ci - cubitus interruptus Gene
Also Known as Ce; CG2125; Ci; CI; ci-D; Ci/Gli; Ci/GLI; ci155; Ci155; ciA; ciD; CiD; CID; ciR; ci[D]; Ci[D]; d Ci; Dmel\CG2125; Gli; l(4)102ABc; l(4)13; l(4)17; Siah
Species: Drosophila melanogaster
Summary
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding protein binding activity; and protein homodimerization activity. Involved in several processes, including animal organ development; regionalization; and regulation of transcription by RNA polymerase II. Located in cytosol; membrane; and nucleus. Part of Hedgehog signaling complex. Is expressed in several structures, including ectoderm; ectoderm anlage; embryonic epidermis; extended germ band embryo; and imaginal disc. Used to study primary Bacterial infectious disease. Human ortholog(s) of this gene implicated in several diseases, including Culler-Jones syndrome; Pallister-Hall syndrome; anodontia; holoprosencephaly 9; and synostosis (multiple). Orthologous to several human genes including GLI2 (Gli family zinc finger 2) and GLI3 (Gli family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]
ci Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001258473.1 | NP_001245402.1 | cubitus interruptus, isoform B [Drosophila melanogaster] |
| NM_001258472.2 | NP_001245401.1 | cubitus interruptus, isoform C [Drosophila melanogaster] |
| NM_079878.5 | NP_524617.3 | cubitus interruptus, isoform A [Drosophila melanogaster] |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of Hedgehog signaling complex |
IPI
IPI: Inferred from physical interaction
|
9244297 | FlyBase |
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
7577671 | FlyBase |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
7577671 | FlyBase |
| part of protein-containing complex |
IPI
IPI: Inferred from physical interaction
|
9601642 | FlyBase |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cubitus interruptus |
|
|