Cyp1a1 - cytochrome P450, family 1, subfamily a, polypeptide 1 Gene

Also Known as AHH; AHRR; CP11; CYPIA1; P450-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13076

Summary

Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including hydrogen peroxide biosynthetic process; response to toxic substance; and toxin metabolic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including genitourinary system; liver; maxillary process; spleen; and upper jaw. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); and lung disease (multiple). Orthologous to human CYP1A1 (Cytochrome P450 family 1 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp1a1 Products (2)

mRNA Protein Name
NM_001136059.2 NP_001129531.1 cytochrome P450 1A1
NM_009992.4 NP_034122.1 cytochrome P450 1A1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables monooxygenase activity IDA
IDA: Inferred from direct assay
14642533 MGI
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
IDA: Inferred from direct assay
8274012 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within amine metabolic process IMP
IMP: Inferred from mutant phenotype
17052995 MGI
NOT acts upstream of or within dibenzo-p-dioxin metabolic process IMP
IMP: Inferred from mutant phenotype
16636061 MGI
acts upstream of or within hydrogen peroxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
14980704 MGI
acts upstream of or within phenol-containing compound metabolic process IMP
IMP: Inferred from mutant phenotype
17052995 MGI
acts upstream of or within response to toxic substance IMP
IMP: Inferred from mutant phenotype
16377763 MGI
acts upstream of or within toxin metabolic process IMP
IMP: Inferred from mutant phenotype
17166882 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450 1A1

  • cytochrome P450 form 6

  • cytochrome P450 subfamily I, polypeptide 1

  • cytochrome P450, 1a1, aromatic compound inducible

  • cytochrome P450-C

  • cytochrome P450-P1

  • hydroperoxy icosatetraenoate dehydratase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0822 Fipronil 99.49% Unkown
HY-B1234 Octinoxate 99.84% Unkown
HY-W017113 2-Mercaptobenzothiazole 99.85% Yes
HY-B0822R Fipronil (Standard) 99.49% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-109173 Filapixant 99.10% Phase 2
HY-16031A AFP464 / Phase 2
HY-135829 BAY 2416964 Antagonist 99.59% Phase 1

Pre-clinical Phase

Bioactive Molecules (96)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0382 Galangin 99.99% Unkown
HY-19340 TMS Inhibitor 99.40% Unkown
HY-N2194 Bergamottin Inhibitor 99.94% Unkown
HY-N0563 Alizarin 99.48% Unkown
HY-D0145 7-Ethoxyresorufin Inhibitor 99.61% Unkown
HY-133677 Mono(2-ethyl-5-hydroxyhexyl) phthalate 99.03% Unkown
HY-134217 KYN-101 Inhibitor 98.03% Unkown
HY-Y0110 2-Naphthol 99.91% Unkown
HY-112628 CAY10464 Antagonist 99.77% Unkown
HY-W007700 8-Bromooctanoic acid 99.89% Unkown
HY-16265 JI-101 Inhibitor 98.99% Unkown
HY-N2374 Eupatorin Inhibitor 99.53% Unkown
HY-N4205 Tetrahydropiperine Inhibitor 99.41% Unkown
HY-D0932 Sudan IV 98.0% Unkown
HY-G0006 Omeprazole sulfide 99.88% Unkown
HY-N2625A Harmalol hydrochloride 99.91% Unkown
HY-117102 ANI-7 Activator 99.01% Unkown
HY-G0007 Omeprazole sulfone Control 99.23% Unkown
HY-101285 DMU2139 Inhibitor 98.0% Unkown
HY-17663 KMR-206 98.86% Unkown
HY-22024 5-Hydroxyflavone Substrate 99.83% Unkown
HY-N1082 Visnagin 99.34% Unkown
HY-124421 5F-203 Inducer 98.04% Unkown
HY-152118 CYP1B1-IN-4 Inhibitor 99.09% Unkown
HY-B0973 Dibenzothiophene Inhibitor 99.92% Unkown
HY-147128 PY109 Agonist 99.15% Unkown
HY-120377 CYP1A1 inhibitor 8a Inhibitor 98.00% Unkown
HY-124404 12(R)-HETE 99.90% Unkown
HY-N5132 (-)-Fenchone 98.0% Unkown
HY-159006 CYP1B1 ligand 3 Inhibitor 99.83% Unkown
HY-101284 DMU2105 Inhibitor 99.31% Unkown
HY-103223 Phortress Inducer 98.19% Unkown
HY-146393 PROTAC CYP1B1 degrader-1 Inhibitor 98.09% Unkown
HY-157942 CYP1B1-IN-7 Inhibitor 99.88% Unkown
HY-N8382 Chalepensin Inhibitor 98.98% Unkown
HY-RS03443 CYP1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W008003 2-Hydroxybenzimidazole Control 99.98% Unkown
HY-W713284 2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate 99.87% Unkown
HY-D0145S 7-Ethoxyresorufin-d5 Inhibitor 98.89% Unkown
HY-Y0110S1 2-Naphthol-d7 99.37% Unkown
HY-B0822S1 Fipronil-13C6 98% Unkown
HY-113040A (17R,18S)-Epoxyeicosatetraenoic acid Inhibitor 93.0% Unkown
HY-118474 GW 610 Activator 99.78% Unkown
HY-N6264 26-Deoxyactein Inhibitor 99.76% Unkown
HY-W067374 Aripiprazole impurity 38 97.79% Unkown
HY-118216 Bitertanol 98.70% Unkown
HY-128920 Phortress free base Inhibitor / Unkown
HY-14225 BMS-764459 / Unkown
HY-148592 Antitumor agent-87 Inhibitor / Unkown
HY-148595 CYP1A1-IN-2 Inhibitor / Unkown
HY-150557 CYP1B1-IN-1 Inhibitor / Unkown
HY-150558 CYP1B1-IN-2 Inhibitor / Unkown
HY-152079 CYP1B1-IN-3 Inhibitor / Unkown
HY-152196 CYP1B1-IN-5 Inhibitor 98.03% Unkown
HY-158429 PROTAC CYP1B1 degrader-2 / Unkown
HY-158430 CYP1B1 ligand 2 / Unkown
HY-161403 CYP1B1-IN-8 Inhibitor / Unkown
HY-162051 CYP1B1-IN-6 Inhibitor / Unkown
HY-16265A JI-101 hydrochloride Inhibitor / Unkown
HY-174425 CYP1B1-IN-9 Inhibitor / Unkown
HY-175554 CYP1B1-IN-10 Inhibitor / Unkown
HY-175760 CYP1B1-IN-11 Inhibitor / Unkown
HY-175836 CYP1B1-IN-12 / Unkown
HY-178053 AHR agonist 10 / Unkown
HY-181472 10(11)-Cl-BBQ / Unkown
HY-181550A CYP1B1-IN-14 TFA Inhibitor / Unkown
HY-181629 ZSTK3744 / Unkown
HY-181629A ZSTK3744 hydrochloride / Unkown
HY-183304 Anticancer agent 318 Substrate / Unkown
HY-B0973S Dibenzothiophene-d8 Inhibitor / Unkown
HY-G0007S Omeprazole sulfone-d3 Control / Unkown
HY-G0007S1 Omeprazole sulfone-13C,d3 Control / Unkown
HY-N0382R Galangin (Standard) / Unkown
HY-N0382S Galangin-13C3 / Unkown
HY-N10344 Glucoarabin Activator / Unkown
HY-N2689 (R)-6',7'-Dihydroxybergamottin Inhibitor / Unkown
HY-RS03441 CYP1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W762015 1,2,3,6,7,8-Hexachlorodibenzofuran Inducer / Unkown
HY-Y0110S 2-Naphthol-d8 / Unkown
HY-101284A (E/Z)-DMU2105 Inhibitor / Unkown
HY-119416 Sequoiaflavone Inhibitor / Unkown
HY-126308 (E/Z)-DMU2139 Inhibitor / Unkown
HY-129247 Versicolorin A / Unkown
HY-158431 (S,R,S)-AHPC-Me-8-bromooctanoic acid / Unkown
HY-167632 meso-Zeaxanthin 93.09% Unkown
HY-174333 CYP1A1-IN-1 Inhibitor / Unkown
HY-B1234S Octinoxate-13C,d3 / Unkown
HY-D0932S Sudan IV-d6 / Unkown
HY-N0922 Methysticin Activator / Unkown
HY-RS16737 Cyp1a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16945 Cyp1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23174 Cyp1a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23388 Cyp1b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W472509 11-HETE Activator / Unkown
HY-W517092 1,2,3,4,7,8,9-Heptachlorodibenzofuran / Unkown
HY-W775354 1,2,3,4,7,8-Hexachlorodibenzofuran / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp1a1 NCBI NCBI:1543