TD1092
Based on 1 Customer Validation
TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research.
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- Purity: 98.23%
- CAS No.: 3037417-26-5
- 화학식: C55H70N8O9
- 분자량:987.19
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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cIAP1 |
cIAP2 |
XIAP |
Caspase 3 |
Caspase-7 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | GI50 |
0.396 μM
Compound: 12; TD-1092
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Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
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[PMID: 36410083] |
TD1092 (0.1 μM-10 μM; 0.5-6 h) potently degrades cIAP1, cIAP2, and XIAP in a dose- and time-dependent manner[1].
TD1092 (0.01, 0.1 and 1 μM; 18 h) activates caspase 3/7 in MCF-7 cells[1].
TD1092 (1 μM; 48 h and 72 h) promotes cancer cell death[1].
TD1092 (0.1 μM; 24 h) inhibits TNFα-induced migration and invasion against triple-negative breast cancer cells[1].
TD1092 (1 μM; 6 h) inhibits TNFα-induced NF-κB signaling pathway and epithelial-mesenchymal transition (EMT) via IAP degradation[1].
TD1092 (1 μM; 72 h) inhibits MCF-7 cells growth with an IG50 value of 0.395 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:(1) 0, 0.1, 1, 10 μM or 0.1 μM
(2) 0.1 μM, with or without 100 ng/mL TNFα -
Incubation Time:18 hours or 0.5, 1, 2, 4, 6 hours for (1) and 4 hours for (2)
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Result:Dose- and time-dependently decreases the protein level of cIAP1, cIAP2, and XIAP.
Inhibited the phosphorylation of IKK, IkBα, p65, and p38 mediated by TNFα.
Counterbalanced the effect of TNFα on the levels of E-cadherin (CDH1; an epithelial marker) and vimentin (VIM; a mesenchymal marker).
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Cell Line:MDA-MB-231 and MDA-MB-157 cells
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Concentration:0.1 μM; with or without 100 ng/mL TNFα
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Incubation Time:24 hours
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Result:Inhibited TNFα-induced (100 ng/mL) migration and invasion against two triple-negative breast cancer (TNBC; MDA-MB-231 and MDA-MB-157) cell lines.
Chemical Information
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CAS No. 3037417-26-5
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Appearance Solid
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분자량 987.19
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화학식 C55H70N8O9
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Color Light yellow to yellow
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SMILES
O=C(N[C@@H]1CCCC2=C1C=CC=C2)[C@H]3N(C([C@@H](NC([C@H](C)NC)=O)C(C)(C)C)=O)CC4=C(C=CC(OCCCCCCCCNC(C(C5)CN5C(C=C6C7=O)=CC=C6C(N7C8CCC(NC8=O)=O)=O)=O)=C4)C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
DMSO : ≥ 100 mg/mL (101.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0130 mL | 5.0649 mL | 10.1298 mL | 25.3244 mL |
| 5 mM | 0.2026 mL | 1.0130 mL | 2.0260 mL | 5.0649 mL | |
| 10 mM | 0.1013 mL | 0.5065 mL | 1.0130 mL | 2.5324 mL | |
| 15 mM | 0.0675 mL | 0.3377 mL | 0.6753 mL | 1.6883 mL | |
| 20 mM | 0.0506 mL | 0.2532 mL | 0.5065 mL | 1.2662 mL | |
| 25 mM | 0.0405 mL | 0.2026 mL | 0.4052 mL | 1.0130 mL | |
| 30 mM | 0.0338 mL | 0.1688 mL | 0.3377 mL | 0.8441 mL | |
| 40 mM | 0.0253 mL | 0.1266 mL | 0.2532 mL | 0.6331 mL | |
| 50 mM | 0.0203 mL | 0.1013 mL | 0.2026 mL | 0.5065 mL | |
| 60 mM | 0.0169 mL | 0.0844 mL | 0.1688 mL | 0.4221 mL | |
| 80 mM | 0.0127 mL | 0.0633 mL | 0.1266 mL | 0.3166 mL | |
| 100 mM | 0.0101 mL | 0.0506 mL | 0.1013 mL | 0.2532 mL |
TD1092 Related Classifications
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