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Ganciclovir

(Synonyms: BW 759; 2'-Nor-2'-deoxyguanosine)
28 Cited Publications
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Based on 28 publication(s) in Google Scholar

Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain.

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  • Reinheit: 99.89%
  • CAS. Nr.: 82410-32-0
  • Formel: C9H13N5O4
  • Molecular Weight:255.23
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Ganciclovir Chemical Structure
    Ganciclovir Chemical Structure
  • Experimental Validation Results for Ganciclovir
  • Experimental Validation Results for Ganciclovir
  • Experimental Validation Results for Ganciclovir
  • Experimental Validation Results for Ganciclovir
  • Experimental Validation Results for Ganciclovir
  • Experimental Validation Results for Ganciclovir
  • Experimental Validation Results for Ganciclovir
  • Experimental Validation Results for Ganciclovir
  • Experimental Validation Results for Ganciclovir
  • Experimental Validation Results for Ganciclovir
  • Experimental Validation Results for Ganciclovir
CAS. Nr.: 82410-32-0
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Bio/Physico-chemical AssayOthersMicrobiological AssayCell Proliferation/Viability AssayIn Vivo Efficacy StudyHistological Imaging/StainingIF
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  • Ganciclovir Chemical Structure
    Ganciclovir Chemical Structure
    1/16
  • 1/16

    Ganciclovir purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 17;15(1):3311. [Abstract]

    Customer Validation
     Viability of HEK293T cells transfected with the indicated constructs and grown in the presence of Ganciclovir (Ganciclovir sodium, 100 µg/mL). Mock transfected cells represent the negative control. Cell viability is reported as a percentage of the viability of mock transfected cells in the absence of doxycycline.

  • 1/16

    Ganciclovir purchased from MedChemExpress. Usage Cited in: Pharmaceutics. 2023 Nov 27;15(12):2680. [Abstract]

    Customer Validation
     GCV (1-30 μM) exhibited a dose-dependent decrease in newly synthesized DNA due to its inhibitory impact on the viral polymerase processing activity.

  • 1/16

    Ganciclovir purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2022 Jul 20;20(1):340. [Abstract]

    Customer Validation
     Long-term GCV (50 mg/kg, ip)-trigged nanoparticle-based therapy in ovarian cancer model.

  • 1/16

    Ganciclovir purchased from MedChemExpress. Usage Cited in: Sci Data. 2022 Oct 8;9(1):610. [Abstract]

    Customer Validation
     Exemplary overviews of one screening plate for each virus screen. Individual images of each well were stitched yielding the overviews. First two columns of each plate contained DMSO control solvent, the following 20 columns PCL compounds, and the last two columns the positive controls (BafA1 for RV and IAV, and GCV (25 μM) for HSV-1). Scale bar represents 10 mm.

  • 1/16

    Ganciclovir purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Mar:197:114917. [Abstract]

    Customer Validation
     The scotopic ERG responses showed that GCV (Ganciclovir sodium, 50-100 mg/kg, ip) treatment evidently improved the impaired a- and b-wave amplitudes in the EAU model.

  • 1/16

    Ganciclovir purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Mar:197:114917. [Abstract]

    Customer Validation
     Consistent with SD-OCT observation, retinal leukocyte adhesion analysis also demonstrated that a large number of inflammatory cells were stuck in the EAU retinal vessels, but only a few adherent leukocytes were observed in the GCV (Ganciclovir sodium-treated) EAU retinal vessels.

  • 1/16

    Ganciclovir purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Mar:197:114917. [Abstract]

    Customer Validation
     The immunofluorescence of Iba1 and GFAP were observed in all layers of the PBS-treated EAU retinas, but GCV (Ganciclovir sodium-treated) treatment dampened their immunoactivities.

  • 1/16

    Ganciclovir purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Mar:197:114917. [Abstract]

    Customer Validation
     In line with the decreased number of Th17 and inflammatory cells, GCV (Ganciclovir sodium-treated) treatment could evidently decrease transcription of Th17-related genes in the EAU retinas, such as IL-17a and STAT3.

  • 1/16

    Ganciclovir purchased from MedChemExpress. Usage Cited in: Cell. 2020 Nov 25;183(5):1402-1419.e18. [Abstract]

    Customer Validation
     In vivo studies of miR-124-HSV-tk-GFP teratomas in the presence of GCV administration (80mg/kg/d, 10 weeks) using both intratumoral (IT) and intratumoral and intraperitoneal injection methods. A heatmap showing cell type fraction log fold-change for each teratoma replicate compared to a control miR-124-HSV-tk-GFP teratoma in the absence of GCV. Z-scores for each cell type fraction change are plotted as well, with standard deviations calculated using a pooled variance.

  • 1/16

    Ganciclovir purchased from MedChemExpress. Usage Cited in: Cells. 2019 Dec 20;9(1):31. [Abstract]

    Customer Validation
     Antiviral effects of eltrombopag in combination with Ganciclovir (0.61-10000 nM). Effects of equimolar drug concentrations on HCMV LA expression in HCMV Hi91 (MOI 0.02) HFFs 120 h post infection. * p < 0.05 compared to either single treatment.

  • 1/16

    Ganciclovir purchased from MedChemExpress. Usage Cited in: Eur J Pharm Sci. 2019 Jan 15:127:29-37. [Abstract]

    Customer Validation
     Viral reporter GFP expression after inoculation and compound treatment. Infected cells treated with DMSO control, BIO, Ganciclovir (GCV) or Letermovir (LTR)

  • Ganciclovir