Art. -Nr.: HY-W010649

Isoxazole

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Isoxazole is a member of the five-membered heterocycle drug scaffold. Isoxazole has been used as a BET bromodomain inhibitor and can improve β-cell function in a diabetic mouse model. Isoxazole and its derivatives exhibit broad biological activities (such as antimicrobial, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, analgesic, anti-tuberculosis, and anti-diabetic effects). For example, the bicyclic Isoxazole can act as an HSP90 inhibitor, and the tricyclic Isoxazole is promising as a selective multidrug resistance protein (MRP1) inhibitor.

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Reinheit: 99.98%
CAS. Nr.: 288-14-2
Formel: C₃H₃NO
Molecular Weight:69.06

Speicherung:

Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Isoxazole Chemical Structure

CAS. Nr.: 288-14-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Multidrug resistance proteins (MRPs)

Alle HSP Isoform-spezifische Produkte anzeigen :

Alle Epigenetic Reader Domain Isoform-spezifische Produkte anzeigen :

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

In Vitro

Isoxazole (20 µM, 48 hours) improves β-cell function by inhibiting excessive proliferation of MIN6 cells (mouse pancreatic β-cells) and altering the gene expression profile of MIN6 cells (enhancing the neuroendocrine phenotype)^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[5]

Cell Line:

MIN6 mouse β-cell line
Concentration:

20 µM
Incubation Time:

48 h
Result:

Significantly upregulates gene expression of STMN2.

Western Blot Analysis^[5]

Cell Line:

MIN6 mouse β-cell line
Concentration:

20 µM
Incubation Time:

48 h
Result:

Upregulates STMN2 protein expression.

Cell Proliferation Assay^[5]

Cell Line:

INS1E mouse β-cell line
Concentration:

20 µM
Incubation Time:

72 h
Result:

Reduced cell number, indicating inhibition of cell proliferation.

In Vivo

Isoxazole (16 mg/kg, i.p., once daily for 4 weeks) improves β-cell function in diabetes mice model (PANIC-ATTAC mice model induced by dimerizer (e.g., AP20187, HY-13992)^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Diabetes model in PANIC-ATTAC mice induced by dimerizer (e.g., AP20187 (HY-13992))^[5]
Dosage:

16 mg/kg
Administration:

Intraperitoneal injection (i.p.), once daily for 4 weeks
Result:

Significant reduced blood glucose after oral glucose tolerance test (OGTT).
Caused that pancreas insulin content increased approaching significance.

Chemical Information

CAS. Nr. 288-14-2
Appearance Liquid (Density: 1.078 g/cm³)
Molecular Weight 69.06
Formel C₃H₃NO
Color Colorless to light yellow
SMILES

C1=CON=C1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (1448.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

14.4802 mL

72.4008 mL

144.8016 mL

5 mM

2.8960 mL

14.4802 mL

28.9603 mL

10 mM

1.4480 mL

7.2401 mL

14.4802 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
SDS (466 KB)
- English - EN (466 KB)
- Français - FR (466 KB)
- Deutsch - DE (466 KB)
- Norwegian - NO (466 KB)
- Español - ES (466 KB)
- Swedish - SV (466 KB)
- Italian - IT (466 KB)
- Korean - KR (466 KB)
- Portuguese - PT (466 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhu J, et al. The recent progress of isoxazole in medicinal chemistry. Bioorg Med Chem. 2018 Jul 23;26(12):3065-3075. [Content Brief]

[2]. Sysak A, et al. Isoxazole ring as a useful scaffold in a search for new therapeutic agents. Eur J Med Chem. 2017 Sep 8;137:292-309. [Content Brief]

[3]. Norman BH, et al. Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1)[J]. Bioorg Med Chem Lett. 2002 Mar 25;12(6):883-6. [Content Brief]

[4]. Agrawal N, Mishra P. The synthetic and therapeutic expedition of isoxazole and its analogs[J]. Med Chem Res. 2018;27(5):1309-1344. [Content Brief]

[5]. Kalwat MA, et al. Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells. ACS Chem Biol. 2016 Apr 15;11(4):1128-36. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	14.4802 mL	72.4008 mL	144.8016 mL	362.0041 mL
	5 mM	2.8960 mL	14.4802 mL	28.9603 mL	72.4008 mL
	10 mM	1.4480 mL	7.2401 mL	14.4802 mL	36.2004 mL
	15 mM	0.9653 mL	4.8267 mL	9.6534 mL	24.1336 mL
	20 mM	0.7240 mL	3.6200 mL	7.2401 mL	18.1002 mL
	25 mM	0.5792 mL	2.8960 mL	5.7921 mL	14.4802 mL
	30 mM	0.4827 mL	2.4134 mL	4.8267 mL	12.0668 mL
	40 mM	0.3620 mL	1.8100 mL	3.6200 mL	9.0501 mL
	50 mM	0.2896 mL	1.4480 mL	2.8960 mL	7.2401 mL
	60 mM	0.2413 mL	1.2067 mL	2.4134 mL	6.0334 mL
	80 mM	0.1810 mL	0.9050 mL	1.8100 mL	4.5251 mL
	100 mM	0.1448 mL	0.7240 mL	1.4480 mL	3.6200 mL

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Isoxazole

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Drug Fragment Library

Alle HSP Isoform-spezifische Produkte anzeigen

Alle Epigenetic Reader Domain Isoform-spezifische Produkte anzeigen

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Isoxazole Related Classifications

HY-W010649 Related Classifications