HSD17B13 - hydroxysteroid 17-beta dehydrogenase 13 Gene

Also Known as FLDP; SCDR9; NIIL497; SDR16C3; HMFN0376

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 345275

About HSD17B13

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:87,303,794-87,322,882 (from NCBI)

This gene has 2 transcripts (splice variants), 89 orthologues and 25 paralogues. Biased expression in liver (RPKM 126.6) and fat (RPKM 7.3).

Summary

Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and steroid dehydrogenase activity. Acts upstream of or within positive regulation of lipid biosynthetic process. Located in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]

HSD17B13 Products (2)

mRNA Protein Name
NM_001136230.3 NP_001129702.1 17-beta-hydroxysteroid dehydrogenase 13 isoform B
NM_178135.5 NP_835236.2 17-beta-hydroxysteroid dehydrogenase 13 isoform A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within positive regulation of lipid biosynthetic process IDA
IDA: Inferred from direct assay
25028495 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in lipid droplet IDA
IDA: Inferred from direct assay
25028495 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSD17B13 Protein Structure

adh_short

adh_short: short chain dehydrogenase (38 - 203)

  • 0
  • 100
  • 200
  • 300 a.a.
Protein Preferred Names Protein Names

17-beta-hydroxysteroid dehydrogenase 13

  • 17-beta hydroxysteroid dehydrogenase

HSD17B13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
HSD17B13 Q7Z5P4 NRM Homo sapiens Q8IXM6
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 SLC35B4 Homo sapiens Q969S0
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 SLC25A46 Homo sapiens Q96AG3
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 SLC30A3 Homo sapiens Q99726
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 SERP1 Homo sapiens Q9Y6X1
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 VAPA Homo sapiens Q9P0L0
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 ADGRE2 Homo sapiens Q9UHX3
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 AIG1 Homo sapiens Q9NVV5-2
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 CLDND2 Homo sapiens Q8NHS1
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 MIEF2 Homo sapiens Q96C03-3
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 ANKRD46 Homo sapiens Q86W74-2
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 FAXDC2 Homo sapiens Q96IV6
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TMEM229B Homo sapiens Q8NBD8
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 CLDN19 Homo sapiens Q8N6F1-2
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TMEM203 Homo sapiens Q969S6
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TMEM243 Homo sapiens Q9BU79
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 ST6GAL2 Homo sapiens Q96JF0-2
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 FETUB Homo sapiens Q9UGM5
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 REEP6 Homo sapiens Q96HR9-2
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TREX1 Homo sapiens Q9NSU2-1
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 BBC3 Homo sapiens Q96PG8
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 AGPAT4 Homo sapiens Q9NRZ5
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TMEM167B Homo sapiens Q9NRX6
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TMEM14C Homo sapiens Q9P0S9
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 MARCHF5 Homo sapiens Q9NX47
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 SCAMP5 Homo sapiens Q8TAC9
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 AGPAT3 Homo sapiens Q9NRZ7
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 CMTM7 Homo sapiens Q96FZ5
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TMEM140 Homo sapiens Q9NV12
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 NAT8 Homo sapiens Q9UHE5
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TMEM255B Homo sapiens Q8WV15
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 THSD7A Homo sapiens Q9UPZ6
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TMEM222 Homo sapiens Q9H0R3
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 SFXN1 Homo sapiens Q9H9B4
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 SACM1L Homo sapiens Q9NTJ5
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 HSD3B7 Homo sapiens Q9H2F3
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 NAPB Homo sapiens Q9H115
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 DIABLO Homo sapiens Q9NR28
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 SFXN2 Homo sapiens Q96NB2
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TBRG4 Homo sapiens Q969Z0
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 GOLM1 Homo sapiens Q8NBJ4
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 RABAC1 Homo sapiens Q9UI14
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 ORMDL3 Homo sapiens Q8N138
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TMEM120A Homo sapiens Q9BXJ8
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 PBX3 Homo sapiens Q96AL5
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TMEM19 Homo sapiens Q96HH6
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 FATE1 Homo sapiens Q969F0
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 YIPF2 Homo sapiens Q9BWQ6
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 YIPF4 Homo sapiens Q9BSR8
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TSPAN10 Homo sapiens Q9H1Z9
Anti Tag CoIP
33961781
Intra
HSD17B13 Q7Z5P4 TSPAN10 Homo sapiens Q9H1Z9
Anti Tag CoIP
28514442
Intra
HSD17B13 Q7Z5P4 INSIG2 Homo sapiens Q9Y5U4
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 RUSF1 Homo sapiens Q96GQ5
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 TMEM100 Homo sapiens Q9NV29
Validated Y2H
32296183
Intra
HSD17B13 Q7Z5P4 CCDC167 Homo sapiens Q9P0B6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mucopolysaccharidosis Iii

  • Sanfilippo Syndrome

  • Mucopolysaccharidosis Type Iii

  • Mucopolysaccharidosis Type 3

  • Mps Iii

  • Mpsiii

  • Sanfilippo Disease

  • Heparan Sulfate Sulfatase Deficiency

  • Mucopolysaccharidosis, Mps-Iii

  • N-Sulphoglucosamine Sulphohydrolase Deficiency

  • Naglu Deficiency

  • Sanfilippo'S Syndrome

  • Mucopoly-Saccharidosis Type 3

  • Mps3

  • Sanfilippos Syndrome

  • Mucopolysaccharidosis Type Iiia

  • Mps Iii B
Non-Alcoholic Fatty Liver Disease

  • Fatty Liver

  • Non-Alcoholic Fatty Liver

  • Nafld

  • Nonalcoholic Fatty Liver Disease

  • Nonalcoholic Steatohepatitis

  • Steatosis

  • Nafl

  • Nash

  • Non-Alcoholic Steatohepatitis

  • Susceptibility To Nonalcoholic Fatty Liver Disease

  • Steatohepatitis

  • Fatty Degeneration

  • Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

  • Nafld Without Nash

  • Nafld Without Mention Of Nash
Fatty Liver Disease

  • Alcoholic Fatty Liver

  • Fatty Liver

  • Fatty Liver, Alcoholic

  • Fatty Change Of Liver

  • Hepatic Lipidosis

  • Steatosis Of Liver

  • Fatty Liver Alcoholic

  • Steatohepatitis

  • Etoh Fatty Liver

  • Etoh Fatty Liver Metamorphosis

  • Fatty Etoh Liver Necrosis
Benign Meningioma

  • Meningioma, Benign
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (120)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-148814 BI-3231 Inhibitor 99.83% Unkown
HY-W003696 tert-Butyl 5-bromoisoindoline-2-carboxylate 99.44% Unkown
HY-128145 HSD17B13-IN-41 Inhibitor 97.0% Unkown
HY-148926 HSD17B13-IN-1 Inhibitor / Unkown
HY-156735 HSD17B13-IN-2 Inhibitor 99.72% Unkown
HY-156736 HSD17B13-IN-3 Inhibitor 99.78% Unkown
HY-157627 HSD17B13-IN-9 Inhibitor 99.92% Unkown
HY-157630 HSD17B13-IN-10 Inhibitor / Unkown
HY-161212 HSD17B13-IN-8 Inhibitor 99.97% Unkown
HY-161227 HSD17B13-IN-43 Inhibitor 99.68% Unkown
HY-172122 FXR/HSD17B13 modulator 1 Modulator 96.64% Unkown
HY-177634 Gatuzosiran Inhibitor / Unkown
HY-RS06393 HSD17B13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17283 Hsd17b13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-157601 HSD17B13-IN-4 Inhibitor / Unkown
HY-157613 HSD17B13-IN-5 Inhibitor / Unkown
HY-157615 HSD17B13-IN-6 Inhibitor / Unkown
HY-157632 HSD17B13-IN-13 Inhibitor / Unkown
HY-157650 HSD17B13-IN-20 Inhibitor / Unkown
HY-157653 HSD17B13-IN-22 Inhibitor / Unkown
HY-157654 HSD17B13-IN-26 Inhibitor / Unkown
HY-157662 HSD17B13-IN-33 Inhibitor / Unkown
HY-157663 HSD17B13-IN-36 Inhibitor / Unkown
HY-157664 HSD17B13-IN-38 Inhibitor / Unkown
HY-157665 HSD17B13-IN-39 Inhibitor / Unkown
HY-157667 HSD17B13-IN-44 Inhibitor / Unkown
HY-157671 HSD17B13-IN-45 Inhibitor / Unkown
HY-157674 HSD17B13-IN-46 Inhibitor / Unkown
HY-157676 HSD17B13-IN-47 Inhibitor / Unkown
HY-157708 HSD17B13-IN-67 Inhibitor / Unkown
HY-157710 HSD17B13-IN-68 Inhibitor / Unkown
HY-157717 HSD17B13-IN-70 Inhibitor / Unkown
HY-157720 HSD17B13-IN-72 Inhibitor / Unkown
HY-157722 HSD17B13-IN-73 Inhibitor / Unkown
HY-157723 HSD17B13-IN-74 Inhibitor / Unkown
HY-157724 HSD17B13-IN-76 Inhibitor / Unkown
HY-157726 HSD17B13-IN-77 Inhibitor / Unkown
HY-159651 PTOTAC HSD17B13 degrader 1 / Unkown
HY-159660 E3 ligase Ligand 31 / Unkown
HY-159661 E3 Ligase Ligand-linker Conjugate 114 / Unkown
HY-159662 HSD17B13-IN-106 / Unkown
HY-161211 HSD17B13-IN-7 / Unkown
HY-161213 HSD17B13-IN-11 Inhibitor / Unkown
HY-161214 HSD17B13-IN-12 Inhibitor / Unkown
HY-161215 HSD17B13-IN-14 Inhibitor / Unkown
HY-161216 HSD17B13-IN-15 Inhibitor / Unkown
HY-161217 HSD17B13-IN-16 Inhibitor / Unkown
HY-161218 HSD17B13-IN-17 Inhibitor / Unkown
HY-161219 HSD17B13-IN-18 Inhibitor / Unkown
HY-161220 HSD17B13-IN-19 Inhibitor / Unkown
HY-161221 HSD17B13-IN-21 Inhibitor / Unkown
HY-161222 HSD17B13-IN-23 Inhibitor / Unkown
HY-161223 HSD17B13-IN-27 Inhibitor / Unkown
HY-161224 HSD17B13-IN-31 Inhibitor / Unkown
HY-161225 HSD17B13-IN-40 Inhibitor / Unkown
HY-161226 HSD17B13-IN-42 Inhibitor / Unkown
HY-161228 HSD17B13-IN-48 Inhibitor / Unkown
HY-161229 HSD17B13-IN-69 Inhibitor / Unkown
HY-161230 HSD17B13-IN-75 Inhibitor / Unkown
HY-161231 HSD17B13-IN-78 Inhibitor / Unkown
HY-161232 HSD17B13-IN-79 Inhibitor / Unkown
HY-161277 HSD17B13-IN-100 Inhibitor / Unkown
HY-161278 HSD17B13-IN-102 Inhibitor / Unkown
HY-161979 HSD17B13-IN-103 Inhibitor / Unkown
HY-162207 HSD17B13-IN-54 Inhibitor / Unkown
HY-162208 HSD17B13-IN-55 Inhibitor / Unkown
HY-162209 HSD17B13-IN-63 Inhibitor / Unkown
HY-162210 HSD17B13-IN-65 Inhibitor / Unkown
HY-162211 HSD17B13-IN-84 Inhibitor / Unkown
HY-162212 HSD17B13-IN-85 Inhibitor / Unkown
HY-162213 HSD17B13-IN-86 Inhibitor / Unkown
HY-162214 HSD17B13-IN-90 Inhibitor / Unkown
HY-162215 HSD17B13-IN-88 Inhibitor / Unkown
HY-162216 HSD17B13-IN-89 Inhibitor / Unkown
HY-162217 HSD17B13-IN-91 Inhibitor / Unkown
HY-162219 HSD17B13-IN-93 Inhibitor / Unkown
HY-162220 HSD17B13-IN-94 Inhibitor / Unkown
HY-162221 HSD17B13-IN-95 Inhibitor / Unkown
HY-162222 HSD17B13-IN-96 Inhibitor / Unkown
HY-162223 HSD17B13-IN-97 Inhibitor / Unkown
HY-162224 HSD17B13-IN-98 Inhibitor / Unkown
HY-162225 HSD17B13-IN-99 Inhibitor / Unkown
HY-162278 HSD17B13-IN-101 Inhibitor / Unkown
HY-163240 HSD17B13-IN-24 Inhibitor / Unkown
HY-163241 HSD17B13-IN-25 Inhibitor / Unkown
HY-163242 HSD17B13-IN-28 Inhibitor / Unkown
HY-163243 HSD17B13-IN-29 Inhibitor / Unkown
HY-163244 HSD17B13-IN-30 Inhibitor / Unkown
HY-163245 HSD17B13-IN-32 Inhibitor / Unkown
HY-163246 HSD17B13-IN-34 Inhibitor / Unkown
HY-163247 HSD17B13-IN-35 Inhibitor / Unkown
HY-163248 HSD17B13-IN-37 Inhibitor / Unkown
HY-163249 HSD17B13-IN-49 Inhibitor / Unkown
HY-163250 HSD17B13-IN-51 Inhibitor / Unkown
HY-163251 HSD17B13-IN-52 Inhibitor / Unkown
HY-163252 HSD17B13-IN-53 Inhibitor / Unkown
HY-163253 HSD17B13-IN-56 Inhibitor / Unkown
HY-163253S HSD17B13-IN-56-d3 Inhibitor / Unkown
HY-163254 HSD17B13-IN-57 Inhibitor / Unkown
HY-163255 HSD17B13-IN-58 Inhibitor / Unkown
HY-163256 HSD17B13-IN-59 Inhibitor / Unkown
HY-163257 HSD17B13-IN-60 Inhibitor / Unkown
HY-163258 HSD17B13-IN-61 Inhibitor / Unkown
HY-163259 HSD17B13-IN-62 Inhibitor / Unkown
HY-163259S HSD17B13-IN-62-d3 Inhibitor / Unkown
HY-163260 HSD17B13-IN-64 Inhibitor / Unkown
HY-163261 HSD17B13-IN-66 Inhibitor / Unkown
HY-163262 HSD17B13-IN-71 Inhibitor / Unkown
HY-163263 HSD17B13-IN-80 Inhibitor / Unkown
HY-163263S HSD17B13-IN-80-d3 Inhibitor / Unkown
HY-163263S1 HSD17B13-IN-80-d2 Inhibitor / Unkown
HY-163264 HSD17B13-IN-81 Inhibitor / Unkown
HY-163265 HSD17B13-IN-82 Inhibitor / Unkown
HY-163266 HSD17B13-IN-83 Inhibitor / Unkown
HY-174133 HSD17B13-IN-104 Inhibitor 95.0% Unkown
HY-174253 HSD17B13-IN-105 Inhibitor / Unkown
HY-177634A Gatuzosiran sodium Inhibitor / Unkown
HY-179015 HSD17B13/PPAR modulator-1 / Unkown
HY-183309 FXR/HSD17B13-modulator-2 / Unkown
HY-RS23738 Hsd17b13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HSD17B13 MGD MGI:2140804
Macaca mulatta HSD17B13 VGNC VGNC:73417
Canis familiaris HSD17B13 VGNC VGNC:41803
Rattus norvegicus HSD17B13 RGD RGD:1359553
Felis catus HSD17B13 VGNC VGNC:62848
Bos taurus HSD17B13 VGNC VGNC:29971
Others HSD17B13 NCBI