KDM1A - lysine demethylase 1A Gene

Also Known as AOF2; CPRF; KDM1; LSD1; BHC110

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23028

About KDM1A

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,019,468-23,083,689 (from NCBI)

This gene has 36 transcripts (splice variants), 215 orthologues, 7 paralogues and is associated with 4 phenotypes. Broad expression in testis (RPKM 45.8), endometrium (RPKM 15.8) and 25 other tissues.

Summary

This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a Histone Demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

KDM1A Products (11)

mRNA	Protein	Name
XM_017000717.2	XP_016856206.1	lysine-specific histone demethylase 1A isoform X6
NM_015013.4	NP_055828.2	lysine-specific histone demethylase 1A isoform b
XM_005245786.3	XP_005245843.1	lysine-specific histone demethylase 1A isoform X2
NM_001410762.1	NP_001397691.1	lysine-specific histone demethylase 1A isoform d
NM_001410763.1	NP_001397692.1	lysine-specific histone demethylase 1A isoform e
XM_047449677.1	XP_047305633.1	lysine-specific histone demethylase 1A isoform X5
XM_017000716.2	XP_016856205.1	lysine-specific histone demethylase 1A isoform X4
NM_001363654.2	NP_001350583.1	lysine-specific histone demethylase 1A isoform c
XM_006710474.4	XP_006710537.1	lysine-specific histone demethylase 1A isoform X1
NM_001009999.3	NP_001009999.1	lysine-specific histone demethylase 1A isoform a
XM_006710473.4	XP_006710536.1	lysine-specific histone demethylase 1A isoform X3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	20833138	GOA
enables FAD-dependent H3K4me/H3K4me3 demethylase activity	IDA IDA: Inferred from direct assay	20228790	GOA
enables MRF binding	IDA IDA: Inferred from direct assay	20833138	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	16079795	GOA
enables demethylase activity	IMP IMP: Inferred from mutant phenotype	17805299	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	17277772	GOA
enables flavin adenine dinucleotide binding	IDA IDA: Inferred from direct assay	15620353	GOA
enables histone H3K4 demethylase activity	IDA IDA: Inferred from direct assay	15620353	GOA
enables histone H3K9 demethylase activity	IDA IDA: Inferred from direct assay	16079795	GOA
enables histone demethylase activity	EXP EXP: Inferred from Experiment	16079795	GOA
enables histone demethylase activity	IDA IDA: Inferred from direct assay	19497860	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	23455924	GOA
enables nuclear androgen receptor binding	IDA IDA: Inferred from direct assay	16079795	GOA
enables nuclear receptor coactivator activity	IMP IMP: Inferred from mutant phenotype	16079795	GOA
enables oxidoreductase activity	IDA IDA: Inferred from direct assay	15620353	GOA
enables p53 binding	IPI IPI: Inferred from physical interaction	17805299	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
NOT enables telomeric DNA binding	IDA IDA: Inferred from direct assay	24529708	GOA
enables telomeric repeat-containing RNA binding	IDA IDA: Inferred from direct assay	24529708	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	20833138	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within DNA repair-dependent chromatin remodeling	IDA IDA: Inferred from direct assay	24217620	GOA
acts upstream of or within cellular response to UV	IDA IDA: Inferred from direct assay	24217620	GOA
acts upstream of or within cellular response to gamma radiation	IMP IMP: Inferred from mutant phenotype	24217620	GOA
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17805299	GOA
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19497860	GOA
involved in negative regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	17805299	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19497860	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17805299	GOA
involved in negative regulation of protein binding	IMP IMP: Inferred from mutant phenotype	17805299	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17805299	GOA
involved in positive regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	27292636	GOA
involved in positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	23400681	GOA
acts upstream of or within positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	24217620	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20833138	GOA
involved in protein demethylation	IMP IMP: Inferred from mutant phenotype	17805299	GOA
involved in regulation of DNA methylation-dependent heterochromatin formation	IDA IDA: Inferred from direct assay	33980486	GOA
acts upstream of or within regulation of double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	24217620	GOA
acts upstream of or within regulation of protein localization	IMP IMP: Inferred from mutant phenotype	24217620	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16079795	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of DNA repair complex	IDA IDA: Inferred from direct assay	24217620	GOA
is active in chromatin	IDA IDA: Inferred from direct assay	27292636	GOA
located in chromatin	IDA IDA: Inferred from direct assay	17277772	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	24529708	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	33980486	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16079795	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	24217620	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM1A Protein Structure

SWIRM

Amino_oxidase

0
200
400
600
800
852 a.a.

Protein Preferred Names	Protein Names
lysine-specific histone demethylase 1A	BRAF35-HDAC complex protein BHC110 FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit [histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A amine oxidase (flavin containing) domain 2 flavin-containing amine oxidase domain-containing protein 2 lysine (K)-specific demethylase 1A lysine-specific histone demethylase 1

KDM1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	KDM1A	O60341	NF2	Homo sapiens	P35240	Y2H	23455924
Intra	KDM1A	O60341	NF2	Homo sapiens	P35240	Validated Y2H	32814053
Intra	KDM1A	O60341	NF2	Homo sapiens	P35240	Y2H Array	32814053
Intra	KDM1A	O60341	NF2	Homo sapiens	P35240	Y2H Pooling	32814053
Intra	KDM1A	O60341	KRT40	Homo sapiens	Q6A162	Validated Y2H	32296183
Intra	KDM1A	O60341	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	KDM1A	O60341	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	NECAB2	Homo sapiens	Q7Z6G3-2	Validated Y2H	32296183
Intra	KDM1A	O60341	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
Intra	KDM1A	O60341	PBX4	Homo sapiens	Q9BYU1	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
Intra	KDM1A	O60341	PBX4	Homo sapiens	Q9BYU1	Y2H Array	32296183
Intra	KDM1A	O60341	SNAI1	Homo sapiens	O95863	Pull Down	20562920
Intra	KDM1A	O60341	SNAI1	Homo sapiens	O95863	Anti Bait CoIP	20389281
Intra	KDM1A	O60341	SNAI1	Homo sapiens	O95863	Anti Tag CoIP	20389281
Intra	KDM1A	O60341	SNAI1	Homo sapiens	O95863	Pull Down	20389281
Intra	KDM1A	O60341	SNAI1	Homo sapiens	O95863	Anti Bait CoIP	20562920
Intra	KDM1A	O60341	AKAP9	Homo sapiens	Q99996	Anti Tag CoIP	23455924
Intra	KDM1A	O60341	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	KDM1A	O60341	KRT33B	Homo sapiens	Q14525	Y2H	23455924
Intra	KDM1A	O60341	KRT33B	Homo sapiens	Q14525	Validated Y2H	32296183
Intra	KDM1A	O60341	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	GAS8	Homo sapiens	O95995	Validated Y2H	32296183
Intra	KDM1A	O60341	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	KDM1A	O60341	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	KDM1A	O60341	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	KDM1A	O60341	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	KDM1A	O60341	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	KDM1A	O60341	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	GOLGA6A	Homo sapiens	Q9NYA3	Validated Y2H	32296183
Intra	KDM1A	O60341	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Array	32296183
Intra	KDM1A	O60341	CAGE1	Homo sapiens	Q8TC20-4	Y2H Array	32296183
Intra	KDM1A	O60341	CAGE1	Homo sapiens	Q8TC20-4	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	CAGE1	Homo sapiens	Q8TC20-4	Validated Y2H	32296183
Intra	KDM1A	O60341	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	KDM1A	O60341	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	KDM1A	O60341	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	CEP57	Homo sapiens	Q86XR8-3	Validated Y2H	32296183
Intra	KDM1A	O60341	CEP57	Homo sapiens	Q86XR8-3	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	CEP57	Homo sapiens	Q86XR8-3	Y2H Array	32296183
Intra	KDM1A	O60341	NR2E1	Homo sapiens	Q9Y466	Anti Tag CoIP	36321378
Intra	KDM1A	O60341	TP53BP2	Homo sapiens	Q05BL1	Validated Y2H	32296183
Intra	KDM1A	O60341	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	KDM1A	O60341	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	KRT39	Homo sapiens	Q6A163	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	KRT39	Homo sapiens	Q6A163	Validated Y2H	32296183
Intra	KDM1A	O60341	KRT39	Homo sapiens	Q6A163	Y2H Array	32296183
Intra	KDM1A	O60341	CCDC14	Homo sapiens	Q49A88-3	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	CCDC14	Homo sapiens	Q49A88-3	Validated Y2H	32296183
Intra	KDM1A	O60341	CCDC14	Homo sapiens	Q49A88-3	Y2H Array	32296183
Intra	KDM1A	O60341	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	KDM1A	O60341	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	KDM1A	O60341	TMEM266	Homo sapiens	Q2M3C6	Validated Y2H	32296183
Intra	KDM1A	O60341	RPRD1A	Homo sapiens	Q96P16-3	Y2H Array	32296183
Intra	KDM1A	O60341	RPRD1A	Homo sapiens	Q96P16-3	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	RPRD1A	Homo sapiens	Q96P16-3	Validated Y2H	32296183
Intra	KDM1A	O60341	UBASH3B	Homo sapiens	Q8TF42	Y2H Array	32296183
Intra	KDM1A	O60341	UBASH3B	Homo sapiens	Q8TF42	Validated Y2H	32296183
Intra	KDM1A	O60341	UBASH3B	Homo sapiens	Q8TF42	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	KDM1A	O60341	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	KDM1A	O60341	RCOR3	Homo sapiens	Q9P2K3-2	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	KDM1A	O60341	RCOR3	Homo sapiens	Q9P2K3-2	Y2H Array	32296183
Intra	KDM1A	O60341	JRK	Homo sapiens	O75564-2	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	JRK	Homo sapiens	O75564-2	Validated Y2H	32296183
Intra	KDM1A	O60341	JRK	Homo sapiens	O75564-2	Y2H Array	32296183
Intra	KDM1A	O60341	TNNT2	Homo sapiens	P45379-11	Validated Y2H	32296183
Intra	KDM1A	O60341	TNNT2	Homo sapiens	P45379-11	Y2H Array	32296183
Intra	KDM1A	O60341	TNNT2	Homo sapiens	P45379-11	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	MBD3	Homo sapiens	O95983	Anti Bait CoIP	19703393
Intra	KDM1A	O60341	NFE2L2	Homo sapiens	Q16236	Y2H Array	32296183
Intra	KDM1A	O60341	NFE2L2	Homo sapiens	Q16236	Validated Y2H	32296183
Intra	KDM1A	O60341	NFE2L2	Homo sapiens	Q16236	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	ELAVL4	Homo sapiens	P26378-2	Validated Y2H	32814053
Intra	KDM1A	O60341	ELAVL4	Homo sapiens	P26378-2	Y2H Array	32814053
Intra	KDM1A	O60341	ELAVL4	Homo sapiens	P26378-2	Y2H Pooling	32814053
Intra	KDM1A	O60341	PHF19	Homo sapiens	Q5T6S3	Y2H	23455924
Intra	KDM1A	O60341	PHF19	Homo sapiens	Q5T6S3	Anti Tag CoIP	23455924
Intra	KDM1A	O60341	SPICE1	Homo sapiens	Q8N0Z3	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	SPICE1	Homo sapiens	Q8N0Z3	Validated Y2H	32296183
Intra	KDM1A	O60341	SPICE1	Homo sapiens	Q8N0Z3	Y2H Array	32296183
Intra	KDM1A	O60341	NRBF2	Homo sapiens	Q96F24	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	NRBF2	Homo sapiens	Q96F24	Validated Y2H	32296183
Intra	KDM1A	O60341	NRBF2	Homo sapiens	Q96F24	Y2H Array	32296183
Intra	KDM1A	O60341	HAUS1	Homo sapiens	Q96CS2	Y2H	23455924
Intra	KDM1A	O60341	NBPF1	Homo sapiens	Q3BBV0	Y2H Array	32296183
Intra	KDM1A	O60341	NBPF1	Homo sapiens	Q3BBV0	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	NBPF1	Homo sapiens	Q3BBV0	Validated Y2H	32296183
Intra	KDM1A	O60341	RASSF3	Homo sapiens	Q86WH2	Validated Y2H	32296183
Intra	KDM1A	O60341	FYCO1	Homo sapiens	Q9BQS8	Anti Tag CoIP	23455924
Intra	KDM1A	O60341	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	KDM1A	O60341	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	PFDN5	Homo sapiens	Q99471	Validated Y2H	32296183
Intra	KDM1A	O60341	PSMC1	Homo sapiens	P62191	Anti Tag CoIP	23455924
Intra	KDM1A	O60341	H3-4	Homo sapiens	Q16695	Enzymatic Study	17537733
Intra	KDM1A	O60341	TRAF4	Homo sapiens	Q9BUZ4	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	KDM1A	O60341	TRAF4	Homo sapiens	Q9BUZ4	Y2H Array	32296183
Intra	KDM1A	O60341	RASSF1	Homo sapiens	Q9NS23	Anti Tag CoIP	23455924
Intra	KDM1A	O60341	CDC5L	Homo sapiens	Q99459	Y2H	17043677
Intra	KDM1A	O60341	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	KDM1A	O60341	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	KDM1A	O60341	VPS37B	Homo sapiens	Q9H9H4	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	VPS37B	Homo sapiens	Q9H9H4	Validated Y2H	32296183
Intra	KDM1A	O60341	VPS37B	Homo sapiens	Q9H9H4	Y2H Array	32296183
Intra	KDM1A	O60341	MYC	Homo sapiens	P01106	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	MYC	Homo sapiens	P01106	Validated Y2H	32296183
Intra	KDM1A	O60341	MYC	Homo sapiens	P01106	Y2H Array	32296183
Intra	KDM1A	O60341	MYC	Homo sapiens	P01106	Y2H	23455924
Intra	KDM1A	O60341	SERGEF	Homo sapiens	Q9UGK8	Y2H	23455924
Intra	KDM1A	O60341	SERGEF	Homo sapiens	Q9UGK8	Anti Tag CoIP	23455924
Intra	KDM1A	O60341	IMMT	Homo sapiens	Q16891	Y2H Pooling	16169070
Intra	KDM1A	O60341	IMMT	Homo sapiens	Q16891	Pull Down	16169070
Intra	KDM1A	O60341	BIRC2	Homo sapiens	Q13490	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	BIRC2	Homo sapiens	Q13490	Validated Y2H	32296183
Intra	KDM1A	O60341	BIRC2	Homo sapiens	Q13490	Y2H Array	32296183
Intra	KDM1A	O60341	CHD3	Homo sapiens	Q12873	Anti Bait CoIP	19703393
Intra	KDM1A	O60341	ANKRD23	Homo sapiens	Q86SG2	Validated Y2H	32296183
Intra	KDM1A	O60341	ANKRD23	Homo sapiens	Q86SG2	Y2H Array	32296183
Intra	KDM1A	O60341	ANKRD23	Homo sapiens	Q86SG2	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	HDAC3	Homo sapiens	O15379	Anti Bait CoIP	23752268
Intra	KDM1A	O60341	GTPBP2	Homo sapiens	Q9BX10	Y2H	23455924
Intra	KDM1A	O60341	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	KDM1A	O60341	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	KDM1A	O60341	EXOC7	Homo sapiens	Q9UPT5-1	Validated Y2H	32296183
Intra	KDM1A	O60341	EXOC7	Homo sapiens	Q9UPT5-1	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	EXOC7	Homo sapiens	Q9UPT5-1	Y2H Array	32296183
Intra	KDM1A	O60341	RBPJ	Homo sapiens	Q06330	TAP	25609649
Intra	KDM1A	O60341	RBPJ	Homo sapiens	Q06330	Anti Tag CoIP	23022380
Intra	KDM1A	O60341	NOTCH1	Homo sapiens	P46531	Anti Tag CoIP	23022380
Intra	KDM1A	O60341	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	21258344
Intra	KDM1A	O60341	RCOR1	Homo sapiens	Q9UKL0	Anti Bait CoIP	20389281
Intra	KDM1A	O60341	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	19703393
Intra	KDM1A	O60341	RCOR1	Homo sapiens	Q9UKL0	Anti Bait CoIP	34031383
Intra	KDM1A	O60341	RCOR1	Homo sapiens	Q9UKL0	Pull Down	26226427
Intra	KDM1A	O60341	RCOR1	Homo sapiens	Q9UKL0	Enzymatic Study	17537733
Intra	KDM1A	O60341	RCOR1	Homo sapiens	Q9UKL0	Anti Bait CoIP	21258344
Intra	KDM1A	O60341	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	32296183
Intra	KDM1A	O60341	WASHC3	Homo sapiens	Q9Y3C0	Y2H Array	32296183
Intra	KDM1A	O60341	WASHC3	Homo sapiens	Q9Y3C0	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	PELP1	Homo sapiens	Q8IZL8	Pull Down	20448663
Intra	KDM1A	O60341	PELP1	Homo sapiens	Q8IZL8	Anti Bait CoIP	20448663
Intra	KDM1A	O60341	FAM161A	Homo sapiens	Q3B820	Validated Y2H	32296183
Intra	KDM1A	O60341	FAM161A	Homo sapiens	Q3B820	Y2H Array	32296183
Intra	KDM1A	O60341	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	RCOR2	Homo sapiens	Q8IZ40	Anti Bait CoIP	28420882
Intra	KDM1A	O60341	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	KRT15	Homo sapiens	P19012	Validated Y2H	32296183
Intra	KDM1A	O60341	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	KDM1A	O60341	CEP70	Homo sapiens	Q8NHQ1	Anti Tag CoIP	23455924
Intra	KDM1A	O60341	ZBED1	Homo sapiens	O96006	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	ZBED1	Homo sapiens	O96006	Y2H Array	32296183
Intra	KDM1A	O60341	ZBED1	Homo sapiens	O96006	Validated Y2H	32296183
Intra	KDM1A	O60341	CEP76	Homo sapiens	Q8TAP6	Validated Y2H	32296183
Intra	KDM1A	O60341	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
Intra	KDM1A	O60341	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	GCC1	Homo sapiens	Q96CN9	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	GCC1	Homo sapiens	Q96CN9	Y2H Array	32296183
Intra	KDM1A	O60341	GCC1	Homo sapiens	Q96CN9	Validated Y2H	32296183
Intra	KDM1A	O60341	TEX9	Homo sapiens	Q8N6V9	Validated Y2H	32296183
Intra	KDM1A	O60341	TEX9	Homo sapiens	Q8N6V9	Y2H Array	32296183
Intra	KDM1A	O60341	TEX9	Homo sapiens	Q8N6V9	Y2H	23455924
Intra	KDM1A	O60341	TEX9	Homo sapiens	Q8N6V9	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	SNF8	Homo sapiens	Q96H20	Anti Tag CoIP	23455924
Intra	KDM1A	O60341	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
Intra	KDM1A	O60341	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183
Intra	KDM1A	O60341	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	SMAD9	Homo sapiens	O15198	Y2H	23455924
Intra	KDM1A	O60341	SMAD9	Homo sapiens	O15198	Anti Tag CoIP	23455924
Intra	KDM1A	O60341	SF3B2	Homo sapiens	Q13435	Y2H	23455924
Intra	KDM1A	O60341	SF3B2	Homo sapiens	Q13435	Anti Tag CoIP	23455924
Intra	KDM1A	O60341	LOXL4	Homo sapiens	Q96JB6	Y2H	23455924
Intra	KDM1A	O60341	ACE2	Homo sapiens	Q9BYF1	Confocal	34031383
Intra	KDM1A	O60341	ACE2	Homo sapiens	Q9BYF1	Demethylase Assay	34031383
Intra	KDM1A	O60341	NR1H3	Homo sapiens	Q13133	Y2H	23455924
Intra	KDM1A	O60341	FAM204A	Homo sapiens	Q9H8W3	Y2H Array	32296183
Intra	KDM1A	O60341	FAM204A	Homo sapiens	Q9H8W3	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	FAM204A	Homo sapiens	Q9H8W3	Validated Y2H	32296183
Intra	KDM1A	O60341	C8orf74	Homo sapiens	Q6P047	Y2H	23455924
Intra	KDM1A	O60341	ODAD3	Homo sapiens	A5D8V7	Y2H	23455924
Intra	KDM1A	O60341	ODAD3	Homo sapiens	A5D8V7	Anti Tag CoIP	23455924
Intra	KDM1A	O60341	FAM9A	Homo sapiens	Q8IZU1	Anti Tag CoIP	23455924
Intra	KDM1A	O60341	FAM9A	Homo sapiens	Q8IZU1	Y2H	23455924
Intra	KDM1A	O60341	HESX1	Homo sapiens	Q9UBX0	Y2H	23455924
Intra	KDM1A	O60341	KLHDC4	Homo sapiens	Q8TBB5	Anti Tag CoIP	23455924
Intra	KDM1A	O60341	OFCC1	Homo sapiens	Q8IZS5	Y2H	23455924
Intra	KDM1A	O60341	OFCC1	Homo sapiens	Q8IZS5	Anti Tag CoIP	23455924
Intra	KDM1A	O60341	STX19	Homo sapiens	Q8N4C7	Y2H	23455924
Intra	KDM1A	O60341	TTC23	Homo sapiens	Q5W5X9-3	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	TTC23	Homo sapiens	Q5W5X9-3	Validated Y2H	32296183
Intra	KDM1A	O60341	TTC23	Homo sapiens	Q5W5X9-3	Y2H Array	32296183
Intra	KDM1A	O60341	COIL	Homo sapiens	P38432	Y2H Array	32296183
Intra	KDM1A	O60341	COIL	Homo sapiens	P38432	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	COIL	Homo sapiens	P38432	Validated Y2H	32296183
Intra	KDM1A	O60341	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	KDM1A	O60341	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	KDM1A	O60341	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	KDM1A	O60341	ZBTB39	Homo sapiens	O15060	Y2H Array	32296183
Intra	KDM1A	O60341	ZBTB39	Homo sapiens	O15060	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KDM1A Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P75551	LSD1 Protein, Human (sf9, His-GST)	O60341-1 (S172-M852)	≥ 90%, as determined by reducing SDS-PAGE.

KDM1A Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80731	KDM1/LSD1 Antibody (YA718)	WB	Human, Mouse, Monkey
HY-P80731A	KDM1/LSD1 Antibody (YA718)(PBS only)	WB	Human, Mouse, Monkey
HY-P83850	KDM1/LSD1 Antibody (YA3547)	WB, IHC-P, ELISA	Human, Mouse, Monkey
HY-P83850A	KDM1/LSD1 Antibody (YA3547)(PBS only)	WB, IHC-P, ELISA	Human, Mouse, Monkey
HY-P83851	KDM1/LSD1 Antibody (YA3548)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Monkey
HY-P83851A	KDM1/LSD1 Antibody (YA3548)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Monkey
HY-P85442	KDM1/LSD1 Antibody (YA5134)	WB, IHC-P, ICC/IF	Human, Mouse, Bovine, Dog, Pig
HY-P85484	KDM1/LSD1 Antibody (YA5176)	WB, ICC/IF, IP	Human, Monkey
HY-P86559	KDM1/LSD1 Antibody (YA6251)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Spherocytosis, Type 2	Hereditary Spherocytosis Type 2 SPH2 Spherocytosis, Hereditary, 2 Hs2 Hereditary Spherocytosis 2 Spherocytosis 2 Spherocytosis, Type 2, Autosomal Dominant
Cleft Palate, Psychomotor Retardation, And Distinctive Facial Features	Palatal Anomalies-Widely Spaced Teeth-Facial Dysmorphism-Developmental Delay Syndrome CPRF Palatal Anomalies-Multiple Diastemata-Facial Dysmorphism-Developmental Delay Syndrome
Rhabdomyosarcoma
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma Primitive Neuroectodermal Tumor ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Ewing Family Of Tumors Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Primary Hyperoxaluria	Hyperoxaluria, Primary Oxalosis Hyperoxaluria Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I
Cleft Palate, Cardiac Defects, And Mental Retardation	Cardiac Malformation, Cleft Lip/Palate, Microcephaly, And Digital Anomalies CPCMR Cleft Palate, Cardiac Defects, And Intellectual Disabillity Cleft Palate, Cardiac Defects, And Intellectual Disability Cardiac Malformation, Cleft Lip-Palate, Microcephaly And Digital Anomalies
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Kabuki Syndrome 1	Kabuki Syndrome Niikawa-Kuroki Syndrome Kabuki Make-Up Syndrome Kms KABUK1 Kabuki Make Up Syndrome Nks Kabuki Makeup Syndrome Kabuki Syndrome, Type 1
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson-Gilford Disease Hutchinson Gilford Progeria Syndrome Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-109117	Iadademstat		99.82%	Phase 2
HY-103713	Seclidemstat	Inhibitor	99.77%	Phase 2
HY-18632A	GSK2879552 dihydrochloride	Inhibitor	99.82%	Phase 2
HY-12782T	Iadademstat dihydrochloride	Inhibitor	99.98%	Phase 1
HY-138830	TAK-418	Inhibitor	99.81%	Phase 1
HY-183067	TAS1440		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (15)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-18632	GSK2879552	Inhibitor	99.98%	Unkown
HY-19612A	DDP-38003 dihydrochloride	Inhibitor	99.31%	Unkown
HY-103713A	Seclidemstat mesylate	Inhibitor	99.80%	Unkown
HY-RS07205	KDM1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-19612B	DDP-38003 trihydrochloride	Inhibitor	/	Unkown
HY-112304	NCD38 TFA	Inhibitor	/	Unkown
HY-112304A	(1R,2S)-NCD38 TFA	Inhibitor	/	Unkown
HY-123577	TPC-144		/	Unkown
HY-143238	FY-56	Inhibitor	/	Unkown
HY-183067A	TAS1440 benzoate		/	Unkown
HY-186116	LSD1-IN-49	Inhibitor	/	Unkown
HY-186116A	LSD1-IN-49 hydrochloride	Inhibitor	/	Unkown
HY-19612	DDP-38003	Inhibitor	/	Unkown
HY-RS07206	Kdm1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07207	Kdm1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KDM1A	RGD	RGD:1562975
Canis familiaris	KDM1A	VGNC	VGNC:42318
Bos taurus	KDM1A	VGNC	VGNC:30522
Mus musculus	KDM1A	MGD	MGI:1196256
Macaca mulatta	KDM1A	VGNC	VGNC:73928
Felis catus	KDM1A	VGNC	VGNC:63067
Others	KDM1A	NCBI