GPX4 - glutathione peroxidase 4 Gene

Also Known as MCSP; SMDS; GPx-4; PHGPx; snGPx; GSHPx-4; snPHGPx

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2879

About GPX4

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,103,994-1,106,779 (from NCBI)

This gene has 11 transcripts (splice variants), 162 orthologues, 7 paralogues and is associated with 3 phenotypes. Broad expression in fat (RPKM 347.9), testis (RPKM 229.8) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the Glutathione Peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. [provided by RefSeq, Dec 2018]

GPX4 Products (4)

mRNA Protein Name
NM_001039847.3 NP_001034936.1 phospholipid hydroperoxide glutathione peroxidase isoform B precursor
NM_001039848.4 NP_001034937.1 phospholipid hydroperoxide glutathione peroxidase isoform C
NM_001367832.1 NP_001354761.1 phospholipid hydroperoxide glutathione peroxidase isoform D
NM_002085.5 NP_002076.2 phospholipid hydroperoxide glutathione peroxidase isoform A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutathione peroxidase activity IDA
IDA: Inferred from direct assay
36608588 GOA
enables glutathione peroxidase activity IMP
IMP: Inferred from mutant phenotype
17630701 GOA
enables identical protein binding IMP
IMP: Inferred from mutant phenotype
17630701 GOA
enables phospholipid-hydroperoxide glutathione peroxidase activity IDA
IDA: Inferred from direct assay
11115402 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23355646 GOA
Biological Process GO Annotation Evidence References Source
involved in arachidonate metabolic process IDA
IDA: Inferred from direct assay
11115402 GOA
involved in lipoxygenase pathway IDA
IDA: Inferred from direct assay
11115402 GOA
involved in protein polymerization IMP
IMP: Inferred from mutant phenotype
17630701 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
11115402 GOA
part of protein-containing complex IMP
IMP: Inferred from mutant phenotype
17630701 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPX4 Protein Structure

GSHPx

GSHPx: Glutathione peroxidase (41 - 148)

  • 0
  • 100
  • 197 a.a.
Protein Preferred Names Protein Names

phospholipid hydroperoxide glutathione peroxidase

  • epididymis secretory sperm binding protein

GPX4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80450 GPX4 Antibody (YA399) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P80450A GPX4 Antibody (YA399)(PBS only) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P80692 GPX4 Antibody WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat
HY-P80692A GPX4 Antibody (YA9649)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat
HY-P86239 GPX4 Antibody (YA5931) WB, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Spondylometaphyseal Dysplasia, Sedaghatian Type

  • SMDS

  • Sedaghatian Chondrodysplasia

  • Spondylometaphyseal Dysplasia Sedaghatian Type

  • Congenital Lethal Metaphyseal Chondrodysplasia

  • Metaphyseal Chondrodysplasia, Congenital Lethal

  • Lethal Metaphyseal Dysplasia
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Pontocerebellar Hypoplasia, Type 2d

  • Pontocerebellar Hypoplasia Type 2d

  • Pcca

  • PCH2D

  • Progressive Cerebello-Cerebral Atrophy

  • Cerebellocerebral Atrophy, Progressive

  • Pontocerebellar Hypoplasia 2d

  • Progressive Cerebellocerebral Atrophy

  • Hypoplasia, Pontocerebellar, Type 2d
Gum Cancer

  • Malignant Neoplasm Of Gum

  • Malignant Tumor Of Gum

  • Malignant Gingival Tumor

  • Malignant Neoplasm Of Other Sites Of Gum

  • Malignant Tumour Of Gingiva
Infertility
Encephalomalacia
Periventricular Leukomalacia

  • Leukomalacia, Periventricular

  • Pvl

  • Leukomalacia Periventricular
Spondyloepimetaphyseal Dysplasia, Strudwick Type

  • Spondylometaphyseal Dysplasia

  • Strudwick Syndrome

  • Dappled Metaphysis Syndrome

  • Semd, Strudwick Type

  • Spondylometaepiphyseal Dysplasia Congenita, Strudwick Type

  • Smed, Strudwick Type

  • Smd

  • Smed Strudwick Type

  • SEMDSTWK

  • Smed, Type I

  • Semdc

  • Smed Type 1

  • Spondyloepimetaphyseal Dysplasia Strudwick Type

  • Sed Strudwick

  • Spondyloepimetaphyseal Dysplasia Congenita, Strudwick Type

  • Smed Type I

  • Spondyloepiphyseal Dysplasia Congenita With Dappled Metaphyses

  • Dysplasia, Spondyloepimetaphyseal, Strudwick Type

  • Dysplasia, Spondylometaphyseal
Fanconi Anemia, Complementation Group D2

  • Fanconi Anemia Complementation Group D2

  • FANCD2

  • Fad2

  • Fa4

  • Fancd

  • Fanconi Pancytopenia Type 4

  • Fanconi Anemia, Complementation Group D

  • Fanconi Pancytopenia, Type 4

  • Facd

  • Fanconi Anemia Complementation Group D
Cerebral Palsy

  • Infantile Cerebral Palsy

  • Mixed Cerebral Palsy

  • Palsy Cerebral

  • Palsy, Cerebral

  • Cerebral Palsy, Mixed
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17355B Dexpramipexole Activator 99.56% Yes

Pre-clinical Phase

Bioactive Molecules (106)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100218A RSL3 Inhibitor 99.87% Unkown
HY-112654 GCN2iB Activator 99.83% Unkown
HY-100003 ML-210 Inhibitor 99.93% Unkown
HY-100002 ML162 Inhibitor 99.52% Unkown
HY-Y0669 Pipecolic acid Inhibitor 99.92% Unkown
HY-120912 Gingerenone A Activator 99.95% Unkown
HY-138153 JKE-1674 Inhibitor 99.97% Unkown
HY-141809 GPX4-IN-3 Inhibitor 99.83% Unkown
HY-W001083 3-Hydroxyphenylacetic acid Activator 99.77% Unkown
HY-N0070 Solasonine Inhibitor 99.19% Unkown
HY-P5381 gp91 ds-tat Activator 99.00% Unkown
HY-115627 PKUMDL-LC-101-D04 Activator 99.83% Unkown
HY-171007 IRF1-IN-2 Activator 99.83% Unkown
HY-157068 icFSP1 99.94% Unkown
HY-N0353 Curdione 99.80% Unkown
HY-W018161 Hexadecanedioic acid 98.0% Unkown
HY-175032 ATF3-IN-1 Agonist 96.30% Unkown
HY-155663 GPX4-IN-5 Inhibitor 99.73% Unkown
HY-161929 GPX4 activator 2 Activator 99.23% Unkown
HY-W014940 Ethylene glycol dimethacrylate Activator 99.52% Unkown
HY-P2833 Glutathione Peroxidase / Unkown
HY-149236 PROTAC GPX4 degrader-1 Degrader 98.53% Unkown
HY-138556 GPX4-IN-2 Control 98.32% Unkown
HY-W015600 2-Acetamidophenol Activator 99.73% Unkown
HY-Y0669S Pipecolic acid-d9 Inhibitor 99.9% Unkown
HY-149923 GPX4-IN-4 Inhibitor 98.94% Unkown
HY-34765 Propiolamide Inhibitor 99.94% Unkown
HY-153748 ML162-yne 99.06% Unkown
HY-161928 GPX4 activator 1 Activator 99.02% Unkown
HY-179041 SZ0232 Activator 99.25% Unkown
HY-N8698 Picein Activator 99.98% Unkown
HY-167888 NPD4928 Inhibitor 99.48% Unkown
HY-155664 GPX4-IN-6 Inhibitor 99.65% Unkown
HY-139001 JKE-1716 Inhibitor 98.04% Unkown
HY-157762 GPX4-IN-9 Inhibitor 99.18% Unkown
HY-W015600S 2-Acetamidophenol-d3 99.48% Unkown
HY-138544 GPX4-IN-1 Inhibitor 99.76% Unkown
HY-N3097 Pellitorine Agonist 99.84% Unkown
HY-135832 Demethyl-RSL3 Ligand 98.40% Unkown
HY-174086 PROTAC GPX4 degrader-4 Degrader 99.68% Unkown
HY-175615A RSL3-NH2 hydrochloride Inhibitor / Unkown
HY-151212 BCP-T.A ≥99.0% Unkown
HY-176758 GPX4-IN-17 Inhibitor 98.1% Unkown
HY-159990 GPX4-IN-15 Inhibitor 98.79% Unkown
HY-175615 RSL3-NH2 Inhibitor / Unkown
HY-176557 NCI677397 Inhibitor / Unkown
HY-177204 DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW Activator 95.0% Unkown
HY-183294 GPX4-IN-24 Inhibitor / Unkown
HY-183544 Platinum(IV) Prodrug-1 Inhibitor / Unkown
HY-184448 CIB-Q22 Inhibitor / Unkown
HY-162106 PROTAC GPX4 degrader-2 Degrader / Unkown
HY-181574 PDI-IN-5 Inhibitor / Unkown
HY-181953 STIM1-TFR1-IN-1 / Unkown
HY-155075 NC-R17 Degrader / Unkown
HY-168958 Ferroptosis-IN-18 Activator / Unkown
HY-174345 Ferroptosis inducer-8 Inhibitor / Unkown
HY-169133 GDCNF-11 Degrader / Unkown
HY-112654A GCN2iB acetate Activator / Unkown
HY-179384 PROTAC FSP1 degrader 1 Activator / Unkown
HY-182072 GPX4-IN-23 Inhibitor / Unkown
HY-175903 GPX4 ligand-1 Ligand / Unkown
HY-168011 GPX4-IN-14 Inhibitor / Unkown
HY-175852 Ferroptosis inducer-11 Inhibitor / Unkown
HY-181656 GPX4 degrader-2 Inhibitor / Unkown
HY-175614 RSL3-NH2-Ala-Val-DBCO-PEG4-Maleimide Inhibitor / Unkown
HY-186143 KY0418 Inhibitor / Unkown
HY-176220 GPX4-AUTAC Degrader / Unkown
HY-112005G DOPE (GMP) Inhibitor / Unkown
HY-172761 AX-53802 Inducer / Unkown
HY-170509 Ferroptosis-IN-17 Activator / Unkown
HY-184667 β-Lactamase/Ferroptosis-IN-1 Activator / Unkown
HY-W001083S1 3-Hydroxyphenylacetic acid-d5 Activator / Unkown
HY-176271 MAO-B-IN-45 Activator / Unkown
HY-182802 Ferroptosis inducer-15 Inhibitor / Unkown
HY-180245 STAT3-IN-51 Inhibitor / Unkown
HY-157788 ZX703 Degrader / Unkown
HY-182052 Ferroptosis inducer-16 Inhibitor / Unkown
HY-175811 Ferroptosis inducer-10 Inhibitor / Unkown
HY-149717 Antitumor agent-122 / Unkown
HY-184583 S27-1047 Activator / Unkown
HY-162717 GPX4-IN-11 Inhibitor / Unkown
HY-178925 PROTAC GPX4 degrader-5 Degrader 95.0% Unkown
HY-175698 Ferroptosis inducer-9 Inhibitor / Unkown
HY-183554 Fa-Au Inhibitor / Unkown
HY-168879 GPX4-IN-16 Inhibitor / Unkown
HY-175633 ML210-ansaFc Inhibitor 96.0% Unkown
HY-161972 ZX782 Degrader / Unkown
HY-181598 GPX4 degrader-1 Degrader / Unkown
HY-173408 Nur77 agonist-1 Inhibitor / Unkown
HY-162963 DN203316 Activator / Unkown
HY-184506 R4VPL3-1 Inhibitor / Unkown
HY-184173 OXPHOS-IN-3 Inhibitor / Unkown
HY-178115 MB-Buf Degrader / Unkown
HY-179294 POI ligand-2 Ligand / Unkown
HY-155852 Lepadin H Inhibitor / Unkown
HY-183791A Ferroptosis/apoptosis inducer-5 Inhibitor / Unkown
HY-184662 Ferroptosis inducer-17 Inhibitor / Unkown
HY-179481 Ferroptosis inducer-13 Inhibitor / Unkown
HY-172675 DEL-I25 Activator / Unkown
HY-181447 GPX4 (S)-9i Inhibitor / Unkown
HY-175041 GPX4-IN-18 Inhibitor 95.79% Unkown
HY-161930 PROTAC GPX4 degrader-3 Degrader / Unkown
HY-401204 GPX4 ligand-2 Ligand / Unkown
HY-175826 USP30-IN-20 Degrader / Unkown
HY-180199 GPX4-IN-21 Inhibitor / Unkown
HY-149455 GPX4-IN-8 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GPX4 MGD MGI:104767
Rattus norvegicus GPX4 RGD RGD:69226
Bos taurus GPX4 VGNC VGNC:106759
Felis catus GPX4 VGNC VGNC:80055
Others GPX4 NCBI