RPS6-IN-1
RPS6-IN-1 (Compound 22o) inhibits cell metastasis, induces cell apoptosis (increases the expression of Bax, p53, cleaved-caspase 3, and cleaved-PARP). RPS6-IN-1 decreases mitochondrial membrane potential. RPS6-IN-1 activates autophagy through the PI3K-Akt-mTOR signaling pathway, damages intracellular mitochondria and lysosomes, and cause ER stress. RPS6-IN-1 inhibits RPS6 phosphorylation. RPS6-IN-1 is an anticancer agent with low systemic toxicity.
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- Formule: C16H18Cl2N4O4S
- Masse moléculaire:433.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
RPS6-IN-1 inhibits cancer cell growth, with IC50s of 3.82 μM (HCT-116), 2.80 μM (HeLa), 5.54 μM (MCF-7), 45.96 (A549), 32.71 μM (HepG2), 13.02 μM (PANC-1) respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- RNA extraction experimental
- Western Blot
- Mitochondrial membrane-potential fluorescent assay
- Annexin V plus membrane-impermeant dye apoptosis staining
- Acute Systemic Toxicity Study
- Kinase activity and phosphorylation assays
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Fluorescent plasma-membrane potential dye assay
- Mitochondrial membrane-potential and mitochondrial mass staining
- Autophagy
- Subchronic/Chronic Toxicity Study
- Apoptosis Solutions
- Lysosome and acidic-vesicle live-cell staining
- Protocol for Kinase activity and phosphorylation assays
- Macroautophagy Solutions
- Orthotopic Cell-Line Xenograft
Chemical Information
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Masse moléculaire 433.31
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Formule C16H18Cl2N4O4S
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SMILES
ClC1=NC(Cl)=NC2=C1N=CN2C3(C(OCC)=O)CSC[C@H]3CC(OCC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RPS6-IN-1 Related Classifications
HY-161874 Related Classifications
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