DB1113
Based on 1 Customer Validation
DB1113 is a multi-kinase PROTAC degrader. DB1113 induces the ubiquitination and degradation of ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used to study diseases or disorders mediated by aberrant kinase activity.
(Pink: Multi kinase ligand (HY-176367); Blue: VHL ligand (HY-112078); Black: linker).
For research use only. We do not sell to patients.
- Purity : 99.22%
- CAS No.: 2769753-53-7
- Formula: C59H68F3N13O6S
- Molecular Weight:1144.31
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
CDK4 |
CDK11B |
MAP4K2 |
QIK/SIK2 |
QSK/SIK3 |
MAP4K5 |
HPK1 |
GLK/MAP4K3 |
ULK1 |
LIMK1 |
VHL |
In Vitro
DB1113 (Example 24) degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2769753-53-7
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Appearance Solid
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Molecular Weight 1144.31
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Formula C59H68F3N13O6S
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Color White to off-white
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SMILES
O=C1N(C2=CC(NC(C3=CC(C(F)(F)F)=CC=C3)=O)=CC=C2C)CC4=CN=C(NC5=CN=C(N6CCN(CC6)CCCCC(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(N[C@H](C8=CC=C(C9=C(N=CS9)C)C=C8)C)=O)=O)=O)C=C5)N=C4N1C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 60 mg/mL (52.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8739 mL | 4.3694 mL | 8.7389 mL | 21.8472 mL |
| 5 mM | 0.1748 mL | 0.8739 mL | 1.7478 mL | 4.3694 mL | |
| 10 mM | 0.0874 mL | 0.4369 mL | 0.8739 mL | 2.1847 mL | |
| 15 mM | 0.0583 mL | 0.2913 mL | 0.5826 mL | 1.4565 mL | |
| 20 mM | 0.0437 mL | 0.2185 mL | 0.4369 mL | 1.0924 mL | |
| 25 mM | 0.0350 mL | 0.1748 mL | 0.3496 mL | 0.8739 mL | |
| 30 mM | 0.0291 mL | 0.1456 mL | 0.2913 mL | 0.7282 mL | |
| 40 mM | 0.0218 mL | 0.1092 mL | 0.2185 mL | 0.5462 mL | |
| 50 mM | 0.0175 mL | 0.0874 mL | 0.1748 mL | 0.4369 mL |
DB1113 Related Classifications
HY-148061 Related Classifications
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