Dhodh - dihydroorotate dehydrogenase (quinone) Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65156

About Dhodh

Primary_assembly 19: 37,558,177-37,591,654 reverse strand.mRatBN7.2:CM026992.1

This gene has 5 transcripts (splice variants), 173 orthologues, 1 paralogue and is associated with 12 phenotypes. Biased expression in Adrenal (RPKM 46.5), Thymus (RPKM 4.8) and 9 other tissues.

Summary

Enables FMN binding activity; Dihydroorotate Dehydrogenase activity; and ubiquinone binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; lactation; and response to L-arginine. Located in mitochondrial inner membrane and neuronal cell body. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (Dihydroorotate Dehydrogenase (quinone)). [provided by Alliance of Genome Resources, Apr 2022]

Dhodh Products (1)

mRNA Protein Name
NM_001008553.2 NP_001008553.1 dihydroorotate dehydrogenase (quinone), mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables FMN binding IDA
IDA: Inferred from direct assay
9693067 RGD
enables dihydroorotate dehydrogenase activity IDA
IDA: Inferred from direct assay
1313236 RGD
enables quinone binding IPI
IPI: Inferred from physical interaction
15044733 RGD
enables ubiquinone binding IDA
IDA: Inferred from direct assay
9179295 RGD
Biological Process GO Annotation Evidence References Source
involved in 'de novo' pyrimidine nucleobase biosynthetic process IDA
IDA: Inferred from direct assay
1476792 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
1476792 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
1476792 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15182735 RGD
involved in regulation of mitochondrial fission IMP
IMP: Inferred from mutant phenotype
16120318 RGD
involved in response to L-arginine IEP
IEP: Inferred from expression pattern
6167833 RGD
involved in response to caffeine IEP
IEP: Inferred from expression pattern
6149265 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
9879809 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
6331524 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
9123312 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
10727948 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
20544541 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dhodh Protein Structure

DHOD_2_like

DHOD_2_like: cd04738 (42 - 372)

  • 0
  • 100
  • 200
  • 300
  • 395 a.a.
Protein Preferred Names Protein Names

dihydroorotate dehydrogenase (quinone), mitochondrial

  • DHOdehase

  • dihydroorotate dehydrogenase, mitochondrial

  • dihydroorotate oxidase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0083 Leflunomide Inhibitor 99.82% Yes
HY-N0157 Orotic acid Chemical 99.98% Unkown
HY-N0157R Orotic acid (Standard) Chemical 99.51% Unkown
HY-N0157A Orotic acid zinc Chemical 99.84% Unkown

Clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Phase
HY-104029 Olorofim Inhibitor 99.38% Phase 3
HY-124593 PTC299 Inhibitor 99.71% Phase 3
HY-108325 Brequinar Inhibitor 99.94% Phase 2
HY-129239 Farudodstat 99.68% Phase 2
HY-101813 Laflunimus Inhibitor 99.70% Phase 2
HY-14908A Vidofludimus hemicalcium / Phase 2
HY-112645 BAY-2402234 Inhibitor 99.90% Phase 1
HY-139189 JNJ-74856665 Inhibitor 99.88% Phase 1
HY-137463 AG-636 Inhibitor 98.07% Phase 1
HY-152851 Izumerogant Inhibitor 99.95% Phase 1

Pre-clinical Phase

Bioactive Molecules (74)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W015495 L-Dihydroorotic acid Substrate 99.97% Unkown
HY-14908 Vidofludimus 99.14% Yes
HY-15510 Tenovin-6 98.00% Unkown
HY-148394 UCK2 Inhibitor-1 Inhibitor 96.32% Unkown
HY-N6961 Lapachol Inhibitor 99.49% Unkown
HY-100688 ML390 Inhibitor 99.95% Unkown
HY-13423 Tenovin-1 99.88% Unkown
HY-128068 DHODH-IN-17 Inhibitor 99.91% Unkown
HY-N0157S1 Orotic acid-13C,15N2 monohydrate 99.93% Unkown
HY-15510B Tenovin-6 Hydrochloride 98.88% Unkown
HY-135282 DHODH-IN-1 Inhibitor 98.65% Unkown
HY-153112 DHODH-IN-23 Inhibitor 98.75% Unkown
HY-32757 5-Bromo-2-fluoro-3-methylpyridine 99.90% Unkown
HY-RS03734 DHODH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-148396 UCK2 Inhibitor-3 98.65% Unkown
HY-132171A DSM705 hydrochloride Inhibitor 98.22% Unkown
HY-132174 CHIKV-IN-2 Inhibitor 99.21% Unkown
HY-128787 hDHODH-IN-4 Inhibitor 99.73% Unkown
HY-135664 hDHODH-IN-5 Inhibitor 98.55% Unkown
HY-135678 DHODH-IN-14 Inhibitor 99.81% Unkown
HY-148395 UCK2 Inhibitor-2 Inhibitor 99.25% Unkown
HY-N3097 Pellitorine 99.84% Unkown
HY-N7961 (E/Z)-Ginkgolic acid C17:2 Inhibitor 99.37% Unkown
HY-132170 DSM502 Inhibitor 99.74% Unkown
HY-135675 DHODH-IN-11 Inhibitor 99.69% Unkown
HY-175352 Nurr1 agonist 14 99.42% Unkown
HY-176728 DHODH-IN-27 Inhibitor 99.77% Unkown
HY-170780A (S)-DSM1465 Inhibitor 99.53% Unkown
HY-120924 BRD9185 Inhibitor / Unkown
HY-132171 DSM705 Inhibitor / Unkown
HY-135618 DHODH-IN-3 Inhibitor / Unkown
HY-135619 DHODH-IN-4 Inhibitor / Unkown
HY-135666 DHODH-IN-8 Inhibitor / Unkown
HY-135667 hDHODH-IN-7 Inhibitor / Unkown
HY-135676 DHODH-IN-12 Inhibitor / Unkown
HY-135677 DHODH-IN-13 Inhibitor / Unkown
HY-135679 DHODH-IN-15 Inhibitor / Unkown
HY-139825 Indoluidin E Inhibitor / Unkown
HY-139889 DHODH-IN-18 Inhibitor / Unkown
HY-142834 RORγt/DHODH-IN-2 Inhibitor / Unkown
HY-142843 RORγt/DHODH-IN-1 Inhibitor / Unkown
HY-142847 RORγt/DHODH-IN-3 Inhibitor / Unkown
HY-144169 DHODH-IN-19 Inhibitor / Unkown
HY-144371 DHODH-IN-20 Inhibitor / Unkown
HY-146317 P1788 Inhibitor / Unkown
HY-149030 DHODH-IN-21 Inhibitor / Unkown
HY-149031 DHODH-IN-22 Inhibitor / Unkown
HY-149877 hDHODH-IN-12 Inhibitor / Unkown
HY-158023 DHODH-IN-26 / Unkown
HY-163158 DHODH-IN-24 Inhibitor / Unkown
HY-163328 DHODH-IN-25 Inhibitor / Unkown
HY-174816 DHODH-IN-28 Inhibitor / Unkown
HY-175259 DHODH-IN-29 Inhibitor / Unkown
HY-178156 DHODH-IN-31 Inhibitor 99.55% Unkown
HY-178941 DHODH-IN-32 / Unkown
HY-179531 DHODH-IN-33 / Unkown
HY-182550 Indoluidin D Inhibitor / Unkown
HY-B0083S Leflunomide-d4 Inhibitor 99.5% Unkown
HY-RS03735 Dhodh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03736 Dhodh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W347485 DHODH-IN-35 / Unkown
HY-108325S Brequinar-d3 Inhibitor / Unkown
HY-117908 DSM267 Inhibitor / Unkown
HY-120462 Genz-669178 Inhibitor / Unkown
HY-129253 GSK984 Control / Unkown
HY-135662 DHODH-IN-34 Inhibitor / Unkown
HY-15510S Tenovin-6-d6 / Unkown
HY-165191 LY214352 Inhibitor / Unkown
HY-169220S RORγ/DHODH-IN-1 Inhibitor / Unkown
HY-169222S RORγ/DHODH-IN-2 Inhibitor / Unkown
HY-175423 DHODH-IN-30 Inhibitor / Unkown
HY-181588 NR4A agonist-2 Agonist / Unkown
HY-183925 Redoxal Inhibitor / Unkown
HY-B0083S1 Leflunomide-13C6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dhodh NCBI NCBI:1723