Smarca2 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 Gene

Also Known as brm; Snf2l2; brahma; SNF2alpha; 2610209L14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67155

Summary

Predicted to enable several functions, including chromatin binding activity; transcription cis-regulatory region binding activity; and transcription coactivator activity. Acts upstream of or within aortic smooth muscle cell differentiation; hematopoietic stem cell homeostasis; and negative regulation of cell population proliferation. Located in nucleus. Part of nBAF complex and npBAF complex. Is expressed in several structures, including cerebral cortex; early conceptus; genitourinary system; heart; and vitelline artery. Orthologous to human SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2). [provided by Alliance of Genome Resources, Apr 2022]

Smarca2 Products (10)

mRNA Protein Name
NM_001347439.2 NP_001334368.1 probable global transcription activator SNF2L2 isoform 3 precursor
NM_001405130.1 NP_001392059.1 probable global transcription activator SNF2L2 isoform 1
NM_001405131.1 NP_001392060.1 probable global transcription activator SNF2L2 isoform 1
NM_001405132.1 NP_001392061.1 probable global transcription activator SNF2L2 isoform 1
NM_001405133.1 NP_001392062.1 probable global transcription activator SNF2L2 isoform 4
NM_001405134.1 NP_001392063.1 probable global transcription activator SNF2L2 isoform 4
NM_001405135.1 NP_001392064.1 probable global transcription activator SNF2L2 isoform 4
NM_001405136.1 NP_001392065.1 probable global transcription activator SNF2L2 isoform 4
NM_011416.3 NP_035546.2 probable global transcription activator SNF2L2 isoform 1
NM_026003.3 NP_080279.1 probable global transcription activator SNF2L2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12368262 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within aortic smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
19342595 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
9843504 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
9843504 MGI
acts upstream of or within hematopoietic stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
26880577 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
9843504 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
9843504 MGI
Cellular Component GO Annotation Evidence References Source
part of SWI/SNF superfamily-type complex IDA
IDA: Inferred from direct assay
12368262 MGI
part of nBAF complex IDA
IDA: Inferred from direct assay
17640523 MGI
part of npBAF complex IDA
IDA: Inferred from direct assay
17640523 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9603422 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

probable global transcription activator SNF2L2

  • ATP-dependent helicase SMARCA2

  • BAF190B

  • BRG1-associated factor 190B

  • SNF2-alpha

  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

  • protein brahma homolog

  • subunit of the SWI/SNF chromatin remodeling complex

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-159607 PRT3789 Degrader 98.08% Phase 2

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145388 AU-15330 Degrader 99.89% Unkown
HY-128359 ACBI1 Degrader 99.92% Unkown
HY-44012 SMARCA-BD ligand 1 for PROTAC Ligand 99.07% Unkown
HY-44012B SMARCA-BD ligand 1 for PROTAC hydrochloride Ligand 99.24% Unkown
HY-44012A SMARCA-BD ligand 1 for PROTAC dihydrochloride Ligand 98.08% Unkown
HY-46618 SMARCA2/4-ligand-8 Ligand / Unkown
HY-170824 SMD-3236 Degrader / Unkown
HY-185075 FHD-909 Inhibitor / Unkown
HY-168237 SMARCA2 ligand-10 Ligand / Unkown
HY-162814 SMARCA2/4-ligand-3 Ligand / Unkown
HY-169280 PXR Ligand 2 / Unkown
HY-170354 SMARCA2/4-ligand-4 Ligand / Unkown
HY-161885 SMARCA2/4-IN-4 Inhibitor / Unkown
HY-170349 SMARCA2 ligand-11 Ligand / Unkown
HY-163949 SMARCA2/4-IN-3 Inhibitor / Unkown
HY-44824 SMARCA2 ligand-13 Ligand / Unkown
HY-180960 NEP202 Degrader / Unkown
HY-171765 SMARCA2/4-ligand-6 Ligand / Unkown
HY-178225 PROTAC SMARCA2/4 degrader-39 Degrader / Unkown
HY-168248 BRM/BRG1 ligand 2 Ligand / Unkown
HY-181909 PROTAC SMARCA2 degrader-36 Degrader / Unkown
HY-153425 PROTAC SMARCA2/4 degrader-41 Degrader / Unkown
HY-168230 SMARCA2 ligand-9 Ligand / Unkown
HY-180931 PROTAC A515 Degrader / Unkown
HY-170817 SMI-1074 Inhibitor / Unkown
HY-181910 SMARCA2 ligand-19 Ligand / Unkown
HY-169487 SMARCA2 ligand-12 / Unkown
HY-180932 SMARCA2 ligand-17 Ligand / Unkown
HY-176871 PROTAC SMARCA2 degrader-35 Degrader / Unkown
HY-168252 BRM/BRG1 ligand 3 Ligand / Unkown
HY-172446 SMARCA2/4-ligand-5 / Unkown
HY-159472 SMARCA2/4-ligand-1 Inhibitor / Unkown
HY-W539427 BRM/BRG1 ligand 1 Ligand / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smarca2 NCBI NCBI:6595