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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
zika virus infection
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "zika virus infection" in MCE Product Catalog:
34
34 Publications Verification
Synonyms: RR82 TFA
Research Areas:
Pyridostatin (RR82) TFA is a G-quadruplex (G4) inducer/stabilizer with a Kd of 490 nM. Pyridostatin TFA also acts as an inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC50 of 11.0 μM. Pyridostatin TFA interacts with G-quadruplex structures, regulates the expression of SRC and SUB1, and induces replication- and transcription-dependent DNA damage, growth arrest, and genomic instability. Pyridostatin TFA exhibits antiproliferative and antiviral activities. Pyridostatin TFA can be used in studies related to breast cancer, cervical cancer, and Zika virus infection .
34
34 Publications Verification
Cat. No.: HY-15176C
CAS No.: 2517456-88-9
Synonyms: RR82 trihydrochloride
Research Areas:
Pyridostatin (RR82) trihydrochloride is a G-quadruplex (G4) inducer/stabilizer with a Kd of 490 nM. Pyridostatin trihydrochloride also acts as an inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC50 of 11.0 μM. Pyridostatin trihydrochloride interacts with G-quadruplex structures, regulates the expression of SRC and SUB1, and induces replication- and transcription-dependent DNA damage, growth arrest, and genomic instability. Pyridostatin trihydrochloride exhibits antiproliferative and antiviral activities. Pyridostatin trihydrochloride can be used in studies related to breast cancer, cervical cancer, and Zika virus infection .
2
2 Cited Publications
Synonyms: (-)-Cephaeline; NSC 32944 free base
1
1 Cited Publications
Cat. No.: HY-128788A
Research Areas:
ddhCTP trisodium solution (100 mM ± 3 mM) is an endogenously produced pyrimidine base analog with a Kd of 17.0 nM for LLDH and an IC50 of 55.8 μM for GAPDH. By inhibiting key metabolic enzymes such as GAPDH, ddhCTP trisodium reduces glycolytic flux and shifts metabolic flow toward the pentose phosphate pathway, thereby regulating the redox balance of cells. As a competitive CTP analog, ddhCTP trisodium terminates RNA synthesis by flavivirus RdRps and SARS-CoV-2 RdRp, and inhibits Zika virus replication in vivo. ddhCTP trisodium can be used in studies related to viral infections, COVID-19 and Zika virus infections .
Synonyms: DAQ B1; L-783281; Dimethylasterriquinone
Target:
Insulin Receptor Akt NO Synthase NADPH Oxidase JAK STAT FOXO DNA/RNA Synthesis ERK Flavivirus
Research Areas:
Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology
Demethylasterriquinone B1 (DAQ B1; L-783281) is an orally active insulin receptor (insulin receptor) agonist and AKT activator. By activating AKT, Demethylasterriquinone B1 upregulates the expression and activity of eNOS to increase NO production, while downregulating the expression of the NADPH oxidase subunit p22phox to reduce oxidative stress and improve vascular endothelial dysfunction in hypertensive rats. Demethylasterriquinone B1 combind with an AKT inhibitor targets the insulin signaling pathway to activate two antiviral pathways, RNA interference and JAK/STAT, in mosquitoes, thereby reducing Zika virus infection .
Synonyms: C8-HSL
Target:
Research Areas:
N-Octanoyl-L-homoserine lactone (C8-HSL) is an autoinducer. It mainly serves as a key inter- and intra-species communication medium or "signal molecule" in Gram-negative bacteria. N-Octanoyl-L-homoserine lactone microparticles exhibit adjuvant potential when used in combination with various particulate vaccines .
Cat. No.: HY-128788
CAS No.: 2279171-34-3
Research Areas:
ddhCTP is an endogenously produced pyrimidine base analog with a Kd of 17.0 nM for LLDH and an IC50 of 55.8 μM for GAPDH. By inhibiting key metabolic enzymes such as GAPDH, ddhCTP reduces glycolytic flux and shifts metabolic flow toward the pentose phosphate pathway, thereby regulating the redox balance of cells. As a competitive CTP analog, ddhCTP terminates RNA synthesis by flavivirus RdRps and SARS-CoV-2 RdRp, and inhibits Zika virus replication in vivo. ddhCTP can be used in studies related to viral infections, COVID-19 and Zika virus infections.
Target:
Research Areas:
NS2B/NS3-IN-3 is an inhibitor of Flavivirus NS2B-NS3 protease, with an IC50 of 0.32 μM against Zika virus NS2B-NS3 protease. NS2B/NS3-IN-3 also exhibits inhibitory effects on dengue virus type 2 NS2B-NS3 protease and West Nile virus NS2B-NS3 protease. NS2B/NS3-IN-3 inhibits the intracellular replication of Zika virus. NS2B/NS3-IN-3 can be used in studies related to flavivirus infections .
Target:
Research Areas:
NS2B/NS3-IN-3 hydrochloride is an inhibitor of Flavivirus NS2B-NS3 protease, with an IC50 of 0.32 μM against Zika virus NS2B-NS3 protease. NS2B/NS3-IN-3 hydrochloride also exhibits inhibitory effects on dengue virus type 2 NS2B-NS3 protease and West Nile virus NS2B-NS3 protease. NS2B/NS3-IN-3 hydrochloride inhibits the intracellular replication of Zika virus. NS2B/NS3-IN-3 hydrochloride can be used in studies related to flavivirus infections .
Cat. No.: HY-P990817
Target:
Research Areas:
Synonyms: (-)-Cephaeline hydrochloride; NSC 32944 monohydrochloride
Cat. No.: HY-124237AR
CAS No.: 147852-84-4
Synonyms: C8-HSL (Standard)
Target:
Research Areas:
N-Octanoyl-L-homoserine lactone (Standard) (C8-HSL (Standard)) is the analytical standard of N-Octanoyl-L-homoserine lactone (HY-124237A). This product is intended for research and analytical applications. N-Octanoyl-L-homoserine lactone (C8-HSL) is an autoinducer. It mainly serves as a key inter- and intra-species communication medium or "signal molecule" in Gram-negative bacteria. N-Octanoyl-L-homoserine lactone microparticles exhibit adjuvant potential when used in combination with various particulate vaccines .
Cat. No.: HY-151446
CAS No.: 947699-46-9
Research Areas:
ZIKV-IN-3 (compound 5a), an andrographolide derivatives, is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 18.34 μM. ZIKV-IN-3 inhibits ZIKV replication and infection. ZIKV-IN-3 can be used in research of Zika virus (ZIKV) .
Cat. No.: HY-146418
CAS No.: 2407570-07-2
Target:
Research Areas:
Antiviral agent 20 (Compound 17b) is a selective inhibitor against Zika virus infection with an EC50 of 4.5 µM. Antiviral agent 20 has low cytotoxicity .
Cat. No.: HY-161806
Target:
Research Areas:
ZXH-8-004 is a DENV E PROTAC degrader with a DC50 value of 0.21 µM in Huh7.5 cells. ZXH-8-004 induces CRBN- and proteasome-dependent degradation of intracellular dengue virus envelope protein. ZXH-8-004 inhibits envelope-mediated membrane fusion during viral entry and reduces the production of infectious dengue virus particles. ZXH-8-004 can be used in studies related to dengue virus infection, Zika virus infection, Japanese encephalitis virus infection, West Nile virus infection, and yellow fever virus infection .
Cat. No.: HY-176433
CAS No.: 79514-43-5
Target:
Research Areas:
NSC-323241 is a potent STT3A-mediated mega protein complex assembly inhibitor. NSC-323241 disrupts he endoplasmic reticulum (ER) mega complex nucleated by STT3A during dengue virus (DENV) and Zika virus (ZIKV) infection. NSC-323241 targets the binding of STT3A subcomplex with viral nonstructural proteins (e.g., NS2B, NS3) and host translocon proteins, disrupting the formation of viral replication microenvironment. NSC-323241 is promising for research of flavivirus infection, such as dengue fever and Zika virus .
Cat. No.: HY-161804
Target:
Research Areas:
GNF-2-deg is a PROTAC degrader targeting the dengue virus envelope protein (DENV E protein), with a DC50 of 0.83 μM in Huh7.5 cells. GNF-2-deg induces CRBN- and proteasome-dependent proteolysis of intracellular E protein. GNF-2-deg inhibits E protein-mediated membrane fusion and blocks viral particle production. GNF-2-deg reduces viral yield in infected cells and retains activity against E protein βOG pocket mutant virus-like particles (VLP). GNF-2-deg can be used in the research of dengue virus infection, Zika virus infection, Japanese encephalitis, West Nile virus infection and yellow fever .
Synonyms: (-)-Cephaeline (Standard); NSC 32944 free base (Standard)
Cat. No.: HY-162073
CAS No.: 3022924-04-2
Target:
Research Areas:
ZIKV-IN-8 (Compound 9b) is a noncompetitive Zika virus (ZIKV) inhibitor. ZIKV-IN-8 shows the best anti-ZIKV activity with a selectivity index of 22.4. ZIKV-IN-8 has significant inhibition of ZIKV with an IC50 value of 25.6 μM. ZIKV-IN-8 can be used for the research of ZIKV infection .
Cat. No.: HY-151445
CAS No.: 910582-16-0
Research Areas:
ZIKV-IN-2 (compound 3a) is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 38.86 μM. ZIKV-IN-2 inhibits ZIKV replication and infection. ZIKV-IN-2 can be used in research of Zika virus (ZIKV) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
