Dhodh - dihydroorotate dehydrogenase Gene

Also Known as 2810417D19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56749

About Dhodh

Chromosome 8: 110,317,975-110,335,305 reverse strand.GRCm39:CM001001.3

This gene has 11 transcripts (splice variants), 173 orthologues, 1 paralogue and is associated with 6 phenotypes. Ubiquitous expression in ovary adult (RPKM 7.7), CNS E11.5 (RPKM 7.) and 28 other tissues.

Summary

Enables dihydroorotase activity and Dihydroorotate Dehydrogenase activity. Involved in 'de novo' UMP biosynthetic process and UDP biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; branchial arch; limb bud; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (Dihydroorotate Dehydrogenase (quinone)). [provided by Alliance of Genome Resources, Apr 2022]

Dhodh Products (1)

mRNA Protein Name
NM_020046.3 NP_064430.1 dihydroorotate dehydrogenase (quinone), mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables dihydroorotase activity IMP
IMP: Inferred from mutant phenotype
20413687 MGI
enables dihydroorotate dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
6249586 MGI
Biological Process GO Annotation Evidence References Source
involved in 'de novo' UMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
6249586 MGI
involved in UDP biosynthetic process IMP
IMP: Inferred from mutant phenotype
6249586 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dhodh Protein Structure

DHOD_2_like

DHOD_2_like: cd04738 (42 - 372)

  • 0
  • 100
  • 200
  • 300
  • 395 a.a.
Protein Preferred Names Protein Names

dihydroorotate dehydrogenase (quinone), mitochondrial

  • DHOdehase

  • dihydroorotate dehydrogenase, mitochondrial

  • dihydroorotate oxidase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0083 Leflunomide Inhibitor 99.82% Yes
HY-N0157 Orotic acid Chemical 99.98% Unkown
HY-N0157R Orotic acid (Standard) Chemical 99.51% Unkown
HY-N0157A Orotic acid zinc Chemical 99.84% Unkown

Clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Phase
HY-104029 Olorofim Inhibitor 99.38% Phase 3
HY-124593 PTC299 Inhibitor 99.71% Phase 3
HY-108325 Brequinar Inhibitor 99.94% Phase 2
HY-129239 Farudodstat 99.68% Phase 2
HY-101813 Laflunimus Inhibitor 99.70% Phase 2
HY-14908A Vidofludimus hemicalcium / Phase 2
HY-112645 BAY-2402234 Inhibitor 99.90% Phase 1
HY-139189 JNJ-74856665 Inhibitor 99.88% Phase 1
HY-137463 AG-636 Inhibitor 98.07% Phase 1
HY-152851 Izumerogant Inhibitor 99.95% Phase 1

Pre-clinical Phase

Bioactive Molecules (74)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W015495 L-Dihydroorotic acid Substrate 99.97% Unkown
HY-14908 Vidofludimus 99.14% Yes
HY-15510 Tenovin-6 98.00% Unkown
HY-148394 UCK2 Inhibitor-1 Inhibitor 96.32% Unkown
HY-N6961 Lapachol Inhibitor 99.49% Unkown
HY-100688 ML390 Inhibitor 99.95% Unkown
HY-13423 Tenovin-1 99.88% Unkown
HY-128068 DHODH-IN-17 Inhibitor 99.91% Unkown
HY-N0157S1 Orotic acid-13C,15N2 monohydrate 99.93% Unkown
HY-15510B Tenovin-6 Hydrochloride 98.88% Unkown
HY-135282 DHODH-IN-1 Inhibitor 98.65% Unkown
HY-153112 DHODH-IN-23 Inhibitor 98.75% Unkown
HY-32757 5-Bromo-2-fluoro-3-methylpyridine 99.90% Unkown
HY-RS03734 DHODH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-148396 UCK2 Inhibitor-3 98.65% Unkown
HY-132171A DSM705 hydrochloride Inhibitor 98.22% Unkown
HY-132174 CHIKV-IN-2 Inhibitor 99.21% Unkown
HY-128787 hDHODH-IN-4 Inhibitor 99.73% Unkown
HY-135664 hDHODH-IN-5 Inhibitor 98.55% Unkown
HY-135678 DHODH-IN-14 Inhibitor 99.81% Unkown
HY-148395 UCK2 Inhibitor-2 Inhibitor 99.25% Unkown
HY-N3097 Pellitorine 99.84% Unkown
HY-N7961 (E/Z)-Ginkgolic acid C17:2 Inhibitor 99.37% Unkown
HY-132170 DSM502 Inhibitor 99.74% Unkown
HY-135675 DHODH-IN-11 Inhibitor 99.69% Unkown
HY-175352 Nurr1 agonist 14 99.42% Unkown
HY-176728 DHODH-IN-27 Inhibitor 99.77% Unkown
HY-170780A (S)-DSM1465 Inhibitor 99.53% Unkown
HY-120924 BRD9185 Inhibitor / Unkown
HY-132171 DSM705 Inhibitor / Unkown
HY-135618 DHODH-IN-3 Inhibitor / Unkown
HY-135619 DHODH-IN-4 Inhibitor / Unkown
HY-135666 DHODH-IN-8 Inhibitor / Unkown
HY-135667 hDHODH-IN-7 Inhibitor / Unkown
HY-135676 DHODH-IN-12 Inhibitor / Unkown
HY-135677 DHODH-IN-13 Inhibitor / Unkown
HY-135679 DHODH-IN-15 Inhibitor / Unkown
HY-139825 Indoluidin E Inhibitor / Unkown
HY-139889 DHODH-IN-18 Inhibitor / Unkown
HY-142834 RORγt/DHODH-IN-2 Inhibitor / Unkown
HY-142843 RORγt/DHODH-IN-1 Inhibitor / Unkown
HY-142847 RORγt/DHODH-IN-3 Inhibitor / Unkown
HY-144169 DHODH-IN-19 Inhibitor / Unkown
HY-144371 DHODH-IN-20 Inhibitor / Unkown
HY-146317 P1788 Inhibitor / Unkown
HY-149030 DHODH-IN-21 Inhibitor / Unkown
HY-149031 DHODH-IN-22 Inhibitor / Unkown
HY-149877 hDHODH-IN-12 Inhibitor / Unkown
HY-158023 DHODH-IN-26 / Unkown
HY-163158 DHODH-IN-24 Inhibitor / Unkown
HY-163328 DHODH-IN-25 Inhibitor / Unkown
HY-174816 DHODH-IN-28 Inhibitor / Unkown
HY-175259 DHODH-IN-29 Inhibitor / Unkown
HY-178156 DHODH-IN-31 Inhibitor 99.55% Unkown
HY-178941 DHODH-IN-32 / Unkown
HY-179531 DHODH-IN-33 / Unkown
HY-182550 Indoluidin D Inhibitor / Unkown
HY-B0083S Leflunomide-d4 Inhibitor 99.5% Unkown
HY-RS03735 Dhodh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03736 Dhodh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W347485 DHODH-IN-35 / Unkown
HY-108325S Brequinar-d3 Inhibitor / Unkown
HY-117908 DSM267 Inhibitor / Unkown
HY-120462 Genz-669178 Inhibitor / Unkown
HY-129253 GSK984 Control / Unkown
HY-135662 DHODH-IN-34 Inhibitor / Unkown
HY-15510S Tenovin-6-d6 / Unkown
HY-165191 LY214352 Inhibitor / Unkown
HY-169220S RORγ/DHODH-IN-1 Inhibitor / Unkown
HY-169222S RORγ/DHODH-IN-2 Inhibitor / Unkown
HY-175423 DHODH-IN-30 Inhibitor / Unkown
HY-181588 NR4A agonist-2 Agonist / Unkown
HY-183925 Redoxal Inhibitor / Unkown
HY-B0083S1 Leflunomide-13C6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dhodh NCBI NCBI:1723