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  2. ci - cubitus interruptus Gene

ci - cubitus interruptus Gene

Drosophila melanogaster

Also known as Ce; CG2125; Ci; CI; ci-D; Ci/Gli; Ci/GLI; ci155; Ci155; ciA; ciD; CiD; CID; ciR; ci[D]; Ci[D]; d Ci; Dmel\CG2125; Gli; l(4)102ABc; l(4)13; l(4)17; Siah

Gene ID: 43767 | Gene type: protein coding

About ci

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding protein binding activity; and protein homodimerization activity. Involved in several processes, including animal organ development; regionalization; and regulation of transcription by RNA polymerase II. Located in cytosol; membrane; and nucleus. Part of Hedgehog signaling complex. Is expressed in several structures, including ectoderm; ectoderm anlage; embryonic epidermis; extended germ band embryo; and imaginal disc. Used to study primary Bacterial infectious disease. Human ortholog(s) of this gene implicated in several diseases, including Culler-Jones syndrome; Pallister-Hall syndrome; anodontia; holoprosencephaly 9; and synostosis (multiple). Orthologous to several human genes including GLI2 (Gli family zinc finger 2) and GLI3 (Gli family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]

ci Products(3)

mRNA Protein Name
NM_001258473.1 NP_001245402.1 cubitus interruptus, isoform B [Drosophila melanogaster]
NM_001258472.2 NP_001245401.1 cubitus interruptus, isoform C [Drosophila melanogaster]
NM_079878.5 NP_524617.3 cubitus interruptus, isoform A [Drosophila melanogaster]
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IGI
IGI: Inferred from genetic interaction
10669739 FlyBase
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
20403347 FlyBase
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8769644 FlyBase
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
25941387 FlyBase
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9122207 FlyBase
enables cAMP response element binding protein binding IPI
IPI: Inferred from physical interaction
25941387 FlyBase
enables protein binding IPI
IPI: Inferred from physical interaction
9109493 FlyBase
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
19955409 FlyBase
enables protein kinase binding IDA
IDA: Inferred from direct assay
26403189 FlyBase
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9215627 FlyBase
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
20226779 FlyBase
Biological Process GO Annotation Evidence Reference Source
involved in compound eye morphogenesis IMP
IMP: Inferred from mutant phenotype
16651542 FlyBase
involved in cuticle pattern formation IMP
IMP: Inferred from mutant phenotype
16413529 FlyBase
involved in dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
23977298 FlyBase
involved in genital disc anterior/posterior pattern formation IEP
IEP: Inferred from expression pattern
8798147 FlyBase
involved in heart formation IMP
IMP: Inferred from mutant phenotype
8660881 FlyBase
involved in labial disc development IMP
IMP: Inferred from mutant phenotype
15680366 FlyBase
involved in mucosal immune response IMP
IMP: Inferred from mutant phenotype
25639794 FlyBase
involved in negative regulation of hippo signaling IGI
IGI: Inferred from genetic interaction
26403189 FlyBase
involved in negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16386907 FlyBase
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
8769644 FlyBase
involved in positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
15809036 FlyBase
involved in positive regulation of epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
18633350 FlyBase
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9122207 FlyBase
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
10669739 FlyBase
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
8769644 FlyBase
involved in regulation of cell proliferation involved in compound eye morphogenesis IMP
IMP: Inferred from mutant phenotype
17559828 FlyBase
involved in regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
11279500 FlyBase
involved in segment polarity determination IMP
IMP: Inferred from mutant phenotype
2166702 FlyBase
involved in smoothened signaling pathway IDA
IDA: Inferred from direct assay
9215627 FlyBase
involved in smoothened signaling pathway IEP
IEP: Inferred from expression pattern
8898240 FlyBase
involved in smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
7577671 FlyBase
involved in smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
8658135 FlyBase
involved in spiracle morphogenesis, open tracheal system IMP
IMP: Inferred from mutant phenotype
15930099 FlyBase
involved in wing disc anterior/posterior pattern formation IMP
IMP: Inferred from mutant phenotype
15708556 FlyBase
Cellular Component GO Annotation Evidence Reference Source
part of Hedgehog signaling complex IPI
IPI: Inferred from physical interaction
9244297 FlyBase
located in cytosol IDA
IDA: Inferred from direct assay
7577671 FlyBase
located in nucleus IDA
IDA: Inferred from direct assay
7577671 FlyBase
part of protein-containing complex IPI
IPI: Inferred from physical interaction
9601642 FlyBase
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cubitus interruptus

CG2125-PA

CG2125-PB

CG2125-PC

cell

ci-PA

ci-PB

ci-PC

cubitis interruptus

cubitus

cubitus interuptus

cubitus-interruptus

cubitus-interruptus-Dominant

interruptus

Orthologs Information

Species Symbol Source ID
Canis familiaris ci NCBI
Macaca fascicularis ci NCBI
Canis lupus familiaris ci NCBI
Mus musculus ci NCBI
Susscrofa domestica ci NCBI
Leporidae ci NCBI
Rattus norvegicus ci NCBI
Macaca mulatta ci NCBI