Glp1r - glucagon-like peptide 1 receptor Gene

Also Known as GLP-1R; GLP1Rc

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14652

Summary

Predicted to enable glucagon-like peptide 1 receptor activity and peptide hormone binding activity. Involved in several processes, including learning or memory; positive regulation of blood pressure; and response to psychosocial stress. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and lung. Orthologous to human GLP1R (glucagon like peptide 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Glp1r Products (1)

mRNA Protein Name
NM_021332.2 NP_067307.2 glucagon-like peptide 1 receptor precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive effect hormone secretion IMP
IMP: Inferred from mutant phenotype
23542788 MGI
involved in learning or memory IMP
IMP: Inferred from mutant phenotype
12925848 MGI
acts upstream of negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
23542788 MGI
involved in positive regulation of blood pressure IDA
IDA: Inferred from direct assay
21810595 MGI
acts upstream of or within post-translational protein targeting to membrane, translocation IMP
IMP: Inferred from mutant phenotype
23542788 MGI
involved in regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
12746281 MGI
involved in response to psychosocial stress IMP
IMP: Inferred from mutant phenotype
10650957 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glucagon-like peptide 1 receptor

  • GLP-1 receptor

  • GLP-1-R

Recombinant Glp1r Proteins

Cat. No. Product Name Accession Purity
HY-P72206 GLP1R Protein, Mouse (His-SUMO) O35659 (G22-Y145) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114118 Semaglutide 99.74% Unkown
HY-112185 Orforglipron Agonist 99.64% Unkown
HY-114118A Semaglutide TFA 99.74% Unkown
HY-114118B Semaglutide acetate 99.96% Unkown
HY-112185A Orforglipron hemicalcium hydrate Agonist 99.58% Unkown

Clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Phase
HY-P3375 Mazdutide Agonist 99.97% Phase 3
HY-164535 Maridebart cafraglutide 99.24% Phase 3
HY-P4146A Survodutide TFA Agonist 99.39% Phase 3
HY-P11672 Poterepatide Agonist 99.78% Phase 3
HY-P3506B Retatrutide acetate Agonist 99.69% Phase 3
HY-125824 Danuglipron Agonist 99.85% Phase 2
HY-153865 Lotiglipron Agonist 98.96% Phase 2
HY-P3291 Dapiglutide Agonist 98.52% Phase 2
HY-175701 CT-996 99.97% Phase 2
HY-177295 Naperiglipron 99.43% Phase 2
HY-145632 Pemvidutide Agonist 99.40% Phase 2
HY-P10018 Bamadutide Agonist 99.94% Phase 2
HY-172811 DA-302168S Agonist 98.01% Phase 2
HY-125824A Danuglipron tromethamine Agonist / Phase 2
HY-145458 PF-06954522 Agonist 99.70% Phase 1
HY-P10031 SAR441255 Agonist 99.84% Phase 1

Pre-clinical Phase

Bioactive Molecules (121)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3506 Retatrutide Agonist 99.96% Unkown
HY-P4146 Survodutide Agonist 99.99% Unkown
HY-121835 GLP-1R agonist 2 Agonist 99.57% Unkown
HY-101116 GLP-1R Antagonist 1 Antagonist 99.67% Unkown
HY-P3506A Retatrutide TFA Agonist 99.86% Unkown
HY-P10736A AMG133 peptide payload TFA Agonist 99.70% Unkown
HY-160734 Aleniglipron Agonist 99.88% Unkown
HY-45894 tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu Control 98.04% Unkown
HY-114118S3 Semaglutide-13C6,15N TFA 96.04% Unkown
HY-P10736 AMG133 peptide payload 99.94% Unkown
HY-142162 LSN3318839 Modulator 99.22% Unkown
HY-114118CP Semaglutide (crude) 77.53% Unkown
HY-143312 V-0219 Modulator 99.90% Unkown
HY-P10302A GLP-1R/GIPR agonist-1 (soduim) Agonist 98.24% Unkown
HY-116819 VU0453379 Modulator 98.0% Unkown
HY-153193 LSN3160440 Modulator 98.08% Unkown
HY-114118S Semaglutide-d8 99.88% Unkown
HY-P0264A Exendin(9-39) amide acetate Antagonist 99.41% Unkown
HY-163996 DD202-114 99.27% Unkown
HY-112679 GLP-1 receptor agonist 2 Agonist 98.70% Unkown
HY-147623 GLP-1R agonist 10 Agonist 98.19% Unkown
HY-P3375A Mazdutide TFA Agonist 99.67% Unkown
HY-114118F4 Semaglutide-FITC Agonist 96.42% Unkown
HY-141840 GLP-1R modulator C5 Modulator 99.81% Unkown
HY-P10929 Fmoc-Lys(tBuO-Ara-Glu(AEEA-AEEA)-OtBu)-OH 99.31% Unkown
HY-P11237 Enicepatide Agonist 98.16% Unkown
HY-P10019 Pegsebrenatide Agonist 95.50% Unkown
HY-141842 GLP-1R modulator L7-028 Modulator 99.47% Unkown
HY-P10716 Exendin-P5 Activator 96.32% Unkown
HY-P11235A Berobenatide acetate Agonist 98.65% Unkown
HY-148212 GLP-1R agonist 17 Agonist 99.82% Unkown
HY-P10031A SAR441255 TFA Agonist 99.93% Unkown
HY-114118S1 Semaglutide-d8 tetraTFA 99.87% Unkown
HY-13443F2 Exendin-4, Cy5 labeled 97.16% Unkown
HY-143312A V-0219 hydrochloride Modulator 99.39% Unkown
HY-143312E (S)-V-0219 hydrochloride Modulator 99.71% Unkown
HY-144034 GLP-1R agonist 3 Agonist 95.76% Unkown
HY-145632A Pemvidutide TFA Antagonist 98.03% Unkown
HY-141839 GLP-1R modulator C16 Modulator 98.67% Unkown
HY-143312D (R)-V-0219 hydrochloride Modulator 98.92% Unkown
HY-124803 GPCR modulator-1 Modulator / Unkown
HY-147625 GLP-1R agonist 12 Agonist 95.06% Unkown
HY-P4146B Survodutide sodium Agonist / Unkown
HY-116819A VU0453379 hydrochloride Modulator 99.0% Unkown
HY-144035 GLP-1R agonist 4 Agonist 98.26% Unkown
HY-147622 GLP-1R agonist 9 Agonist / Unkown
HY-P10302 GLP-1R/GIPR agonist-1 Agonist / Unkown
HY-RS05490 GLP1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-142162A (S,R)-LSN3318839 Control 98.25% Unkown
HY-145458A PF-06954522 citrate Agonist / Unkown
HY-153193A (1R)-LSN3160440 98.43% Unkown
HY-N2452 Cochinchinenin C Agonist / Unkown
HY-RS16631 Glp1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-138996 GLP-1 receptor agonist 8 Agonist / Unkown
HY-114118C Semaglutide sodium / Unkown
HY-129657 GLP-1 receptor agonist 4 Agonist / Unkown
HY-143312B (R)-V-0219 Modulator / Unkown
HY-143312C (S)-V-0219 Modulator / Unkown
HY-144033 GLP-1R agonist 1 Agonist / Unkown
HY-144133 GLP-1R agonist 5 Agonist / Unkown
HY-144134 GLP-1R agonist 6 Agonist / Unkown
HY-144135 GLP-1R agonist 7 Agonist / Unkown
HY-144136 GLP-1R agonist 8 Agonist / Unkown
HY-145156 CHU-128 Agonist / Unkown
HY-147626 GLP-1R agonist 13 Agonist / Unkown
HY-147627 GLP-1R agonist 14 Agonist / Unkown
HY-147628 GLP-1R agonist 15 Agonist / Unkown
HY-147629 GLP-1R agonist 16 Agonist / Unkown
HY-160031 GLP-1R agonist 19 Agonist / Unkown
HY-161915 GLP-1R agonist 23 Agonist / Unkown
HY-162306 GLP-1R agonist 18 Agonist / Unkown
HY-162433 GLP-1R agonist 41 Agonist / Unkown
HY-162434 GLP-1R agonist 42 Agonist / Unkown
HY-162435 GLP-1R agonist 20 Agonist / Unkown
HY-162436 GLP-1R agonist 21 Agonist / Unkown
HY-162437 GLP-1R agonist 22 Agonist / Unkown
HY-168481 GLP-1R agonist 27 Agonist / Unkown
HY-171302 GLP-1R/GIPR agonist-2 Agonist / Unkown
HY-171850 GLP-1R modulator-1 Agonist / Unkown
HY-171851 GLP-1R agonist 32 Agonist / Unkown
HY-172410 GLP-1R agonist 28 Agonist / Unkown
HY-172673 GLP-1R agonist 31 Agonist / Unkown
HY-172836S GLP-1 receptor agonist 17-d3 Agonist / Unkown
HY-173479 GLP-1R agonist 30 Agonist / Unkown
HY-176493 GLP-1R agonist 33 Agonist / Unkown
HY-176770 GLP-1R agonist 34 Agonist / Unkown
HY-178768 GLP-1R agonist 35 Antagonist / Unkown
HY-178769 GLP-1R agonist 36 Agonist / Unkown
HY-181709 TPM003 Agonist / Unkown
HY-182502 GLP-1R-agonist-43 Agonist / Unkown
HY-182580 HBK001 / Unkown
HY-182849 GLP-1R agonist 44 Agonist / Unkown
HY-183693 GLP-1 receptor agonist 21 Agonist / Unkown
HY-P0165B Taspoglutide acetate Agonist / Unkown
HY-P10337 OXM-7 Agonist / Unkown
HY-P10842 d-GLP-2 E33A Agonist / Unkown
HY-P11043 GEP44 / Unkown
HY-P11044 GEP12 Agonist / Unkown
HY-P11235 Berobenatide Agonist / Unkown
HY-P11262 GUB021794 Agonist / Unkown
HY-P11275 TC4 Agonist / Unkown
HY-P11279 TC2 Agonist / Unkown
HY-P11487 UTG-4 Agonist / Unkown
HY-P11670 Linvixdutide Agonist / Unkown
HY-P11818 GIPR/GLP-1R/GCGR agonist-1 / Unkown
HY-P11945 NOTA-MAL-Cys39-Exendin-4 Ligand / Unkown
HY-P3506CP Retatrutide (crude) Agonist / Unkown
HY-P3539 Exendin-4 (3-39) / Unkown
HY-P3542 Des His1, Glu8 Exendin-4 Antagonist / Unkown
HY-P4386 (Asp28)-Exenatide Agonist / Unkown
HY-P5161 FC382K10W15 Agonist / Unkown
HY-P5161A FC382K10W15 TFA Agonist / Unkown
HY-W823500 GLP-1R agonist 39 98.37% Unkown
HY-162979 GLP-1R agonist 25 Agonist / Unkown
HY-168585 GLP-1R agonist 26 Agonist / Unkown
HY-172411 GLP-1R agonist 29 Agonist / Unkown
HY-180220 GLP-1R agonist 40 Agonist / Unkown
HY-180489 GLP-1R agonist 38 Agonist / Unkown
HY-187343 GLP-1R agonist 45 Agonist / Unkown
HY-187344 GLP-1R prodrug-1 / Unkown
HY-RS23066 Glp1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990013 Gulgafafusp alfa Inhibitor 95.481% Unkown
HY-P991099 Anti-GLP1R Antibody Inhibitor 97.19% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Glp1r NCBI NCBI:2740