2. Gene
  3. GPX4 - glutathione peroxidase 4 Gene

GPX4 - glutathione peroxidase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Bos taurus

Also known as PHGPx

Gene ID: 286809 | Gene type: protein coding

About GPX4

Summary

The protein encoded by this gene belongs to the Glutathione Peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development. Disruption of this gene in mouse spermatocytes is associated with male infertility. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]

GPX4 Products(3)

mRNA Protein Name
NM_001346430.1 NP_001333359.1 phospholipid hydroperoxide glutathione peroxidase isoform B
NM_001346431.1 NP_001333360.1 phospholipid hydroperoxide glutathione peroxidase isoform C
NM_174770.4 NP_777195.1 phospholipid hydroperoxide glutathione peroxidase isoform A precursor
Protein Preferred Names Protein Names

phospholipid hydroperoxide glutathione peroxidase

GPx-4

GSHPx-4

glutathione peroxidase 4 (phospholipid hydroperoxidase)

phospholipid hydroperoxide glutathione peroxidase, mitochondrial

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17355B Dexpramipexole Activator 99.56% Yes
Pre-clinical Phase
Bioactive Molecules (89)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100218A RSL3 Inhibitor 99.87% Unkown
HY-112654 GCN2iB Activator 99.83% Unkown
HY-100003 ML-210 Inhibitor 99.93% Unkown
HY-100002 ML162 Inhibitor 99.52% Unkown
HY-Y0669 Pipecolic acid Inhibitor 99.92% Unkown
HY-120912 Gingerenone A Activator 99.95% Unkown
HY-138153 JKE-1674 Inhibitor 99.54% Unkown
HY-141809 GPX4-IN-3 Inhibitor 99.83% Unkown
HY-W001083 3-Hydroxyphenylacetic acid Activator 99.77% Unkown
HY-N0070 Solasonine Inhibitor 99.19% Unkown
HY-115627 PKUMDL-LC-101-D04 Activator 99.83% Unkown
HY-P5381 gp91 ds-tat Activator 99.00% Unkown
HY-157068 icFSP1 99.94% Unkown
HY-171007 IRF1-IN-2 Activator 99.83% Unkown
HY-N0353 Curdione 99.80% Unkown
HY-W018161 Hexadecanedioic acid 98.0% Unkown
HY-155663 GPX4-IN-5 Inhibitor 99.73% Unkown
HY-175032 ATF3-IN-1 Agonist 96.30% Unkown
HY-161929 GPX4 activator 2 Activator 99.23% Unkown
HY-W014940 Ethylene glycol dimethacrylate Activator 99.52% Unkown
HY-149236 PROTAC GPX4 degrader-1 Degrader 99.35% Unkown
HY-138556 GPX4-IN-2 Control 98.32% Unkown
HY-P2833 Glutathione Peroxidase / Unkown
HY-Y0669S Pipecolic acid-d9 Inhibitor 99.9% Unkown
HY-W015600 2-Acetamidophenol Activator 99.73% Unkown
HY-149923 GPX4-IN-4 Inhibitor 98.94% Unkown
HY-153748 ML162-yne 99.06% Unkown
HY-161928 GPX4 activator 1 Activator 99.02% Unkown
HY-N8698 Picein Activator 99.98% Unkown
HY-167888 NPD4928 Inhibitor 99.48% Unkown
HY-157762 GPX4-IN-9 Inhibitor 99.18% Unkown
HY-139001 JKE-1716 Inhibitor 98.04% Unkown
HY-155664 GPX4-IN-6 Inhibitor 99.65% Unkown
HY-N3097 Pellitorine Agonist 99.84% Unkown
HY-174086 PROTAC GPX4 degrader-4 Degrader 99.68% Unkown
HY-175615 RSL3-NH2 Inhibitor / Unkown
HY-W015600S 2-Acetamidophenol-d3 99.48% Unkown
HY-151212 BCP-T.A ≥99.0% Unkown
HY-159990 GPX4-IN-15 Inhibitor 98.79% Unkown
HY-176557 NCI677397 Inhibitor / Unkown
HY-177204 DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW Activator 95.0% Unkown
HY-176758 GPX4-IN-17 Inhibitor 98.1% Unkown
HY-169133 GDCNF-11 Degrader / Unkown
HY-155075 NC-R17 Inhibitor / Unkown
HY-183791A Ferroptosis/apoptosis inducer-5 Inhibitor / Unkown
HY-181574 PDI-IN-5 Inhibitor / Unkown
HY-W001083S1 3-Hydroxyphenylacetic acid-d5 Activator / Unkown
HY-179294 POI ligand-2 Ligand / Unkown
HY-181447 GPX4 (S)-9i Inhibitor / Unkown
HY-176220 GPX4-AUTAC Degrader / Unkown
HY-157788 ZX703 Degrader / Unkown
HY-179384 PROTAC FSP1 degrader 1 Activator / Unkown
HY-186143 KY0418 Inhibitor / Unkown
HY-183554 Fa-Au Inhibitor / Unkown
HY-180245 STAT3-IN-51 Inhibitor / Unkown
HY-174345 Ferroptosis inducer-8 Inhibitor / Unkown
HY-182802 Ferroptosis inducer-15 Inhibitor / Unkown
HY-181598 GPX4 degrader-1 Degrader / Unkown
HY-168011 GPX4-IN-14 Inhibitor / Unkown
HY-175633 ML210-ansaFc Inhibitor / Unkown
HY-175811 Ferroptosis inducer-10 Inhibitor / Unkown
HY-155852 Lepadin H Inhibitor / Unkown
HY-162717 GPX4-IN-11 Inhibitor / Unkown
HY-183544 Platinum(IV) Prodrug-1 Inhibitor / Unkown
HY-168879 GPX4-IN-16 Inhibitor / Unkown
HY-170509 Ferroptosis-IN-17 Activator / Unkown
HY-173408 Nur77 agonist-1 Inhibitor / Unkown
HY-179481 Ferroptosis inducer-13 Inhibitor / Unkown
HY-175614 RSL3-NH2-Ala-Val-DBCO-PEG4-Maleimide Inhibitor / Unkown
HY-175698 Ferroptosis inducer-9 Inhibitor / Unkown
HY-178115 MB-Buf Degrader / Unkown
HY-180199 GPX4-IN-21 Inhibitor / Unkown
HY-172675 DEL-I25 Activator / Unkown
HY-161972 ZX782 Degrader / Unkown
HY-178925 PROTAC GPX4 degrader-5 Degrader / Unkown
HY-168958 Ferroptosis-IN-18 Activator / Unkown
HY-175826 USP30-IN-20 Degrader / Unkown
HY-175041 GPX4-IN-18 Inhibitor / Unkown
HY-182072 GPX4-IN-23 Inhibitor / Unkown
HY-172761 AX-53802 Inducer / Unkown
HY-162106 PROTAC GPX4 degrader-2 Degrader / Unkown
HY-112654A GCN2iB acetate Activator / Unkown
HY-183294 GPX4-IN-24 Inhibitor / Unkown
HY-181656 GPX4 degrader-2 Inhibitor / Unkown
HY-176271 MAO-B-IN-45 Activator / Unkown
HY-138544 GPX4-IN-1 Inhibitor 99.76% Unkown
HY-175852 Ferroptosis inducer-11 Inhibitor / Unkown
HY-181953 STIM1-TFR1-IN-1 / Unkown
HY-149455 GPX4-IN-8 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens GPX4 NCBI NCBI:2879