DHODH - dihydroorotate dehydrogenase (quinone) Gene

Also Known as URA1; POADS; DHOdehase

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1723

About DHODH

Cytogenetic location: 16q22.2 Genomic coordinates (GRCh38): 16:72,008,744-72,027,659 (from NCBI)

This gene has 9 transcripts (splice variants), 173 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in liver (RPKM 7.8), kidney (RPKM 1.7) and 24 other tissues.

Summary

The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]

DHODH Products (4)

mRNA	Protein	Name
NM_001361.5	NP_001352.2	dihydroorotate dehydrogenase (quinone), mitochondrial
NM_001025193.1
XM_005255829.5	XP_005255886.1	dihydroorotate dehydrogenase (quinone), mitochondrial isoform X2
XM_047433674.1	XP_047289630.1	dihydroorotate dehydrogenase (quinone), mitochondrial isoform X1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables dihydroorotate dehydrogenase (quinone) activity	IDA IDA: Inferred from direct assay	8925840	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHODH Protein Structure

DHO_dh

0
100
200
300
395 a.a.

Protein Preferred Names	Protein Names
dihydroorotate dehydrogenase (quinone), mitochondrial	dihydroorotate oxidase human complement of yeast URA1

DHODH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DHODH	Q02127	RNF19B	Homo sapiens	Q6ZMZ0	Validated Y2H	32296183
Intra	DHODH	Q02127	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Array	32296183
Intra	DHODH	Q02127	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

DHODH Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811246	DHODH Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Orotic Aciduria	Hereditary Orotic Aciduria Orotidylic Pyrophosphorylase And Orotidylic Decarboxylase Deficiency Uridine Monophosphate Synthase Deficiency Umps Deficiency Uridine Monophosphate Synthetase Deficiency Orotic Aciduria I Orotate Phosphoribosyltransferase And Orotidylic Decarboxylase Deficiency Oprt And Odc Deficiency Ump Synthase Deficiency Orotic Aciduria Ii Oroticaciduria 1 Orotic Aciduria Hereditary Orotic Aciduria Type 1 Hereditary Orotic Aciduria Without Megaloblastic Anemia Orotate Phosphoribosyltransferase And Omp Decarboxylase Deficiency Ump Synthtase Deficiency Umps Orotidylic Decarboxylase Deficiency Orotic Aciduria 1 ORAC1 Aciduria, Orotic Hereditary Orotic Aciduria, Type 1 Orotic Aciduria Nos Orotaciduric Anaemia Orotic Aciduria Anaemia Orotic Aciduria Megaloblastic Anaemia
Progressive Relapsing Multiple Sclerosis	Prms Progressive-Relapsing Ms Multiple Sclerosis, Progressive Relapsing
Progressive Multifocal Leukoencephalopathy	Pml Leukoencephalopathy, Progressive Multifocal Progressive Multifocal Leukoencephalitis Leukoencephalopathy Progressive Multifocal Pml - [Progressive Multifocal Leukoencephalopathy]
Acrofacial Dysostosis 1, Nager Type	Nager Syndrome Nager Acrofacial Dysostosis AFD1 Preaxial Acrofacial Dysostosis Mandibulofacial Dysostosis, Treacher Collins Type, With Limb Anomalies Afd, Nager Type Nager Acrofacial Dysostosis Syndrome Nafd Acrofacial Dysostosis, Nager Type Afd Preaxial Manibulofacial Dysostosis Split Hand Deformity-Mandibulofacial Dysostosis Preaxial Mandibulofacial Dysostosis Mandibulofacial Dysostosis With Preaxial Limb Anomalies Preaxial Acrodysostosis Afd Nager Type Mandibulofacial Dysostosis Treacher Collins Type With Limb Anomalies
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease
Fusariosis	Fusarium Infection
Dysostosis	Dysostoses
Postaxial Acrofacial Dysostosis	Miller Syndrome POADS Genee-Wiedemann Syndrome Postaxial Acrodysostosis Genee-Wiedemann Acrofacial Dysostosis Acrofacial Dysostosis, Genee-Wiedmann Type Mandibulfacial Dysostosis With Postaxial Limb Anomalies Gwafd Poads Syndrome Postaxial Acrofacial Dysostosis Syndrome Wildervanck-Smith Syndrome Acrofacial Dysostosis, Genee-Wiedemann Type Mandibulofacial Dysostosis With Postaxial Limb Anomalies Genée-Wiedemann Syndrome Chromosome 11p Deletion Syndrome
Acrofacial Dysostosis
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Pyrimidine Metabolic Disorder	Disorder Of Pyrimidine Metabolism Pyrimidine Metabolism Disorder
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Primary Progressive Multiple Sclerosis	Ppms Primary-Progressive Ms Multiple Sclerosis, Primary Progressive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0083	Leflunomide	Inhibitor	99.82%	Yes
HY-N0157	Orotic acid	Chemical	99.98%	Unkown
HY-N0157R	Orotic acid (Standard)	Chemical	99.51%	Unkown
HY-N0157A	Orotic acid zinc	Chemical	99.84%	Unkown

Clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Phase
HY-104029	Olorofim	Inhibitor	99.38%	Phase 3
HY-124593	PTC299	Inhibitor	99.71%	Phase 3
HY-108325	Brequinar	Inhibitor	99.94%	Phase 2
HY-129239	Farudodstat		99.68%	Phase 2
HY-101813	Laflunimus	Inhibitor	99.70%	Phase 2
HY-14908A	Vidofludimus hemicalcium		/	Phase 2
HY-112645	BAY-2402234	Inhibitor	99.90%	Phase 1
HY-139189	JNJ-74856665	Inhibitor	99.88%	Phase 1
HY-137463	AG-636	Inhibitor	98.07%	Phase 1
HY-152851	Izumerogant	Inhibitor	99.95%	Phase 1

Pre-clinical Phase

Bioactive Molecules (74)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W015495	L-Dihydroorotic acid	Substrate	99.97%	Unkown
HY-14908	Vidofludimus		99.14%	Yes
HY-15510	Tenovin-6		98.00%	Unkown
HY-148394	UCK2 Inhibitor-1	Inhibitor	96.32%	Unkown
HY-N6961	Lapachol	Inhibitor	99.49%	Unkown
HY-100688	ML390	Inhibitor	99.95%	Unkown
HY-13423	Tenovin-1		99.88%	Unkown
HY-128068	DHODH-IN-17	Inhibitor	99.91%	Unkown
HY-N0157S1	Orotic acid-13C,15N2 monohydrate		99.93%	Unkown
HY-15510B	Tenovin-6 Hydrochloride		98.88%	Unkown
HY-135282	DHODH-IN-1	Inhibitor	98.65%	Unkown
HY-153112	DHODH-IN-23	Inhibitor	98.75%	Unkown
HY-32757	5-Bromo-2-fluoro-3-methylpyridine		99.90%	Unkown
HY-RS03734	DHODH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-148396	UCK2 Inhibitor-3		98.65%	Unkown
HY-132171A	DSM705 hydrochloride	Inhibitor	98.22%	Unkown
HY-132174	CHIKV-IN-2	Inhibitor	99.21%	Unkown
HY-128787	hDHODH-IN-4	Inhibitor	99.73%	Unkown
HY-135664	hDHODH-IN-5	Inhibitor	98.55%	Unkown
HY-135678	DHODH-IN-14	Inhibitor	99.81%	Unkown
HY-148395	UCK2 Inhibitor-2	Inhibitor	99.25%	Unkown
HY-N3097	Pellitorine		99.84%	Unkown
HY-N7961	(E/Z)-Ginkgolic acid C17:2	Inhibitor	99.37%	Unkown
HY-132170	DSM502	Inhibitor	99.74%	Unkown
HY-135675	DHODH-IN-11	Inhibitor	99.69%	Unkown
HY-175352	Nurr1 agonist 14		99.42%	Unkown
HY-176728	DHODH-IN-27	Inhibitor	99.77%	Unkown
HY-170780A	(S)-DSM1465	Inhibitor	99.53%	Unkown
HY-120924	BRD9185	Inhibitor	/	Unkown
HY-132171	DSM705	Inhibitor	/	Unkown
HY-135618	DHODH-IN-3	Inhibitor	/	Unkown
HY-135619	DHODH-IN-4	Inhibitor	/	Unkown
HY-135666	DHODH-IN-8	Inhibitor	/	Unkown
HY-135667	hDHODH-IN-7	Inhibitor	/	Unkown
HY-135676	DHODH-IN-12	Inhibitor	/	Unkown
HY-135677	DHODH-IN-13	Inhibitor	/	Unkown
HY-135679	DHODH-IN-15	Inhibitor	/	Unkown
HY-139825	Indoluidin E	Inhibitor	/	Unkown
HY-139889	DHODH-IN-18	Inhibitor	/	Unkown
HY-142834	RORγt/DHODH-IN-2	Inhibitor	/	Unkown
HY-142843	RORγt/DHODH-IN-1	Inhibitor	/	Unkown
HY-142847	RORγt/DHODH-IN-3	Inhibitor	/	Unkown
HY-144169	DHODH-IN-19	Inhibitor	/	Unkown
HY-144371	DHODH-IN-20	Inhibitor	/	Unkown
HY-146317	P1788	Inhibitor	/	Unkown
HY-149030	DHODH-IN-21	Inhibitor	/	Unkown
HY-149031	DHODH-IN-22	Inhibitor	/	Unkown
HY-149877	hDHODH-IN-12	Inhibitor	/	Unkown
HY-158023	DHODH-IN-26		/	Unkown
HY-163158	DHODH-IN-24	Inhibitor	/	Unkown
HY-163328	DHODH-IN-25	Inhibitor	/	Unkown
HY-174816	DHODH-IN-28	Inhibitor	/	Unkown
HY-175259	DHODH-IN-29	Inhibitor	/	Unkown
HY-178156	DHODH-IN-31	Inhibitor	99.55%	Unkown
HY-178941	DHODH-IN-32		/	Unkown
HY-179531	DHODH-IN-33		/	Unkown
HY-182550	Indoluidin D	Inhibitor	/	Unkown
HY-B0083S	Leflunomide-d4	Inhibitor	/	Unkown
HY-RS03735	Dhodh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03736	Dhodh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W347485	DHODH-IN-35		/	Unkown
HY-108325S	Brequinar-d3	Inhibitor	/	Unkown
HY-117908	DSM267	Inhibitor	/	Unkown
HY-120462	Genz-669178	Inhibitor	/	Unkown
HY-129253	GSK984	Control	/	Unkown
HY-135662	DHODH-IN-34	Inhibitor	/	Unkown
HY-15510S	Tenovin-6-d6		/	Unkown
HY-165191	LY214352	Inhibitor	/	Unkown
HY-169220S	RORγ/DHODH-IN-1	Inhibitor	/	Unkown
HY-169222S	RORγ/DHODH-IN-2	Inhibitor	/	Unkown
HY-175423	DHODH-IN-30	Inhibitor	/	Unkown
HY-181588	NR4A agonist-2	Agonist	/	Unkown
HY-183925	Redoxal	Inhibitor	/	Unkown
HY-B0083S1	Leflunomide-13C6	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DHODH	MGD	MGI:1928378
Canis familiaris	DHODH	VGNC	VGNC:53333
Rattus norvegicus	DHODH	RGD	RGD:68352
Others	DHODH	NCBI