RPS6-IN-1
RPS6-IN-1 (Compound 22o) inhibits cell metastasis, induces cell apoptosis (increases the expression of Bax, p53, cleaved-caspase 3, and cleaved-PARP). RPS6-IN-1 decreases mitochondrial membrane potential. RPS6-IN-1 activates autophagy through the PI3K-Akt-mTOR signaling pathway, damages intracellular mitochondria and lysosomes, and cause ER stress. RPS6-IN-1 inhibits RPS6 phosphorylation. RPS6-IN-1 is an anticancer agent with low systemic toxicity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C16H18Cl2N4O4S
- 分子量:433.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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- 純度とドキュメンテーション
- 参考文献
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生物活性
製品説明
体外実験
RPS6-IN-1 inhibits cancer cell growth, with IC50s of 3.82 μM (HCT-116), 2.80 μM (HeLa), 5.54 μM (MCF-7), 45.96 (A549), 32.71 μM (HepG2), 13.02 μM (PANC-1) respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- RNA extraction experimental
- Western Blot
- Mitochondrial membrane-potential fluorescent assay
- Annexin V plus membrane-impermeant dye apoptosis staining
- Acute Systemic Toxicity Study
- Kinase activity and phosphorylation assays
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Fluorescent plasma-membrane potential dye assay
- Mitochondrial membrane-potential and mitochondrial mass staining
- Autophagy
- Subchronic/Chronic Toxicity Study
- Apoptosis Solutions
- Lysosome and acidic-vesicle live-cell staining
- Protocol for Kinase activity and phosphorylation assays
- Macroautophagy Solutions
- Orthotopic Cell-Line Xenograft
化学情報
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分子量 433.31
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分子式 C16H18Cl2N4O4S
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SMILES
ClC1=NC(Cl)=NC2=C1N=CN2C3(C(OCC)=O)CSC[C@H]3CC(OCC)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
RPS6-IN-1 関連分類
HY-161874 関連分類
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