Cdk5 - cyclin-dependent kinase 5 Gene

Also Known as Crk6

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12568

About Cdk5

Chromosome 5: 24,623,239-24,628,528 reverse strand.GRCm39:CM000998.3

This gene has 3 transcripts (splice variants), 170 orthologues, 25 paralogues and is associated with 21 phenotypes. Ubiquitous expression in CNS E18 (RPKM 36.7), CNS E14 (RPKM 31.7) and 28 other tissues.

Summary

Enables several functions, including HSP90 protein binding activity; acetylcholine receptor activator activity; and signaling receptor binding activity. Involved in regulation of dendritic spine morphogenesis; regulation of glutamatergic synaptic transmission; and regulation of protein localization to plasma membrane. Acts upstream of or within several processes, including chemical synaptic transmission; nervous system development; and regulation of intracellular protein transport. Located in several cellular components, including axon; filopodium; and lamellipodium. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Cdk5 Products (1)

mRNA	Protein	Name
NM_007668.4	NP_031694.1	cyclin-dependent kinase 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ErbB-2 class receptor binding	IDA IDA: Inferred from direct assay	11276227	MGI
enables ErbB-3 class receptor binding	IDA IDA: Inferred from direct assay	11276227	MGI
enables Hsp90 protein binding	IPI IPI: Inferred from physical interaction	17517623	MGI
enables acetylcholine receptor activator activity	IDA IDA: Inferred from direct assay	11276227	MGI
enables p53 binding	IPI IPI: Inferred from physical interaction	17591690	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11276227	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	9126296	MGI
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	14769920	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12941275	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Schwann cell development	IMP IMP: Inferred from mutant phenotype	16203963	MGI
acts upstream of or within apoptotic process	IDA IDA: Inferred from direct assay	9126296	MGI
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	11978846	MGI
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	11163260	MGI
acts upstream of or within behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	18032670	MGI
acts upstream of or within calcium ion import	IMP IMP: Inferred from mutant phenotype	18054859	MGI
acts upstream of or within cell migration	IDA IDA: Inferred from direct assay	12496365	MGI
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	17694053	MGI
acts upstream of or within cell-matrix adhesion	IDA IDA: Inferred from direct assay	12496365	MGI
acts upstream of or within central nervous system neuron development	IMP IMP: Inferred from mutant phenotype	8855328	MGI
acts upstream of or within cerebellar cortex development	IMP IMP: Inferred from mutant phenotype	8855328	MGI
acts upstream of or within cerebellar cortex formation	IMP IMP: Inferred from mutant phenotype	10407039	MGI
acts upstream of or within cerebellum development	IMP IMP: Inferred from mutant phenotype	11226314	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	9698328	MGI
acts upstream of or within corpus callosum development	IMP IMP: Inferred from mutant phenotype	18032654	MGI
acts upstream of or within dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	12372285	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	18054859	MGI
acts upstream of or within excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	17529984	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	17694053	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	11517264	MGI
acts upstream of or within intracellular protein transport	IMP IMP: Inferred from mutant phenotype	8855328	MGI
acts upstream of or within layer formation in cerebral cortex	IMP IMP: Inferred from mutant phenotype	11517264	MGI
acts upstream of or within motor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	16203963	MGI
acts upstream of or within negative regulation of axon extension	IGI IGI: Inferred from genetic interaction	22573681	MGI
acts upstream of or within negative regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	16237170	MGI
acts upstream of or within negative regulation of protein export from nucleus	IMP IMP: Inferred from mutant phenotype	17591690	MGI
acts upstream of or within negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	17591690	MGI
acts upstream of or within negative regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	17529984	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17591690	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	16237170	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	10407039	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	18054859	MGI
acts upstream of or within peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	18054859	MGI
involved in peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	24607229	MGI
acts upstream of or within peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	18054859	MGI
involved in peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	24607229	MGI
acts upstream of or within positive regulation of calcium ion-dependent exocytosis	IDA IDA: Inferred from direct assay	15123626	MGI
acts upstream of or within positive regulation of protein binding	IMP IMP: Inferred from mutant phenotype	18054859	MGI
acts upstream of or within positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	16203963	MGI
acts upstream of or within positive regulation of protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	18054859	MGI
acts upstream of or within protein localization to synapse	IMP IMP: Inferred from mutant phenotype	18054859	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	11517264	MGI
acts upstream of or within protein phosphorylation	IGI IGI: Inferred from genetic interaction	17060449	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	17591690	MGI
acts upstream of or within receptor catabolic process	IMP IMP: Inferred from mutant phenotype	17529984	MGI
acts upstream of or within receptor clustering	IMP IMP: Inferred from mutant phenotype	16203963	MGI
acts upstream of or within regulation of cell migration	IMP IMP: Inferred from mutant phenotype	12941275	MGI
involved in regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	17143272	MGI
acts upstream of or within regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	16203963	MGI
involved in regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	24607229	MGI
involved in regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	24607229	MGI
acts upstream of or within response to cocaine	IMP IMP: Inferred from mutant phenotype	14769920	MGI
acts upstream of or within sensory perception of pain	IMP IMP: Inferred from mutant phenotype	17194758	MGI
acts upstream of or within serine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	15096606	MGI
acts upstream of or within skeletal muscle tissue development	IDA IDA: Inferred from direct assay	9191048	MGI
acts upstream of or within synapse assembly	IMP IMP: Inferred from mutant phenotype	18054859	MGI
acts upstream of or within synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	14769920	MGI
acts upstream of or within synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	14769920	MGI
acts upstream of or within telencephalon development	IMP IMP: Inferred from mutant phenotype	18032654	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	17529984	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	3627430	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	3627430	MGI
located in cytosol	IDA IDA: Inferred from direct assay	9202329	MGI
located in filopodium	IDA IDA: Inferred from direct assay	12496365	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	12496365	MGI
NOT located in nucleolus	IDA IDA: Inferred from direct assay	3627430	MGI
located in nucleus	IDA IDA: Inferred from direct assay	8891282	MGI
part of protein kinase 5 complex	IPI IPI: Inferred from physical interaction	18325333	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk5 Protein Structure

STKc_CDK5

0
100
200
292 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase 5 cyclin-dependent-like kinase 5	CR6 protein kinase TPKII catalytic subunit cell division protein kinase 5 serine/threonine-protein kinase PSSALRE tau protein kinase II catalytic subunit

Protein Preferred Names

Protein Names

cyclin-dependent kinase 5

cyclin-dependent-like kinase 5

CR6 protein kinase
TPKII catalytic subunit
cell division protein kinase 5
serine/threonine-protein kinase PSSALRE
tau protein kinase II catalytic subunit

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16297A	Abemaciclib	Inhibitor	99.97%	Yes
HY-10492	Dinaciclib	Inhibitor	99.80%	Yes
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	Yes

Clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.51%	Phase 3
HY-30237	(R)-Roscovitine	Inhibitor	99.53%	Phase 2
HY-X0009	Tambiciclib	Inhibitor	99.68%	Phase 2
HY-50940	AT7519	Inhibitor	99.69%	Phase 2
HY-137478	KB-0742	Inhibitor	99.63%	Phase 2
HY-103712B	Samuraciclib hydrochloride dihydrate	Inhibitor	99.90%	Phase 2
HY-10012	AZD-5438	Inhibitor	99.91%	Phase 1
HY-10014	R547	Inhibitor	99.57%	Phase 1
HY-12871B	Atuveciclib	Inhibitor	99.75%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.67%	Phase 1

Pre-clinical Phase

Bioactive Molecules (82)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12302	Kenpaullone	Inhibitor	98.20%	Unkown
HY-10580	GSK 3 Inhibitor IX	Inhibitor	99.73%	Unkown
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Unkown
HY-15154	NG 52	Inhibitor	99.88%	Unkown
HY-18340	(R)-CR8	Inhibitor	99.52%	Unkown
HY-18299A	Purvalanol A	Inhibitor	98.61%	Unkown
HY-137478A	KB-0742 dihydrochloride	Inhibitor	98.77%	Unkown
HY-108359	Alsterpaullone	Inhibitor	99.85%	Unkown
HY-144117	GFB-12811	Inhibitor	98.04%	Unkown
HY-11009	CGP60474	Inhibitor	98.90%	Unkown
HY-13461A	PHA-767491 hydrochloride	Inhibitor	99.49%	Unkown
HY-X0150	JSH-150	Inhibitor	98.36%	Unkown
HY-103221	MeBIO	Inhibitor	98.0%	Unkown
HY-18340A	(R)-CR8 trihydrochloride	Inhibitor	99.37%	Unkown
HY-13461	PHA-767491	Inhibitor	99.97%	Unkown
HY-103712	Samuraciclib	Inhibitor	99.55%	Unkown
HY-123772	CDK5 inhibitor 20-223	Inhibitor	99.62%	Unkown
HY-18299	Purvalanol B	Inhibitor	97.0%	Unkown
HY-12280	THZ2	Inhibitor	99.03%	Unkown
HY-112358	GW8510	Inhibitor	99.04%	Unkown
HY-13266A	BS-181 hydrochloride	Inhibitor	99.93%	Unkown
HY-119940	MC180295	Inhibitor	98.07%	Unkown
HY-112272	Lerociclib	Inhibitor	96.42%	Unkown
HY-145694	CDK5-IN-3	Inhibitor	99.49%	Unkown
HY-151071	TMX-3013	Inhibitor	98.02%	Unkown
HY-W011428	Olomoucine	Inhibitor	99.88%	Unkown
HY-112403	(S)-Roscovitine	Inhibitor	99.15%	Unkown
HY-50943	AT7519 Hydrochloride	Inhibitor	99.16%	Unkown
HY-15504A	RGB-286638 free base	Inhibitor	98.09%	Unkown
HY-155218	TMX-2172	Degrader	99.38%	Unkown
HY-117025A	Manzamine A hydrochloride	Inhibitor	99.66%	Unkown
HY-151069	TMX-2039	Inhibitor	99.42%	Unkown
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	Unkown
HY-121035	7BIO	Inhibitor	99.20%	Unkown
HY-107419	NU6140	Inhibitor	99.53%	Unkown
HY-14372	BS-194	Inhibitor	99.13%	Unkown
HY-P10440	Cdk5i peptide	Inhibitor	98.93%	Unkown
HY-137342	SB1-G-187	Degrader	98.70%	Unkown
HY-154851	GSK-3 inhibitor 3	Inhibitor	99.10%	Unkown
HY-139725	CDK5-IN-1	Inhibitor	98.47%	Unkown
HY-123045	PNU-292137	Inhibitor	99.95%	Unkown
HY-136726	CGP-82996	Inhibitor	98.12%	Unkown
HY-119715	AG-012986	Inhibitor	99.78%	Unkown
HY-111930	5-Iodo-indirubin-3'-monoxime	Inhibitor	98.12%	Unkown
HY-15241	NVP-LCQ195	Inhibitor	98.88%	Unkown
HY-50940A	AT7519 TFA	Inhibitor	99.75%	Unkown
HY-X0009A	Tambiciclib dimaleate	Inhibitor	99.53%	Unkown
HY-13266	BS-181	Inhibitor	98.10%	Unkown
HY-114903	(E/Z)-BIO-acetoxime	Inhibitor	99.9%	Unkown
HY-154852	GSK-3 inhibitor 4	Inhibitor	99.02%	Unkown
HY-103381	NSC693868	Inhibitor	99.0%	Unkown
HY-103383	(R)-DRF053 dihydrochloride	Inhibitor	99.30%	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-117025	Manzamine A	Inhibitor	98.2%	Unkown
HY-164906	TMX-2138	Degrader	98.99%	Unkown
HY-112468	PNU112455A hydrochloride	Inhibitor	99.56%	Unkown
HY-N12625	(R)-(+)-O-Demethylbuchenavianine	Inhibitor	98.67%	Unkown
HY-151409	CDK1-IN-5	Inhibitor	/	Unkown
HY-151407	CDK1-IN-3	Inhibitor	/	Unkown
HY-110368	BS-181 dihydrochloride	Inhibitor	/	Unkown
HY-184911	CDK6 ligand-3	Degrader	/	Unkown
HY-145693	CDK5-IN-2	Inhibitor	/	Unkown
HY-163856	CDK7-IN-30	Inhibitor	/	Unkown
HY-178142	Multi-kinase-IN-7	Inhibitor	/	Unkown
HY-112336	Aloisine RP106	Inhibitor	/	Unkown
HY-137478B	KB-0742 hydrochloride	Inhibitor	/	Unkown
HY-182028	17β-HSD10-IN-4		/	Unkown
HY-161463	CDK2-IN-28	Inhibitor	/	Unkown
HY-173347	BLINK11	Inhibitor	/	Unkown
HY-112363	Aloisine A	Inhibitor	/	Unkown
HY-111931	Indirubin-3'-monoxime-5-sulphonic acid	Inhibitor	/	Unkown
HY-151408	CDK1-IN-4	Inhibitor	/	Unkown
HY-184913	JHK-02-102-1	Degrader	/	Unkown
HY-173348	BLINK15	Inhibitor	/	Unkown
HY-151878	CDK7-IN-20	Inhibitor	/	Unkown
HY-161595	CDK5-IN-4	Inhibitor	/	Unkown
HY-111932	Indirubin-5-sulfonate	Inhibitor	/	Unkown
HY-150641	CDK-IN-9	Inhibitor	/	Unkown
HY-182470	AG-012986 dihydrochloride	Inhibitor	/	Unkown
HY-183280	17β-HSD10/CDK5-IN-1	Inhibitor	/	Unkown
HY-182986	LS-Q2	Inhibitor	/	Unkown
HY-183235	NS-0011	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdk5	NCBI	NCBI:1020