2. Gene
  3. Cdk5 - cyclin-dependent kinase 5 Gene

Cdk5 - cyclin-dependent kinase 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Crk6

Gene ID: 12568 | Gene type: protein coding

About Cdk5

Chromosome 5: 24,623,239-24,628,528 reverse strand.GRCm39:CM000998.3

This gene has 3 transcripts (splice variants), 170 orthologues, 25 paralogues and is associated with 21 phenotypes. Ubiquitous expression in CNS E18 (RPKM 36.7), CNS E14 (RPKM 31.7) and 28 other tissues.

Summary

Enables several functions, including HSP90 protein binding activity; acetylcholine receptor activator activity; and signaling receptor binding activity. Involved in regulation of dendritic spine morphogenesis; regulation of glutamatergic synaptic transmission; and regulation of protein localization to plasma membrane. Acts upstream of or within several processes, including chemical synaptic transmission; nervous system development; and regulation of intracellular protein transport. Located in several cellular components, including axon; filopodium; and lamellipodium. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Cdk5 Products(1)

mRNA Protein Name
NM_007668.4 NP_031694.1 cyclin-dependent kinase 5

Cdk5 Protein Structure

STKc_CDK5

STKc_CDK5: cd07839 (2 - 285)

  • 0
  • 100
  • 200
  • 292 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 5

cyclin-dependent-like kinase 5

CR6 protein kinase

TPKII catalytic subunit

cell division protein kinase 5

serine/threonine-protein kinase PSSALRE

tau protein kinase II catalytic subunit

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16297A Abemaciclib Inhibitor 99.96% Yes
HY-10492 Dinaciclib Inhibitor 99.44% Yes
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
Clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Phase
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.74% Phase 4
HY-30237 (R)-Roscovitine Inhibitor 99.84% Phase 2
HY-50940 AT7519 Inhibitor 99.76% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-112272A Lerociclib dihydrochloride Inhibitor 98.11% Phase 2
HY-103712B Samuraciclib hydrochloride hydrate Inhibitor 99.08% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-112272 Lerociclib Inhibitor / Phase 2
HY-10012 AZD-5438 Inhibitor 99.85% Phase 1
HY-12871B Atuveciclib Inhibitor 99.80% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-15504 RGB-286638 Inhibitor 99.84% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.07% Phase 1
HY-50940A AT7519 TFA Inhibitor 98.53% Phase 1
Pre-clinical Phase
Bioactive Molecules (51)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12302 Kenpaullone Inhibitor 98.16% Unkown
HY-15154 NG 52 Inhibitor 99.97% Unkown
HY-11009 CGP60474 Inhibitor 99.23% Unkown
HY-10014 R547 Inhibitor 99.57% Unkown
HY-13461A PHA-767491 hydrochloride Inhibitor 98.06% Unkown
HY-18340 (R)​-​CR8 Inhibitor 99.21% Unkown
HY-18299A Purvalanol A Inhibitor 98.30% Unkown
HY-123772 CDK5 inhibitor 20-223 Inhibitor 99.78% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.80% Unkown
HY-18299 Purvalanol B Inhibitor ≥97.0% Unkown
HY-18340A (R)-CR8 trihydrochloride Inhibitor 98.95% Unkown
HY-W011428 Olomoucine Inhibitor 99.78% Unkown
HY-119940 MC180295 Inhibitor 98.89% Unkown
HY-12280 THZ2 Inhibitor 99.03% Unkown
HY-144117 GFB-12811 Inhibitor 98.00% Unkown
HY-107419 NU6140 Inhibitor 99.07% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.91% Unkown
HY-108359 Alsterpaullone Inhibitor 98.38% Unkown
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Unkown
HY-145694 CDK5-IN-3 Inhibitor 98.00% Unkown
HY-117025A Manzamine A hydrochloride Inhibitor 99.66% Unkown
HY-103221 MeBIO Inhibitor ≥98.0% Unkown
HY-154851 GSK-3 inhibitor 3 Inhibitor 98.72% Unkown
HY-121035 7BIO Inhibitor ≥98.0% Unkown
HY-112468 PNU112455A hydrochloride Inhibitor 99.56% Unkown
HY-112358 GW8510 Inhibitor 99.64% Unkown
HY-111930 5-Iodo-indirubin-3'-monoxime Inhibitor 99.50% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-136726 CGP-82996 Inhibitor / Unkown
HY-14372 BS-194 Inhibitor 99.36% Unkown
HY-103381 NSC693868 Inhibitor ≥99.0% Unkown
HY-114903 (E/Z)-BIO-acetoxime Inhibitor / Unkown
HY-13461 PHA-767491 Inhibitor / Unkown
HY-151409 CDK1-IN-5 Inhibitor / Unkown
HY-151407 CDK1-IN-3 Inhibitor / Unkown
HY-110368 BS-181 dihydrochloride Inhibitor / Unkown
HY-103712 Samuraciclib Inhibitor / Unkown
HY-112336 Aloisine RP106 Inhibitor / Unkown
HY-139725 CDK5-IN-1 Inhibitor / Unkown
HY-111931 Indirubin-3'-monoxime-5-sulphonic acid Inhibitor / Unkown
HY-117025 Manzamine A Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-112363 Aloisine A Inhibitor / Unkown
HY-154852 GSK-3 inhibitor 4 Inhibitor / Unkown
HY-111932 Indirubin-5-sulfonate Inhibitor / Unkown
HY-150641 CDK-IN-9 Inhibitor / Unkown
HY-145693 CDK5-IN-2 Inhibitor / Unkown
HY-151408 CDK1-IN-4 Inhibitor / Unkown
HY-161463 CDK2-IN-28 Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-103383 (R)-DRF053 dihydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk5 NCBI NCBI:1020