Brd3 - bromodomain containing 3 Gene

Also Known as ORFX; Fsrg2; RINGL3; 2410084F24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67382

About Brd3

Chromosome 2: 27,335,591-27,397,674 reverse strand.GRCm39:CM000995.3

This gene has 10 transcripts (splice variants), 150 orthologues and 11 paralogues. Ubiquitous expression in CNS E11.5 (RPKM 15.9), limb E14.5 (RPKM 14.1) and 28 other tissues.

Summary

Predicted to enable lysine-acetylated histone binding activity and nucleosomal histone binding activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin organization. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and retina. Orthologous to human BRD3 (bromodomain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Brd3 Products (3)

mRNA Protein Name
NM_001113574.1 NP_001107046.1 bromodomain-containing protein 3 isoform 1
NM_023336.4 NP_075825.3 bromodomain-containing protein 3 isoform 2
NM_001113573.1 NP_001107045.1 bromodomain-containing protein 3 isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in endodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
32895492 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Brd3 Protein Structure

Bromo_Brdt_I_like

Bromo_Brdt_I_like: cd05497 (32 - 138)

Bromo_Brdt_II_like

Bromo_Brdt_II_like: cd05498 (309 - 410)

BET

BET: pfam17035 (571 - 635)

  • 0
  • 200
  • 400
  • 600
  • 726 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 3

  • bromodomain-containing FSH-like protein FSRG2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-13030 (+)-JQ-1 Inhibitor 99.91% Phase 1
HY-112090 ABBV-744 Inhibitor 99.97% Phase 1
HY-117286 (S)-JQ-35 Inhibitor 99.46% Phase 1

Pre-clinical Phase

Bioactive Molecules (42)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100972 ARV-771 Degrader 99.87% Unkown
HY-78695 JQ-1 carboxylic acid Inhibitor 99.69% Unkown
HY-136570 GSK778 Inhibitor 99.14% Unkown
HY-136571 GSK046 Inhibitor 99.70% Unkown
HY-141438 SIM1 Degrader 99.47% Unkown
HY-153385 TMX1 Degrader 99.57% Unkown
HY-138563 GSK973 Inhibitor 99.97% Unkown
HY-101519 BETd-260 Inhibitor 99.68% Unkown
HY-130622 LT052 Inhibitor 98.02% Unkown
HY-112429 HJB97 Inhibitor 99.12% Unkown
HY-114504 RVX-297 Inhibitor 95.00% Unkown
HY-158764 PROTAC BET Degrader-12 Degrader 98.10% Unkown
HY-114416 GS-626510 Inhibitor 99.46% Unkown
HY-120000 MS402 Inhibitor 98.36% Unkown
HY-112610 CF53 Inhibitor 99.81% Unkown
HY-131061 BET bromodomain inhibitor 1 Inhibitor 99.67% Unkown
HY-145264 OARV-771 Inhibitor 98.77% Unkown
HY-110215 XD14 Inhibitor 95.02% Unkown
HY-170380 XY221 Inhibitor / Unkown
HY-126325 BY27 Inhibitor / Unkown
HY-179589 JQ-1 (carboxylic acid)-amine-PEG8-cyanogen Degrader / Unkown
HY-180901 BRD3 ligand-1 / Unkown
HY-155680 BET BD2-IN-1 Inhibitor / Unkown
HY-169170 PARP1/BRD4-IN-3 Inhibitor / Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-181729 PROTAC BET Degrader-15 Degrader / Unkown
HY-181495 RAJQ14 Degrader / Unkown
HY-170390 AB3067 Degrader / Unkown
HY-143471 WNY0824 Inhibitor / Unkown
HY-180804 CZL-077 Inhibitor / Unkown
HY-181867 PROTAC BET Degrader-16 Degrader / Unkown
HY-168634 SJ46421 Inhibitor / Unkown
HY-181869 PROTAC BET Degrader-17 Degrader / Unkown
HY-180889 PROTAC BRD3 degrader-1 Degrader / Unkown
HY-170900 SJ44236 Degrader / Unkown
HY-175924 BRD3/BRD4-L ligand-2 Ligand / Unkown
HY-179588 PROTAC BET Degrader-14 Degrader / Unkown
HY-182801 PROTAC BRD4 Degrader-46 Degrader / Unkown
HY-168635 SJ46420 Inhibitor / Unkown
HY-182371 BRD4 ligand 15 Ligand / Unkown
HY-181735 BET-IN-30 Inhibitor / Unkown
HY-136570A GSK778 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brd3 NCBI NCBI:8019