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L-5'-halo- dioxolane nucleoside analogue

" in MedChemExpress (MCE) Product Catalog:

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3529

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

221

Peptides

MCE Kits

Inhibitory Antibodies

388

Natural
Products

Recombinant Proteins

229

Isotope-Labeled Compounds

Antibodies

135

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1198

Oligonucleotides

GMP Molecules

Targets Recommended: Nucleoside Transporters Nucleoside Antimetabolite/Analog NTPDase

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-D2270

Halo tag TMR 2 Publications Verification	Fluorescent Dye	Others
Halo tag TMR is a red fluorescent dye composed of Halo tag ligand molecules and TMR (TAMRA). Halo tag can quickly and stably covalently bind to Halo protein with high specificity and affinity (Ex/Em = 550/576 nm) .

HY-A0005

Clofarabine 10+ Cited Publications	Nucleoside Antimetabolite/Analog Autophagy Apoptosis	Metabolic Disease Cancer
Clofarabine, a nucleoside analogue for research of cancer, is a potent inhibitor of ribonucleotide reductase (IC₅₀=65 nM) by binding to the allosteric site on the regulatory subunit .

HY-151716

Halo-DBCO	PROTAC Linkers	Others
Halo-DBCO is a click chemistry reagent containing dibenzocyclooctyne (DBCO). Halo-DBCO can be used as a ligand to react with HaloTag to form covalent HaloTag ligand couples .

HY-17426

Famciclovir 1 Publications Verification BRL 42810	VZV HSV HBV	Infection
Famciclovir (BRL 42810) is an orally active nucleoside analogue. Famciclovir is an antiviral agent with potent activities against HBV, HSV and VZV. Famciclovir can be used for the research of herpesvirus infection .

HY-123055

Adenosine dialdehyde 5+ Cited Publications	Nucleoside Antimetabolite/Analog S-adenosylhomocysteine hydrolase (SAHH)	Cancer
Adenosine dialdehyde, a purine nucleoside analogue, is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (K_i=3.3 nM) . Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research .

HY-13983

IDO-IN-7 1 Publications Verification NLG-919 analogue; GDC-0919 analogue	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-7 (NLG-919 analogue) is a a potent IDO1 inhibitor with an IC₅₀ of 38 nM.

HY-159493

BI2536-PEG2-Halo	Polo-like Kinase (PLK)	Cancer
BI2536-PEG2-Halo is a bifunctional molecule containing a ligand for Halo tag and a Polo-like kinase 1 (PLK1) inhibitor BI-2536 (HY-50698). BI2536-PEG2-Halo inhibits the proliferation of 293T cells with Halo-p53R273H(FL)-mCherry tag (IC₅₀=23 nM), exhibits selective toxicity against p53 mutant cancer cells .

HY-Y1096

2-(2-Bromoethyl)-1,3-dioxolane	PROTAC Linkers	Cancer
2-(2-Bromoethyl)-1,3-dioxolane is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-120832

Azt-pmap	HIV	Infection
Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. Azt-pmap shows anti-HIV activity . AZT is a nucleoside reverse transcriptase inhibitor (NRTI) for HIV infection . Azt-pmap is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W570888

2'-O,4'-C-Methylenecytidine LNA-C(Bz)	Nucleoside Antimetabolite/Analog	Cancer
2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands .

HY-44358

*Remdesivir nucleoside* monophosphate** 3 Publications Verification	Drug Metabolite DNA/RNA Synthesis SARS-CoV	Infection
Remdesivir nucleoside monophosphate is a metabolite of Remdesivir (HY-104077) .

HY-P2724

*Purine nucleoside* phosphorylase, Microorganism** PNP	Endogenous Metabolite	Metabolic Disease
Purine nucleoside phosphorylase, Microorganism (PNP) is a key enzyme in purine metabolism, which is involved in the purine rescue pathway. The deficiency of Purine nucleoside phosphorylase resulted in impaired T cell function. In the presence of inorganic orthophosphate as the second substrate, Purine nucleoside phosphorylase catalyzes the breaking of the glycosidic bond between ribose and deoxyribonucleoside to generate purine base and ribose (deoxyribose) -1-phosphate .

HY-131295

PD0325901-O-C2-dioxolane 2 Publications Verification	MEK Ligands for Target Protein for PROTAC	Cancer
PD0325901-O-C2-dioxolane has main portion of MEK inhibitor PD0325901. PD0325901-O-C2-dioxolane and a ligand of VHL or CRBN E3 ligase can be used in the synthesis of MEK1/2 degrader .

HY-I0606B

*(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde*	Drug Intermediate Endogenous Metabolite
(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde is a chiral molecule with potential chiral catalytic activity. It can be used as an intermediate in organic synthesis and plays a key role in the construction of complex molecular systems. This compound has also been used to develop new compound carriers and exhibits good biocompatibility.

HY-148170

L-I-OddU	EBV DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection
L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC₅₀ value of 0.03μM. L-I-OddU has low cytotoxicity with a CC₅₀ value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis .

HY-11105

Pilaralisib analogue 1 Publications Verification XL147 analogue	PI3K Apoptosis	Cancer
Pilaralisib analogue (XL147 analogue) is a representative and selective PI3Kα inhibitor extracted from patent WO2012006552A1, Compound 147 in Table 1.

HY-153606

*VUBI1 analogue-1*	Drug Derivative HDAC	Cancer
VUBI1 analogue-1 (compound 79) is a VUBI1 (HY-111671) analogue. VUBI1 (SOS1 activator 1) is a SOS1 activator with a K_d of 44 nM. VUBI1 analogue-1 can be used to synthesize (4S)-PROTAC SOS1 degrader-1 (HY-144657) ^{[1] ^.}

HY-E70042

Nucleoside hydrolase (IAGNH)	Endogenous Metabolite	Metabolic Disease
Nucleoside hydrolase (IAGNH) is a glycosidase. Nucleoside hydrolase (IAGNH) catalyzes the cleavage of the N-glycosidic bond in nucleosides to enable the recycling of the nucleobases and Rib .

HY-P11020

*p27 Analogue* CP2**	E1/E2/E3 Enzyme	Cancer
p27 Analogue CP2 is a macrocyclic peptide inhibitor targeting the Cks1-Skp2-Skp1 complex (K_d = 32 nM). p27 Analogue CP2 blocks SCFSkp2/Cks1-mediated ubiquitylation and degradation of p27, restoring p27 levels and inhibiting cell proliferation. p27 Analogue CP2 is promising for research of cancers dependent on Skp2 overexpression such as breast cancer .

HY-153890

NVOC cage-TMP-Halo	Biochemical Assay Reagents	Others
NVOC cage-TMP-Halo is a cell-permeable and photoactivatable protein dimerization inducer. NVOC cage-TMP-Halo can rapidly and reversibly control protein localization in living cells. NVOC cage-TMP-Halo can be used for dynamic cellular processes research .

HY-W040688

2-(Bromomethyl)-1,3-dioxolane	PROTAC Linkers	Cancer
2-(Bromomethyl)-1,3-dioxolane is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-P2881

Nucleoside diphosphate kinase nucleoside 5′-diphosphate kinase	Biochemical Assay Reagents	Cancer
Nucleoside diphosphate kinase (Nucleoside 5′-diphosphate kinase) belongs to the family of structurally and functionally conserved NDPK (Nucleotide diphosphate kinase) enzymes. Nucleoside diphosphate kinase catalyzes the reversible transfer of γ-phosphates between nucleoside di-(NDP) and triphosphates (NTP) through ping-pong bi-bi reaction kinetics. Nucleoside diphosphate kinase is the essential housekeeping proteins that produces CTP (cytidine triphosphate) for lipid syntheses, UTP (Uridine triphosphate) for polysaccharide syntheses, and GTP (guanosine triphosphate) for protein syntheses, signal transduction, and microtubules polymerization .

HY-D2923

*PA-JF549-Halo* ligand**	Fluorescent Dye	Others
PA-JF549-Halo ligand is a covalently linked conjugate comprising the photoactivatable fluorescent dye PA-JF549 and a ligand for the HaloTag protein. PA-JF549-Halo ligand exhibts inherent structural properties and predispose it to localize within mitochondria. PA-JF549-Halo ligand combines the exceptional brightness, photostability, and cell permeability of the JF549 dye with photoactivation capabilities and the high specificity characteristic of HaloTag protein labeling technology. PA-JF549-Halo ligand enables high-quality single-molecule imaging and super-resolution imaging of specific proteins within live cells .

HY-33316

2-(4-Bromobutyl)-1,3-dioxolane	PROTAC Linkers	Cancer
2-(4-Bromobutyl)-1,3-dioxolane is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-153060

*β-D-Ribofuranose analogue* 1**	Nucleoside Antimetabolite/Analog	Others
β-D-Ribofuranose analogue 1 is a nucleoside compound. β-D-Ribofuranose analogue 1 can be used for RNA synthesis .

HY-144712

L5-DA	G-quadruplex Apoptosis	Cancer
L5-DA is a G-quadruplex (G4) ligand and selectively stabilized for G4s over ds26. L5-DA exhibits significant cytotoxicity against HeLa cells (IC₅₀=4.3 μM). L5-DA stabilizes G4s in HeLa cells, induces apoptosis, and cell cycle arrest .

HY-148053

*Rezivertinib analogue* 1**	Drug Metabolite	Cancer
Rezivertinib analogue 1 is a process impurity of osimertinib mesylate. Rezivertinib analogue 1 can be used in the study of non-small cell lung cancer .

HY-106175

Detiviciclovir AM365	Nucleoside Antimetabolite/Analog	Infection
Detiviciclovir (AM365) is an antiviral nucleoside analogue .

HY-117582

Elvucitabine	Reverse Transcriptase HIV	Infection
Elvucitabine is an L-nucleoside analogue. Elvucitabine is a potent nucleoside reverse transcriptase (RT) inhibitor. Elvucitabine can be used in research of viral infection .

HY-W666697

2-(5-Bromopentyl)-1,3-dioxolane	PROTAC Linkers	Cancer
2-(5-Bromopentyl)-1,3-dioxolane is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-W010119

4-Methyl-2-phenyl-1,3-dioxolane	Biochemical Assay Reagents	Others
4-Methyl-2-phenyl-1,3-dioxolane is an organic compound commonly used as a solvent and intermediate. It can be used in some organic synthesis reactions, such as the synthesis of drugs or other organic compounds. In addition, this compound is also widely used in industrial production fields, such as plastics, coatings and glues.

HY-164364B

*DOTAGA.(SA.FAPi)2 analogue* TFA**	FAP	Cancer
DOTAGA.(SA.FAPi)2 analogue TFA is a DOTAGA.(SA.FAPi)2 TFA (HY-164364A) analogue, in which the ligand and the chelator are identical to those of DOTAGA.(SA.FAPi)2 TFA. DOTAGA.(SA.FAPi)2 TFA is a potent dimeric fibroblast-activation protein inhibitor (FAPi) .

HY-150265

TNH TMP-NVOC linker-halo	Kinesin	Others
TNH (TMP-NVOC linker-Halo) is a dimeric protein chemical inducer that can enter living cells and recruit proteins to cellular structures. TNH senses light signals and acts by recruiting proteins to kinetochores and releasing them from kinetochores (depending on CENP-E (kinesin-7)) .

HY-157795

*Exatecan analogue* 1**	ADC Payload Topoisomerase	Cancer
Exatecan analogue 1 (Icp-3) is a Exatecan (HY-13631) analogue. Exatecan analogue 1 can be used in the synthesis of antibody-drug conjugates (ADCs)

HY-77652

Nucleoside-Analog-2 1 Publications Verification	Nucleoside Antimetabolite/Analog HCV	Infection
Nucleoside-Analog-2 is a 4'-Azidocytidine analogue against Hepatitis C virus (HCV) replication. Nucleoside-Analog-2 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-P11216

*Pep2-8 analogue* 18**	PCSK9	Cancer
Pep2-8 analogue 18 is a high affinity PCSK9 (K_D = 6 nM) inhibitory peptide. Pep2-8 analogue 18 restores LDL uptake in HepG2 cells (EC₅₀ = 175 nM). Pep2-8 analogue 18 has good cellular safety. Pep2-8 analogue 18 can be used for research on cardiovascular conditions .

HY-P10973

*Peptide R analogue* 10**	CXCR ERK	Cancer
Peptide R analogue 10 (compound 10) is an analog of the CXCR4 antagonist peptide Peptide R (HY-P4111) with stronger antagonistic potency, specificity and plasma stability. Peptide R analogue 10 can inhibit CXCL12-mediated cell migration, ERK phosphorylation and CXCR4 internalization. Peptide R analogue 10 can be used in the study of CXCR4 overexpressing leukemia and colon cancer .

HY-163902

*SP100030 analogue* 1**	CRM1	Cancer
SP100030 analogue 1 (compound 11), a SP100030 (HY-110177) analogue, is a selective inhibitor of transcriptional activation (SITA) with an EC₅₀ of 137 nM for suppressing the XPO1-dependent upregulation of IL2 by Jurkat-based IL2-Luc reporter assay .

HY-17426R

Famciclovir (Standard) BRL 42810 (Standard)	Reference Standards VZV HSV HBV	Infection
Famciclovir (Standard) is the analytical standard of Famciclovir. This product is intended for research and analytical applications. Famciclovir (BRL 42810) is an orally active nucleoside analogue. Famciclovir is an antiviral agent with potent activities against HBV, HSV and VZV. Famciclovir can be used for the research of herpesvirus infection .

HY-105098

Lobucavir BMS-180194; SQ 34514	HBV HIV CMV EBV Nucleoside Antimetabolite/Analog	Infection
Lobucavir (BMS-180194; SQ 34514)，a nucleoside analogue，is an antiviral agent. Lobucavir shows a broad spectrum of activity against HBV，HIV/AIDS，and α，β，and γ herpes viruses including CMV，herpes-simplex，varicella-zoster，and Epstein-Barr virus .

HY-14184A

Macitentan n-butyl analogue	Endothelin Receptor	Cardiovascular Disease Endocrinology
Macitentan n-butyl analogue is a n-butyl analogue of Macitentan. Macitentan is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

HY-107082

Dioxolane T	HIV Nucleoside Antimetabolite/Analog	Infection
Dioxolane T is a nucleoside analogue. Dioxolane T exhibits anti-HIV activity .

HY-170023

Samidorphan isoquinoline dioxolane	Opioid Receptor	Neurological Disease
Samidorphan isoquinoline dioxolane (Compound 16) is a cyclazocine analogue with opioid receptor binding properties .

HY-W702852

*4-(Bromomethyl)-2,2-dimethyl-1,3-dioxolane-d5* 5-bromomethyl-2,2-dimethyl-1,3-dioxolane-d₅	Isotope-Labeled Compounds	Others
4-(Bromomethyl)-2,2-dimethyl-1,3-dioxolane-d₅ (5-bromomethyl-2,2-dimethyl-1,3-dioxolane-d₅) is the deuterium labeled 4-(Bromomethyl)-2,2-dimethyl-1,3-dioxolane (HY-W018073).

HY-W017415

2-(3-Chloropropyl)-1,3-dioxolane	PROTAC Linkers	Cancer
2-(3-Chloropropyl)-1,3-dioxolane is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-118703

L-Ristosamine nucleoside	HIV HSV	Infection
L-Ristosamine nucleoside is a nucleoside compound with antiviral activity against HIV and HSV-1 .

HY-N16036

*DOPE-PEG(2000)-HALO-TAG ammonium*	Biochemical Assay Reagents	Others
DOPE-PEG(2000)-HALO-TAG ammonium is a PEG polymer containing unsaturated DOPE phospholipids. DOPE-PEG(2000)-HALO-TAG ammonium can be used to prepare liposomes or other nanoparticles for drug delivery.

HY-Y1372S

*2,2-Dimethyl-1,3-dioxolane-4-methanol-d5*	Isotope-Labeled Compounds	Others
2,2-Dimethyl-1,3-dioxolane-4-methanol-d₅ is the deuterium labeled 2,2-Dimethyl-1,3-dioxolane-4-methanol .

HY-160641

*isoG Nucleoside-1*	Others	Others
isoG Nucleoside-1 (compound 15) is an isoguanine (isoG) nucleoside. In the HNA(h)-DNA(d) mosaic scaffold, h-isoG base mismatches follow the order G>C>T, while h-isoG base mismatches follow the order G>C>T .

HY-152982

1-(2-C-β-Methyl-β-D-ribofuranosyl)-5-nitropyridine-2(1H)-one	Nucleoside Antimetabolite/Analog	Others
1-(2-C-β-Methyl-β-D-ribofuranosyl)-5-nitropyridine-2(1H)-one is a nitropyridine nucleoside analogue.

Cat. No.	상품명	Category	Target	Chemical Structure

HY-N0092

Inosine 15+ Cited Publications	Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Adenosine Receptor Endogenous Metabolite
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-16938

5'-Methylthioadenosine 5+ Cited Publications 5'-(Methylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine	Natural Products Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Apoptosis Parasite
5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis . 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis .

HY-B0158

Cytidine 5+ Cited Publications Cytosine β-D-riboside; Cytosine-1-β-D-ribofuranoside	Natural Products Human Gut Microbiota Metabolites Microorganisms other families Animals Disease markers Nervous System Disorder Plants Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog Endogenous Metabolite
Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-14781

Levomefolic acid 3 Publications Verification L-5-MTHF	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Reactive Oxygen Species (ROS) DNA/RNA Synthesis
Levomefolic acid (L-5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements .

HY-125818

Cytidine-5'-triphosphate 3 Publications Verification Cytidine triphosphate; 5'-CTP	Infection Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Endogenous Metabolite
Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii .

HY-17470

Mizoribine 5 Publications Verification NSC 289637; HE 69	Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	HCV SARS-CoV Antibiotic Parasite
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-113061

Pseudouridine 1 Publications Verification	Natural Products Human Gut Microbiota Metabolites Other disease Classification of Application Fields Disease markers Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
Pseudouridine is an isomer of uridine and the most abundant modified nucleoside in non-coding RNA. It fine-tunes and stabilizes regional structures in rRNA and tRNA, maintaining their functions in mRNA decoding, ribosome assembly, processing, and translation. Pseudouridine-modified tRNA fragments can inhibit aberrant protein synthesis and hold promise for research on myelodysplastic syndrome (MDS)-related leukemia. ^[5].

HY-B1716

L-5-Hydroxytryptophan 3 Publications Verification L-5-HTP; Oxitriptan	Monophenols other families Phenols Amino acids Plants Endogenous metabolite	Endogenous Metabolite
L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia ^[5].

HY-17026E

Gemcitabine triphosphate trisodium dFdCTP trisodium	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Drug Metabolite DNA/RNA Synthesis Apoptosis
Gemcitabine triphosphate (dFdCTP) trisodium is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate trisodium cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate trisodium shows a K_i of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε. Gemcitabine triphosphate trisodium partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate trisodium disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate trisodium can be used for the research of pancreatic cancer and non-small cell lung cancer .

HY-113128C

(Rac)-sn-Glycerol 3-phosphate DL-α-Glycerol phosphate	Structural Classification Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Lipid Source Classification	Endogenous Metabolite
(Rac)-sn-Glycerol 3-phosphate is an a-site substrate analogue. (Rac)-sn-Glycerol 3-phosphate is bound to the a-site, the rate of reaction of indole and nucleophilic indole analogues with E(A-A) is strongly inhibited .

HY-134356

AICA-riboside, 5′-phosphate AICAR-5'-MP	Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
AICA-riboside, 5′-phosphate is AICA riboside with a phosphate group. The functions of AICA riboside include: 1) conversion into AMP mimetic to selectively activate AMPK; 2) competition with adenosine for the uptake of nucleoside transporters, reversible blocking of adenosine reuptake, increasing extracellular adenosine concentration, and indirectly activating adenosine A1 receptors. AICA riboside is involved in metabolic regulation (promoting catabolism and inhibiting anabolism) and adenosine-dependent neuroprotection (inhibiting excitatory synaptic transmission). AICA riboside can be used in the study of metabolic diseases (such as diabetes and obesity) and neurological diseases (such as ischemia and epilepsy), and has central nervous system protective activity .

HY-N2387

Pinosylvin	Infection Stilbenes Classification of Application Fields Polygonaceae Reynoutria japonica Houtt. Phenols Polyphenols Plants Disease Research Fields Source Classification	Bacterial Apoptosis Autophagy
Pinosylvin is a?pre-infectious stilbenoid toxin?isolated from the heartwood of Pinus species, has anti-bacterial activities . Pinosylvin is a resveratrol analogue, can induce cell apoptosis and autophapy in leukemia cells .

HY-W091784

3'-O-Methylguanosine	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Orthopoxvirus Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
3'-O-Methylguanosine is a methylated nucleoside analog and RNA chain terminator. 3'-O-Methylguanosine can inhibit the synthesis of early vaccinia virus-specific RNA .

HY-17564

2'-Deoxycytidine (hydrochloride) 5+ Cited Publications 2'-Deoxycytidine monohydrochloride; Deoxycytidine hydrochloride; NSC 83251	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Nucleoside Antimetabolite/Analog
2'-Deoxycytidine hydrochloride (2'-Deoxycytidine monohydrochloride; NSC 83251) is an orally active nucleic acid biosynthesis enzyme inhibitor. 2'-Deoxycytidine hydrochloride competes with nucleic acid biosynthesis enzymes and nucleoside transporters, thereby reducing the toxicity of cytarabine. 2'-Deoxycytidine hydrochloride can be used in the research of L1210 lymphoblastic leukemia .

HY-W013715A

Deoxythymidine-5'-triphosphate trisodium solution (100 mM) dTTP trisodium solution (100 mM)	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Endogenous Metabolite
Deoxythymidine-5'-triphosphate (dTTP) (trisodium) solution (100 mM) is one of the raw materials used by DNA polymerase to synthesize long DNA strands during DNA replication. Deoxythymidine-5'-triphosphate (trisodium) solution (100 mM) is used in polymerase chain reaction (PCR) for DNA amplification. This product is supplied as an aqueous solution.

HY-W012313

2,2'-Anhydrouridine 2,2'-Cyclouridine; O2,2'-Cyclouridine	Infection Classification of Application Fields Disease Research Fields	Drug Intermediate Nucleoside Antimetabolite/Analog
2,2'-Anhydrouridine (2,2'-Cyclouridine) is a nucleoside analog. 2,2'-Anhydrouridine is an important intermediate in the synthesis of other nucleoside-related compounds .

HY-101400A

Deoxycytidine triphosphate trisodium solution (100 mM) 1 Publications Verification dCTP trisodium solution (100 mM); 2′-Deoxycytidine-5′-triphosphate trisodium solution (100 mM)	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Endogenous Metabolite
Deoxycytidine triphosphate trisodium (dCTP trisodium) solution (100 mM) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate trisodium salt has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing .

HY-118384

Sangivamycin 3 Publications Verification NSC 65346; BA-90912	Natural Products Microorganisms Classification of Application Fields Disease Research Fields Cancer Source Classification	PKC Nucleoside Antimetabolite/Analog
Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an K_i of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers .

HY-21088

3-Amino-2-piperidinone Cyclo-ornithine	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate
3-Amino-2-piperidinone (Cyclo-ornithine) is a cyclic ornithine analogue and can be used as drug intermediate .

HY-19480

Ulodesine 1 Publications Verification BCX4208	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Ulodesine is a *purine nucleoside* phosphorylase (PNP) inhibitor. Ulodesine inhibits PNP with IC₅₀** value of 2.293 nM/L. Ulodesine can be used for the research of hyporucicemia .

HY-N5102

D-(+)-Fucose	Ipomoea muricata Other Diseases Plants Convolvulaceae Disease Research Fields Saccharides Source Classification	Others
D-(+)-Fucose is a nonmetabolizable analogue of l-arabinose. D-(+)-Fucose prevents growth of Escherichia coli B/r on a mineral salts medium plus l-arabinose by inhibiting induction of the l-arabinose operon. D-fucose is a potent inducer of beta-methylgalactoside permease (MGP) .

HY-125650

Pseudouridimycin 1 Publications Verification PUM	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic DNA/RNA Synthesis Bacterial Nucleoside Antimetabolite/Analog
Pseudouridimycin (PUM) is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC₅₀ of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis .

HY-N6002

3'-Hydroxypterostilbene 1 Publications Verification	Stilbenes Classification of Application Fields Leguminosae Phenols Polyphenols Sphaerophysa salsula (Pall.) DC. Plants Disease Research Fields Source Classification Cancer	Apoptosis Autophagy
3'-Hydroxypterostilbene is a Pterostilbene (HY-N0828) analogue. 3'-Hydroxypterostilbene inhibits the growth of COLO 205, HCT-116 and HT-29 cells with IC₅₀s of 9.0, 40.2 and 70.9 μM, respectively. 3'-Hydroxypterostilbene significantly down-regulates PI3K/Akt and MAPKs signaling pathways and effectively inhibits the growth of human colon cancer cells by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene can be used for the research of cancer .

HY-108776

(Rac)-sn-Glycerol 3-phosphate sodium DL-α-Glycerol phosphate sodium	Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
(Rac)-sn-Glycerol 3-phosphate sodium is an a-site substrate analogue. (Rac)-sn-Glycerol 3-phosphate sodium is bound to the a-site, the rate of reaction of indole and nucleophilic indole analogues with E(A-A) is strongly inhibited .

HY-141472

7-Methylguanosine 5'-diphosphate sodium 7-Methyl-GDP sodium; m7GDP sodium	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
7-Methylguanosine 5'-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues .

HY-103694

Nebularine	Natural Products Microorganisms Source Classification	Nucleoside Antimetabolite/Analog
Nebularine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-137680

GP4G Diguanosine tetraphosphate	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
GP4G (Diguanosine tetraphosphate) is a symmetrical bis-diphospho nucleoside that can be isolated from the cysts of Artemia salina. GP4G is an epithelial cell and hair growth regulator .

HY-N8377

Capsiate 4 Publications Verification	Monophenols Capsicum annuum L. Classification of Application Fields Phenols Solanaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	TRP Channel
Capsiate, as a capsaicin analogue extracted from a non-pungent cultivar of CH-19 sweet red pepper, is an orally active agonist of TRPV1 .

HY-N2434

[10]-Shogaol 5 Publications Verification	Zingiber officinale Roscoe Structural Classification Monophenols Classification of Application Fields Phenols Plants Disease Research Fields Source Classification Zingiberaceae Cancer	COX Interleukin Related NF-κB Parasite
[10]-Shogaol is an orally active antioxidant. [10]-Shogaol can be extracted from ginger (Zingiber officinale). [10]-Shogaol1 inhibits COX-2 with an IC₅₀ value of 7.5 μM. [10]-Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). [10]-Shogaol inhibits NF-κB phosphorylation. [10]-Shogaol has anti-inflammatory effects. [10]-Shogaol has anticancer effects against Docetaxel (HY-B0011)-resistant prostate cancer. [10]-Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis ^[5].

HY-W008351

L-Ribose	Microorganisms Classification of Application Fields Disease Research Fields Source Classification Cancer	Biochemical Assay Reagents Drug Intermediate
L-Ribose, a non-naturally occurring pentose, is an ideal starting material for use in synthesizing L-nucleosides analogues. L-Ribose can be used for the synthesis of various anticancer and antiviral agents such as Telbivudine (HY-B0017) .

HY-W006267

4-Chloroindole-3-acetic acid 4-Cl-IAA	Alkaloids Leguminosae Pisum sativum Linn Plants Indole Alkaloids Source Classification	Endogenous Metabolite
4-Chloroindole-3-acetic acid (4-Cl-IAA) is a chlorinated analogue of indole-3-acetic acid (IAA) (HY-18569) auxin that functions as a plant hormone, which is found in the seeds of Medicago truncatula、Melilotus indicus and Trifolium .

HY-121305A

L-Ribulose	Infection Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Source Classification Cancer	Drug Intermediate
L-Ribulose is an L-form pentulose. L-Ribulose serves as a key precursor for the synthesis of L-ribose and L-nucleoside analogs .

HY-N0092R

Inosine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Adenosine Receptor Endogenous Metabolite
Inosine (Standard) is the analytical standard of Inosine. This product is intended for research and analytical applications. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors . In Vitro:Inosine dose-dependently stimulates cAMP production mediated through the A_2AR . Inosine dose-dependently induces hA_2AR-mediated ERK1/2 phosphorylation . Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes . In Vivo:Inosine (10-100 mg/kg; i.p.) exhibits antinociceptive effect in mice .

HY-113061R

Pseudouridine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Other disease Disease markers Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
Pseudouridine (Standard) is the analytical standard of Pseudouridine. This product is intended for research and analytical applications. Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation [4].

HY-B0158R

Cytidine (Standard) Cytosine β-D-riboside (Standard); Cytosine-1-β-D-ribofuranoside (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms other families Animals Disease markers Nervous System Disorder Plants Endogenous metabolite Source Classification	Reference Standards Nucleoside Antimetabolite/Analog Endogenous Metabolite
Cytidine (Standard) is the analytical standard of Cytidine. This product is intended for research and analytical applications. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function . In Vivo:Cytidine decreases glutamate/glutamine levels and induces earlier improvement of depressive symptoms .

HY-B1716R

L-5-Hydroxytryptophan (Standard) 3 Publications Verification L-5-HTP (Standard); Oxitriptan (Standard)	Structural Classification Alkaloids Monophenols other families Ketones, Aldehydes, Acids Phenols Amino acids Plants Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
L-5-Hydroxytryptophan (Standard) is the analytical standard of L-5-Hydroxytryptophan. This product is intended for research and analytical applications. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia ^[5].

HY-N7256

Dihydrocephalomannine	Other Terpenoids Structural Classification Classification of Application Fields Terpenoids Plants Cephalotaxaceae Disease Research Fields Cephalotaxus fortunei Hooker Source Classification Cancer	Microtubule/Tubulin
Dihydrocephalomannine (compound 1b), an analogue of Paclitaxel, shows reduced cytotoxicity and tubulin binding compared to Paclitaxel .

HY-17470R

Mizoribine (Standard) NSC 289637 (Standard); HE 69 (Standard)	Alkaloids Structural Classification Microorganisms Other Alkaloids Source Classification	Reference Standards HCV SARS-CoV Antibiotic Parasite
Mizoribine (Standard) is the analytical standard of Mizoribine. This product is intended for research and analytical applications. Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-W019870A

Glufosinate	Microorganisms Source Classification	Herbicide
Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity .

HY-125927

8-Aminoadenosine 1 Publications Verification 8-NH2-Ado	Natural Products Endogenous metabolite Source Classification	DNA/RNA Synthesis Akt mTOR Autophagy Apoptosis
8-Aminoadenosine (8-NH2-Ado), a RNA-directed nucleoside analogue, reduces cellular ATP levels and inhibits mRNA synthesis. 8-Aminoadenosine blocks Akt/mTOR signaling and induces autophagy and apoptosis in a p53-independent manner. 8-Aminoadenosine has antitumor activity .

HY-N8395

Tunicamycin V 2 Publications Verification Tunicamycin A	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial
Tunicamycin V (Tunicamycin A) is a nucleoside natural product that inhibits bacterial phospho-N-acetylmuramyl-pentapeptide transferase (MraY) with an IC₅₀ of 0.35?μM. Tunicamycin V has antibacterial activties .

HY-N2012

7-Hydroxyaristolochic acid A	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Phenols Aristolochia Plants Aristolochiaceae Inflammation/Immunology Disease Research Fields Source Classification	Others
7-Hydroxyaristolochic acid A is an aristolochic acid analogue found in Aristolochia plants. Aristolochic acid can be used as an anti-inflammatory agent .

HY-138615

Deoxythymidine-5'-triphosphate dTTP	Infection Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Endogenous Metabolite
Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA .

HY-125150

AL-3138 11-Deoxy-16-fluoro PGF2α	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Prostaglandin Receptor Endogenous Metabolite
AL-3138 (11-Deoxy-16-fluoro PGF2α) is a prostaglandin F2 alpha (PGF2alpha) analogue that antagonises FP prostaglandin receptor-mediated inositol phosphate production .

HY-N9340

Hypoglaunine D	Infection Alkaloids Classification of Application Fields Celastraceae Pyridine Alkaloids Plants Disease Research Fields Tripterygium hypoglaucum (Levl. ) Hutch. Source Classification	HIV
Hypoglaunine D is an analogue of Triptonine B and acts as an anti-HIV compound. Hypoglaunine D inhibits HIV replication in H9 lymphocytes with an EC₅₀ value of 22 μg/ml .

HY-U00082

Tigloidin Tigloyl pseudotropine; Tiglylpseudotropine; Tiglyssin	Alkaloids Classification of Application Fields Datura innoxia Miller Other Alkaloids Solanaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	mAChR
Tigloidin is an analogue of atropine, with anticholinergic activity.

HY-N0224A

Goitrin (S)-Goitrin; L-5-Vinyl-2-thiooxazolidone	Natural Products Cruciferous vegetables Classification of Application Fields Metabolic Disease Plants Brassicaceae Endogenous metabolite Disease Research Fields Source Classification	Influenza Virus
Goitrin ((S)-Goitrin), a product of glucosinolate-myrosinase reactions, is a potent inhibitor of thyroid peroxidase. Goitrin can inhibit iodine utilization by the thyroid. Goitrin also exhibits anti-influenza virus (H1N1) activity .

HY-138615A

Deoxythymidine-5'-triphosphate sodium hydrate dTTP sodium hydrate	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Endogenous Metabolite
Deoxythymidine-5'-triphosphate (dTTP) sodium hydrate is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate trisodium salt is used in the synthesis of DNA .

HY-N8609

Uralsaponin C	Triterpenes Leguminosae Ketones, Aldehydes, Acids Terpenoids Plants Glycyrrhiza uralensis Fisch. Source Classification	Others
Uralsaponin C is an analogue of oleanane-type triterpenoid saponin. Uralsaponin C can be isolated from the roots of Glycyrrhiza uralensis Fisch .

HY-N8495

4'-Hydroxyflavanone	Flavonoids Monophenols Microorganisms Classification of Application Fields Flavonones Phenols Metabolic Disease Disease Research Fields Source Classification	Others
4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. 4'-Hydroxyflavanone is a synthetic analogue of flavanone, has potential for hepatic steatosis and dyslipidemia research .

Cat. No.	상품명	Chemical Structure

HY-104077S1

Remdesivir-d4
Remdesivir-d₄ (GS-5734-d₄) is deuterium labeled Remdesivir (HY-104077). Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection .

HY-A0020S

Eldecalcitol-d6
Eldecalcitol-d₆ is the deuterium labeled Eldecalcitol. Eldecalcitol is an orally active analogue of active vitamin D used in the treatment of osteoporosis.

HY-B0158S7

Cytidine-13C9
Cytidine- ¹³C₉ (Cytosine β-D-riboside- ¹³C₉) is ¹³C labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-B1716S

L-5-Hydroxytryptophan-d3

L-5-Hydroxytryptophan-d₃ is the deuterium labeled L-5-Hydroxytryptophan. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia ^[5].

HY-14781S1

Levomefolic acid-13C,d3
Levomefolic acid- ¹³C,d₃ is the deuterium labeled Levomefolic acid (HY-14781) . Levomefolic acid (5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements .

HY-12522S

PF-06380101-d8 2 Publications Verification
PF-06380101-d₈ (Aur0101-d₈) is a deuterium labeled PF-06380101 (HY-12522). PF-06380101, an Auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue .

HY-N0097S6

Guanosine-13C10,15N5
Guanosine- ¹³C₁₀, ¹⁵N₅ is the ¹³C and ¹⁵N labeled Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .

HY-104077S

Remdesivir-d5 2 Publications Verification
Remdesivir-d₅ (GS-5734-d₅) is a deuterium labeled Remdesivir (HY-104077). Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection .

HY-W751165

Uridine-13C9,15N2
Uridine-13C9,15N2 (β-Uridine-13C9,15N2) is ¹³C and ¹⁵N labeled Uridine (HY-B1449). Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond .

HY-13637S

Ganciclovir-d5

Ganciclovir-d₅ is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC₅₀ of 5.2 μM for feline herpesvirus type-1 (FHV-1) .

HY-W011834S

2'-O-Methylcytidine-d3
2'-O-Methylcytidine-d₃ is deuterium labeled 2'-O-Methylcytidine (HY-W011834). 2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.

HY-138615S2

Deoxythymidine-5'-triphosphate-13C10 dilithium
Deoxythymidine-5'-triphosphate- ¹³C₁₀ (dTTP- ¹³C₁₀) dilithium is ¹³C-labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.

HY-W714356

N-6-Methyl-2-deoxyadenosine-d3
N-6-Methyl-2-deoxyadenosine-d3 is the deuterium labeled N-6-Methyl-2-deoxyadenosine (HY-W011725). N-6-Methyl-2-deoxyadenosine is an adenine nucleoside analogue .

HY-125818S3

Cytidine-5'-triphosphate-13C9 dilithium

Cytidine-5'-triphosphate- ¹³C₉ (Cytidine triphosphate- ¹³C₉ dilithium; 5'-CTP- ¹³C₉) dilithium is ¹³C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.

HY-B1716S2

L-5-Hydroxytryptophan-d4

L-5-Hydroxytryptophan-d₄ (L-5-HTP-d₄; Oxitriptan-d₄) is a deuterium labeled L-5-Hydroxytryptophan (HY-B1716). L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia ^[5] .

HY-17413S

Zidovudine-d3
Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.

HY-17413S2

Zidovudine-d4
Zidovudine-d₄ is deuterated labeled Zidovudine (HY-17413). Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.

HY-17413S1

Zidovudine-13C,d3
Zidovudine- ¹³C,d₃ is the ¹³C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.

HY-B0158S1

Cytidine-13C
Cytidine- ¹³C is the ¹³C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine

HY-112582S

N1-Methylpseudouridine-d3
N1-Methylpseudouridine-d3 is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-Y1373S1

Cyclohexanecarboxylic acid-d11 1 Publications Verification
Cyclohexanecarboxylic acid-d₁₁ is the deuterium labeled Cyclohexanecarboxylic acid . Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action .

HY-90005S

Etravirine D4
Etravirine-d₄ is the deuterium labeled Etravirine. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

HY-14781S2

Levomefolic acid-13C5
Levomefolic acid- ¹³C₅ is the ¹³C labeled Levomefolic acid . Levomefolic acid (L-5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements .

HY-13677S

6-Mercaptopurine-d2
6-Mercaptopurine-d₂ is the deuterium labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent .

HY-W768839

5-(Hydroxymethyl)cytidine-13C,d2
5-(Hydroxymethyl)cytidine- ¹³C,d₂ is the deuterium labeled and ¹³C-labeled 5-(Hydroxymethyl)cytidine (HY-152854). 5-(Hydroxymethyl)cytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-B0656S

Rabeprazole-d4
Rabeprazole-d₄ is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux .

HY-W653970

5-Azacytidine-15N4
5-Azacytidine- ¹⁵N₄ is ¹³C and ¹⁵N labeled 5-Azacytidine. 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy .

HY-B1449S12

Uridine-d12
Uridine-d12 (β-Uridine-d12) is the deuterium labeled Uridine (HY-B1449). Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond .

HY-14781S3

Levomefolic acid-d3
Levomefolic acid-d₃ (L-5-MTHF-d₃) is deuterium labeled Levomefolic acid. Levomefolic acid (L-5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements .

HY-17423S

Abacavir-d4
Abacavir-d₄ is the deuterium labeled Abacavir. Abacavir is a potent nucleoside analog reverse-transcriptase inhibitor (NRTI)[1][2].

HY-A0096S

Iloprost-d4
Iloprost-d₄ (Ciloprost-d₄) is the deuterium labeled Iloprost. Iloprost (ZK 36374) is a synthetic analogue of prostacyclin PGI2 .

HY-W702852

*4-(Bromomethyl)-2,2-dimethyl-1,3-dioxolane-d5*
4-(Bromomethyl)-2,2-dimethyl-1,3-dioxolane-d₅ (5-bromomethyl-2,2-dimethyl-1,3-dioxolane-d₅) is the deuterium labeled 4-(Bromomethyl)-2,2-dimethyl-1,3-dioxolane (HY-W018073).

HY-W744788

Amitriptylinoxide-d6
Amitriptylinoxide-d₆ (Equilibrin-d₆) is the deuterium labeled Amitriptylinoxide (HY-107032). Amitriptylinoxide (Equilibrin) is an analogue and metabolite of amitriptyline with similar antidepressant efficacy .

HY-W009444S1

5-Methyluridine-1′-13C
5-Methyluridine-1′- ¹³C is the ¹³C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu .

HY-W009444S2

5-Methyluridine-2′-13C
5-Methyluridine-2′- ¹³C is the ¹³C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu .

HY-B0158S2

Cytidine-13C-1
Cytidine- ¹³C-1 is the ¹³C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholami

HY-17427S

Emtricitabine-15N,d2
Emtricitabine- ¹⁵N,d₂ is a ¹⁵N-labeled and deuterium labeled Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

HY-Y1372S

*2,2-Dimethyl-1,3-dioxolane-4-methanol-d5*
2,2-Dimethyl-1,3-dioxolane-4-methanol-d₅ is the deuterium labeled 2,2-Dimethyl-1,3-dioxolane-4-methanol .

HY-44745S

*4-Ethyl-1,4,7,8-tetrahydro-3H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolane]-3,10-dione-d5*
4-Ethyl-1,4,7,8-tetrahydro-3H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolane]-3,10-dione-d5 is the deuterium labeled 4-Ethyl-1,4,7,8-tetrahydro-3H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolane]-3,10-dione .

HY-W770206

IDO-IN-7-d10
IDO-IN-7-d₁₀ (NLG-919 analogue-d₁₀; GDC-0919 analogue-d₁₀) is the deuterium labeled IDO-IN-7 (HY-13983). IDO-IN-7 (NLG-919 analogue) is a a potent IDO1 inhibitor with an IC₅₀ of 38 nM.

HY-113061S

Pseudouridine-O18
Pseudouridine- ¹⁸O is the ¹⁸O labeled Pseudouridine (HY-113061). Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation.

HY-138615S1

Deoxythymidine-5'-triphosphate-15N2 dilithium
Deoxythymidine-5'-triphosphate- ¹⁵N₂ (dTTP- ¹⁵N₂) dilithium is ¹⁵N labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.

HY-B0158S8

Cytidine-d13
Cytidine-d₁₃ (Cytosine β-D-riboside-d₁₃) is deuterium labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-147338S1

5-Methylcytidine 5′-triphosphate-15N2,13C trisodium
5-Methylcytidine 5′-triphosphate- ¹⁵N₂, ¹³C (5-Methyl-CTP- ¹⁵N₂, ¹³C) trisodium is the ¹⁵N and ¹³C labled 5-Methylcytidine 5′-triphosphate (HY-147338). 5-Methylcytidine 5′-triphosphate is a modified nucleoside triphosphate .

HY-138615S4

Deoxythymidine-5'-triphosphate-13C10,15N2 dilithium
Deoxythymidine-5'-triphosphate- ¹³C₁₀, ¹⁵N₂ (dTTP- ¹³C₁₀, ¹⁵N₂) dilithium is ¹³C and ¹⁵N-labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.

HY-138615S3

Deoxythymidine-5'-triphosphate-15N2,d15 dilithium
Deoxythymidine-5'-triphosphate- ¹⁵N₂,d₁₅ (dTTP- ¹⁵N₂,d₁₅) dilithium is deuterium and ¹⁵N labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.

HY-135330

Lamivudine-13C,15N2
Lamivudine- ¹³C, ¹⁵N₂ is a labelled impurity of Lamivudine (BCH-189). Lamivudine is a nucleoside reverse transcriptase inhibitors (NRTIs), and can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus .

HY-101400S

Deoxycytidine triphosphate-d14 dilithium
Deoxycytidine triphosphate-d₁₄ (dCTP-d₁₄ dilithium; 2′-Deoxycytidine-5′-triphosphate-d₁₄) dilithium is deuterium labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.

HY-101400S3

Deoxycytidine triphosphate-15N3 dilithium
Deoxycytidine triphosphate- ¹⁵N₃ (dCTP- ¹⁵N₃ dilithium; 2′-Deoxycytidine-5′-triphosphate- ¹⁵N₃) dilithium is ¹⁵N labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.

HY-101400S4

Deoxycytidine triphosphate-13C9 dilithium
Deoxycytidine triphosphate- ¹³C₉ (dCTP- ¹³C₉ dilithium; 2′-Deoxycytidine-5′-triphosphate- ¹³C₉) dilithium is ¹³C-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.

Targets Recommended: Nucleoside Transporters Nucleoside Antimetabolite/Analog NTPDase

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-101445G

Trolox	Reactive Oxygen Species (ROS) Ferroptosis Apoptosis	Cancer
Trolox (GMP) is Trolox (HY-101445) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage .

HY-13642G

RG108	DNA Methyltransferase	Cancer
RG108 (GMP) is RG108 (HY-13642) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RG108 (N-Phthalyl-L-tryptophan) is a non-nucleoside DNA methyltransferases (DNMTs) inhibitor (IC₅₀=115 nM) that blocks the DNMTs active site. RG108 (N-Phthalyl-L-tryptophan) causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences .

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