DHODH - dihydroorotate dehydrogenase (quinone) Gene

Homo sapiens

Also known as URA1; POADS; DHOdehase

Gene ID: 1723 | Gene type: protein coding

About DHODH

Cytogenetic location: 16q22.2 Genomic coordinates (GRCh38): 16:72,008,744-72,027,659 (from NCBI)

This gene has 9 transcripts (splice variants), 173 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in liver (RPKM 7.8), kidney (RPKM 1.7) and 24 other tissues.

Summary

The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]

DHODH Products(4)

mRNA	Protein	Name
NM_001361.5	NP_001352.2	dihydroorotate dehydrogenase (quinone), mitochondrial
NM_001025193.1
XM_005255829.5	XP_005255886.1	dihydroorotate dehydrogenase (quinone), mitochondrial isoform X2
XM_047433674.1	XP_047289630.1	dihydroorotate dehydrogenase (quinone), mitochondrial isoform X1

DHODH Protein Structure

DHO_dh

0
100
200
300
395 a.a.

Protein Preferred Names

Protein Names

dihydroorotate dehydrogenase (quinone), mitochondrial

dihydroorotate oxidase

human complement of yeast URA1

Recombinant DHODH Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78957	Dihydroorotate Dehydrogenase Protein, Human (His)	Q02127 (T31-R395)	≥95%

Related Diseases

Diseases

Alias

Orotic Aciduria

Hereditary Orotic Aciduria	Orotidylic Pyrophosphorylase And Orotidylic Decarboxylase Deficiency
Uridine Monophosphate Synthase Deficiency	Umps Deficiency
Uridine Monophosphate Synthetase Deficiency	Orotic Aciduria I
Orotate Phosphoribosyltransferase And Orotidylic Decarboxylase Deficiency	Oprt And Odc Deficiency
Ump Synthase Deficiency	Orotic Aciduria Ii
Oroticaciduria 1	Orotic Aciduria Hereditary
Orotic Aciduria Type 1	Hereditary Orotic Aciduria Without Megaloblastic Anemia
Orotate Phosphoribosyltransferase And Omp Decarboxylase Deficiency	Ump Synthtase Deficiency
Umps	Orotidylic Decarboxylase Deficiency
Orotic Aciduria 1	ORAC1
Aciduria, Orotic	Hereditary Orotic Aciduria, Type 1
Orotic Aciduria Nos	Orotaciduric Anaemia
Orotic Aciduria Anaemia	Orotic Aciduria Megaloblastic Anaemia

Progressive Relapsing Multiple Sclerosis

Prms	Progressive-Relapsing Ms
Multiple Sclerosis, Progressive Relapsing

Progressive Multifocal Leukoencephalopathy

Pml	Leukoencephalopathy, Progressive Multifocal
Progressive Multifocal Leukoencephalitis	Leukoencephalopathy Progressive Multifocal
Pml - [Progressive Multifocal Leukoencephalopathy]

Acrofacial Dysostosis 1, Nager Type

Nager Syndrome	Nager Acrofacial Dysostosis
AFD1	Preaxial Acrofacial Dysostosis
Mandibulofacial Dysostosis, Treacher Collins Type, With Limb Anomalies	Afd, Nager Type
Nager Acrofacial Dysostosis Syndrome	Nafd
Acrofacial Dysostosis, Nager Type	Afd
Preaxial Manibulofacial Dysostosis	Split Hand Deformity-Mandibulofacial Dysostosis
Preaxial Mandibulofacial Dysostosis	Mandibulofacial Dysostosis With Preaxial Limb Anomalies
Preaxial Acrodysostosis	Afd Nager Type
Mandibulofacial Dysostosis Treacher Collins Type With Limb Anomalies

Parasitic Protozoa Infectious Disease

Protozoan Infections	Mastigophora Infectious Disease
Sarcomastigophora Infectious Disease

Fusariosis

Fusarium Infection

Dysostosis

Dysostoses

Postaxial Acrofacial Dysostosis

Miller Syndrome	POADS
Genee-Wiedemann Syndrome	Postaxial Acrodysostosis
Genee-Wiedemann Acrofacial Dysostosis	Acrofacial Dysostosis, Genee-Wiedmann Type
Mandibulfacial Dysostosis With Postaxial Limb Anomalies	Gwafd
Poads Syndrome	Postaxial Acrofacial Dysostosis Syndrome
Wildervanck-Smith Syndrome	Acrofacial Dysostosis, Genee-Wiedemann Type
Mandibulofacial Dysostosis With Postaxial Limb Anomalies	Genée-Wiedemann Syndrome
Chromosome 11p Deletion Syndrome

Acrofacial Dysostosis

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Pyrimidine Metabolic Disorder

Disorder Of Pyrimidine Metabolism

Pyrimidine Metabolism Disorder

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Primary Progressive Multiple Sclerosis

Ppms	Primary-Progressive Ms
Multiple Sclerosis, Primary Progressive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0083	Leflunomide	Inhibitor	99.74%	Yes
HY-N0157	Orotic acid	Chemical	98.14%	Unkown
HY-110159	(E/Z)-Teriflunomide	Inhibitor	99.86%	Yes
HY-N0157A	Orotic acid zinc	Chemical	≥98.0%	Unkown
HY-N0157R	Orotic acid (Standard)	Chemical	/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108325	Brequinar	Inhibitor	99.75%	Phase 2
HY-14908	Vidofludimus		99.11%	Phase 2
HY-129239	Farudodstat		99.70%	Phase 2
HY-112645	BAY-2402234	Inhibitor	99.88%	Phase 1

Pre-clinical Phase

Bioactive Molecules (52)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124593	PTC299	Inhibitor	99.52%	Unkown
HY-15510	Tenovin-6		98.33%	Unkown
HY-N6961	Lapachol	Inhibitor	99.06%	Unkown
HY-137463	AG-636	Inhibitor	98.25%	Unkown
HY-13423	Tenovin-1		99.88%	Unkown
HY-100688	ML390	Inhibitor	99.96%	Unkown
HY-139189	DHODH-IN-16	Inhibitor	99.88%	Unkown
HY-104029	Olorofim	Inhibitor	98.76%	Yes
HY-15510B	Tenovin-6 Hydrochloride		≥98.0%	Unkown
HY-128787	hDHODH-IN-4	Inhibitor	99.68%	Unkown
HY-132174	CHIKV-IN-2	Inhibitor	98.15%	Unkown
HY-101813	Laflunimus	Inhibitor	99.76%	Unkown
HY-128068	DHODH-IN-17	Inhibitor	99.91%	Unkown
HY-135282	DHODH-IN-1	Inhibitor	/	Unkown
HY-153112	DHODH-IN-23	Inhibitor	99.82%	Unkown
HY-132170	DSM502	Inhibitor	99.57%	Unkown
HY-132171A	DSM705 hydrochloride	Inhibitor	99.56%	Unkown
HY-135675	DHODH-IN-11	Inhibitor	99.94%	Unkown
HY-N7961	(E/Z)-Ginkgolic acid C17:2	Inhibitor	95.02%	Unkown
HY-120924	BRD9185	Inhibitor	/	Unkown
HY-132171	DSM705	Inhibitor	/	Unkown
HY-14908A	Vidofludimus hemicalcium		/	Unkown
HY-135618	DHODH-IN-3	Inhibitor	/	Unkown
HY-135619	DHODH-IN-4	Inhibitor	/	Unkown
HY-135664	hDHODH-IN-5	Inhibitor	/	Unkown
HY-135666	DHODH-IN-8	Inhibitor	/	Unkown
HY-135667	hDHODH-IN-7	Inhibitor	/	Unkown
HY-135676	DHODH-IN-12	Inhibitor	/	Unkown
HY-135677	DHODH-IN-13	Inhibitor	/	Unkown
HY-135678	DHODH-IN-14	Inhibitor	/	Unkown
HY-135679	DHODH-IN-15	Inhibitor	/	Unkown
HY-139825	Indoluidin E	Inhibitor	/	Unkown
HY-139889	DHODH-IN-18	Inhibitor	/	Unkown
HY-142834	RORγt/DHODH-IN-2	Inhibitor	/	Unkown
HY-142843	RORγt/DHODH-IN-1	Inhibitor	/	Unkown
HY-142847	RORγt/DHODH-IN-3	Inhibitor	/	Unkown
HY-144169	DHODH-IN-19	Inhibitor	/	Unkown
HY-144371	DHODH-IN-20	Inhibitor	/	Unkown
HY-146317	P1788	Inhibitor	/	Unkown
HY-148395	UCK2 Inhibitor-2	Inhibitor	/	Unkown
HY-148396	UCK2 Inhibitor-3		/	Unkown
HY-149030	DHODH-IN-21	Inhibitor	/	Unkown
HY-149031	DHODH-IN-22	Inhibitor	/	Unkown
HY-149877	hDHODH-IN-12	Inhibitor	/	Unkown
HY-158023	DHODH-IN-26		/	Unkown
HY-163158	DHODH-IN-24	Inhibitor	/	Unkown
HY-163328	DHODH-IN-25	Inhibitor	/	Unkown
HY-B0083S	Leflunomide-d4	Inhibitor	/	Unkown
HY-N0157S1	Orotic acid-13C,15N2 monohydrate		/	Unkown
HY-RS03734	DHODH Human Pre-designed siRNA Set A		/	Unkown
HY-RS03735	Dhodh Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS03736	Dhodh Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DHODH	MGD	MGI:1928378
Canis familiaris	DHODH	VGNC	VGNC:53333
Rattus norvegicus	DHODH	RGD	RGD:68352
Others	DHODH	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.