FFAR2 - free fatty acid receptor 2 Gene

Also Known as FFA2R; GPR43

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 2867

About FFAR2

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,448,257-35,451,767 (from NCBI)

This gene has 3 transcripts (splice variants), 333 orthologues and 15 paralogues. Biased expression in appendix (RPKM 7.9), bone marrow (RPKM 5.6) and 11 other tissues.

Summary

This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009]

FFAR2 Products (2)

mRNA	Protein	Name
NM_001370087.1	NP_001357016.1	free fatty acid receptor 2
NM_005306.3	NP_005297.1	free fatty acid receptor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	12496283	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21037097	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12496283	GOA
involved in cell surface pattern recognition receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21037097	GOA
involved in cellular response to fatty acid	IDA IDA: Inferred from direct assay	12496283	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	21037097	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in plasma membrane	IDA IDA: Inferred from direct assay	18801738	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FFAR2 Protein Structure

7tm_1

0
100
200
300
330 a.a.

Protein Preferred Names	Protein Names
free fatty acid receptor 2	G-protein coupled receptor 43

FFAR2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	FFAR2	O15552	EDDM3B	Homo sapiens	P56851	Validated Y2H	32296183
Intra	FFAR2	O15552	SMAGP	Homo sapiens	Q0VAQ4	Validated Y2H	32296183
Intra	FFAR2	O15552	TTMP	Homo sapiens	Q5BVD1	Validated Y2H	32296183
Intra	FFAR2	O15552	RTP2	Homo sapiens	Q5QGT7	Validated Y2H	32296183
Intra	FFAR2	O15552	NRM	Homo sapiens	Q8IXM6	Validated Y2H	32296183
Intra	FFAR2	O15552	CYB561A3	Homo sapiens	Q8NBI2	Validated Y2H	32296183
Intra	FFAR2	O15552	SLC35B4	Homo sapiens	Q969S0	Validated Y2H	32296183
Intra	FFAR2	O15552	TEX264	Homo sapiens	Q9Y6I9	Validated Y2H	32296183
Intra	FFAR2	O15552	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	FFAR2	O15552	FAM20B	Homo sapiens	O75063	Validated Y2H	32296183
Intra	FFAR2	O15552	AGTRAP	Homo sapiens	Q6RW13-2	Validated Y2H	32296183
Intra	FFAR2	O15552	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	FFAR2	O15552	TMEM239	Homo sapiens	Q8WW34-2	Validated Y2H	32296183
Intra	FFAR2	O15552	CFHR5	Homo sapiens	Q9BXR6	Validated Y2H	32296183
Intra	FFAR2	O15552	O00602-PRO_0000009136	Homo sapiens	O00602-PRO_0000009136	Y2H	21037097
Intra	FFAR2	O15552	CLDND2	Homo sapiens	Q8NHS1	Validated Y2H	32296183
Intra	FFAR2	O15552	CLEC1A	Homo sapiens	Q8NC01	Validated Y2H	32296183
Intra	FFAR2	O15552	C4orf3	Homo sapiens	Q8WVX3-2	Validated Y2H	32296183
Intra	FFAR2	O15552	KTN1	Homo sapiens	Q86UP2-3	Validated Y2H	32296183
Intra	FFAR2	O15552	TMEM86A	Homo sapiens	Q8N2M4	Validated Y2H	32296183
Intra	FFAR2	O15552	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	FFAR2	O15552	ATP13A1	Homo sapiens	Q9HD20-3	Validated Y2H	32296183
Intra	FFAR2	O15552	MS4A13	Homo sapiens	Q5J8X5	Validated Y2H	32296183
Intra	FFAR2	O15552	TMEM97	Homo sapiens	Q5BJF2	Validated Y2H	32296183
Intra	FFAR2	O15552	FAXDC2	Homo sapiens	Q96IV6	Validated Y2H	32296183
Intra	FFAR2	O15552	CNIH1	Homo sapiens	O95406	Validated Y2H	32296183
Intra	FFAR2	O15552	FXYD3	Homo sapiens	Q14802-3	Validated Y2H	32296183
Intra	FFAR2	O15552	PLP1	Homo sapiens	P60201-2	Validated Y2H	32296183
Intra	FFAR2	O15552	TSPO2	Homo sapiens	Q5TGU0	Validated Y2H	32296183
Intra	FFAR2	O15552	STRIT1	Homo sapiens	P0DN84	Validated Y2H	32296183
Intra	FFAR2	O15552	COL4A5	Homo sapiens	P29400-2	Validated Y2H	32296183
Intra	FFAR2	O15552	UPK1B	Homo sapiens	O75841	Validated Y2H	32296183
Intra	FFAR2	O15552	GUCA2A	Homo sapiens	Q02747	Validated Y2H	32296183
Intra	FFAR2	O15552	SLC41A1	Homo sapiens	Q8IVJ1	Validated Y2H	32296183
Intra	FFAR2	O15552	TMEM203	Homo sapiens	Q969S6	Validated Y2H	32296183
Intra	FFAR2	O15552	SCGB1D1	Homo sapiens	O95968	Validated Y2H	32296183
Intra	FFAR2	O15552	TMEM144	Homo sapiens	Q7Z5S9	Validated Y2H	32296183
Intra	FFAR2	O15552	OR10AG1	Homo sapiens	Q8NH19	Validated Y2H	32296183
Intra	FFAR2	O15552	SLC35E3	Homo sapiens	Q7Z769	Y2H Prey Pooling	32296183
Intra	FFAR2	O15552	SLC35E3	Homo sapiens	Q7Z769	Validated Y2H	32296183
Intra	FFAR2	O15552	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	FFAR2	O15552	AGPAT4	Homo sapiens	Q9NRZ5	Validated Y2H	32296183
Intra	FFAR2	O15552	CGRRF1	Homo sapiens	Q99675	Validated Y2H	32296183
Intra	FFAR2	O15552	YIF1A	Homo sapiens	O95070	Validated Y2H	32296183
Intra	FFAR2	O15552	CMTM7	Homo sapiens	Q96FZ5	Validated Y2H	32296183
Intra	FFAR2	O15552	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	FFAR2	O15552	SLC39A9	Homo sapiens	Q9NUM3	Validated Y2H	32296183
Intra	FFAR2	O15552	C11orf24	Homo sapiens	Q96F05	Validated Y2H	32296183
Intra	FFAR2	O15552	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
Intra	FFAR2	O15552	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	FFAR2	O15552	NAT8	Homo sapiens	Q9UHE5	Validated Y2H	32296183
Intra	FFAR2	O15552	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183
Intra	FFAR2	O15552	GPR37L1	Homo sapiens	O60883	Validated Y2H	32296183
Intra	FFAR2	O15552	KRT1	Homo sapiens	P04264	Validated Y2H	32296183
Intra	FFAR2	O15552	FIS1	Homo sapiens	Q9Y3D6	Validated Y2H	32296183
Intra	FFAR2	O15552	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	FFAR2	O15552	TNF	Homo sapiens	P01375	Validated Y2H	32296183
Intra	FFAR2	O15552	ALOX5AP	Homo sapiens	P20292	Validated Y2H	32296183
Intra	FFAR2	O15552	GJB2	Homo sapiens	P29033	Validated Y2H	32296183
Intra	FFAR2	O15552	CXCL9	Homo sapiens	Q07325	Validated Y2H	32296183
Intra	FFAR2	O15552	SACM1L	Homo sapiens	Q9NTJ5	Validated Y2H	32296183
Intra	FFAR2	O15552	NKG7	Homo sapiens	Q16617	Validated Y2H	32296183
Intra	FFAR2	O15552	MFSD5	Homo sapiens	Q6N075	Validated Y2H	32296183
Intra	FFAR2	O15552	BMP10	Homo sapiens	O95393	Validated Y2H	32296183
Intra	FFAR2	O15552	GALNT15	Homo sapiens	Q8N3T1	Validated Y2H	32296183
Intra	FFAR2	O15552	CBLIF	Homo sapiens	P27352	Validated Y2H	32296183
Intra	FFAR2	O15552	DERL1	Homo sapiens	Q9BUN8	Validated Y2H	32296183
Intra	FFAR2	O15552	EMP1	Homo sapiens	P54849	Validated Y2H	32296183
Intra	FFAR2	O15552	NSG1	Homo sapiens	P42857	Validated Y2H	32296183
Intra	FFAR2	O15552	CD82	Homo sapiens	P27701	Validated Y2H	32296183
Intra	FFAR2	O15552	GYPA	Homo sapiens	P02724	Validated Y2H	32296183
Intra	FFAR2	O15552	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	FFAR2	O15552	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183
Intra	FFAR2	O15552	APOD	Homo sapiens	P05090	Validated Y2H	32296183
Intra	FFAR2	O15552	ATP6V0C	Homo sapiens	P27449	Validated Y2H	32296183
Intra	FFAR2	O15552	LAPTM4A	Homo sapiens	Q15012	Validated Y2H	32296183
Intra	FFAR2	O15552	TMEM11	Homo sapiens	P17152	Validated Y2H	32296183
Intra	FFAR2	O15552	SYNDIG1	Homo sapiens	Q9H7V2	Validated Y2H	32296183
Intra	FFAR2	O15552	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	FFAR2	O15552	FZD7	Homo sapiens	O75084	Validated Y2H	32296183
Intra	FFAR2	O15552	BNIP3	Homo sapiens	Q12983	Validated Y2H	32296183
Intra	FFAR2	O15552	MALL	Homo sapiens	Q13021	Validated Y2H	32296183
Intra	FFAR2	O15552	LEPROTL1	Homo sapiens	O95214	Validated Y2H	32296183
Intra	FFAR2	O15552	YIPF2	Homo sapiens	Q9BWQ6	Validated Y2H	32296183
Intra	FFAR2	O15552	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	FFAR2	O15552	UNC50	Homo sapiens	Q53HI1	Validated Y2H	32296183
Intra	FFAR2	O15552	IFITM3	Homo sapiens	Q01628	Validated Y2H	32296183
Intra	FFAR2	O15552	LAT	Homo sapiens	O43561-2	Validated Y2H	32296183
Intra	FFAR2	O15552	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	FFAR2	O15552	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	FFAR2	O15552	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
Intra	FFAR2	O15552	BTN2A2	Homo sapiens	Q8WVV5	Validated Y2H	32296183
Intra	FFAR2	O15552	TM4SF4	Homo sapiens	P48230	Validated Y2H	32296183
Intra	FFAR2	O15552	PNLIPRP1	Homo sapiens	P54315	Validated Y2H	32296183
Intra	FFAR2	O15552	CCDC167	Homo sapiens	Q9P0B6	Validated Y2H	32296183
Intra	FFAR2	O15552	NIPAL4	Homo sapiens	Q0D2K0	Validated Y2H	32296183
Intra	FFAR2	O15552	SELENOK	Homo sapiens	Q9Y6D0	Validated Y2H	32296183
Intra	FFAR2	O15552	CACNG1	Homo sapiens	Q06432	Validated Y2H	32296183
Intra	FFAR2	O15552	PEX16	Homo sapiens	Q9Y5Y5	Validated Y2H	32296183
Intra	FFAR2	O15552	SLC38A1	Homo sapiens	Q9H2H9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

FFAR2 抗体

製品番号	製品名	アプリケーション	反応性
HY-P81225	GPR43 Antibody	IHC-P, IHC-F, ICC/IF, ELISA, IF-Tissue	Human, Mouse

関連疾患

Diseases	Alias
Diversion Colitis
Inflammatory Bowel Disease 16	IBD16 Inflammatory Bowel Disease 16, Susceptibility To
Constipation
Autotopagnosia	Body-Image Agnosia
Anaerobic Meningitis
Noonan Syndrome 8	NS8 Noonan Syndrome, Type 8
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-186246	TUG-2304	Antagonist	/	Unkown
HY-182729	FFA2 agonist-2	Agonist	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	FFAR2	VGNC	VGNC:40831
Macaca mulatta	FFAR2	VGNC	VGNC:72706
Mus musculus	FFAR2	MGD	MGI:2441731
Rattus norvegicus	FFAR2	RGD	RGD:1359614
Others	FFAR2	NCBI