GSPT1 - G1 to S phase transition 1 Gene

Also Known as GST1; ETF3A; eRF3a; 551G9.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2935

About GSPT1

Cytogenetic location: 16p13.13 Genomic coordinates (GRCh38): 16:11,868,128-11,916,654 (from NCBI)

This gene has 10 transcripts (splice variants), 283 orthologues and 18 paralogues. Ubiquitous expression in thyroid (RPKM 16.3), colon (RPKM 15.7) and 25 other tissues.

Summary

Enables translation release factor activity. Involved in regulation of translational termination. Acts upstream of or within protein methylation. Predicted to be located in cytosol. Predicted to be part of translation release factor complex. [provided by Alliance of Genome Resources, Apr 2022]

GSPT1 Products (3)

mRNA Protein Name
NM_001130006.2 NP_001123478.2 eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 2
NM_001130007.2 NP_001123479.1 eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 3
NM_002094.4 NP_002085.3 eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activity IDA
IDA: Inferred from direct assay
15987998 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9620853 GOA
enables translation release factor activity IDA
IDA: Inferred from direct assay
15987998 GOA
enables translation release factor activity IMP
IMP: Inferred from mutant phenotype
15326224 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within protein methylation IDA
IDA: Inferred from direct assay
18539146 GOA
involved in regulation of translational termination IMP
IMP: Inferred from mutant phenotype
30682371 GOA
involved in translational termination IDA
IDA: Inferred from direct assay
15987998 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytosolic ribosome IDA
IDA: Inferred from direct assay
15987998 GOA
part of translation release factor complex IDA
IDA: Inferred from direct assay
27863242 GOA
part of translation release factor complex IPI
IPI: Inferred from physical interaction
19417105 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSPT1 Protein Structure

GTP_EFTU

GTP_EFTU: Elongation factor Tu GTP binding domain (72 - 271)

GTP_EFTU_D2

GTP_EFTU_D2: Elongation factor Tu domain 2 (314 - 381)

GTP_EFTU_D3

GTP_EFTU_D3: Elongation factor Tu C-terminal domain (391 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 499 a.a.
Protein Preferred Names Protein Names

eukaryotic peptide chain release factor GTP-binding subunit ERF3A

  • G1 to S phase transition protein 1 homolog

GSPT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GSPT1 P15170 UPF1 Homo sapiens Q92900
Anti Tag CoIP
35271311
Intra
GSPT1 P15170 ETF1 Homo sapiens P62495
Anti Tag CoIP
35271311
Intra
GSPT1 P15170 ETF1 Homo sapiens P62495
Anti Tag CoIP
18256688
Intra
GSPT1 P15170 PABPC1 Homo sapiens P11940
Anti Tag CoIP
35271311
Intra
GSPT1 P15170 PABPC1 Homo sapiens P11940
Anti Tag CoIP
18256688
Cross: Cross-species interaction Intra: Intraspecies interaction

GSPT1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83766 eRF3a Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Duane-Radial Ray Syndrome

  • Okihiro Syndrome

  • DRRS

  • Dr Syndrome

  • Duane Anomaly With Radial Ray Abnormalities And Deafness

  • Acrorenoocular Syndrome

  • Acrorenocular Syndrome

  • Duane Anomaly With Radial Abnormalities And Deafness

  • Acro-Renal-Ocular Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-130800 Eragidomide 99.93% Phase 2
HY-153356 MRT-2359 Inducer 99.98% Phase 2
HY-164202 ORM-5029 96.53% Phase 1

Pre-clinical Phase

Bioactive Molecules (73)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101488 CC-885 99.26% Unkown
HY-132199 SJ6986 Degrader 98.35% Unkown
HY-145448 MC-VC-PABC-amide-PEG1-CH2-CC-885 99.93% Unkown
HY-W1135319 SB-405483 99.33% Unkown
HY-148837 GT19630 98.85% Unkown
HY-151902 SJ988497 Degrader 99.03% Unkown
HY-176444 CDK2 degrader 6 Degrader 99.81% Unkown
HY-150259 MDEG-541 Degrader 98.68% Unkown
HY-153803 GBD-9 Degrader 99.91% Unkown
HY-147158 ZXH-1-161 98.43% Unkown
HY-130122 MG-277 Inducer 98.68% Unkown
HY-170952 LYG-409 Degrader 98.11% Unkown
HY-156641 Sontigidomide Degrader 98.62% Unkown
HY-76719 (Z)-Sunitinib carboxylic acid Ligand ≥98.0% Unkown
HY-150616 SJPYT-195 Inhibitor 98.07% Unkown
HY-161101 MG degrader 1 Degrader 99.30% Unkown
HY-115728 PROTAC CDK9 degrader-4 99.65% Unkown
HY-171792 BMS-986497 Inhibitor / Unkown
HY-168936 DP-15 99.06% Unkown
HY-172770 KMG-1068 99.73% Unkown
HY-W998347 ABS-752 hydrochloride 98.81% Unkown
HY-137340 WH-10417-099 Degrader 98.14% Unkown
HY-161696 AN5777 Inducer 98.37% Unkown
HY-170820 XYD049 Inhibitor 99.46% Unkown
HY-175453 MRT-23227 99.45% Unkown
HY-177761 GSPT1 degrader-15 95.05% Unkown
HY-RS05868 GSPT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-143435 AG6033 Inducer / Unkown
HY-155552 GSPT1 degrader-1 / Unkown
HY-156747 GSPT1 degrader-2 / Unkown
HY-159609 GSPT1 degrader-9 / Unkown
HY-159610 GSPT1 degrader-10 / Unkown
HY-159619 Boc-azetidine-2C-oxotetrahydropyrimidin-bromophenyl / Unkown
HY-159620 Thalidomide 5-azetidine-2C-oxotetrahydropyrimidin-bromophenyl / Unkown
HY-159622 Boc-Pip-C-oxotetrahydropyrimidin-bromophenyl / Unkown
HY-159623 Thalidomide 5-Pip-C-oxotetrahydropyrimidin-bromophenyl / Unkown
HY-162533 GSPT1 degrader-4 Degrader / Unkown
HY-162534 GSPT1 degrader-5 Degrader / Unkown
HY-162535 GSPT1 degrader-6 Inhibitor / Unkown
HY-163938A PROTAC erf3a Degrader-2 / Unkown
HY-164340 Boc-NH-PAB(triacetyl-β-D-glucopyranuronate)-PNP / Unkown
HY-170405 YB-3–17 Inhibitor / Unkown
HY-173386 HDAC6 ligand-4 Inhibitor / Unkown
HY-174238 GSPT1 degrader-7 / Unkown
HY-174266 WB156 Degrader / Unkown
HY-174428 PROTAC JAK2 degrader-1 / Unkown
HY-175040 PROTAC FLT-3 degrader 5 Degrader / Unkown
HY-175283 ABT-002 Degrader / Unkown
HY-175334 DHC-286 98.00% Unkown
HY-175810 GSPT1 degrader-8 Degrader / Unkown
HY-176128 BWA-6047 / Unkown
HY-177724 GSPT1 degrader-11 Degrader / Unkown
HY-177744 GSPT2 degrader-1 / Unkown
HY-177750 TD-522 Inducer / Unkown
HY-177751 GSPT1 degrader-12 / Unkown
HY-177752 GSPT1 degrader-13 / Unkown
HY-177753 GSPT1 degrader-14 / Unkown
HY-177758 PROTAC HDAC6 degrader 8 Degrader / Unkown
HY-177765 GSPT1 degrader-16 / Unkown
HY-177766 GSPT1 degrader-17 Inducer / Unkown
HY-179499 PROTAC EZH2 Degrader-9 / Unkown
HY-180836 DIX-01 / Unkown
HY-181084 PROTAC BCL6/GSPT1 Degrader-1 / Unkown
HY-181620 CDK2 degrader 9 Degrader / Unkown
HY-182623 WB214 Degrader / Unkown
HY-182807 CRBN ligand-899 / Unkown
HY-182813 MC-amide-C2-amide-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 / Unkown
HY-184248 FM-74-103 Inhibitor / Unkown
HY-W1128213 IKZF2-degrader 2 Degrader / Unkown
HY-W599025 5-Br-4-Cl-Pyrrolo-pyroxypyridine / Unkown
HY-W599279 ABS-752 Degrader / Unkown
HY-RS16544 Gspt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22976 Gspt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P9S0124 Anti-CD33 Antibody (OR000283) / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GSPT1 MGD MGI:1316728
Canis familiaris GSPT1 VGNC VGNC:41533
Felis catus GSPT1 VGNC VGNC:67487
Rattus norvegicus GSPT1 RGD RGD:2751
Macaca mulatta GSPT1 VGNC VGNC:73300
Bos taurus GSPT1 VGNC VGNC:29681
Others GSPT1 NCBI