ci - cubitus interruptus Gene

Also Known as Ce; CG2125; Ci; CI; ci-D; Ci/Gli; Ci/GLI; ci155; Ci155; ciA; ciD; CiD; CID; ciR; ci[D]; Ci[D]; d Ci; Dmel\CG2125; Gli; l(4)102ABc; l(4)13; l(4)17; Siah

Species: Drosophila melanogaster

Gene Type: protein coding
Gene ID: 43767

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding protein binding activity; and protein homodimerization activity. Involved in several processes, including animal organ development; regionalization; and regulation of transcription by RNA polymerase II. Located in cytosol; membrane; and nucleus. Part of Hedgehog signaling complex. Is expressed in several structures, including ectoderm; ectoderm anlage; embryonic epidermis; extended germ band embryo; and imaginal disc. Used to study primary Bacterial infectious disease. Human ortholog(s) of this gene implicated in several diseases, including Culler-Jones syndrome; Pallister-Hall syndrome; anodontia; holoprosencephaly 9; and synostosis (multiple). Orthologous to several human genes including GLI2 (Gli family zinc finger 2) and GLI3 (Gli family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]

ci Products (3)

mRNA Protein Name
NM_001258473.1 NP_001245402.1 cubitus interruptus, isoform B [Drosophila melanogaster]
NM_001258472.2 NP_001245401.1 cubitus interruptus, isoform C [Drosophila melanogaster]
NM_079878.5 NP_524617.3 cubitus interruptus, isoform A [Drosophila melanogaster]
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IGI
IGI: Inferred from genetic interaction
10669739 FlyBase
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
20403347 FlyBase
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8769644 FlyBase
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
25941387 FlyBase
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9122207 FlyBase
enables cAMP response element binding protein binding IPI
IPI: Inferred from physical interaction
25941387 FlyBase
enables protein binding IPI
IPI: Inferred from physical interaction
9109493 FlyBase
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
19955409 FlyBase
enables protein kinase binding IDA
IDA: Inferred from direct assay
26403189 FlyBase
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9215627 FlyBase
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
20226779 FlyBase
Biological Process GO Annotation Evidence References Source
involved in compound eye morphogenesis IMP
IMP: Inferred from mutant phenotype
16651542 FlyBase
involved in cuticle pattern formation IMP
IMP: Inferred from mutant phenotype
16413529 FlyBase
involved in dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
23977298 FlyBase
involved in genital disc anterior/posterior pattern formation IEP
IEP: Inferred from expression pattern
8798147 FlyBase
involved in heart formation IMP
IMP: Inferred from mutant phenotype
8660881 FlyBase
involved in labial disc development IMP
IMP: Inferred from mutant phenotype
15680366 FlyBase
involved in mucosal immune response IMP
IMP: Inferred from mutant phenotype
25639794 FlyBase
involved in negative regulation of hippo signaling IGI
IGI: Inferred from genetic interaction
26403189 FlyBase
involved in negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16386907 FlyBase
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
8769644 FlyBase
involved in positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
15809036 FlyBase
involved in positive regulation of epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
18633350 FlyBase
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9122207 FlyBase
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
10669739 FlyBase
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
8769644 FlyBase
involved in regulation of cell proliferation involved in compound eye morphogenesis IMP
IMP: Inferred from mutant phenotype
17559828 FlyBase
involved in regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
11279500 FlyBase
involved in segment polarity determination IMP
IMP: Inferred from mutant phenotype
2166702 FlyBase
involved in smoothened signaling pathway IDA
IDA: Inferred from direct assay
9215627 FlyBase
involved in smoothened signaling pathway IEP
IEP: Inferred from expression pattern
8898240 FlyBase
involved in smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
7577671 FlyBase
involved in smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
8658135 FlyBase
involved in spiracle morphogenesis, open tracheal system IMP
IMP: Inferred from mutant phenotype
15930099 FlyBase
involved in wing disc anterior/posterior pattern formation IMP
IMP: Inferred from mutant phenotype
15708556 FlyBase
Cellular Component GO Annotation Evidence References Source
part of Hedgehog signaling complex IPI
IPI: Inferred from physical interaction
9244297 FlyBase
located in cytosol IDA
IDA: Inferred from direct assay
7577671 FlyBase
located in nucleus IDA
IDA: Inferred from direct assay
7577671 FlyBase
part of protein-containing complex IPI
IPI: Inferred from physical interaction
9601642 FlyBase
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cubitus interruptus

  • CG2125-PA

  • CG2125-PB

  • CG2125-PC

  • cell

  • ci-PA

  • ci-PB

  • ci-PC

  • cubitis interruptus

  • cubitus

  • cubitus interuptus

  • cubitus-interruptus

  • cubitus-interruptus-Dominant

  • interruptus