AN-7
AN-7 is an orally active histone deacetylase (HDAC) inhibitor that induces histone hyperacetylation and differentiation in vitro and in vivo, and inhibits the proliferation of human prostate 22Rv1 cancer cells. AN-7 can increase the expression of the pro-apoptotic protein Bax, reduce the expression of the anti-apoptotic protein Bcl-2, and promote apoptosis by activating caspase-3, and can be used in the study of prostate cancer.
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- CAS. Nr.: 213262-83-0
- Formel: C9H19O6P
- Molecular Weight:254.22
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U-251 | IC50 |
89 μM
Compound: 12
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Cytotoxicity against human U251 cells after 72 hrs by Hoechst test
Cytotoxicity against human U251 cells after 72 hrs by Hoechst test
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[PMID: 19007111] |
Chemical Information
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CAS. Nr. 213262-83-0
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Molecular Weight 254.22
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Formel C9H19O6P
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SMILES
CCCC(OCOP(OCC)(OCC)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AN-7 Related Classifications
HY-117136 Related Classifications
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