)	WB	Human
HY-P83460A	M-CSF Receptor Antibody (YA3205)(PBS only)	WB	Human

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16749	Pexidartinib		99.64%	Yes
HY-16749A	Pexidartinib hydrochloride		99.82%	Yes
HY-12297	Sulfatinib	Inhibitor	99.52%	Unkown

Clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132166	Velzatinib	Inhibitor	99.40%	Phase 3
HY-109190	Seralutinib	Inhibitor	99.94%	Phase 3
HY-145601	Tinengotinib	Inhibitor	99.57%	Phase 3
HY-124526	Chiauranib	Inhibitor	98.97%	Phase 3
HY-153920A	Pimicotinib hydrochloride	Inhibitor	/	Phase 3
HY-12768	Sotuletinib	Inhibitor	99.97%	Phase 2
HY-109086	Edicotinib	Inhibitor	99.68%	Phase 2
HY-19772	GSK3117391	Inhibitor	99.40%	Phase 2
HY-159838	Enrupatinib	Inhibitor	98.90%	Phase 2
HY-161025	SYHA1813	Inhibitor	99.46%	Phase 2
HY-136362	ARRY-382	Inhibitor	99.95%	Phase 2
HY-159503A	Segigratinib hydrochloride	Inhibitor	/	Phase 2
HY-114153A	PLX5622 hemifumarate	Inhibitor	99.93%	Phase 1
HY-100491	H3B-6527	Inhibitor	98.0%	Phase 1
HY-111787	Elzovantinib	Inhibitor	99.93%	Phase 1
HY-101768	PRN1371	Inhibitor	99.78%	Phase 1
HY-10204	OSI-930		98.33%	Phase 1

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99245	Emactuzumab	Inhibitor	97.60%	Phase 3
HY-P990043	Iluzanebart		98.63%	Phase 2
HY-P99452	Axatilimab	Inhibitor	99.59%	Phase 2
HY-P99259	Cabiralizumab	Inhibitor	99.73%	Phase 2
HY-P99368	Lacnotuzumab	Inhibitor	99.9%	Phase 2
HY-P991048	AMG-820	Inhibitor	98%	Phase 2

Pre-clinical Phase

Bioactive Molecules (62)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114153	PLX5622	Inhibitor	99.95%	Unkown
HY-114153C	PLX5622 in AIN-76A Diet (1200 ppm)	Inhibitor	/	Unkown
HY-50905	Dovitinib	Inhibitor	99.88%	Yes
HY-12768A	Sotuletinib hydrochloride	Inhibitor	99.43%	Unkown
HY-153920	Pimicotinib	Inhibitor	99.92%	Unkown
HY-10408	Ki20227	Inhibitor	99.51%	Unkown
HY-101774	CSF1R-IN-1	Inhibitor	98.04%	Unkown
HY-159108	AZ683	Inhibitor	98.57%	Unkown
HY-117244	AZD7507	Inhibitor	99.57%	Unkown
HY-147615	CSF1R-IN-12		98.75%	Unkown
HY-122906	JTE-952	Inhibitor	99.86%	Unkown
HY-152830	Adrixetinib		99.55%	Unkown
HY-126297	c-Fms-IN-10	Inhibitor	98.63%	Unkown
HY-139990	CSF1R-IN-3	Inhibitor	98.10%	Unkown
HY-112451	cFMS Receptor Inhibitor II	Inhibitor	99.88%	Unkown
HY-132935	BPR1R024	Inhibitor	98.50%	Unkown
HY-160842	CSF1R-IN-24	Inhibitor	98.10%	Unkown
HY-117273	AZ304	Inhibitor	99.77%	Unkown
HY-119942	c-Fms-IN-8	Inhibitor	99.50%	Unkown
HY-152830A	Adrixetinib TFA		99.82%	Unkown
HY-101526	GENZ-882706	Inhibitor	/	Unkown
HY-13075	c-Fms-IN-3	Inhibitor	98.83%	Unkown
HY-132935A	BPR1R024 mesylate	Inhibitor	/	Unkown
HY-RS03228	CSF1R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-13493	AC710	Inhibitor	99.57%	Unkown
HY-13496	JNJ-28312141	Inhibitor	/	Unkown
HY-101034	CHMFL-ABL/KIT-155		/	Unkown
HY-12768B	Sotuletinib dihydrochloride	Inhibitor	/	Unkown
HY-174366	JMC14	Inhibitor	/	Unkown
HY-109086A	Edicotinib hydrochloride	Inhibitor	/	Unkown
HY-13496A	JNJ-28312141 hydrochloride	Inhibitor	/	Unkown
HY-144040	CSF1R-IN-4		/	Unkown
HY-144041	CSF1R-IN-5	Inhibitor	/	Unkown
HY-144042	CSF1R-IN-6		/	Unkown
HY-147608	CSF1R-IN-7	Inhibitor	/	Unkown
HY-147609	CSF1R-IN-8	Inhibitor	/	Unkown
HY-147610	CSF1R-IN-9	Inhibitor	/	Unkown
HY-147611	CSF1R-IN-10	Inhibitor	/	Unkown
HY-147616	CSF1R-IN-13		/	Unkown
HY-147617	CSF1R-IN-14		/	Unkown
HY-153012	Axl/Mer/CSF1R-IN-1	Inhibitor	/	Unkown
HY-153243	IACS-9439	Inhibitor	/	Unkown
HY-153277	Axl/Mer/CSF1R-IN-2	Inhibitor	/	Unkown
HY-155001	CSF1R-IN-15	Inhibitor	/	Unkown
HY-155550	CSF1R-IN-17	Antagonist	/	Unkown
HY-157422	CSF1R-IN-19	Inhibitor	/	Unkown
HY-157996	CSF1R-IN-21	Inhibitor	/	Unkown
HY-158050	PXB17	Inhibitor	/	Unkown
HY-158148	CSF1R-IN-23	Inhibitor	/	Unkown
HY-158363	CSF1R-IN-25	Inhibitor	/	Unkown
HY-161084	CSF1R-IN-18	Inhibitor	/	Unkown
HY-162309	CSF1R-IN-20	Inhibitor	/	Unkown
HY-162415	CSF1R-IN-22		/	Unkown
HY-168954	CSF1R-IN-26		/	Unkown
HY-176194	Antifibrotic agent 1		/	Unkown
HY-183569	CSF1R-IN-27	Inhibitor	/	Unkown
HY-183931	NPA101.3	Inhibitor	/	Unkown
HY-RS03229	Csf1r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03230	Csf1r Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-13493A	AC710 Mesylate	Inhibitor	/	Unkown
HY-164529	SJ-C1044	Inhibitor	98.63%	Unkown
HY-174606	Human IL34 mRNA		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990125	Anti-Mouse CSF1R/CD115 Antibody (AFS98)		99.38%	Unkown
HY-P990849	Anti-CSF1R/CD115 Antibody (2-4A5-4)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Csf1r	NCBI	NCBI:1436