ICA-1S
ICA-1S is a specific PKC-ι inhibitor. ICA-1S can inhibit MAPK/JNK signaling pathway and downregulate the levels of c-Jun and TNF-α. ICA-1S inhibits the proliferation of breast cancer cells. ICA-1S induces apoptosis of breast cancer cells. ICA-1S can be used in breast cancer-related research.
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- CAS No.: 90597-15-2
- Formule: C10H16N4O4
- Masse moléculaire:256.26
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
ICA-1S (2.5-30 μM; 120 h) potently inhibits the proliferation of BT-549 and MCF-7 breast cancer cells, with IC50 values of 10 μM and 20 μM respectively after 5 days of treatment[1].
Treatment with ICA-1S (10-20 μM; 120 h) at the IC50 concentration for 5 days induces apoptosis in BT-549 (via upregulation of cleaved Caspase 3 and cleaved PARP) and MCF-7 (via upregulation of cleaved PARP) breast cancer cells[1].
ICA-1S (10-20 μM (MCF-7); 120 h) downregulates the levels of PKC-ι and PKC-ζ in BT-549 and MCF-7 breast cancer cells, but exerts no such effect on MCF-7 cells[1].
ICA-1S (10-20 μM; 120 h) inhibits the oncogenic MAPK/JNK pathway and reduces the levels of phosphorylated and total pathway proteins, c-Jun, and TNF-α in BT-549 and MCF-7 breast cancer cells[1].
ICA-1S (10-20 μM; 120 h) reduces c-Jun mRNA levels by 50% in BT-549 breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BT-549, MCF-7 breast cancer cell lines
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Concentration:2.5 μM, 5 μM, 10 μM, 20 μM, 30 μM
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Incubation Time:120 h, with treatments every 24 h
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Result:Significantly reduced cell proliferation in both cell lines.
Achieved an IC50 of 10 μM, resulting in 45% inhibition for BT-549 cells.
Achieved an IC50 of 20 μM, resulting in 43% inhibition for MCF-7 cells.
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Cell Line:BT-549, MCF-7 breast cancer cell lines
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Concentration:10 μM (BT-549); 20 μM (MCF-7)
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Incubation Time:120 h
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Result:Reduced c-Jun mRNA levels by 50% in BT-549 cells compared to untreated controls.
Had no significant effect on c-Jun mRNA levels in MCF-7 cells.
Chemical Information
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CAS No. 90597-15-2
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Masse moléculaire 256.26
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Formule C10H16N4O4
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SMILES
O[C@H]1[C@H](N2C(N)=C(N=C2)C(N)=O)C[C@@H]([C@H]1O)CO
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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