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F3 - coagulation factor III, tissue factor Gene

Also Known as TF

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25584

Summary

Enables protease binding activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; positive regulation of smooth muscle cell migration; and response to estradiol. Located in cell surface; cytoplasm; and extracellular space. Biomarker of disseminated intravascular coagulation; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; COVID-19; disseminated intravascular coagulation; and von Willebrand's disease. Orthologous to human F3 (coagulation factor III, tissue factor). [provided by Alliance of Genome Resources, Apr 2022]

F3 Products (1)

mRNA	Protein	Name
NM_013057.2	NP_037189.2	tissue factor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protease binding	IPI IPI: Inferred from physical interaction	18315926	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	10190887	RGD
involved in cellular response to low-density lipoprotein particle stimulus	IEP IEP: Inferred from expression pattern	10190887	RGD
involved in positive regulation of smooth muscle cell migration	IDA IDA: Inferred from direct assay	10840019	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	15481788	RGD
involved in response to fluid shear stress	IEP IEP: Inferred from expression pattern	9974408	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	16113797	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	15293323	RGD
involved in response to temperature stimulus	IEP IEP: Inferred from expression pattern	16902157	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	16902157	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	12083485	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tissue factor	coagulation factor 3 coagulation factor III (thromboplastin, tissue factor)

Recombinant F3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73592	Tissue Factor Protein, Rat (HEK293, His)	Q66HI4 (A29-E252)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-104010	Asciminib	Inhibitor	99.61%	Yes
HY-104010A	Asciminib hydrochloride	Inhibitor	99.79%	Yes

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99271A	Tisotumab (powder)		/	Phase 3
HY-P991378	MORAb-066	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (127)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125845	(S,R,S)-AHPC		99.13%	Unkown
HY-18960	CHZ868	Inhibitor	98.69%	Unkown
HY-13491	GNF-5837	Inhibitor	99.44%	Unkown
HY-130709	PROTAC CDK2/9 Degrader-1	Degrader	99.85%	Unkown
HY-113437A	1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium		98.0%	Unkown
HY-11007	GNF-2	Inhibitor	99.82%	Unkown
HY-125834	GMB-475		98.69%	Unkown
HY-157229	STX-721	Inhibitor	98.25%	Unkown
HY-134877	BAY 2476568	Inhibitor	99.88%	Unkown
HY-N0600	Ginsenoside F3		99.84%	Unkown
HY-159147	SIAIS039		99.68%	Unkown
HY-131906	JAK2-IN-7		98.31%	Unkown
HY-E70134	Endo-β-N-acetylglucosaminidase F3		/	Unkown
HY-126619	Aspochalasin D		95.0%	Unkown
HY-162645	BPR5K230	Inhibitor	99.82%	Unkown
HY-164397	XMU-MP-5		99.00%	Unkown
HY-18952A	(Z)-SU5614		98.09%	Unkown
HY-B2203	Monocalcium glycerophosphate	Inhibitor	98.0%	Unkown
HY-133551	WF-47-JS03	Inhibitor	99.63%	Unkown
HY-110026	GTP-14564	Inhibitor	99.91%	Unkown
HY-12083	PPY-A	Inhibitor	98.02%	Unkown
HY-139997	DDC-01-163	Degrader	99.05%	Unkown
HY-16983	GNE-3500	Antagonist	98.90%	Unkown
HY-170820	XYD049	Inhibitor	99.46%	Unkown
HY-174981	LC-MF-4		98.05%	Unkown
HY-RS03482	CYP4F3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W1048555A	Mal-PEG2000-SCM		92.0%	Unkown
HY-W081348	1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one	Inhibitor	99.54%	Unkown
HY-107662	TCS PrP Inhibitor 13	Inducer	99.72%	Unkown
HY-113437	1,2-Dipalmitoyl-sn-glycerol 3-phosphate		/	Unkown
HY-151048	JBJ-07-149	Inhibitor	99.09%	Unkown
HY-162940	MerTK/Axl-IN-1	Inhibitor	/	Unkown
HY-170928	DA-0157	Inhibitor	99.59%	Unkown
HY-RS04112	E2F3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-113437AS	1,2-Dipalmitoyl-sn-glycerol 3-phosphate-d62 sodium		99.0%	Unkown
HY-N8448	3,4-Di-O-caffeoyl quinic acid methyl ester	Inhibitor	98.77%	Unkown
HY-RS19322	E2f3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W784556	5'-DMTr-dU(Allylamine-CO-F3)-3'-CE-phosphoramidite		98.0%	Unkown
HY-110402	(S,R,S)-AHPC TFA		/	Unkown
HY-136526	BCR-ABL-IN-3	Inhibitor	/	Unkown
HY-101763B	(S,R,S)-AHPC dihydrochloride		/	Unkown
HY-104010S	Asciminib-d4	Inhibitor	/	Unkown
HY-112378	D-65476	Inhibitor	/	Unkown
HY-113777	22-HDHA		/	Unkown
HY-116597	L-783483	Agonist	/	Unkown
HY-121888	20-HEPE	Agonist	/	Unkown
HY-126920	AFG206		/	Unkown
HY-129764	Prostaglandin F3α	Substrate	/	Unkown
HY-129764A	(17E)-Prostaglandin F3α	Control	/	Unkown
HY-131244	ALK-IN-9	Inhibitor	/	Unkown
HY-142922	BCR-ABL-IN-4	Inhibitor	/	Unkown
HY-144451	TRK-IN-12	Inhibitor	/	Unkown
HY-146807	Type II TRK inhibitor 1	Inhibitor	/	Unkown
HY-147813	HIF-1α-IN-3	Inhibitor	/	Unkown
HY-149965	TRK-IN-23		/	Unkown
HY-154465	3’-F-3’-dG(iBu)-2’-phosphoramidite		/	Unkown
HY-155302	FLT3-IN-22	Inhibitor	/	Unkown
HY-156086	TRK-IN-24	Inhibitor	/	Unkown
HY-156102	c-ABL-IN-5		/	Unkown
HY-157432	EGFR-IN-97		/	Unkown
HY-158313	PROTAC EGFR degrader 13	Inhibitor	/	Unkown
HY-158465	GPEP FA2-KVANKT glycopeptide		/	Unkown
HY-161269	EGFR-IN-101	Inhibitor	/	Unkown
HY-162881	DS06652923	Inhibitor	/	Unkown
HY-163004	Type II TRK inhibitor 2	Inhibitor	/	Unkown
HY-163366	TRK-IN-28	Inhibitor	/	Unkown
HY-170497	EGFR-IN-140	Inhibitor	/	Unkown
HY-170852	QZ2135	Degrader	/	Unkown
HY-170927	JAK-IN-40		/	Unkown
HY-171884	BI-8128	Inhibitor	/	Unkown
HY-172478	DSPE-PEG1000-F3		/	Unkown
HY-172479	DSPE-PEG2000-F3		/	Unkown
HY-172479A	DSPE-PEG3400-F3		/	Unkown
HY-172480	DSPE-PEG5000-F3		/	Unkown
HY-174330	TRK-IN-31	Inhibitor	/	Unkown
HY-174330A	TRK-IN-31 hydrochloride	Inhibitor	/	Unkown
HY-174415	ZSH-2117		/	Unkown
HY-174437B	FLT3-IN-32 hydrochloride		/	Unkown
HY-174974	ISM7594	Inhibitor	/	Unkown
HY-175302	TRK-IN-32		/	Unkown
HY-175610	PROTAC FLT3/JAK2/BRD4 Degrader-1	Degrader	/	Unkown
HY-175864	EGFR-IN-173	Inhibitor	/	Unkown
HY-176259	F3-PEG8-RiboTAC		/	Unkown
HY-177030	RNase L ligand 3		/	Unkown
HY-178057	EGFR-IN-176		/	Unkown
HY-180172	TRK-IN-33		/	Unkown
HY-180967	PROTAC BCR-ABL Degrader-2		/	Unkown
HY-184598	CYB-5067		/	Unkown
HY-E70881	Endoglycosidase F3 (D165A mutant)		/	Unkown
HY-P10997	F3 peptide		/	Unkown
HY-R01574	hsa-miR-518f-3p mimic		/	Unkown
HY-R01574A	hsa-miR-518f-3p agomir		/	Unkown
HY-R01603	hsa-miR-520f-3p mimic		/	Unkown
HY-R01603A	hsa-miR-520f-3p agomir		/	Unkown
HY-R01683	hsa-miR-548f-3p mimic		/	Unkown
HY-R01683A	hsa-miR-548f-3p agomir		/	Unkown
HY-R03051	mmu-miR-344f-3p mimic		/	Unkown
HY-R03051A	mmu-miR-344f-3p agomir		/	Unkown
HY-R03176	mmu-miR-466f-3p mimic		/	Unkown
HY-R03176A	mmu-miR-466f-3p agomir		/	Unkown
HY-R03467	mmu-miR-669f-3p mimic		/	Unkown
HY-R03467A	mmu-miR-669f-3p agomir		/	Unkown
HY-RI01574	hsa-miR-518f-3p inhibitor		/	Unkown
HY-RI01574A	hsa-miR-518f-3p antagomir		/	Unkown
HY-RI01603	hsa-miR-520f-3p inhibitor		/	Unkown
HY-RI01603A	hsa-miR-520f-3p antagomir		/	Unkown
HY-RI01683	hsa-miR-548f-3p inhibitor		/	Unkown
HY-RI01683A	hsa-miR-548f-3p antagomir		/	Unkown
HY-RI03051	mmu-miR-344f-3p inhibitor		/	Unkown
HY-RI03051A	mmu-miR-344f-3p antagomir		/	Unkown
HY-RI03176	mmu-miR-466f-3p inhibitor		/	Unkown
HY-RI03176A	mmu-miR-466f-3p antagomir		/	Unkown
HY-RI03467	mmu-miR-669f-3p inhibitor		/	Unkown
HY-RI03467A	mmu-miR-669f-3p antagomir		/	Unkown
HY-RS02926	CNTN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04643	F3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10899	POU2F3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10902	POU3F3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10906	POU4F3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13207	SLC35F3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-116008	8-iso Prostaglandin F3α		/	Unkown
HY-154031	3'-F-3'-dA(Bz)-2'-Phosphoramidite		/	Unkown
HY-177031	RNA binder 3		/	Unkown
HY-RS16867	F3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23308	F3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23917	Cntn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25813	E2f3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99271	Tisotumab		99.90%	Unkown
HY-P990222	Anti-Mouse/Rat IL-17A Antibody (17F3)	Inhibitor	99.41%	Unkown
HY-P990212	Anti-Mouse IL-6 Antibody (MP5-20F3)	Inhibitor	99.36%	Unkown
HY-P990145	Anti-Mouse VISTA Antibody (13F3)	Inhibitor	≥95.0%	Unkown
HY-P991451	Anti-ALPP Antibody	Inhibitor	95.34%	Unkown
HY-P992374	huDMB5F3	Inhibitor	/	Unkown
HY-P990411	Anti-F3/Factor III/Tissue Factor/CD142 Antibody	Inhibitor	98.88%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	F3	NCBI	NCBI:2152