2. Gene
  3. Cftr - CF transmembrane conductance regulator Gene

Cftr - CF transmembrane conductance regulator Gene

  • Gene
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1561193

Gene ID: 24255 | Gene type: protein coding

About Cftr

Primary_assembly 4: 46,560,885-46,728,756 forward strand.mRatBN7.2:CM026977.1

This gene has 5 transcripts (splice variants), 215 orthologues, 11 paralogues and is associated with 83 phenotypes.

Summary

Predicted to enable several functions, including PDZ domain binding activity; Sec61 translocon complex binding activity; and anion transmembrane transporter activity. Involved in several processes, including animal organ development; anion transport; and regulation of cell development. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and microvillus. Colocalizes with early endosome. Used to study congenital bilateral absence of vas deferens; cystic fibrosis; dental enamel hypoplasia; duodenal ulcer; and gastric ulcer. Biomarker of autosomal recessive polycystic kidney disease; cholestasis; and salpingitis. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Orthologous to human CFTR (CF transmembrane conductance regulator). [provided by Alliance of Genome Resources, Apr 2022]

Cftr Products(1)

mRNA Protein Name
NM_031506.1 NP_113694.1 cystic fibrosis transmembrane conductance regulator

Related Agents

Approval
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13017 Ivacaftor Agonist 99.90% Yes
HY-13262 Lumacaftor Modulator 99.83% Yes
HY-15206 Glibenclamide Inhibitor 99.92% Yes
HY-15448 Tezacaftor Modulator 99.94% Yes
HY-14832 Ataluren Inhibitor 99.82% Yes
HY-111772 Elexacaftor Modulator 99.50% Yes
HY-13017S Ivacaftor-d9 Activator 99.83% Unkown
HY-13017A Ivacaftor benzenesulfonate Agonist / Unkown
HY-13017B Ivacaftor hydrate Agonist / Unkown
Clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-106203A Crinecerfont hydrochloride Antagonist 98.06% Phase 3
HY-15448S Tezacaftor-d4 Modulator ≥97.0% Phase 3
HY-106203 Crinecerfont Antagonist / Phase 3
HY-111680 Nesolicaftor Modulator 99.37% Phase 2
HY-18337 IOWH-032 Inhibitor 99.63% Phase 2
HY-126394 Bamocaftor Modulator 99.09% Phase 2
HY-109187A Posenacaftor sodium Modulator 99.79% Phase 2
HY-125381 CFTR corrector 2 Modulator 98.29% Phase 2
HY-145603 Vanzacaftor Modulator 98.06% Phase 1
Pre-clinical Phase
Bioactive Molecules (54)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16671 CFTR(inh)-172 Inhibitor 99.25% Unkown
HY-18336 GlyH-101 Inhibitor 98.24% Unkown
HY-19778 (R)-BPO-27 Inhibitor 99.66% Unkown
HY-150090 SRI-41315 Activator 99.94% Unkown
HY-111099 GLPG1837 Agonist 99.86% Unkown
HY-109152 Navocaftor Modulator 99.05% Unkown
HY-109027 Cavosonstat Modulator 99.22% Yes
HY-111111 Galicaftor Modulator 98.93% Yes
HY-N6818 5,​7,​4'-​Trimethoxyflavone Activator 99.65% Unkown
HY-14179 PPQ-102 Inhibitor 99.82% Unkown
HY-19778A BPO-27 racemate Inhibitor 98.61% Unkown
HY-150089 SRI-37240 Modulator 99.21% Unkown
HY-109177 Icenticaftor Activator 99.87% Unkown
HY-115878 NJH-2-057 Modulator 98.87% Unkown
HY-108575 Chromanol 293B Inhibitor ≥99.0% Unkown
HY-112267 Olacaftor Modulator 99.26% Unkown
HY-19970 KM11060 Activator 99.59% Unkown
HY-119936 GLPG2451 Activator 99.68% Unkown
HY-P1106A K41498 TFA Antagonist 98.64% Unkown
HY-145603A (R)-Vanzacaftor Modulator 98.07% Unkown
HY-13017S3 Ivacaftor-d4 Agonist ≥96.0% Unkown
HY-143344 NJH-2-056 Modulator 98.23% Unkown
HY-136939 CFTR corrector 6 Activator 99.87% Unkown
HY-13017S2 Ivacaftor-d18 / Unkown
HY-15206S1 Glyburide-d3 Inhibitor ≥98.0% Unkown
HY-N5101 Kobusin Activator 99.93% Unkown
HY-103369 PG01 Activator ≥98.0% Unkown
HY-P1108A Astressin 2B TFA Antagonist / Unkown
HY-111772A (R)-Elexacaftor Modulator 99.70% Unkown
HY-135279 CFTR corrector 4 Modulator 99.60% Unkown
HY-133013 GLPG-3221 / Unkown
HY-109187 Posenacaftor Modulator / Unkown
HY-145126 CP-628006 Activator / Unkown
HY-15206S Glyburide-d11 Inhibitor / Unkown
HY-155742 CFTR corrector 12 Modulator / Unkown
HY-15448A (Rac)-Tezacaftor Modulator / Unkown
HY-158144 GLPG2737 Modulator / Unkown
HY-112363 Aloisine A Activator / Unkown
HY-114725 VRT-532 Modulator 98.98% Unkown
HY-158002 IDOR-4 Modulator / Unkown
HY-156522 CRF1 receptor antagonist-1 Antagonist / Unkown
HY-112267A (R)-Olacaftor Modulator 98.07% Unkown
HY-13017S1 Ivacaftor-d19 Agonist / Unkown
HY-147315 CFTR corrector 9 Modulator 98.84% Unkown
HY-153133 CFTR corrector 11 Modulator / Unkown
HY-152264 CFTR activator 1 Activator / Unkown
HY-109187B (R)-Posenacaftor sodium Inhibitor 98.96% Unkown
HY-P1108 Astressin 2B Antagonist / Unkown
HY-P3597 Urocortin III (mouse) (free acid) Agonist / Unkown
HY-148806 Zatonacaftor Modulator / Unkown
HY-15206A Glibenclamide potassium Inhibitor / Unkown
HY-126394B Bamocaftor potassium Modulator / Unkown
HY-147249 CFTR corrector 8 Modulator 96.00% Unkown
HY-119179 UCCF-853 Modulator 99.93% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cftr NCBI NCBI:1080