Apoptosis inducer 45
Apoptosis inducer 45 is an apoptosis inducer. Apoptosis inducer 45 is cytotoxically active against the MCF-7 cell line. Apoptosis inducer 45 elicits MCF-7 cell apoptosis via the mitochondrial pathway (increases the Bax/Bcl-2 ratio) by activating cleavage of caspase-9, thereby inducing the fragmentation of DNA repair protein PARP. Apoptosis inducer 45 also can induce caspase-8 cleavage, subsequently initiating cleavage of caspase-3 and its downstream protein PARP to culminate in the extrinsic apoptosis. Apoptosis inducer 45 can be used in the research of breast cancer.
For research use only. We do not sell to patients.
- Formula: C41H57N3O3
- Molecular Weight:639.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Biological Activity
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Caspase 3 |
Caspase 9 |
Caspase 8 |
PARP |
Bax |
Bcl-2 |
Apoptosis inducer 45 (Compound 11s) inhibits cell proliferation with IC50 values of 3.56, 4.93, 7.76 and 13.35 μM against A549, MCF-7, HL-7702 and MDA-MB-231 cells[1].
Apoptosis inducer 45 (2.5-10 μM, 24 h) induces MCF-7 cell apoptosis via both the exogenous and endogenous pathways[1].
Apoptosis inducer 45 (2.5-10 μM, 24 h-14 d) shows a concentration- and time-dependent inhibition of MCF-7 cell growth and inhibits colony formation[1].
Apoptosis inducer 45 (2.5-10 μM, 72 h) significantly reduces the migration ability of the MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:2.5, 5 and 10 μM
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Incubation Time:24 h
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Result:led to the typical apoptotic morphological characteristics of MCF-7 cells.
Increased apoptosis rates as the concentration rises.
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Cell Line:MCF-7 cells
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Concentration:2.5, 5 and 10 μM
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Incubation Time:72 h
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Result:Significantly reduced the migration ability, and the migration inhibition effect persisted for 72 hours of observation.
Chemical Information
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Molecular Weight 639.91
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Formula C41H57N3O3
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SMILES
[H][C@]1(C(CC[C@@]2(C(C)([C@@H](CC[C@@]12C)O)C)[H])=C)CC/C(C)=C/C(N3CCN(CC3)CC4=CC=C(C=C4)C(NCCC5=CC=C(C=C5)C)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 45 Related Classifications
HY-178099 Related Classifications
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