Cs - citrate synthase Gene

Also Known as Cis; Ahl4; 2610511A05Rik; 9030605P22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12974

Summary

The protein encoded by this gene is a central metabolic pathway enzyme, catalyzing the first step of the tricarboxylic acid cycle in which acetyl coenzyme A and oxaloacetate are converted to citrate and coenzyme A. This enzyme is found in nearly all cells capable of oxidative metabolism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2016]

Cs Products (1)

mRNA Protein Name
NM_026444.4 NP_080720.1 citrate synthase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables acyltransferase activity, acyl groups converted into alkyl on transfer IDA
IDA: Inferred from direct assay
18729827 MGI
enables citrate (Si)-synthase activity IDA
IDA: Inferred from direct assay
32212192 MGI
enables citrate (Si)-synthase activity IGI
IGI: Inferred from genetic interaction
31857692 MGI
Cellular Component GO Annotation Evidence Références Source
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
31857692 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

citrate synthase, mitochondrial

  • citrate (Si)-synthase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (12)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-50935 Troglitazone 99.78% Unkown
HY-109015 Tucidinostat Inhibitor 98.74% Unkown
HY-B0165A Pravastatin sodium 99.38% Yes
HY-16276 Osilodrostat Inhibitor 99.90% Yes
HY-17005 Olmesartan medoxomil Inhibitor 98.95% Unkown
HY-B0023 Azelnidipine Inhibitor 99.79% Unkown
HY-100471 Esaxerenone Antagonist 99.93% Unkown
HY-16276A Osilodrostat phosphate Inhibitor 98.83% Yes
HY-N7101 Cefpodoxime Proxetil Inhibitor 98.93% Unkown
HY-B1595 Cefmetazole Inhibitor 98.82% Unkown
HY-14818A Laninamivir octanoate Inhibitor 98.57% Unkown
HY-B0165 Pravastatin / Unkown

Clinical Phase

Bioactive Molecules (17)
Cat. No. Nom du produit Effect
Pureté Phase
HY-160929 Linafexor Agonist 99.58% Phase 3
HY-124526 Chiauranib Inhibitor 98.97% Phase 3
HY-100401 Pactimibe Inhibitor 99.98% Phase 3
HY-16445 Sapacitabine Chemical 98.69% Phase 3
HY-141511 Coppersensor 1 ≥98.0% Phase 2
HY-14955 Managlinat dialanetil Inhibitor 99.67% Phase 2
HY-116228 Cadrofloxacin Inhibitor 98.21% Phase 2
HY-14783 Apricoxib Inhibitor 98.84% Phase 2
HY-106888A CS-722 / Phase 2
HY-123022 Tomopenem Inhibitor / Phase 2
HY-137005 CS1 / Phase 2
HY-14792 Inolitazone Agonist / Phase 2
HY-P6306A CS-6253 TFA 98.08% Phase 1
HY-100413 CS-526 Antagonist / Phase 1
HY-145995 CS12192 Inhibitor / Phase 1
HY-14976 CS-0777 Modulator / Phase 1
HY-19404 Embeconazole Inhibitor / Phase 1
Inhibitory Antibodies (2)
Cat. No. Nom du produit Effect
Pureté Phase
HY-P99758 Nofazinlimab Inhibitor 98.83% Phase 3
HY-P99270 Tigatuzumab Inducer 98.18% Phase 2

Pre-clinical Phase

Bioactive Molecules (84)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-B1692 L-Methionine-DL-sulfoximine Inhibitor ≥98.0% Unkown
HY-P6306 CS-6253 98.84% Unkown
HY-148907 CS640 Inhibitor 99.48% Unkown
HY-148913 CS587 Inhibitor 98.18% Unkown
HY-P2727 Chondroitinase ABC / Unkown
HY-P3522 REDV 99.89% Unkown
HY-B0165AR Pravastatin sodium (Standard) 98.10% Unkown
HY-W753658 Coppersensor-3 97.0% Unkown
HY-124704 Chst15-IN-1 Inhibitor 98.01% Unkown
HY-130086 Bis-​PEG4-​NHS ester 97.0% Unkown
HY-121447 Heneicosanoic acid 98.0% Unkown
HY-150611 EGFR-IN-70 Inhibitor 98.12% Unkown
HY-14792B Inolitazone dihydrochloride Agonist 98.45% Unkown
HY-43962 CS-1-65 99.54% Unkown
HY-14180 PHA 408 Inhibitor 99.40% Unkown
HY-100401A Pactimibe sulfate Inhibitor 98.0% Unkown
HY-15801 HG-14-10-04 Inhibitor 98.53% Unkown
HY-17005R Olmesartan medoxomil (Standard) Inhibitor 99.35% Unkown
HY-50935S Troglitazone-d4 98.19% Unkown
HY-D0798 Catechol violet 90.0% Unkown
HY-P10948A CS-VIP 8 hydrochloride Inhibitor 96.04% Unkown
HY-105268 AzddMeC Inhibitor 98.96% Unkown
HY-106174 Lapisteride Inhibitor 99.0% Unkown
HY-106850 3′-Azido-2′,3′-dideoxyuridine Inhibitor 99.59% Unkown
HY-108493 CS-2100 Agonist 99.12% Unkown
HY-109015S Tucidinostat-d4 Inhibitor 98.63% Unkown
HY-111640 3'-Azido-3'-deoxy-5-methylcytidine Inhibitor 99.90% Unkown
HY-P1816 Fibronectin CS1 Peptide 99.10% Unkown
HY-P3522A REDV TFA 99.81% Unkown
HY-B0165CS Pravastatin-d3 sodium salt 99.02% Unkown
HY-Q51222 ZINC110492 Ligand 90.0% Unkown
HY-100471S Esaxerenone-d4 Antagonist / Unkown
HY-105114A Imitrodast sodium Inhibitor / Unkown
HY-106789 Plaunotol / Unkown
HY-106888 CS-722 Free base / Unkown
HY-128562 CS-1-69 / Unkown
HY-133606 3,4,5-Trichlorosyringol / Unkown
HY-143445 EGFR-IN-48 Inhibitor / Unkown
HY-14792C Inolitazone hydrochloride hydrate Agonist / Unkown
HY-14818C Laninamivir octanoate hydrate / Unkown
HY-148863 Cavα2δ1&NET-IN-2 Inhibitor / Unkown
HY-14977 CS-0777-P Agonist / Unkown
HY-15115 SUAM 1221 Inhibitor / Unkown
HY-159936 CS4 / Unkown
HY-163752 CS17919 Inhibitor / Unkown
HY-169247 Pam2CS-DMAPA / Unkown
HY-169427 FRF-06-057 Inhibitor / Unkown
HY-169982 EGFR-IN-136 Inhibitor / Unkown
HY-17005S Olmesartan medoxomil-d6 Inhibitor / Unkown
HY-171958 PROTAC EGFR degrader 12 Degrader / Unkown
HY-173132 AKR1Cs-IN-1 / Unkown
HY-175806 CS47 / Unkown
HY-178242 PROTAC EGFR degrader 16 Degrader / Unkown
HY-179238 CS-1-103 Inhibitor / Unkown
HY-182626 CS1P1 Antagonist / Unkown
HY-186232 CS-1-102 / Unkown
HY-186233 CS-1-174 Inhibitor / Unkown
HY-19633 CS-003 Free base Antagonist / Unkown
HY-19633A CS-003 / Unkown
HY-B0023S Azelnidipine-d7 Inhibitor / Unkown
HY-B0165AS Pravastatin-13C,d3 sodium / Unkown
HY-B0165S Pravastatin-d9 sodium / Unkown
HY-D3202 Lyso-CS2 / Unkown
HY-N7101S Cefpodoxime proxetil-d7 / Unkown
HY-P10797 TAT-N24 Inhibitor / Unkown
HY-P10948 CS-VIP 8 Inhibitor / Unkown
HY-P4021 Mca-KKEDVV-Abu-CS-Abu-S-(NO2)F-KK-NH2 / Unkown
HY-RS03221 CS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W743398 Mexazolam / Unkown
HY-W783351 CS790AM / Unkown
HY-107163 CS 461 Inhibitor / Unkown
HY-116228A Cadrofloxacin (hydrochloride) Inhibitor / Unkown
HY-138024 Tacapenem Inhibitor / Unkown
HY-14955A (Rac)-Managlinat dialanetil / Unkown
HY-174532 Human TGFB3 mRNA / Unkown
HY-175198 Cs-2d Inhibitor / Unkown
HY-175489 D-CS319 Inhibitor / Unkown
HY-178019 NDM-1-IN-10 Inhibitor / Unkown
HY-184611 Chitosan stabilized selenium nanoparticles / Unkown
HY-N7101S1 Cefpodoxime Proxetil-d6 Inhibitor / Unkown
HY-RS16750 Cs Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23189 Cs Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W667933 S-Propyl-L-cysteine sulfoxide / Unkown
HY-U00211 CS476 Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P992337 CS5001 Antibody Inhibitor / Unkown
HY-P992511 CS2009 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cs NCBI NCBI:1431