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Cat. No.: HY-168893

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K882

K882 (Compound 4e) is a Src inhibitor, with K_D of 0.315 μM. K882 induces Apoptosis. K882 inhibits XIAP and Survivin. K882 inhibits the activation of PI3K/Akt/mTOR, Jak1/Stat3, Ras/MAPK signaling pathways. K882 shows anti-tumor activity against non-small cell lung cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₁₈H₁₆N₂O₂
분자량:292.33

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

K882 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

PI3Kα

XIAP

JAK1

Stat-3

All Src Isoforms :

All IAP Isoforms :

All Akt Isoforms :

All mTOR Isoforms :

All JAK Isoforms :

All STAT Isoforms :

All Ras Isoforms :

All p38 MAPK Isoforms :

In Vitro

K882 (0.5-8 μM, 24-72 h) exhibits remarkable inhibitory activities on proliferation, migration and invasion in KRAS^G12C mutant NCI-H358 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

NCI-H358
Concentration:

0.5, 1, 2 and 4 μM
Incubation Time:

24 h
Result:

Blocked the NCI-H358 cell cycle in the G2/M phase.

Cell Cycle Analysis^[1]

Cell Line:

NCI-H358
Concentration:

1, 2, 4, 8 μM
Incubation Time:

24 h
Result:

Increased the rate of apoptotic cells concentration-dependently.
Inhibited the expressions of two apoptosis inhibitory proteins (XIAP and Survivin).

In Vivo

K882 (25-100 mg/kg, i.p., once a day, 31 days) inhibits the growth of KRAS^G12C mutant NSCLC xenograft in a NCI-H358 xenograft tumor mice model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NCI-H358 xenograft tumor mice model^[1]
Dosage:

25, 50 and 100 mg/kg,
Administration:

Intraperitoneal injection (i.p.), once a day, 31 days
Result:

Decreased tumor volume.
Showed the tumor inhibitory rates of 42.48 % (25 mg/kg), 49.72% (50 mg/kg) and 60.39 % (100 mg/kg).
Abrogated the phosphorylation at Y416 of Src.
Did not exhibit any apparent damage in the vital organs.

Chemical Information

분자량 292.33
화학식 C₁₈H₁₆N₂O₂
SMILES

COC1=CC(/C=C/C2=NC=NC3=CC=CC=C23)=C(OC)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ma X, et al. Identification of a novel Src inhibitor K882 derived from quinazoline-based stilbenes with anti-NSCLC effect. Bioorg Chem. 2025 Mar;156:108185. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

K882

All Src Isoforms

All IAP Isoforms

All Akt Isoforms

All mTOR Isoforms

All JAK Isoforms

All STAT Isoforms

All Ras Isoforms

All p38 MAPK Isoforms