Apoptosis inducer 44
Apoptosis inducer 44 is an apoptosis inducer. Apoptosis inducer 44 triggers apoptosis in MDA-MB-231 cells by increasing the levels of Bax and Cyt C, reducing Bcl-2, and initiating caspase-3 cleavage. Apoptosis inducer 44 suppresses the invasion and migration of MDA-MB-231 cells by down-regulating MMP-2 and MMP-9 expression and up-regulating E-cadherin protein levels. Apoptosis inducer 44 can be used for the study of breast cancer.
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- Formule: C30H36F3NO
- Masse moléculaire:483.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Caspase 3 |
Bax |
Bcl-2 |
MMP-2 |
MMP-9 |
Apoptosis inducer 44 (Compound 19) (72 h) shows cytotoxic activity against MDA-MB-231 cells, MCF-7 cells, 4T1 cells and Aml-12 cells, with IC50 values of 4.13, 8.60, 39.95 and 31.60 μM[1].
Apoptosis inducer 44 (10‑40 μM) induces MDA-MB-231 cells apoptosis via the mitochondrial pathway[1].
Apoptosis inducer 44 (5-40 μM) suppresses the invasion and migration of MDA-MB-231 cells by down-regulating MMP-2/MMP-9 expression and up-regulating E-cadherin protein levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 483.61
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Formule C30H36F3NO
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SMILES
OC1=CC=C(/C=C/C(C=C)(C)CC/C=C(C)\C)C=C1C(N2CCCCC2)C3=CC(F)=C(F)C(F)=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 44 Related Classifications
HY-175815 Related Classifications
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