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Cat. No.: HY-W726101

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Glaucine hydrobromide

Name: Glaucine hydrobromide
Brand: MedChemExpress
SKU: HY-W726101
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(Synonyms: O,O-Dimethylisoboldine hydrobromide; S-(+)-Glaucine hydrobromide; NSC 34396 hydrobromide)

Glaucine hydrobromide (O,O-Dimethylisoboldine hydrobromide; S-(+)-Glaucine hydrobromide; NSC 34396 hydrobromide) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine hydrobromide acts as a selective and orally active inhibitor of phosphodiesterase 4 (PDE4), with a K_i of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine hydrobromide induces relaxation of human isolated bronchi by antagonizing calcium channels. Additionally, Glaucine hydrobromide inhibits the activation of NF-κB, leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine hydrobromide holds potential for research in asthma and breast cancer.

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CAS No.: 5996-06-5
화학식: C₂₁H₂₆BrNO₄
분자량:436.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Glaucine hydrobromide Chemical Structure

CAS No.: 5996-06-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

PDE4

All Phosphodiesterase (PDE) Isoforms :

All Calcium Channel Isoforms :

All MMP Isoforms :

All NF-κB Isoforms :

In Vitro

Glaucine (0.1 μM-1 mM; 30 min) hydrobromide produces a concentration-dependent inhibition of both spontaneous tension and histamine (HY-B1204)-induced tension in isolated human bronchial tissues^[1].
Glaucine (10 μM-1 mM; 30 min) hydrobromide concentration-dependently inhibits the concentration of calcium ions in isolated human bronchial tissues induced by potassium depolarization^[1].
Glaucine (0.1-3 mM; 120 min) hydrobromide concentration-dependently inhibits the release of peroxidase from human eosinophils^[1].
Glaucine (0-50 μM; 24 and 48 h) hydrobromide inhibits the proliferation of MCF-7 cells induced by Phorbol 12-myristate 13-acetate (HY-18739) in a concentration-dependent manner^[4].
Glaucine (0-30 μM; 36 h) hydrobromide significantly blocks the expression and activity of MMP-9 in MCF-7 cells induced by Phorbol 12-myristate 13-acetate (HY-18739) in a dose-dependent manner^[4].
Glaucine (0-30 μM; 24 h) hydrobromide significantly inhibits the invasion of MDA-MB-231 cells in a dose-dependent manner^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[4]

Cell Line:

PMA-induced MCF-7 cells
Concentration:

0, 1, 3, 15, 30 and 50 µM
Incubation Time:

24 and 48 h
Result:

Inhibited PMA-induced colony formation by 48 and 63 % at a dose of 15 and 30 µM.

Western Blot Analysis^[4]

Cell Line:

PMA-induced MCF-7 cells
Concentration:

0, 15 and 30 µM
Incubation Time:

36 h
Result:

Inhibited PMA-induced phosphorylation of IκBα in a dose-dependent manner and decreased nuclear NF-κB p65 subunit levels.

In Vivo

Glaucine (5-10 mg/mL; inhale; 3 min) hydrobromide inhibits acute bronchoconstriction and microvascular leakage at all airway levels induced by inhalation of aerosol antigens in guinea pigs sensitized with ovalbumins (HY-W250978)^[5].
Glaucine (10-100 mg/kg; p.o.; 60 min) hydrobromide can effectively inhibit carrageenan (HY-125474)-induced paw edema and LPS (HY-D1056)-induced fever in rats, as well as acetic acid (HY-Y0319)-induced abdominal contraction in mice^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ovalbumins (HY-W250978) sensitized guinea pigs to inhaled aerosol antigens^[5]
Dosage:

10 mg/mL
Administration:

inhale; 10 min
Result:

Reduced airway hyperresponsiveness to histamine and lung eosinophil accumulation 30 minutes and 3 hours after inhalation of the antigen.
Increased eosinophil peroxidase activity in bronchoalveolar lavage fluid 24 hours after inhalation of aerosol antigen.

Related Protocols :

Chemical Information

CAS No. 5996-06-5
분자량 436.34
화학식 C₂₁H₂₆BrNO₄
SMILES

CN1CCC2=CC(OC)=C(OC)C3=C2[C@]1([H])CC4=CC(OC)=C(OC)C=C34.Br
Synonyms

O,O-Dimethylisoboldine hydrobromide; S-(+)-Glaucine hydrobromide; NSC 34396 hydrobromide
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. J Cortijo, et al. Bronchodilator and Anti-Inflammatory Activities of Glaucine: In Vitro Studies in Human Airway Smooth Muscle and Polymorphonuclear Leukocytes. Br J Pharmacol. 1999 Aug;127(7):1641-51. [Content Brief]

[2]. Golo M J Meyer, et al. Studies on the in Vivo Contribution of Human Cytochrome P450s to the Hepatic Metabolism of Glaucine, a New Drug of Abuse. Biochem Pharmacol. 2013 Nov 15;86(10):1497-506. [Content Brief]

[3]. Maya Spasova, et al. Cinnamoyl- And Hydroxycinnamoyl Amides of Glaucine and Their Antioxidative and Antiviral Activities. Bioorg Med Chem. 2008 Aug 1;16(15):7457-61. [Content Brief]

[4]. Hyereen Kang, et al. "Glaucine inhibits breast cancer cell migration and invasion by inhibiting MMP-9 gene expression through the suppression of NF-κB activation." Molecular and cellular biochemistry 403 (2015): 85-94. [Content Brief]

[5]. Pons, et al. "Effects of inhaled glaucine on pulmonary responses to antigen in sensitized guinea pigs." European journal of pharmacology 397.1 (2000): 187-195. [Content Brief]

[6]. PINTO, et al. "Anti‐inflammatory, analgesic and antipyretic effects of glaucine in rats and mice." Pharmacy and Pharmacology Communications 4.10 (1998): 502-505.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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Glaucine hydrobromide

All Phosphodiesterase (PDE) Isoforms

All Calcium Channel Isoforms

All MMP Isoforms

All NF-κB Isoforms