CHNQD-01426
CHNQD-01426 (Compound 4a) is an anticancer agent. CHNQD-01426 has cytotoxic activities against cancer cells. CHNQD-01426 significantly inhibits hepatocellular carcinoma cells proliferation via arresting S and G2/M phase cell cycle and induces apoptosis by inducing ROS production and elevating apoptosis-related proteins expression. CHNQD-01426 potently inhibits tumor growth in HepG2 xenograft mice model.
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- CAS No.: 2673232-30-7
- Formule: C18H16N2O5
- Masse moléculaire:340.33
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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Caspase 3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3.88 μM
Compound: 4a
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Cytotoxicity against human A549 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
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[PMID: 34237623] |
| Bel-7402 | IC50 |
1.71 μM
Compound: 4a
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Cytotoxicity against human Bel-7402 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human Bel-7402 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
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[PMID: 34237623] |
| HCT-116 | IC50 |
5.47 μM
Compound: 4a
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Cytotoxicity against human HCT116 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
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[PMID: 34237623] |
| HepG2 | IC50 |
1.22 μM
Compound: 4a
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Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
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[PMID: 34237623] |
| L02 | IC50 |
6.01 μM
Compound: 4a
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Cytotoxicity against human L-O2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human L-O2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
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[PMID: 34237623] |
| NCI-H1299 | IC50 |
13.94 μM
Compound: 4a
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Cytotoxicity against human NCI-H1299 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H1299 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
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[PMID: 34237623] |
| U-251 | IC50 |
5.48 μM
Compound: 4a
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Cytotoxicity against human U251 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human U251 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
|
[PMID: 34237623] |
Chemical Information
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CAS No. 2673232-30-7
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Masse moléculaire 340.33
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Formule C18H16N2O5
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SMILES
O=C1NC(C(C2=CC(OC)=C(OC)C(OC)=C2)=O)=NC3=CC=CC=C31
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CHNQD-01426 Related Classifications
HY-177268 Related Classifications
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