2. Gene
  3. Csf1r - colony stimulating factor 1 receptor Gene

Csf1r - colony stimulating factor 1 receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Fms; Fim2; CD115; Csfmr; Fim-2; CSF-1R; M-CSFR; M-CSF-R

Gene ID: 12978 | Gene type: protein coding

About Csf1r

Chromosome 18: 61,233,670-61,265,221 forward strand.GRCm39:CM001011.3

This gene has 6 transcripts (splice variants), 273 orthologues, 53 paralogues and is associated with 73 phenotypes. Broad expression in spleen adult (RPKM 69.7), placenta adult (RPKM 34.8) and 23 other tissues.

Summary

Enables several functions, including macrophage colony-stimulating factor receptor activity; protein homodimerization activity; and protein Phosphatase binding activity. Involved in several processes, including nervous system development; positive regulation of protein phosphorylation; and protein phosphorylation. Located in cell surface and plasma membrane. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and limb. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Csf1r Products(1)

mRNA Protein Name
NM_001037859.2 NP_001032948.2 macrophage colony-stimulating factor 1 receptor precursor

Csf1r Protein Structure

IG

IG: smart00409 (27 - 100)

IG_like

IG_like: smart00410 (112 - 194)

Ig

Ig: cl11960 (202 - 294)

Ig

Ig: cd00096 (219 - 223)

Ig

Ig: cd00096 (233 - 237)

Ig

Ig: cd00096 (258 - 262)

Ig

Ig: cd00096 (274 - 279)

Ig

Ig: cd00096 (287 - 290)

Ig

Ig: cl11960 (298 - 397)

Ig

Ig: cd00096 (318 - 322)

Ig

Ig: cd00096 (332 - 336)

Ig

Ig: cd00096 (361 - 365)

Ig

Ig: cd00096 (375 - 380)

Ig

Ig: cd00096 (388 - 391)

Ig_3

Ig_3: pfam13927 (398 - 486)

PTKc_CSF-1R

PTKc_CSF-1R: cd05106 (540 - 912)

  • 0
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  • 800
  • 977 a.a.
Protein Preferred Names Protein Names

macrophage colony-stimulating factor 1 receptor

CSF-1 receptor

CSF-1-R

c-fms

proto-oncogene c-Fms

proto-oncogene fms

Recombinant Csf1r Proteins

Cat. No. Product Name Accession Purity
HY-P72951 CSF1R Protein, Mouse (HEK293, Fc) P09581 (A20-S511) ≥95%
HY-P72952 CSF1R Protein, Mouse (HEK293, His) P09581 (A20-S511) ≥95%
HY-P72953 CSF1R Protein, Mouse (Biotinylated, HEK293, His) P09581 (A20-S511) ≥95%
HY-P78706 CSF1R Protein, Mouse (492a.a, HEK293, His) P09581 (A20-S511) ≥95%
HY-P78707 CSF1R Protein, Mouse (492a.a, HEK293, Fc) P09581 (A20-S511) ≥95%
HY-P78892 CSF1R Protein, Mouse (Biotinylated, HEK293, His-Avi) P09581 (A20-S511) ≥95%

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16749 Pexidartinib 99.64% Yes
HY-16749A Pexidartinib hydrochloride 99.86% Yes
HY-12297 Sulfatinib Inhibitor 98.65% Unkown
Clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Phase
HY-50905 Dovitinib Inhibitor 99.94% Phase 3
HY-124526 Chiauranib Inhibitor 99.28% Phase 3
HY-12768 Sotuletinib Inhibitor 99.78% Phase 2
HY-109086 Edicotinib Inhibitor 98.78% Phase 2
HY-111787 Elzovantinib Inhibitor 99.97% Phase 2
HY-109190 Seralutinib Inhibitor 99.77% Phase 2
HY-12768A Sotuletinib hydrochloride Inhibitor 98.84% Phase 2
HY-114153 PLX5622 Inhibitor 99.95% Phase 1
HY-114153A PLX5622 hemifumarate Inhibitor 99.64% Phase 1
HY-101768 PRN1371 Inhibitor 99.43% Phase 1
HY-10204 OSI-930 98.57% Phase 1
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P99245 Emactuzumab Inhibitor 97.60% Phase 3
HY-P99259 Cabiralizumab Inhibitor 99.59% Phase 2
HY-P99452 Axatilimab Inhibitor 99.59% Phase 2
HY-P99368 Lacnotuzumab Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (44)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10408 Ki20227 Inhibitor 99.17% Unkown
HY-117244 AZD7507 Inhibitor 99.45% Unkown
HY-132935 BPR1R024 Inhibitor 99.06% Unkown
HY-101774 CSF1R-IN-1 Inhibitor 98.11% Unkown
HY-117273 AZ304 Inhibitor 99.96% Unkown
HY-153920 Pimicotinib Inhibitor 99.69% Unkown
HY-112451 cFMS Receptor Inhibitor II Inhibitor 99.80% Unkown
HY-136362 ARRY-382 Inhibitor 99.63% Unkown
HY-139990 CSF1R-IN-3 Inhibitor 98.26% Unkown
HY-13493 AC710 Inhibitor 98.56% Unkown
HY-100491 H3B-6527 Inhibitor ≥98.0% Unkown
HY-119942 c-Fms-IN-8 Inhibitor 99.47% Unkown
HY-122906 JTE-952 Inhibitor 99.95% Unkown
HY-101526 GENZ-882706 Inhibitor / Unkown
HY-126297 c-Fms-IN-10 Inhibitor 98.04% Unkown
HY-132935A BPR1R024 mesylate Inhibitor / Unkown
HY-12768B Sotuletinib dihydrochloride Inhibitor / Unkown
HY-144040 CSF1R-IN-4 / Unkown
HY-144041 CSF1R-IN-5 Inhibitor / Unkown
HY-144042 CSF1R-IN-6 / Unkown
HY-147608 CSF1R-IN-7 Inhibitor / Unkown
HY-147609 CSF1R-IN-8 Inhibitor / Unkown
HY-147610 CSF1R-IN-9 Inhibitor / Unkown
HY-147611 CSF1R-IN-10 Inhibitor / Unkown
HY-147615 CSF1R-IN-12 / Unkown
HY-147616 CSF1R-IN-13 / Unkown
HY-147617 CSF1R-IN-14 / Unkown
HY-153012 Axl/Mer/CSF1R-IN-1 Inhibitor / Unkown
HY-153243 IACS-9439 Inhibitor / Unkown
HY-153277 Axl/Mer/CSF1R-IN-2 Inhibitor / Unkown
HY-155001 CSF1R-IN-15 Inhibitor / Unkown
HY-155550 CSF1R-IN-17 Antagonist / Unkown
HY-157422 CSF1R-IN-19 Inhibitor / Unkown
HY-157996 CSF1R-IN-21 Inhibitor / Unkown
HY-158050 PXB17 Inhibitor / Unkown
HY-158148 CSF1R-IN-23 Inhibitor / Unkown
HY-161025 SYHA1813 Inhibitor / Unkown
HY-161084 CSF1R-IN-18 Inhibitor / Unkown
HY-162309 CSF1R-IN-20 Inhibitor / Unkown
HY-RS03228 CSF1R Human Pre-designed siRNA Set A / Unkown
HY-RS03229 Csf1r Mouse Pre-designed siRNA Set A / Unkown
HY-RS03230 Csf1r Rat Pre-designed siRNA Set A / Unkown
HY-13493A AC710 Mesylate Inhibitor / Unkown
HY-101034 CHMFL-ABL/KIT-155 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Csf1r NCBI NCBI:1436
Macaca fascicularis Csf1r NCBI NCBI:102124214
Rattus norvegicus Csf1r NCBI NCBI:307403
Macaca mulatta Csf1r NCBI NCBI:711512