Art. -Nr.: HY-B1971

Deltamethrin

(Synonyms: Decamethrin)

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control.

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Reinheit: 99.96%
CAS. Nr.: 52918-63-5
Formel: C₂₂H₁₉Br₂NO₃
Molecular Weight:505.20

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Deltamethrin Chemical Structure

CAS. Nr.: 52918-63-5

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Caspase 3

Bcl-2

Bax

IL-1β

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

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In Vitro

Deltamethrin (5-60 μM, 24 h) increases cytosolic free Ca²⁺ concentration and induces apoptosis in a concentration-dependent manner in OC2 human oral cancer cells^[2].
Deltamethrin (0.5-100 μM, 24 h) inhibits thymocytes viability^[3].
Deltamethrin (10-50 μM, 1-6 h) shows a concentration- and time-dependent enhancement in caspase-3 activity in murine thymocytes^[3].
Deltamethrin (10-50 μM, 18 h) induces apoptosis in thymocytes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

Murine thymocytes
Concentration:

0.5 μM, 1 μM, 10 μM, 25 μM, 50 μM, 100 μM
Incubation Time:

6 h, 18 h
Result:

Caused 32% and 59% loss in cell viability at 25 μM and 100 μM at 6 h.
Caused 46% and 68% loss in cell viability at 25 μM and 100 μM at 18 h.

Cell Cycle Analysis^[3]

Cell Line:

Murine thymocytes
Concentration:

10 μM, 25 μM, 50 μM
Incubation Time:

18 h
Result:

Increased the number of apoptotic cells in a concentration-dependent manner.

In Vivo

Deltamethrin (5.6-18 mg/kg, Oral, once a day for 15 days) induces oxidative stress in mice^[4].
Deltamethrin (60 mg/kg, Intraperitoneal injection, single dose) can increase the activity of Choline acetyltransferase (ChAT) in the striatum in rats^[5].
Deltamethrin (15-45 mg/kg, Gavage, once a day for 12 weeks) promotes cardiomyocyte inflammation and apoptosis through inhibiting the Nrf2/HO-1 signaling pathway in quails^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss albino male mice^[4]
Dosage:

5.6 mg/kg, 18 mg/kg
Administration:

Oral
Result:

Significantly induced lipid peroxidation (LPO) in liver and kidney.
Suppressed the activities of vital antioxidant enzymes such as glutathione peroxidase (GPx), glutathione S-transferase (GST) and catalase (CAT).
Decreased the glutathione (GSH) level.

Animal Model:

Male Sprague-Dawley rats^[5]
Dosage:

60 mg/kg
Administration:

Intraperitoneal injection (i.p.)
Result:

Modulated the hippocampal high-affinity choline uptake (HACU).
Increased the activity of ChAT in the hippocampus and cortex.
Increased the activity of striatal ChAT.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 52918-63-5
Appearance Solid
Molecular Weight 505.20
Formel C₂₂H₁₉Br₂NO₃
Color White to off-white
SMILES

O=C([C@H]1C(C)(C)[C@H]1/C=C(Br)\Br)O[C@H](C#N)C2=CC=CC(OC3=CC=CC=C3)=C2
Synonyms

Decamethrin
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Toxicol Appl Pharmacol

Pharmacological inhibition of USP7 attenuates deltamethrin-induced neuronal ferroptosis via GPX4 stabilization. [Abstract]

2026 Mar:508:117716. PMID: 41539346
Toxicol In Vitro

MEK1 inhibition ameliorates mitochondrial-dependent apoptosis induced by deltamethrin in mouse hippocampal neuron HT22 cells. [Abstract]

2025 Jun:106:106047. PMID: 40058615

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (197.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9794 mL

9.8971 mL

19.7941 mL

5 mM

0.3959 mL

1.9794 mL

3.9588 mL

10 mM

0.1979 mL

0.9897 mL

1.9794 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (4.95 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (4.95 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (4.95 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (565 KB)
- English - EN (565 KB)
- Français - FR (565 KB)
- Deutsch - DE (565 KB)
- Norwegian - NO (565 KB)
- Español - ES (565 KB)
- Swedish - SV (565 KB)
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- Portuguese - PT (565 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lu Q, et al. Deltamethrin toxicity: A review of oxidative stress and metabolism [J]. Environmental research, 2019, 170: 260-281. [Content Brief]

[2]. Chi C C, et al. Effect of the pesticide, deltamethrin, on Ca2+ signaling and apoptosis in OC2 human oral cancer cells [J]. Drug and Chemical Toxicology, 2014, 37(1): 25-31. [Content Brief]

[3]. Kumar A, et al. Deltamethrin induced an apoptogenic signalling pathway in murine thymocytes: exploring the molecular mechanism [J]. Journal of Applied Toxicology, 2014, 34(12): 1303-1310. [Content Brief]

[4]. Rehman H, et al. The modulatory effect of deltamethrin on antioxidants in mice [J]. Clinica Chimica Acta, 2006, 369(1): 61-65. [Content Brief]

[5]. Hossain M M, et al. Neuromechanical effects of pyrethroids, allethrin, cyhalothrin and deltamethrin on the cholinergic processes in rat brain [J]. Life sciences, 2005, 77(7): 795-807 [Content Brief]

[6]. Yang X, et al. The heart as a target for deltamethrin toxicity: Inhibition of Nrf2/HO-1 pathway induces oxidative stress and results in inflammation and apoptosis [J]. Chemosphere, 2022, 300: 134479. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9794 mL	9.8971 mL	19.7941 mL	49.4854 mL
	5 mM	0.3959 mL	1.9794 mL	3.9588 mL	9.8971 mL
	10 mM	0.1979 mL	0.9897 mL	1.9794 mL	4.9485 mL
	15 mM	0.1320 mL	0.6598 mL	1.3196 mL	3.2990 mL
	20 mM	0.0990 mL	0.4949 mL	0.9897 mL	2.4743 mL
	25 mM	0.0792 mL	0.3959 mL	0.7918 mL	1.9794 mL
	30 mM	0.0660 mL	0.3299 mL	0.6598 mL	1.6495 mL
	40 mM	0.0495 mL	0.2474 mL	0.4949 mL	1.2371 mL
	50 mM	0.0396 mL	0.1979 mL	0.3959 mL	0.9897 mL
	60 mM	0.0330 mL	0.1650 mL	0.3299 mL	0.8248 mL
	80 mM	0.0247 mL	0.1237 mL	0.2474 mL	0.6186 mL
	100 mM	0.0198 mL	0.0990 mL	0.1979 mL	0.4949 mL

Keywords

Deltamethrin

2 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Deltamethrin

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Alle Caspase Isoform-spezifische Produkte anzeigen

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Alle Calcium Channel Isoform-spezifische Produkte anzeigen

Alle NF-κB Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Deltamethrin Related Classifications

HY-B1971 Related Classifications