Jun - Jun proto-oncogene, AP-1 transcription factor subunit Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24516

About Jun

Primary_assembly 5: 109,893,145-109,897,656 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 226 orthologues, 1 paralogue and is associated with 40 phenotypes.

Summary

Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and HMG box domain binding activity. Involved in several processes, including cellular response to potassium ion starvation; positive regulation of macromolecule biosynthetic process; and positive regulation of monocyte differentiation. Located in cytosol and nucleus. Part of protein-containing complex. Colocalizes with chromatin. Used to study hypertension. Biomarker of mental depression and renal carcinoma. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Jun Products (1)

mRNA Protein Name
NM_021835.3 NP_068607.1 transcription factor Jun

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
17428807 RGD
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
10830307 RGD
enables HMG box domain binding IPI
IPI: Inferred from physical interaction
16582099 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
10830307 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
9369238 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
14610205 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9369238 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10830307 RGD
Biological Process GO Annotation Evidence References Source
involved in DNA-templated transcription IDA
IDA: Inferred from direct assay
16582099 RGD
involved in angiogenesis IMP
IMP: Inferred from mutant phenotype
15126605 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
8593588 RGD
involved in cellular response to potassium ion starvation IMP
IMP: Inferred from mutant phenotype
17428807 RGD
involved in cellular response to prolactin IEP
IEP: Inferred from expression pattern
8584023 RGD
involved in cellular response to zinc ion starvation IEP
IEP: Inferred from expression pattern
21893222 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
10987819 RGD
involved in learning IMP
IMP: Inferred from mutant phenotype
7948848 RGD
involved in membrane depolarization IDA
IDA: Inferred from direct assay
11571252 RGD
involved in positive regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
9487126 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16582099 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12441106 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15609298 RGD
involved in positive regulation of miRNA transcription IDA
IDA: Inferred from direct assay
18384814 RGD
involved in positive regulation of monocyte differentiation IDA
IDA: Inferred from direct assay
7947389 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
12514131 RGD
involved in positive regulation of smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
11571252 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19255142 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17428807 RGD
involved in release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
11301023 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
18280640 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
18280640 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
22576626 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
11053775 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
20818503 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
11389931 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
15126239 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
11113530 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
21948387 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
12093589 RGD
involved in transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10830307 RGD
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
9300399 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
19255142 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Jun Protein Structure

Jun

Jun: pfam03957 (5 - 242)

bZIP_Jun

bZIP_Jun: cd14696 (256 - 316)

bZIP_Jun

bZIP_Jun: cd14696 (257 - 308)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

transcription factor Jun

  • AP1

  • Avian sarcoma virus 17 (v-jun) oncogene homolog

  • Jun oncogene

  • V-jun avian sarcoma virus 17 oncogene homolog

  • activator protein 1

  • proto-oncogene c-jun

  • transcription factor AP-1

  • transcription factor AP-1 subunit Jun

  • v-jun sarcoma virus 17 oncogene homolog

Jun Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Jun P17325 Mapk8 Rattus norvegicus P49185
Pull Down
18046461
Intra
Jun P17325 Fos Rattus norvegicus P12841
Anti Bait CoIP
32949970
Intra
Jun P17325 Fos Rattus norvegicus P12841
Anti Bait CoIP
16876161
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1198 Piperonyl butoxide Inhibitor 98.0% Unkown
HY-B1451A Imidapril Inhibitor 99.0% Yes
HY-B1451 Imidapril hydrochloride Inhibitor 99.91% Yes
HY-B1198R Piperonyl butoxide (Standard) Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-145601 Tinengotinib Inhibitor 99.57% Phase 3
HY-14604 Xaliproden hydrochloride 98.40% Phase 3
HY-119820 Xaliproden free base / Phase 3
HY-12270 T-5224 Inhibitor 99.59% Phase 2
HY-13241 Ralimetinib dimesylate 99.97% Phase 2
HY-138304 CC-90001 Inhibitor 99.98% Phase 2
HY-114250 Cantrixil Inducer 99.32% Phase 1

Pre-clinical Phase

Bioactive Molecules (86)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162723 FOSL1 degrader 1 Degrader 99.66% Unkown
HY-13866 Ro 31-8220 mesylate 99.57% Unkown
HY-107598 JNK Inhibitor VIII Inhibitor 99.58% Unkown
HY-N2593 Isorhapontigenin 99.82% Unkown
HY-128326 ZAK-IN-1 Inhibitor 98.43% Unkown
HY-148510 HKB99 99.65% Unkown
HY-11010 AS601245 Inhibitor 98.19% Unkown
HY-114332 GNE-8505 Inhibitor 99.53% Unkown
HY-160469 INY-05-040 Degrader 98.54% Unkown
HY-W010983 SC-236 99.59% Unkown
HY-N5048 Galloylpaeoniflorin Inhibitor 98.30% Unkown
HY-N6983 Licoricesaponin G2 99.87% Unkown
HY-W020952 Palladium(Ⅱ) acetylacetonate 98.2% Unkown
HY-152142 DN-1289 Inhibitor 99.63% Unkown
HY-A0299 H-Gly-Pro-Hyp-OH Inhibitor 99.48% Unkown
HY-N0863 Methyl protodioscin 99.67% Unkown
HY-107599 AEG3482 Inhibitor 99.79% Unkown
HY-141582 Ceramide 3 Inhibitor 98.0% Unkown
HY-P10506 CMX-8933 Activator 99.77% Unkown
HY-W050000 OR-1855 Inhibitor 98.31% Unkown
HY-157403 Jun12682 Inhibitor 99.60% Unkown
HY-114331 DLK-IN-1 Inhibitor 98.27% Unkown
HY-P1190 c-JUN peptide 99.60% Unkown
HY-125838 J30-8 Inhibitor 99.51% Unkown
HY-107621 U0124 98.0% Unkown
HY-13866B Ro 31-8220 formic 99.76% Unkown
HY-169021 JNK-1-IN-3 Inhibitor 98.44% Unkown
HY-101287 MPT0B392 99.63% Unkown
HY-172920 Wnt/β-catenin-IN-6 98.34% Unkown
HY-B1198S Piperonyl butoxide-d9 Inhibitor 98.68% Unkown
HY-107600 IQ-3 Inhibitor 99.61% Unkown
HY-134975 NY2267 Inhibitor 98.53% Unkown
HY-10851 JNK-9L Inhibitor 98.06% Unkown
HY-118529 JUN-1111 Inhibitor 98.57% Unkown
HY-121683 (E)-2-Hexadecenal 99.9% Unkown
HY-168895 c-Fos-IN-1 97.24% Unkown
HY-171980 OZO-H 97.07% Unkown
HY-RS07054 JUN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07055 Jun Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13866A Ro 31-8220 / Unkown
HY-141582S Ceramide 3-d3 Inhibitor 98.0% Unkown
HY-113443 12(S)-HPETE Activator / Unkown
HY-12270S T-5224-d8 / Unkown
HY-151928 JNK3 inhibitor-3 Inhibitor / Unkown
HY-155593 JNK-1-IN-2 Inhibitor / Unkown
HY-162922 MAP4K4-IN-6 Inhibitor / Unkown
HY-164111 JNK-IN-17 Inhibitor / Unkown
HY-168337 SET-171 Inhibitor / Unkown
HY-168859 JNK3 inhibitor-9 Inhibitor / Unkown
HY-168895A (E,E)-c-Fos-IN-1 / Unkown
HY-168916 Jun13296 Inhibitor / Unkown
HY-169177 JNK-1-IN-4 Inhibitor / Unkown
HY-169314 JNK-IN-19 Inhibitor / Unkown
HY-176213 JNK2/3-IN-1 Inhibitor / Unkown
HY-178692 JNK-IN-25 Inhibitor / Unkown
HY-181263 Jun13698 Inhibitor / Unkown
HY-181556 JNK3-IN-10 / Unkown
HY-181662 DLK-IN-2 Inhibitor / Unkown
HY-181812 JNK2/MKK7 PPI-IN-1 Inhibitor / Unkown
HY-181993 JNK3-IN-11 Inhibitor / Unkown
HY-183010 VP1 ligand-1 / Unkown
HY-183011 CRBN ligand-901 / Unkown
HY-183014 VP1 ligand-Linker Conjugate 1 Ligand / Unkown
HY-183252 ICA-1S / Unkown
HY-184396 GR2-128 / Unkown
HY-D2898 Jun14157 Ligand / Unkown
HY-E70837 JNK2 Recombinant Human Active Protein Kinase / Unkown
HY-N1326 Santamarine 98.85% Unkown
HY-N1961 Ophiopogonin B 99.90% Unkown
HY-P10048 TAT-JIP Inhibitor / Unkown
HY-P11650 HE4-1 leech peptide Inhibitor / Unkown
HY-P4699 (Thr17)-c-Jun (11-23) / Unkown
HY-P6177 SGP8 Inhibitor / Unkown
HY-RS07056 Jun Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107091R Aspartyl-alanyl-diketopiperazine (Standard) Inhibitor / Unkown
HY-11010A AS601245 TFA Inhibitor / Unkown
HY-138844 3-AP-Me Activator / Unkown
HY-157305 Jun11165 Inhibitor / Unkown
HY-158751 Jun9-72-2 Inhibitor / Unkown
HY-159985 Jun13728 Inhibitor / Unkown
HY-174814 Jun15716 Inhibitor / Unkown
HY-174815 Jun15799 Inhibitor / Unkown
HY-175165 Jun6504 Inhibitor / Unkown
HY-182924 Jun15702 Inhibitor / Unkown
HY-B1451S Imidapril-d3 hydrochloride Inhibitor / Unkown
HY-P10401 TAT-GluR6-9c Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jun NCBI NCBI:3725