Apoptosis inducer 45
Apoptosis inducer 45 is an apoptosis inducer. Apoptosis inducer 45 is cytotoxically active against the MCF-7 cell line. Apoptosis inducer 45 elicits MCF-7 cell apoptosis via the mitochondrial pathway (increases the Bax/Bcl-2 ratio) by activating cleavage of caspase-9, thereby inducing the fragmentation of DNA repair protein PARP. Apoptosis inducer 45 also can induce caspase-8 cleavage, subsequently initiating cleavage of caspase-3 and its downstream protein PARP to culminate in the extrinsic apoptosis. Apoptosis inducer 45 can be used in the research of breast cancer.
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- 分子式: C41H57N3O3
- 分子量:639.91
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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生物活性
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Caspase 3 |
Caspase 9 |
Caspase 8 |
PARP |
Bax |
Bcl-2 |
Apoptosis inducer 45 (Compound 11s) inhibits cell proliferation with IC50 values of 3.56, 4.93, 7.76 and 13.35 μM against A549, MCF-7, HL-7702 and MDA-MB-231 cells[1].
Apoptosis inducer 45 (2.5-10 μM, 24 h) induces MCF-7 cell apoptosis via both the exogenous and endogenous pathways[1].
Apoptosis inducer 45 (2.5-10 μM, 24 h-14 d) shows a concentration- and time-dependent inhibition of MCF-7 cell growth and inhibits colony formation[1].
Apoptosis inducer 45 (2.5-10 μM, 72 h) significantly reduces the migration ability of the MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:2.5, 5 and 10 μM
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Incubation Time:24 h
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Result:led to the typical apoptotic morphological characteristics of MCF-7 cells.
Increased apoptosis rates as the concentration rises.
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Cell Line:MCF-7 cells
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Concentration:2.5, 5 and 10 μM
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Incubation Time:72 h
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Result:Significantly reduced the migration ability, and the migration inhibition effect persisted for 72 hours of observation.
化学情報
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分子量 639.91
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分子式 C41H57N3O3
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SMILES
[H][C@]1(C(CC[C@@]2(C(C)([C@@H](CC[C@@]12C)O)C)[H])=C)CC/C(C)=C/C(N3CCN(CC3)CC4=CC=C(C=C4)C(NCCC5=CC=C(C=C5)C)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Apoptosis inducer 45 関連分類
HY-178099 関連分類
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