BRD3 - bromodomain containing 3 Gene

Also Known as ORFX; RING3L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8019

About BRD3

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:134,030,305-134,068,548 (from NCBI)

This gene has 6 transcripts (splice variants), 150 orthologues, 11 paralogues and is associated with 77 phenotypes. Ubiquitous expression in endometrium (RPKM 8.0), brain (RPKM 7.5) and 25 other tissues.

Summary

This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]

BRD3 Products (8)

mRNA Protein Name
NM_007371.4 NP_031397.1 bromodomain-containing protein 3
XM_047423904.1 XP_047279860.1 bromodomain-containing protein 3 isoform X1
XM_047423903.1 XP_047279859.1 bromodomain-containing protein 3 isoform X1
XM_047423905.1 XP_047279861.1 bromodomain-containing protein 3 isoform X2
XM_047423906.1 XP_047279862.1 bromodomain-containing protein 3 isoform X2
XM_011519052.3 XP_011517354.1 bromodomain-containing protein 3 isoform X1
XM_017015165.3 XP_016870654.1 bromodomain-containing protein 3 isoform X2
XM_006717291.4 XP_006717354.1 bromodomain-containing protein 3 isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
18406326 GOA
enables lncRNA binding IDA
IDA: Inferred from direct assay
32895492 GOA
enables lysine-acetylated histone binding IDA
IDA: Inferred from direct assay
22464331 GOA
enables molecular condensate scaffold activity IDA
IDA: Inferred from direct assay
32895492 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20195357 GOA
Biological Process GO Annotation Evidence References Source
involved in endodermal cell differentiation IDA
IDA: Inferred from direct assay
32895492 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
32895492 GOA
involved in protein localization to chromatin IDA
IDA: Inferred from direct assay
29567837 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18406326 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
32895492 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25593309 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRD3 Protein Structure

Bromodomain

Bromodomain: Bromodomain (46 - 126)

Bromodomain

Bromodomain: Bromodomain (315 - 403)

  • 0
  • 200
  • 400
  • 600
  • 726 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 3

  • RING3-like protein

BRD3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BRD3 Q15059 MYC Homo sapiens P01106
Display Tech
20195357
Intra
BRD3 Q15059 MYC Homo sapiens P01106
TAP
20195357
Cross: Cross-species interaction Intra: Intraspecies interaction

BRD3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810946 BRD3 Antibody WB, IHC-P, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Foodborne Botulism

  • Botulism

  • Botulism Poisoning

  • Intoxication With Clostridium Botulinum Toxin

  • Wound Botulism

  • Food Poisoning Due To Clostridium Botulinum

  • Infection Due To Clostridium Botulinum

  • Infant Botulism

  • Intoxication Botulism

  • Botulism, Infantile

  • Clostridium Botulinum Poisoning

  • Botulism Nos
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Leukemia, Myeloid, Acute

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Infant Botulism

  • Infant Intestinal Botulism

  • Infant Intestinal Toxemia Botulism

  • Infant Intestinal Toxin-Mediated Botulism

  • Infantile Botulism

  • Botulism, Infantile
Nut Midline Carcinoma

  • Nuclear Protein In Testis Midline Carcinoma

  • Nmc
Wound Botulism

  • Cutaneous Infectious Botulism

  • Cutaneous Toxin-Mediated Botulism

  • Inoculation Botulism

  • Skin Infectious Botulism

  • Skin Toxin-Mediated Botulism
Bladder Sarcoma

  • Sarcoma Of Bladder

  • Sarcoma Of The Urinary Bladder
Intestinal Botulism

  • Intestinal Colonization Botulism

  • Intestinal Toxemia Botulism

  • Intestinal Toxin-Mediated Botulism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-13030 (+)-JQ-1 Inhibitor 99.91% Phase 1
HY-112090 ABBV-744 Inhibitor 99.97% Phase 1
HY-117286 (S)-JQ-35 Inhibitor 99.46% Phase 1

Pre-clinical Phase

Bioactive Molecules (54)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100972 ARV-771 Degrader 99.87% Unkown
HY-78695 JQ-1 carboxylic acid Inhibitor 99.69% Unkown
HY-136570 GSK778 Inhibitor 99.14% Unkown
HY-136571 GSK046 Inhibitor 99.70% Unkown
HY-141438 SIM1 Degrader 99.47% Unkown
HY-153385 TMX1 Degrader 99.57% Unkown
HY-138563 GSK973 Inhibitor 99.97% Unkown
HY-101519 BETd-260 Inhibitor 99.68% Unkown
HY-130622 LT052 Inhibitor 98.02% Unkown
HY-103633 PROTAC BET Degrader-1 Inhibitor 99.41% Unkown
HY-112429 HJB97 Inhibitor 99.12% Unkown
HY-114504 RVX-297 Inhibitor 95.00% Unkown
HY-158764 PROTAC BET Degrader-12 Degrader 98.10% Unkown
HY-114416 GS-626510 Inhibitor 99.46% Unkown
HY-120000 MS402 Inhibitor 98.36% Unkown
HY-112610 CF53 Inhibitor 99.81% Unkown
HY-111875 SNIPER(BRD)-1 Degrader 99.68% Unkown
HY-130256 β-NF-JQ1 Degrader 98.05% Unkown
HY-131061 BET bromodomain inhibitor 1 Inhibitor 99.67% Unkown
HY-115568 BETd-246 Inhibitor 98.34% Unkown
HY-114228 PROTAC BET degrader-2 Inhibitor 98.21% Unkown
HY-145264 OARV-771 Inhibitor 98.77% Unkown
HY-110215 XD14 Inhibitor 95.02% Unkown
HY-145390 Nrf2 activator-1 Ligand 98.66% Unkown
HY-170380 XY221 Inhibitor / Unkown
HY-139620 MS83 Degrader / Unkown
HY-126325 BY27 Inhibitor / Unkown
HY-179589 JQ-1 (carboxylic acid)-amine-PEG8-cyanogen Degrader / Unkown
HY-182371 BRD4 ligand 15 Ligand / Unkown
HY-170900 SJ44236 Degrader / Unkown
HY-175924 BRD3/BRD4-L ligand-2 Ligand / Unkown
HY-181867 PROTAC BET Degrader-16 Degrader / Unkown
HY-182801 PROTAC BRD4 Degrader-46 Degrader / Unkown
HY-181869 PROTAC BET Degrader-17 Degrader / Unkown
HY-179588 PROTAC BET Degrader-14 Degrader / Unkown
HY-153414 GXF-111 Degrader / Unkown
HY-180889 PROTAC BRD3 degrader-1 Degrader / Unkown
HY-155393 PROTAC BRD4 Degrader-22 Degrader / Unkown
HY-155680 BET BD2-IN-1 Inhibitor / Unkown
HY-181729 PROTAC BET Degrader-15 Degrader / Unkown
HY-139996 Pomalidomide-C5-Dovitinib Degrader / Unkown
HY-143471 WNY0824 Inhibitor / Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-181495 RAJQ14 Degrader / Unkown
HY-155371 BT-PROTAC Degrader / Unkown
HY-13031 GW 841819X Inhibitor / Unkown
HY-168635 SJ46420 Inhibitor / Unkown
HY-168634 SJ46421 Inhibitor / Unkown
HY-169170 PARP1/BRD4-IN-3 Inhibitor / Unkown
HY-170390 AB3067 Degrader / Unkown
HY-181735 BET-IN-30 Inhibitor / Unkown
HY-180901 BRD3 ligand-1 / Unkown
HY-180804 CZL-077 Inhibitor / Unkown
HY-136570A GSK778 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus BRD3 VGNC VGNC:60167
Mus musculus BRD3 MGD MGI:1914632
Bos taurus BRD3 VGNC VGNC:26558
Macaca mulatta BRD3 VGNC VGNC:70281
Canis familiaris BRD3 VGNC VGNC:103661
Rattus norvegicus BRD3 RGD RGD:1308925
Others BRD3 NCBI