Cat. No.: HY-N0152

Myricitrin

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Myricitrin, a naturally occurring flavonoid, is an orally active nitric oxide (NO) and PKC inhibitor. Myricitrin has central nervous system activity, including anxiolytic-like action. Myricitrin possesses antioxidant, anti-inflammatory, antifibrotic and anti-malarial effects.

For research use only. We do not sell to patients.

Purity: 99.76%
CAS No.: 17912-87-7
Formula: C₂₁H₂₀O₁₂
Molecular Weight:464.38

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Myricitrin Chemical Structure

CAS No.: 17912-87-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All PKC Isoforms :

All NO Synthase Isoforms :

All TNF Receptor Isoforms :

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	>100 μM Compound: 4	Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction	[PMID: 27623545]
KB	ED₅₀	8.3 μg/mL Compound: NSC-19803	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 469554]

In Vitro

Myricitrin has strong antioxidant activity as radical scavenger and metal-ion chelator. Myricitrin has been reported to inhibit the aldose reductase activity and the oxidation of low-density lipoprotein, and has anti-malarial effect^[1].
Myricitrin exhibits a strong scavenging activity against DPPH and NO radicals, as well as H₂O₂ (IC₅₀ = 1.31 μg/mL, 21.54 μg/mL and 28.46 μg/mL, respectively)^[2].
Raw264.7 cells are pre-treated with Myricitrin (0.2-1 mM) for 2 h and stimulates with LPS (HY-D1056) at a concentration of 100 ng/mL for 4 h. Myricitrin inhibits TNFα production and enhances RANTES (regulated on activation normal T-cell expressed and secreted) production in LPS-stimulated Raw264.7 cells. It should be noted that the inhibitory effect of Myricitrin is not observed when Myricitrin was added either simultaneously or after LPS stimulation^[3].
Myricitrin shows proliferation inhibition of Plasmodium falciparum, with IC₅₀ value of 5.4 µg/mL^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Myricitrin (10-100 mg/kg; oral gavage; once daily; for two consecutive days) exhibits antioxidant, anti-inflammatory and antifibrotic activity in Carbon tetrachloride (CCl4) (HY-Y0298)-intoxicated mice^[2].
Myricitrin (5-30 mg/kg; i.p.; once) dose-dependently blocks the stereotypy and climbing induced by Apomorphine (HY-12723) at doses that does not induce catalepsy^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/cN mice (10-12 weeks old, 23-27 g) following CCl4-intoxication^[2]
Dosage:

10, 30 and 100 mg/kg (0.5% Methylcellulose (HY-125861))
Administration:

Oral gavage; once daily; for two consecutive days
Result:

Significantly ameliorated CCl4-induced increase in serum aspartate transaminase (AST) and alanine transaminase (ALT) levels and histopathological changes in the liver.
Hepatic oxidative stress was reduced, as evidenced by the decrease in lipid peroxidation, with concomitant increase in GSH level and CYP2E1 expression.
COX-2 and TNF-α overexpression in the liver was reduced.
The expression of TGF-β1 and α-SMA was markedly ameliorated.
Increased proliferating cell nuclear antigen (PCNA) expression.

Animal Model:

Male adult Swiss albino mice (30-40 g)^[5]
Dosage:

5 mg/kg, 10 mg/kg, and 30 mg/kg (Tween 80/saline)
Administration:

i.p.; once
Result:

Dose-dependently blocked the stereotypy and climbing induced by Apomorphine (HY-12723) at doses.

Chemical Information

CAS No. 17912-87-7
Appearance Solid
Molecular Weight 464.38
Formula C₂₁H₂₀O₁₂
Color White to yellow
SMILES

O=C1C(O[C@H]2[C@@H]([C@@H]([C@H]([C@H](C)O2)O)O)O)=C(C3=CC(O)=C(O)C(O)=C3)OC4=CC(O)=CC(O)=C14
Structure Classification
- Flavonoids
- Flavonols
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (3)

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Journal Impact Factor

Food Chem

Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]

2025 Dec 30:497:146992. PMID: 41285060
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 Oct 15:489:144992. PMID: 40466530
Ind Crops Prod

2025 Dec 11;239:122458.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (215.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1534 mL

10.7670 mL

21.5341 mL

5 mM

0.4307 mL

2.1534 mL

4.3068 mL

10 mM

0.2153 mL

1.0767 mL

2.1534 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.38 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hwang IW, et al. Isolation and Identification of Myricitrin, an Antioxidant Flavonoid, from Daebong PersimmonPeel. Prev Nutr Food Sci. 2018 Dec;23(4):341-346. [Content Brief]

[2]. Domitrović R, et al. Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice. Chem Biol Interact. 2015 Mar 25;230:21-9. [Content Brief]

[3]. Shimosaki S, et al. Anti-allergic effect of the flavonoid myricitrin from Myrica rubra leaf extracts in vitro and in vivo. Nat Prod Res. 2011 Feb;25(4):374-80. [Content Brief]

[4]. Y. Liu,N. et al. Antimalarial Flavonol Glycosides from Euphorbia hirta. Pharmaceutical Biology, Volume 45, 2007-Issue 4.

[5]. Pereira M, et al. Myricitrin, a nitric oxide and protein kinase C inhibitor, exerts antipsychotic-like effects in animal models. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1636-44. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1534 mL	10.7670 mL	21.5341 mL	53.8352 mL
	5 mM	0.4307 mL	2.1534 mL	4.3068 mL	10.7670 mL
	10 mM	0.2153 mL	1.0767 mL	2.1534 mL	5.3835 mL
	15 mM	0.1436 mL	0.7178 mL	1.4356 mL	3.5890 mL
	20 mM	0.1077 mL	0.5384 mL	1.0767 mL	2.6918 mL
	25 mM	0.0861 mL	0.4307 mL	0.8614 mL	2.1534 mL
	30 mM	0.0718 mL	0.3589 mL	0.7178 mL	1.7945 mL
	40 mM	0.0538 mL	0.2692 mL	0.5384 mL	1.3459 mL
	50 mM	0.0431 mL	0.2153 mL	0.4307 mL	1.0767 mL
	60 mM	0.0359 mL	0.1795 mL	0.3589 mL	0.8973 mL
	80 mM	0.0269 mL	0.1346 mL	0.2692 mL	0.6729 mL
	100 mM	0.0215 mL	0.1077 mL	0.2153 mL	0.5384 mL

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Myricitrin

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Publications Citing Use of MedChemExpress (MCE) Myricitrin

All PKC Isoforms

All NO Synthase Isoforms

All TNF Receptor Isoforms

All Parasite Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table