Apoptosis inducer 44
Apoptosis inducer 44 is an apoptosis inducer. Apoptosis inducer 44 triggers apoptosis in MDA-MB-231 cells by increasing the levels of Bax and Cyt C, reducing Bcl-2, and initiating caspase-3 cleavage. Apoptosis inducer 44 suppresses the invasion and migration of MDA-MB-231 cells by down-regulating MMP-2 and MMP-9 expression and up-regulating E-cadherin protein levels. Apoptosis inducer 44 can be used for the study of breast cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C30H36F3NO
- 分子量:483.61
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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生物活性
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Caspase 3 |
Bax |
Bcl-2 |
MMP-2 |
MMP-9 |
Apoptosis inducer 44 (Compound 19) (72 h) shows cytotoxic activity against MDA-MB-231 cells, MCF-7 cells, 4T1 cells and Aml-12 cells, with IC50 values of 4.13, 8.60, 39.95 and 31.60 μM[1].
Apoptosis inducer 44 (10‑40 μM) induces MDA-MB-231 cells apoptosis via the mitochondrial pathway[1].
Apoptosis inducer 44 (5-40 μM) suppresses the invasion and migration of MDA-MB-231 cells by down-regulating MMP-2/MMP-9 expression and up-regulating E-cadherin protein levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 483.61
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分子式 C30H36F3NO
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SMILES
OC1=CC=C(/C=C/C(C=C)(C)CC/C=C(C)\C)C=C1C(N2CCCCC2)C3=CC(F)=C(F)C(F)=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Apoptosis inducer 44 関連分類
HY-175815 関連分類
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