PP124
PP124 is a multi-kinase inhibitor. PP124 inhibits the phosphoinositide 3-kinase (PI3K) catalytic isoforms p110α, p110β, p110δ, and p110γ (IC50 = 4 μM, 7 μM, 0.966 μM, and 1.5 μM), mTOR and DNAPK (IC50 = 0.493 μM and 0.054 μM), as well as the tyrosine kinases Abl, Hck, Src, mutant Src (T/I), VEGFR, EGFR, and EphB4 (IC50 = 0.165 μM, 0.005 μM, 0.017 μM, 0.25 μM, 0.134 μM, 0.085 μM, and 0.17 μM). PP124 can be used for cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1092788-95-8
- 分子式: C18H18N6
- 分子量:318.38
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
p110α 4 μM (IC50) |
p110β 7 μM (IC50) |
p110δ 0.966 μM (IC50) |
p110γ 1.5 μM (IC50) |
EPHB4 0.17 μM (IC50) |
Abl 0.165 μM (IC50) |
Hck 0.005 μM (IC50) |
体外実験
Effective research across multiple cancers requires simultaneous inhibition of multiple oncogenic kinases. The reason is that tumor cells rapidly develop resistance to single-kinase inhibitors.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
化学情報
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CAS 番号 1092788-95-8
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分子量 318.38
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分子式 C18H18N6
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SMILES
N=1C=NC2=C(C1N)C(=NN2C3CCCC3)C=4C=CC=5C=CNC5C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PP124 関連分類
HY-134468 関連分類
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