Tyk2 - tyrosine kinase 2 Gene

Rattus norvegicus

Gene ID: 100361294 | Gene type: protein coding

About Tyk2

Primary_assembly 8: 19,641,884-19,667,044 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 197 orthologues, 32 paralogues and is associated with 12 phenotypes. Biased expression in Spleen (RPKM 89.), Thymus (RPKM 65.1) and 9 other tissues.

Summary

Enables type 1 Angiotensin Receptor binding activity. Predicted to be involved in intracellular signal transduction and peptidyl-tyrosine phosphorylation. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 35. Orthologous to human Tyk2 (tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tyk2 Products(1)

mRNA	Protein	Name
NM_001257347.1	NP_001244276.1	non-receptor tyrosine-protein kinase TYK2

Tyk2 Protein Structure

FERM_F1

FERM_F2

Jak1_Phl

SH2

PKc_like

PTKc_Tyk2_rpt2

0
200
400
600
800
1000
1186 a.a.

Protein Preferred Names

Protein Names

non-receptor tyrosine-protein kinase TYK2

Related Agents

Approval

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50856	Ruxolitinib	Inhibitor	99.99%	Yes
HY-117287	Deucravacitinib	Inhibitor	99.87%	Yes
HY-15315	Baricitinib	Inhibitor	99.97%	Yes
HY-19569	Upadacitinib	Inhibitor	99.98%	Yes
HY-50858	Ruxolitinib phosphate	Inhibitor	99.98%	Yes
HY-16379	Pacritinib	Inhibitor	99.93%	Yes
HY-18300	Filgotinib	Inhibitor	99.68%	Yes
HY-107429	Abrocitinib	Inhibitor	99.26%	Unkown
HY-19568	Peficitinib	Inhibitor	99.43%	Yes
HY-15315A	Baricitinib phosphate	Inhibitor	99.91%	Yes
HY-109053	Delgocitinib	Inhibitor	99.87%	Unkown
HY-13577A	Oclacitinib maleate	Inhibitor	99.63%	Unkown
HY-13577	Oclacitinib	Inhibitor	99.23%	Unkown
HY-19569A	Upadacitinib tartrate tetrahydrate	Inhibitor	/	Unkown
HY-18300A	Filgotinib maleate	Inhibitor	/	Unkown
HY-16379A	Pacritinib hydrochloride	Inhibitor	/	Unkown
HY-50859	Ruxolitinib sulfate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15999	Cerdulatinib	Inhibitor	98.96%	Phase 3
HY-12469	Decernotinib	Inhibitor	99.67%	Phase 3
HY-112724	Ivarmacitinib	Inhibitor	99.82%	Phase 3
HY-15999A	Cerdulatinib hydrochloride	Inhibitor	99.89%	Phase 3
HY-13034	Gandotinib	Inhibitor	99.82%	Phase 2
HY-15270	BMS-911543	Inhibitor	98.53%	Phase 2
HY-19631A	Ilginatinib	Inhibitor	99.53%	Phase 2
HY-19631B	Ilginatinib hydrochloride	Inhibitor	≥98.0%	Phase 2
HY-19631	Ilginatinib maleate	Inhibitor	99.87%	Phase 2
HY-131968	BMS-986202	Inhibitor	99.92%	Phase 1

Pre-clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14435	Pyridone 6	Inhibitor	98.13%	Unkown
HY-100895	SAR-20347	Inhibitor	97.12%	Unkown
HY-14722	NVP-BSK805	Inhibitor	99.89%	Unkown
HY-111745	Tyk2-IN-5	Inhibitor	98.87%	Unkown
HY-101762	TyK2-IN-2	Inhibitor	98.64%	Unkown
HY-14722A	NVP-BSK805 dihydrochloride	Inhibitor	99.36%	Unkown
HY-131906	JAK2-IN-7	Inhibitor	99.15%	Unkown
HY-126242S	Tyk2-IN-7	Inhibitor	99.62%	Unkown
HY-120469	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide	Inhibitor	98.78%	Unkown
HY-13961	GLPG0634 analog	Inhibitor	98.58%	Unkown
HY-111750	JAK-IN-3	Inhibitor	98.92%	Unkown
HY-14722C	NVP-BSK805 trihydrochloride	Inhibitor	/	Unkown
HY-152080	TUL01101	Inhibitor	/	Unkown
HY-143885	JAK1/TYK2-IN-3	Inhibitor	/	Unkown
HY-16640	TCJL37	Inhibitor	/	Unkown
HY-153058	LRRK2-IN-8	Inhibitor	/	Unkown
HY-150720	TYK2-IN-12	Inhibitor	/	Unkown
HY-143884	JAK2/TYK2-IN-1	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-153103	LRRK2/NUAK1/TYK2-IN-1	Inhibitor	/	Unkown
HY-163304	Tyk2-IN-16	Inhibitor	/	Unkown
HY-153440	JAK-IN-25	Inhibitor	98.44%	Unkown
HY-148060	JAK-IN-21	Inhibitor	99.72%	Unkown
HY-154994	JAK-IN-30	Inhibitor	/	Unkown
HY-147754	JAK3/BTK-IN-6	Inhibitor	/	Unkown
HY-149296	JAK1-IN-12	Inhibitor	/	Unkown
HY-157121	JAK-IN-34	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tyk2	NCBI	NCBI:7297

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