イソオキサゾール
Based on 1 Customer Validation
Isoxazole is a member of the five-membered heterocycle drug scaffold. Isoxazole has been used as a BET bromodomain inhibitor and can improve β-cell function in a diabetic mouse model. Isoxazole and its derivatives exhibit broad biological activities (such as antimicrobial, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, analgesic, anti-tuberculosis, and anti-diabetic effects). For example, the bicyclic Isoxazole can act as an HSP90 inhibitor, and the tricyclic Isoxazole is promising as a selective multidrug resistance protein (MRP1) inhibitor.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.98%
- CAS 番号: 288-14-2
- 分子式: C3H3NO
- 分子量:69.06
-
保管条件:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-W010649R
Isoxazole (Standard)
-
HY-B0322
Sulfamethoxazole
-
HY-W010434
Leflunomide impurity 4
-
HY-B0322R
Sulfamethoxazole (Standard)
-
HY-W010434R
5-Methylisoxazole-4-carboxylic acid (Standard)
-
HY-W041676
5-Methylisoxazol-3-amine
-
HY-W103317
1,2-Benzisoxazole
-
HY-B0322B
Sulfamethoxazole 1000 µg/mL in methanol
-
HY-W032938
COX-1-IN-4
-
HY-W007329
Isoxazol-3-amine
-
HY-34631
Oxazole
-
HY-69155
Oxazole-4-carboxylic acid
Antibiotic アイソフォーム固有の製品をすべて表示
More
生物活性
|
Multidrug resistance proteins (MRPs) |
Isoxazole (20 µM, 48 hours) improves β-cell function by inhibiting excessive proliferation of MIN6 cells (mouse pancreatic β-cells) and altering the gene expression profile of MIN6 cells (enhancing the neuroendocrine phenotype)[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MIN6 mouse β-cell line
-
Concentration:20 µM
-
Incubation Time:48 h
-
Result:Significantly upregulates gene expression of STMN2.
-
Cell Line:MIN6 mouse β-cell line
-
Concentration:20 µM
-
Incubation Time:48 h
-
Result:Upregulates STMN2 protein expression.
-
Cell Line:INS1E mouse β-cell line
-
Concentration:20 µM
-
Incubation Time:72 h
-
Result:Reduced cell number, indicating inhibition of cell proliferation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Diabetes model in PANIC-ATTAC mice induced by dimerizer (e.g., AP20187 (HY-13992))[5]
-
Dosage:16 mg/kg
-
Administration:Intraperitoneal injection (i.p.), once daily for 4 weeks
-
Result:Significant reduced blood glucose after oral glucose tolerance test (OGTT). Caused that pancreas insulin content increased approaching significance.
化学情報
-
CAS 番号 288-14-2
-
性状 Liquid (Density: 1.078 g/cm3)
-
分子量 69.06
-
分子式 C3H3NO
-
Color Colorless to light yellow
-
SMILES
C1=CON=C1
-
別名
Isoxazole
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (1448.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (285 KB)
-
SDS (466 KB)
- English - EN (466 KB)
- Français - FR (466 KB)
- Deutsch - DE (466 KB)
- Norwegian - NO (466 KB)
- Español - ES (466 KB)
- Swedish - SV (466 KB)
- Italian - IT (466 KB)
- Korean - KR (466 KB)
- Portuguese - PT (466 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Zhu J, et al. The recent progress of isoxazole in medicinal chemistry. Bioorg Med Chem. 2018 Jul 23;26(12):3065-3075. [Content Brief]
[2]. Sysak A, et al. Isoxazole ring as a useful scaffold in a search for new therapeutic agents. Eur J Med Chem. 2017 Sep 8;137:292-309. [Content Brief]
[3]. Norman BH, et al. Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1)[J]. Bioorg Med Chem Lett. 2002 Mar 25;12(6):883-6. [Content Brief]
[4]. Agrawal N, Mishra P. The synthetic and therapeutic expedition of isoxazole and its analogs[J]. Med Chem Res. 2018;27(5):1309-1344. [Content Brief]
[5]. Kalwat MA, et al. Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells. ACS Chem Biol. 2016 Apr 15;11(4):1128-36. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 14.4802 mL | 72.4008 mL | 144.8016 mL | 362.0041 mL |
| 5 mM | 2.8960 mL | 14.4802 mL | 28.9603 mL | 72.4008 mL | |
| 10 mM | 1.4480 mL | 7.2401 mL | 14.4802 mL | 36.2004 mL | |
| 15 mM | 0.9653 mL | 4.8267 mL | 9.6534 mL | 24.1336 mL | |
| 20 mM | 0.7240 mL | 3.6200 mL | 7.2401 mL | 18.1002 mL | |
| 25 mM | 0.5792 mL | 2.8960 mL | 5.7921 mL | 14.4802 mL | |
| 30 mM | 0.4827 mL | 2.4134 mL | 4.8267 mL | 12.0668 mL | |
| 40 mM | 0.3620 mL | 1.8100 mL | 3.6200 mL | 9.0501 mL | |
| 50 mM | 0.2896 mL | 1.4480 mL | 2.8960 mL | 7.2401 mL | |
| 60 mM | 0.2413 mL | 1.2067 mL | 2.4134 mL | 6.0334 mL | |
| 80 mM | 0.1810 mL | 0.9050 mL | 1.8100 mL | 4.5251 mL | |
| 100 mM | 0.1448 mL | 0.7240 mL | 1.4480 mL | 3.6200 mL |
Isoxazole 関連分類
HY-W010649 関連分類
Powered by Bioz