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製品番号: HY-177268

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CHNQD-01426

CHNQD-01426 (Compound 4a) is an anticancer agent. CHNQD-01426 has cytotoxic activities against cancer cells. CHNQD-01426 significantly inhibits hepatocellular carcinoma cells proliferation via arresting S and G2/M phase cell cycle and induces apoptosis by inducing ROS production and elevating apoptosis-related proteins expression. CHNQD-01426 potently inhibits tumor growth in HepG2 xenograft mice model.

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CAS 番号: 2673232-30-7
分子式: C₁₈H₁₆N₂O₅
分子量:340.33

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CHNQD-01426 構造式

CAS 番号: 2673232-30-7

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

Caspase 3

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.88 μM Compound: 4a	Cytotoxicity against human A549 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay	[PMID: 34237623]
Bel-7402	IC₅₀	1.71 μM Compound: 4a	Cytotoxicity against human Bel-7402 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay Cytotoxicity against human Bel-7402 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay	[PMID: 34237623]
HCT-116	IC₅₀	5.47 μM Compound: 4a	Cytotoxicity against human HCT116 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay	[PMID: 34237623]
HepG2	IC₅₀	1.22 μM Compound: 4a	Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay	[PMID: 34237623]
L02	IC₅₀	6.01 μM Compound: 4a	Cytotoxicity against human L-O2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay Cytotoxicity against human L-O2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay	[PMID: 34237623]
NCI-H1299	IC₅₀	13.94 μM Compound: 4a	Cytotoxicity against human NCI-H1299 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H1299 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay	[PMID: 34237623]
U-251	IC₅₀	5.48 μM Compound: 4a	Cytotoxicity against human U251 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay Cytotoxicity against human U251 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay	[PMID: 34237623]

化学情報

CAS 番号 2673232-30-7
分子量 340.33
分子式 C₁₈H₁₆N₂O₅
SMILES

O=C1NC(C(C2=CC(OC)=C(OC)C(OC)=C2)=O)=NC3=CC=CC=C31
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang CJ, et al. Discovery of penipanoid C-inspired 2-(3,4,5-trimethoxybenzoyl)quinazolin-4(3H)-one derivatives as potential anticancer agents by inhibiting cell proliferation and inducing apoptosis in hepatocellular carcinoma cells. Eur J Med Chem. 2021 Nov 15;224:113671. [Content Brief]

[2]. Zhang Q, et al. Recent advances of bioactive marine natural products in drug discovery[J]. Journal of Ocean University of China, 2024, 23(5): 1297-1318.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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CHNQD-01426

PARP アイソフォーム固有の製品をすべて表示

Caspase アイソフォーム固有の製品をすべて表示

Akt アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

CHNQD-01426 関連分類

HY-177268 関連分類