CHNQD-01426
CHNQD-01426 (Compound 4a) is an anticancer agent. CHNQD-01426 has cytotoxic activities against cancer cells. CHNQD-01426 significantly inhibits hepatocellular carcinoma cells proliferation via arresting S and G2/M phase cell cycle and induces apoptosis by inducing ROS production and elevating apoptosis-related proteins expression. CHNQD-01426 potently inhibits tumor growth in HepG2 xenograft mice model.
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- No. CAS: 2673232-30-7
- Fòrmula: C18H16N2O5
- Peso molecular:340.33
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Ver todos los productos específicos de isoformas Caspase
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Actividad biológica
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Caspase 3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3.88 μM
Compound: 4a
|
Cytotoxicity against human A549 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
|
[PMID: 34237623] |
| Bel-7402 | IC50 |
1.71 μM
Compound: 4a
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Cytotoxicity against human Bel-7402 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human Bel-7402 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
|
[PMID: 34237623] |
| HCT-116 | IC50 |
5.47 μM
Compound: 4a
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Cytotoxicity against human HCT116 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
|
[PMID: 34237623] |
| HepG2 | IC50 |
1.22 μM
Compound: 4a
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Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
|
[PMID: 34237623] |
| L02 | IC50 |
6.01 μM
Compound: 4a
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Cytotoxicity against human L-O2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human L-O2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
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[PMID: 34237623] |
| NCI-H1299 | IC50 |
13.94 μM
Compound: 4a
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Cytotoxicity against human NCI-H1299 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H1299 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
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[PMID: 34237623] |
| U-251 | IC50 |
5.48 μM
Compound: 4a
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Cytotoxicity against human U251 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human U251 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
|
[PMID: 34237623] |
Chemical Information
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No. CAS 2673232-30-7
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Peso molecular 340.33
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Fòrmula C18H16N2O5
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SMILES
O=C1NC(C(C2=CC(OC)=C(OC)C(OC)=C2)=O)=NC3=CC=CC=C31
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CHNQD-01426 Related Classifications
HY-177268 Related Classifications
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