RAN - RAN, member RAS oncogene family Gene

Also Known as TC4; Gsp1; ARA24

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5901

About RAN

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:130,872,066-130,877,678 (from NCBI)

This gene has 12 transcripts (splice variants) and 298 orthologues. Ubiquitous expression in lymph node (RPKM 71.4), testis (RPKM 70.1) and 25 other tissues.

Summary

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the Ras superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several Other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during Mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an Androgen Receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the Androgen Receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]

RAN Products (3)

mRNA	Protein	Name
NM_001300796.2	NP_001287725.1	GTP-binding nuclear protein Ran isoform 2
NM_001300797.2	NP_001287726.1	GTP-binding nuclear protein Ran isoform 2
NM_006325.5	NP_006316.1	GTP-binding nuclear protein Ran isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables G protein activity	IDA IDA: Inferred from direct assay	11336674	GOA
enables GDP binding	IDA IDA: Inferred from direct assay	11336674	GOA
enables GDP binding	IMP IMP: Inferred from mutant phenotype	18938132	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	1961752	GOA
enables GTP binding	IMP IMP: Inferred from mutant phenotype	18938132	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	8636225	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	11336674	GOA
contributes to pre-miRNA binding	IDA IDA: Inferred from direct assay	14681208	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1961752	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11336674	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in GTP metabolic process	IDA IDA: Inferred from direct assay	26272610	GOA
involved in mitotic sister chromatid segregation	IMP IMP: Inferred from mutant phenotype	29040603	GOA
involved in positive regulation of protein binding	IDA IDA: Inferred from direct assay	16449645	GOA
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	18691641	GOA
involved in protein export from nucleus	IDA IDA: Inferred from direct assay	10944119	GOA
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	9822603	GOA
involved in protein import into nucleus	IMP IMP: Inferred from mutant phenotype	8636225	GOA
involved in protein localization to nucleolus	IMP IMP: Inferred from mutant phenotype	18938132	GOA
involved in ribosomal large subunit export from nucleus	IMP IMP: Inferred from mutant phenotype	12773398	GOA
involved in ribosomal small subunit export from nucleus	IMP IMP: Inferred from mutant phenotype	12773398	GOA
involved in snRNA import into nucleus	IMP IMP: Inferred from mutant phenotype	8636225	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
NOT located in Flemming body	IDA IDA: Inferred from direct assay	19166812	GOA
part of RNA nuclear export complex	IDA IDA: Inferred from direct assay	14681208	GOA
located in centriole	IDA IDA: Inferred from direct assay	19166812	GOA
located in chromatin	IDA IDA: Inferred from direct assay	1961752	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	1961752	GOA
located in midbody	IDA IDA: Inferred from direct assay	19166812	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	27541860	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	18938132	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	18938132	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9822603	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	11336674	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	10557333	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	24561039	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAN Protein Structure

Ras

0
100
200
216 a.a.

Protein Preferred Names	Protein Names
GTP-binding nuclear protein Ran	GTPase Ran

RAN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	RAN	P62826	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	32814053
Intra	RAN	P62826	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Pooling	32814053
Intra	RAN	P62826	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32814053
Intra	RAN	P62826	ZBTB14	Homo sapiens	O43829	Y2H Array	32814053
Intra	RAN	P62826	ZBTB14	Homo sapiens	O43829	Y2H Pooling	32814053
Intra	RAN	P62826	ZBTB14	Homo sapiens	O43829	Validated Y2H	32814053
Intra	RAN	P62826	LPAL2	Homo sapiens	Q16609	Validated Y2H	32814053
Intra	RAN	P62826	LPAL2	Homo sapiens	Q16609	Y2H Pooling	32814053
Intra	RAN	P62826	LPAL2	Homo sapiens	Q16609	Y2H Array	32814053
Intra	RAN	P62826	tmp_locus_54	Homo sapiens	Q53NU3	Validated Y2H	32814053
Intra	RAN	P62826	tmp_locus_54	Homo sapiens	Q53NU3	Y2H Array	32814053
Intra	RAN	P62826	tmp_locus_54	Homo sapiens	Q53NU3	Y2H Pooling	32814053
Intra	RAN	P62826	RUSC1-AS1	Homo sapiens	Q66K80	Y2H Pooling	32814053
Intra	RAN	P62826	RUSC1-AS1	Homo sapiens	Q66K80	Validated Y2H	32814053
Intra	RAN	P62826	RUSC1-AS1	Homo sapiens	Q66K80	Y2H Array	32814053
Intra	RAN	P62826	ASCL4	Homo sapiens	Q6XD76	Validated Y2H	32814053
Intra	RAN	P62826	ASCL4	Homo sapiens	Q6XD76	Y2H Array	32814053
Intra	RAN	P62826	ASCL4	Homo sapiens	Q6XD76	Y2H Pooling	32814053
Intra	RAN	P62826	LINC00518	Homo sapiens	Q8N0U6	Y2H Array	32814053
Intra	RAN	P62826	LINC00518	Homo sapiens	Q8N0U6	Validated Y2H	32814053
Intra	RAN	P62826	LINC00518	Homo sapiens	Q8N0U6	Y2H Pooling	32814053
Intra	RAN	P62826	CAPN2	Homo sapiens	P17655	Y2H Pooling	32814053
Intra	RAN	P62826	CAPN2	Homo sapiens	P17655	Validated Y2H	32814053
Intra	RAN	P62826	CAPN2	Homo sapiens	P17655	Y2H Array	32814053
Intra	RAN	P62826	WBP1L	Homo sapiens	Q9NX94	Validated Y2H	32814053
Intra	RAN	P62826	WBP1L	Homo sapiens	Q9NX94	Y2H Array	32814053
Intra	RAN	P62826	WBP1L	Homo sapiens	Q9NX94	Y2H Pooling	32814053
Intra	RAN	P62826	PPP1R11	Homo sapiens	O60927	Y2H Pooling	32814053
Intra	RAN	P62826	PPP1R11	Homo sapiens	O60927	Validated Y2H	32814053
Intra	RAN	P62826	PPP1R11	Homo sapiens	O60927	Y2H Array	32814053
Intra	RAN	P62826	ATG10	Homo sapiens	Q9H0Y0	Validated Y2H	32814053
Intra	RAN	P62826	ATG10	Homo sapiens	Q9H0Y0	Y2H Array	32814053
Intra	RAN	P62826	ATG10	Homo sapiens	Q9H0Y0	Y2H Pooling	32814053
Intra	RAN	P62826	RHEB	Homo sapiens	Q15382	Y2H Pooling	32814053
Intra	RAN	P62826	RHEB	Homo sapiens	Q15382	Validated Y2H	32814053
Intra	RAN	P62826	RHEB	Homo sapiens	Q15382	Y2H Array	32814053
Intra	RAN	P62826	TRIM69	Homo sapiens	Q86WT6-2	Validated Y2H	32814053
Intra	RAN	P62826	TRIM69	Homo sapiens	Q86WT6-2	Y2H Array	32814053
Intra	RAN	P62826	TRIM69	Homo sapiens	Q86WT6-2	Y2H Pooling	32814053
Intra	RAN	P62826	DNAJA3	Homo sapiens	Q96EY1-3	Validated Y2H	32814053
Intra	RAN	P62826	DNAJA3	Homo sapiens	Q96EY1-3	Y2H Array	32814053
Intra	RAN	P62826	DNAJA3	Homo sapiens	Q96EY1-3	Y2H Pooling	32814053
Intra	RAN	P62826	CAPN3	Homo sapiens	P20807-4	Y2H Array	32814053
Intra	RAN	P62826	CAPN3	Homo sapiens	P20807-4	Y2H Pooling	32814053
Intra	RAN	P62826	CAPN3	Homo sapiens	P20807-4	Validated Y2H	32814053
Intra	RAN	P62826	CFAP100	Homo sapiens	Q494V2-2	Y2H Pooling	32814053
Intra	RAN	P62826	CFAP100	Homo sapiens	Q494V2-2	Validated Y2H	32814053
Intra	RAN	P62826	CFAP100	Homo sapiens	Q494V2-2	Y2H Array	32814053
Intra	RAN	P62826	VRK2	Homo sapiens	Q86Y07-1	Pull Down	18617507
Intra	RAN	P62826	VRK2	Homo sapiens	Q86Y07-5	Pull Down	18617507
Intra	RAN	P62826	C11orf54	Homo sapiens	Q9H0W9-3	Validated Y2H	32814053
Intra	RAN	P62826	C11orf54	Homo sapiens	Q9H0W9-3	Y2H Array	32814053
Intra	RAN	P62826	C11orf54	Homo sapiens	Q9H0W9-3	Y2H Pooling	32814053
Intra	RAN	P62826	CD209	Homo sapiens	Q9NNX6-10	Validated Y2H	32814053
Intra	RAN	P62826	CD209	Homo sapiens	Q9NNX6-10	Y2H Pooling	32814053
Intra	RAN	P62826	CD209	Homo sapiens	Q9NNX6-10	Y2H Array	32814053
Intra	RAN	P62826	WDR77	Homo sapiens	Q9BQA1	Y2H Array	32814053
Intra	RAN	P62826	WDR77	Homo sapiens	Q9BQA1	Y2H Pooling	32814053
Intra	RAN	P62826	WDR77	Homo sapiens	Q9BQA1	Validated Y2H	32814053
Intra	RAN	P62826	ZC2HC1C	Homo sapiens	Q53FD0-2	Validated Y2H	32814053
Intra	RAN	P62826	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Array	32814053
Intra	RAN	P62826	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Pooling	32814053
Intra	RAN	P62826	LRRC56	Homo sapiens	Q8IYG6	Validated Y2H	32814053
Intra	RAN	P62826	LRRC56	Homo sapiens	Q8IYG6	Y2H Array	32814053
Intra	RAN	P62826	LRRC56	Homo sapiens	Q8IYG6	Y2H Pooling	32814053
Intra	RAN	P62826	VRK1	Homo sapiens	Q99986	Anti Bait CoIP	18617507
Intra	RAN	P62826	VRK1	Homo sapiens	Q99986	Pull Down	18617507
Intra	RAN	P62826	VRK1	Homo sapiens	Q99986	IF	18617507
Intra	RAN	P62826	ZNF829	Homo sapiens	Q3KNS6-3	Validated Y2H	32814053
Intra	RAN	P62826	ZNF829	Homo sapiens	Q3KNS6-3	Y2H Array	32814053
Intra	RAN	P62826	ZNF829	Homo sapiens	Q3KNS6-3	Y2H Pooling	32814053
Intra	RAN	P62826	C3orf36	Homo sapiens	Q3SXR2	Y2H Array	32814053
Intra	RAN	P62826	C3orf36	Homo sapiens	Q3SXR2	Y2H Pooling	32814053
Intra	RAN	P62826	C3orf36	Homo sapiens	Q3SXR2	Validated Y2H	32814053
Intra	RAN	P62826	SYMPK	Homo sapiens	Q92797-2	Y2H Pooling	32814053
Intra	RAN	P62826	SYMPK	Homo sapiens	Q92797-2	Validated Y2H	32814053
Intra	RAN	P62826	SYMPK	Homo sapiens	Q92797-2	Y2H Array	32814053
Intra	RAN	P62826	KLHDC4	Homo sapiens	Q8TBB5-2	Validated Y2H	32814053
Intra	RAN	P62826	KLHDC4	Homo sapiens	Q8TBB5-2	Y2H Array	32814053
Intra	RAN	P62826	KLHDC4	Homo sapiens	Q8TBB5-2	Y2H Pooling	32814053
Intra	RAN	P62826	OGFOD2	Homo sapiens	Q6N063-2	Y2H Array	32814053
Intra	RAN	P62826	OGFOD2	Homo sapiens	Q6N063-2	Y2H Pooling	32814053
Intra	RAN	P62826	OGFOD2	Homo sapiens	Q6N063-2	Validated Y2H	32814053
Intra	RAN	P62826	BTBD9	Homo sapiens	Q96Q07-2	Validated Y2H	32814053
Intra	RAN	P62826	BTBD9	Homo sapiens	Q96Q07-2	Y2H Array	32814053
Intra	RAN	P62826	BTBD9	Homo sapiens	Q96Q07-2	Y2H Pooling	32814053
Intra	RAN	P62826	UBE2A	Homo sapiens	P49459	Y2H Array	32814053
Intra	RAN	P62826	UBE2A	Homo sapiens	P49459	Y2H Pooling	32814053
Intra	RAN	P62826	UBE2A	Homo sapiens	P49459	Validated Y2H	32814053
Intra	RAN	P62826	DPF1	Homo sapiens	Q92782-2	Validated Y2H	32814053
Intra	RAN	P62826	DPF1	Homo sapiens	Q92782-2	Y2H Pooling	32814053
Intra	RAN	P62826	DPF1	Homo sapiens	Q92782-2	Y2H Array	32814053
Intra	RAN	P62826	RGPD5	Homo sapiens	Q99666	Anti Tag CoIP	33961781
Intra	RAN	P62826	RGPD5	Homo sapiens	Q99666	Anti Tag CoIP	28514442
Intra	RAN	P62826	RGPD5	Homo sapiens	Q99666	Y2H	21988832
Cross	RAN	P62826	Xpo1	Mus musculus	Q6P5F9	SAXS	23850451
Intra	RAN	P62826	ANXA4	Homo sapiens	P09525	Y2H Array	32814053
Intra	RAN	P62826	ANXA4	Homo sapiens	P09525	Y2H Pooling	32814053
Intra	RAN	P62826	ANXA4	Homo sapiens	P09525	Validated Y2H	32814053
Intra	RAN	P62826	HAUS8	Homo sapiens	Q9BT25	Validated Y2H	32814053
Intra	RAN	P62826	HAUS8	Homo sapiens	Q9BT25	Y2H Array	32814053
Intra	RAN	P62826	HAUS8	Homo sapiens	Q9BT25	Y2H Pooling	32814053
Intra	RAN	P62826	OTUD7B	Homo sapiens	Q6GQQ9-2	Validated Y2H	32814053
Intra	RAN	P62826	OTUD7B	Homo sapiens	Q6GQQ9-2	Y2H Array	32814053
Intra	RAN	P62826	OTUD7B	Homo sapiens	Q6GQQ9-2	Y2H Pooling	32814053
Intra	RAN	P62826	a0a384mdv8_human	Homo sapiens	A0A384MDV8	Validated Y2H	32814053
Intra	RAN	P62826	a0a384mdv8_human	Homo sapiens	A0A384MDV8	Y2H Pooling	32814053
Intra	RAN	P62826	a0a384mdv8_human	Homo sapiens	A0A384MDV8	Y2H Array	32814053
Intra	RAN	P62826	NUDT1	Homo sapiens	P36639-4	Validated Y2H	32814053
Intra	RAN	P62826	NUDT1	Homo sapiens	P36639-4	Y2H Array	32814053
Intra	RAN	P62826	NUDT1	Homo sapiens	P36639-4	Y2H Pooling	32814053
Intra	RAN	P62826	RGR	Homo sapiens	P47804-3	Validated Y2H	32814053
Intra	RAN	P62826	RGR	Homo sapiens	P47804-3	Y2H Array	32814053
Intra	RAN	P62826	RGR	Homo sapiens	P47804-3	Y2H Pooling	32814053
Intra	RAN	P62826	ACTL7B	Homo sapiens	Q9Y614	Y2H Array	32814053
Intra	RAN	P62826	ACTL7B	Homo sapiens	Q9Y614	Y2H Pooling	32814053
Intra	RAN	P62826	ACTL7B	Homo sapiens	Q9Y614	Validated Y2H	32814053
Intra	RAN	P62826	TMEFF2	Homo sapiens	Q9UIK5-2	Y2H Pooling	32814053
Intra	RAN	P62826	TMEFF2	Homo sapiens	Q9UIK5-2	Validated Y2H	32814053
Intra	RAN	P62826	TMEFF2	Homo sapiens	Q9UIK5-2	Y2H Array	32814053
Intra	RAN	P62826	FAM135B	Homo sapiens	Q49AJ0-4	Y2H Array	32814053
Intra	RAN	P62826	FAM135B	Homo sapiens	Q49AJ0-4	Y2H Pooling	32814053
Intra	RAN	P62826	FAM135B	Homo sapiens	Q49AJ0-4	Validated Y2H	32814053
Intra	RAN	P62826	VPS54	Homo sapiens	Q9P1Q0-4	Y2H Pooling	32814053
Intra	RAN	P62826	VPS54	Homo sapiens	Q9P1Q0-4	Validated Y2H	32814053
Intra	RAN	P62826	VPS54	Homo sapiens	Q9P1Q0-4	Y2H Array	32814053
Intra	RAN	P62826	ZNF248	Homo sapiens	Q05CR2	Y2H Pooling	32814053
Intra	RAN	P62826	ZNF248	Homo sapiens	Q05CR2	Validated Y2H	32814053
Intra	RAN	P62826	ZNF248	Homo sapiens	Q05CR2	Y2H Array	32814053
Intra	RAN	P62826	LHX5	Homo sapiens	Q9H2C1	Validated Y2H	32814053
Intra	RAN	P62826	LHX5	Homo sapiens	Q9H2C1	Y2H Pooling	32814053
Intra	RAN	P62826	LHX5	Homo sapiens	Q9H2C1	Y2H Array	32814053
Intra	RAN	P62826	MLST8	Homo sapiens	A0A0A0MR05	Validated Y2H	32814053
Intra	RAN	P62826	MLST8	Homo sapiens	A0A0A0MR05	Y2H Pooling	32814053
Intra	RAN	P62826	MLST8	Homo sapiens	A0A0A0MR05	Y2H Array	32814053
Intra	RAN	P62826	MRM1	Homo sapiens	Q6IN84-2	Validated Y2H	32814053
Intra	RAN	P62826	MRM1	Homo sapiens	Q6IN84-2	Y2H Pooling	32814053
Intra	RAN	P62826	MRM1	Homo sapiens	Q6IN84-2	Y2H Array	32814053
Intra	RAN	P62826	CNST	Homo sapiens	Q6PJW8-3	Validated Y2H	32814053
Intra	RAN	P62826	CNST	Homo sapiens	Q6PJW8-3	Y2H Array	32814053
Intra	RAN	P62826	CNST	Homo sapiens	Q6PJW8-3	Y2H Pooling	32814053
Intra	RAN	P62826	SPSB1	Homo sapiens	Q96BD6	Y2H Pooling	32814053
Intra	RAN	P62826	SPSB1	Homo sapiens	Q96BD6	Validated Y2H	32814053
Intra	RAN	P62826	SPSB1	Homo sapiens	Q96BD6	Y2H Array	32814053
Intra	RAN	P62826	YIF1A	Homo sapiens	O95070	Validated Y2H	32814053
Intra	RAN	P62826	YIF1A	Homo sapiens	O95070	Y2H Pooling	32814053
Intra	RAN	P62826	YIF1A	Homo sapiens	O95070	Y2H Array	32814053
Intra	RAN	P62826	SLFN12	Homo sapiens	Q8IYM2	Y2H Array	32814053
Intra	RAN	P62826	SLFN12	Homo sapiens	Q8IYM2	Validated Y2H	32814053
Intra	RAN	P62826	SLFN12	Homo sapiens	Q8IYM2	Y2H Pooling	32814053
Intra	RAN	P62826	XPO7	Homo sapiens	Q9UIA9	Validated Y2H	32296183
Intra	RAN	P62826	TNPO1	Homo sapiens	Q92973	Anti Tag CoIP	35271311
Intra	RAN	P62826	RPS4X	Homo sapiens	P62701	Validated Y2H	32814053
Intra	RAN	P62826	RPS4X	Homo sapiens	P62701	Y2H Array	32814053
Intra	RAN	P62826	RPS4X	Homo sapiens	P62701	Y2H Pooling	32814053
Intra	RAN	P62826	SPRY4	Homo sapiens	Q9C004	Y2H Pooling	32814053
Intra	RAN	P62826	SPRY4	Homo sapiens	Q9C004	Validated Y2H	32814053
Intra	RAN	P62826	SPRY4	Homo sapiens	Q9C004	Y2H Array	32814053
Intra	RAN	P62826	POLR1D	Homo sapiens	P0DPB6	Y2H Array	32814053
Intra	RAN	P62826	POLR1D	Homo sapiens	P0DPB6	Y2H Pooling	32814053
Intra	RAN	P62826	POLR1D	Homo sapiens	P0DPB6	Validated Y2H	32814053
Intra	RAN	P62826	C1D	Homo sapiens	Q13901	Validated Y2H	32814053
Intra	RAN	P62826	C1D	Homo sapiens	Q13901	Y2H Array	32814053
Intra	RAN	P62826	C1D	Homo sapiens	Q13901	Y2H Pooling	32814053
Intra	RAN	P62826	CDS2	Homo sapiens	O95674	Validated Y2H	32814053
Intra	RAN	P62826	CDS2	Homo sapiens	O95674	Y2H Pooling	32814053
Intra	RAN	P62826	CDS2	Homo sapiens	O95674	Y2H Array	32814053
Intra	RAN	P62826	SPATS1	Homo sapiens	Q496A3	Y2H Array	32814053
Intra	RAN	P62826	SPATS1	Homo sapiens	Q496A3	Y2H Pooling	32814053
Intra	RAN	P62826	SPATS1	Homo sapiens	Q496A3	Validated Y2H	32814053
Intra	RAN	P62826	POLR2I	Homo sapiens	P36954	Validated Y2H	32814053
Intra	RAN	P62826	POLR2I	Homo sapiens	P36954	Y2H Array	32814053
Intra	RAN	P62826	POLR2I	Homo sapiens	P36954	Y2H Pooling	32814053
Intra	RAN	P62826	ELL2	Homo sapiens	O00472	Y2H Pooling	32814053
Intra	RAN	P62826	ELL2	Homo sapiens	O00472	Validated Y2H	32814053
Intra	RAN	P62826	ELL2	Homo sapiens	O00472	Y2H Array	32814053
Intra	RAN	P62826	TP53BP1	Homo sapiens	Q12888	Validated Y2H	32814053
Intra	RAN	P62826	TP53BP1	Homo sapiens	Q12888	Y2H Array	32814053
Intra	RAN	P62826	TP53BP1	Homo sapiens	Q12888	Y2H Pooling	32814053
Intra	RAN	P62826	CBX4	Homo sapiens	O00257-3	Validated Y2H	32814053
Intra	RAN	P62826	CBX4	Homo sapiens	O00257-3	Y2H Pooling	32814053
Intra	RAN	P62826	CBX4	Homo sapiens	O00257-3	Y2H Array	32814053
Intra	RAN	P62826	CTNNB1	Homo sapiens	P35222	Y2H Array	32814053
Intra	RAN	P62826	CTNNB1	Homo sapiens	P35222	Validated Y2H	32814053
Intra	RAN	P62826	CTNNB1	Homo sapiens	P35222	Y2H Pooling	32814053
Intra	RAN	P62826	FYN	Homo sapiens	P06241	Validated Y2H	32814053
Intra	RAN	P62826	FYN	Homo sapiens	P06241	Y2H Array	32814053
Intra	RAN	P62826	FYN	Homo sapiens	P06241	Y2H Pooling	32814053
Intra	RAN	P62826	BIRC5	Homo sapiens	O15392	ELISA	23251006
Intra	RAN	P62826	BIRC5	Homo sapiens	O15392	Pull Down	23251006
Intra	RAN	P62826	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	RAN	P62826	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	RAN	P62826	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	RAN	P62826	ARL6IP4	Homo sapiens	Q66PJ3-4	Validated Y2H	32814053
Intra	RAN	P62826	ARL6IP4	Homo sapiens	Q66PJ3-4	Y2H Pooling	32814053
Intra	RAN	P62826	ARL6IP4	Homo sapiens	Q66PJ3-4	Y2H Array	32814053
Intra	RAN	P62826	PPP1R13L	Homo sapiens	Q8WUF5	Confocal	24855949
Intra	RAN	P62826	PPP1R13L	Homo sapiens	Q8WUF5	Far-WB	24855949
Intra	RAN	P62826	PPP1R13L	Homo sapiens	Q8WUF5	Pull Down	24855949
Intra	RAN	P62826	NUTF2	Homo sapiens	P61970	Y2H Array	25416956
Intra	RAN	P62826	NUTF2	Homo sapiens	P61970	Pull Down	24855949
Intra	RAN	P62826	NUTF2	Homo sapiens	P61970	Anti Tag CoIP	28514442
Intra	RAN	P62826	NUTF2	Homo sapiens	P61970	Y2H Prey Pooling	25416956
Intra	RAN	P62826	NUTF2	Homo sapiens	P61970	Anti Tag CoIP	33961781
Intra	RAN	P62826	NUTF2	Homo sapiens	P61970	Anti Tag CoIP	35271311
Intra	RAN	P62826	NUTF2	Homo sapiens	P61970	Validated Y2H	25416956
Intra	RAN	P62826	RBBP4	Homo sapiens	Q09028	Y2H Pooling	32814053
Intra	RAN	P62826	RBBP4	Homo sapiens	Q09028	Validated Y2H	32814053
Intra	RAN	P62826	RBBP4	Homo sapiens	Q09028	Y2H Array	32814053
Intra	RAN	P62826	SNW1	Homo sapiens	Q13573	Validated Y2H	32814053
Intra	RAN	P62826	SNW1	Homo sapiens	Q13573	Y2H Pooling	32814053
Intra	RAN	P62826	SNW1	Homo sapiens	Q13573	Y2H Array	32814053
Intra	RAN	P62826	CIMAP1D	Homo sapiens	Q3SX64	Y2H Array	32814053
Intra	RAN	P62826	CIMAP1D	Homo sapiens	Q3SX64	Y2H Pooling	32814053
Intra	RAN	P62826	CIMAP1D	Homo sapiens	Q3SX64	Validated Y2H	32814053
Intra	RAN	P62826	RSRC1	Homo sapiens	Q96IZ7	Validated Y2H	32814053
Intra	RAN	P62826	RSRC1	Homo sapiens	Q96IZ7	Y2H Pooling	32814053
Intra	RAN	P62826	RSRC1	Homo sapiens	Q96IZ7	Y2H Array	32814053
Intra	RAN	P62826	POLA2	Homo sapiens	Q14181	Y2H Pooling	32814053
Intra	RAN	P62826	POLA2	Homo sapiens	Q14181	Validated Y2H	32814053
Intra	RAN	P62826	POLA2	Homo sapiens	Q14181	Y2H Array	32814053
Intra	RAN	P62826	CRCT1	Homo sapiens	Q9UGL9	Y2H Pooling	32814053
Intra	RAN	P62826	CRCT1	Homo sapiens	Q9UGL9	Validated Y2H	32814053
Intra	RAN	P62826	CRCT1	Homo sapiens	Q9UGL9	Y2H Array	32814053
Intra	RAN	P62826	RNF10	Homo sapiens	Q8N5U6	Y2H Pooling	32814053
Intra	RAN	P62826	RNF10	Homo sapiens	Q8N5U6	Validated Y2H	32814053
Intra	RAN	P62826	RNF10	Homo sapiens	Q8N5U6	Y2H Array	32814053
Intra	RAN	P62826	PAAT	Homo sapiens	Q9H8K7	Validated Y2H	32814053
Intra	RAN	P62826	PAAT	Homo sapiens	Q9H8K7	Y2H Pooling	32814053
Intra	RAN	P62826	PAAT	Homo sapiens	Q9H8K7	Y2H Array	32814053
Intra	RAN	P62826	UCHL1	Homo sapiens	P09936	Y2H Pooling	32814053
Intra	RAN	P62826	UCHL1	Homo sapiens	P09936	Validated Y2H	32814053
Intra	RAN	P62826	UCHL1	Homo sapiens	P09936	Y2H Array	32814053
Intra	RAN	P62826	JPT1	Homo sapiens	Q9UK76	Y2H Array	32814053
Intra	RAN	P62826	JPT1	Homo sapiens	Q9UK76	Y2H Pooling	32814053
Intra	RAN	P62826	JPT1	Homo sapiens	Q9UK76	Validated Y2H	32814053
Intra	RAN	P62826	PHF23	Homo sapiens	Q9BUL5	Validated Y2H	32814053
Intra	RAN	P62826	PHF23	Homo sapiens	Q9BUL5	Y2H Array	32814053
Intra	RAN	P62826	PHF23	Homo sapiens	Q9BUL5	Y2H Pooling	32814053
Intra	RAN	P62826	ZNG1C	Homo sapiens	Q5JTY5	Validated Y2H	32814053
Intra	RAN	P62826	ZNG1C	Homo sapiens	Q5JTY5	Y2H Array	32814053
Intra	RAN	P62826	ZNG1C	Homo sapiens	Q5JTY5	Y2H Pooling	32814053
Intra	RAN	P62826	DPYSL5	Homo sapiens	Q9BPU6	Y2H Array	32814053
Intra	RAN	P62826	DPYSL5	Homo sapiens	Q9BPU6	Y2H Pooling	32814053
Intra	RAN	P62826	DPYSL5	Homo sapiens	Q9BPU6	Validated Y2H	32814053
Intra	RAN	P62826	RELA	Homo sapiens	Q04206	Y2H Pooling	32814053
Intra	RAN	P62826	RELA	Homo sapiens	Q04206	Validated Y2H	32814053
Intra	RAN	P62826	RELA	Homo sapiens	Q04206	Y2H Array	32814053
Intra	RAN	P62826	NUP54	Homo sapiens	Q7Z3B4	Anti Tag CoIP	35271311
Intra	RAN	P62826	NUP54	Homo sapiens	Q7Z3B4	Validated Y2H	32814053
Intra	RAN	P62826	NUP54	Homo sapiens	Q7Z3B4	Y2H Array	32814053
Intra	RAN	P62826	NUP54	Homo sapiens	Q7Z3B4	Y2H Pooling	32814053
Intra	RAN	P62826	CIAO2B	Homo sapiens	Q9Y3D0	Y2H Array	32814053
Intra	RAN	P62826	CIAO2B	Homo sapiens	Q9Y3D0	Validated Y2H	32814053
Intra	RAN	P62826	CIAO2B	Homo sapiens	Q9Y3D0	Y2H Pooling	32814053
Intra	RAN	P62826	IPO13	Homo sapiens	O94829	TSA	23435562
Intra	RAN	P62826	SNF8	Homo sapiens	Q96H20	Validated Y2H	32814053
Intra	RAN	P62826	SNF8	Homo sapiens	Q96H20	Y2H Pooling	32814053
Intra	RAN	P62826	SNF8	Homo sapiens	Q96H20	Y2H Array	32814053
Intra	RAN	P62826	CHMP7	Homo sapiens	Q8WUX9	Validated Y2H	32814053
Intra	RAN	P62826	CHMP7	Homo sapiens	Q8WUX9	Y2H Pooling	32814053
Intra	RAN	P62826	CHMP7	Homo sapiens	Q8WUX9	Y2H Array	32814053
Intra	RAN	P62826	TENT5B	Homo sapiens	Q96A09	Y2H Array	32814053
Intra	RAN	P62826	TENT5B	Homo sapiens	Q96A09	Y2H Pooling	32814053
Intra	RAN	P62826	TENT5B	Homo sapiens	Q96A09	Validated Y2H	32814053
Intra	RAN	P62826	TP53BP2	Homo sapiens	Q13625	Pull Down	24855949
Intra	RAN	P62826	TP53BP2	Homo sapiens	Q13625	SPR	24855949
Intra	RAN	P62826	PPARA	Homo sapiens	Q07869	Validated Y2H	32814053
Intra	RAN	P62826	PPARA	Homo sapiens	Q07869	Y2H Pooling	32814053
Intra	RAN	P62826	PPARA	Homo sapiens	Q07869	Y2H Array	32814053
Intra	RAN	P62826	BCHE	Homo sapiens	P06276	Y2H Array	32814053
Intra	RAN	P62826	BCHE	Homo sapiens	P06276	Y2H Pooling	32814053
Intra	RAN	P62826	BCHE	Homo sapiens	P06276	Validated Y2H	32814053
Intra	RAN	P62826	FGD5	Homo sapiens	Q6ZNL6	Validated Y2H	32814053
Intra	RAN	P62826	FGD5	Homo sapiens	Q6ZNL6	Y2H Pooling	32814053
Intra	RAN	P62826	FGD5	Homo sapiens	Q6ZNL6	Y2H Array	32814053
Intra	RAN	P62826	AK8	Homo sapiens	Q96MA6	Validated Y2H	32814053
Intra	RAN	P62826	AK8	Homo sapiens	Q96MA6	Y2H Array	32814053
Intra	RAN	P62826	AK8	Homo sapiens	Q96MA6	Y2H Pooling	32814053
Intra	RAN	P62826	FAM9A	Homo sapiens	Q8IZU1	Y2H Array	32814053
Intra	RAN	P62826	FAM9A	Homo sapiens	Q8IZU1	Validated Y2H	32814053
Intra	RAN	P62826	FAM9A	Homo sapiens	Q8IZU1	Y2H Pooling	32814053
Intra	RAN	P62826	KRT222	Homo sapiens	Q8N1A0	Y2H Array	32814053
Intra	RAN	P62826	KRT222	Homo sapiens	Q8N1A0	Y2H Pooling	32814053
Intra	RAN	P62826	KRT222	Homo sapiens	Q8N1A0	Validated Y2H	32814053
Intra	RAN	P62826	BAAT	Homo sapiens	Q14032	Validated Y2H	32814053
Intra	RAN	P62826	BAAT	Homo sapiens	Q14032	Y2H Pooling	32814053
Intra	RAN	P62826	BAAT	Homo sapiens	Q14032	Y2H Array	32814053
Intra	RAN	P62826	MYBPHL	Homo sapiens	A2RUH7	Y2H Pooling	32814053
Intra	RAN	P62826	MYBPHL	Homo sapiens	A2RUH7	Validated Y2H	32814053
Intra	RAN	P62826	MYBPHL	Homo sapiens	A2RUH7	Y2H Array	32814053
Intra	RAN	P62826	RANGRF	Homo sapiens	Q9HD47-3	Y2H Pooling	32814053
Intra	RAN	P62826	RANGRF	Homo sapiens	Q9HD47-3	Validated Y2H	32814053
Intra	RAN	P62826	RANGRF	Homo sapiens	Q9HD47-3	Y2H Array	32814053
Intra	RAN	P62826	SEMA4G	Homo sapiens	Q9NTN9-3	Y2H Pooling	32814053
Intra	RAN	P62826	SEMA4G	Homo sapiens	Q9NTN9-3	Validated Y2H	32814053
Intra	RAN	P62826	SEMA4G	Homo sapiens	Q9NTN9-3	Y2H Array	32814053
Intra	RAN	P62826	ZNF597	Homo sapiens	Q96LX8	Y2H Array	32814053
Intra	RAN	P62826	ZNF597	Homo sapiens	Q96LX8	Y2H Pooling	32814053
Intra	RAN	P62826	ZNF597	Homo sapiens	Q96LX8	Validated Y2H	32814053
Intra	RAN	P62826	ANKRD49	Homo sapiens	Q8WVL7	Pull Down	24855949
Intra	RAN	P62826	TCAP	Homo sapiens	O15273	Y2H Pooling	32814053
Intra	RAN	P62826	TCAP	Homo sapiens	O15273	Validated Y2H	32814053
Intra	RAN	P62826	TCAP	Homo sapiens	O15273	Y2H Array	32814053
Intra	RAN	P62826	RANBP2	Homo sapiens	P49792	Anti Tag CoIP	33961781
Intra	RAN	P62826	RANBP2	Homo sapiens	P49792	Y2H	21988832
Intra	RAN	P62826	RANBP2	Homo sapiens	P49792	Pull Down	24855949
Intra	RAN	P62826	RANBP2	Homo sapiens	P49792	X-Ray Diffraction	10078529
Intra	RAN	P62826	RANBP2	Homo sapiens	P49792	Anti Tag CoIP	28514442
Intra	RAN	P62826	RANBP2	Homo sapiens	P49792	Anti Tag CoIP	35271311
Intra	RAN	P62826	RCC1	Homo sapiens	P18754	Anti Bait CoIP	18617507
Intra	RAN	P62826	RCC1	Homo sapiens	P18754	Anti Tag CoIP	35271311
Intra	RAN	P62826	RCC1	Homo sapiens	P18754	Lumier	37398436
Intra	RAN	P62826	RCC1	Homo sapiens	P18754	Comigration in Gel	1961752
Intra	RAN	P62826	RCC1	Homo sapiens	P18754	Pull Down	18617507
Intra	RAN	P62826	RCC1	Homo sapiens	P18754	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

RAN Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82076	Ran Antibody (YA1821)	WB, ICC/IF, IP	Human, Mouse, Monkey
HY-P82076A	Ran Antibody (YA1821)(PBS only)	WB, ICC/IF, IP	Human, Mouse, Monkey
HY-P84432	Ran Antibody (YA4129)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Monkey, Rat
HY-P84432A	Ran Antibody (YA4129)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Monkey, Rat

Related Diseases

Diseases	Alias
Vici Syndrome	Absent Corpus Callosum Cataract Immunodeficiency VICIS Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum Dionisi Vici Sabetta Gambarara Syndrome Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome Dionisi-Vici-Sabetta-Gambarara Syndrome Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum
Teratocarcinoma	Mixed Embryonal Carcinoma And Teratoma
X-Linked Chondrodysplasia Punctata 1	Chondrodysplasia Punctata 1, X-Linked Arylsulfatase E Deficiency Chondrodystrophia Calcificans Congenita Cdpx1 X-Linked Recessive Chondrodysplasia Punctata 1 Brachytelephalangic Chondrodysplasia Punctata
Hypertrichosis Universalis Congenita, Ambras Type	Ambras Syndrome Hypertrichosis, Congenital Generalized HTC1 HTC2 Chromosome Xq27.1 Interchromosomal Insertion Syndrome Cgh Hcg Ambras Type Hypertrichosis Universalis Congenita X-Linked Congenital Generalized Hypertrichosis Congenital Generalized Hypertrichosis, Macias-Flores Type Macias Flores-Garcia Cruz-Rivera Syndrome Htc 1 Hypertrichosis Universalis Congenita Ambras Type Hypertrichosis Congenital Generalized X-Linked Macias-Flores Garcia-Cruz Rivera Syndrome Congenital Generalized Hypertrichosis, Ambras Type
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Thyroid Gland Anaplastic Carcinoma	Anaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-173350	Ran-IN-1		99.89%	Unkown
HY-W250191	Tergitol		/	Unkown
HY-W141374	CB096		98.72%	Unkown
HY-120743	Triplin		/	Unkown
HY-125964	LLP-3	Inhibitor	98.13%	Unkown
HY-RS11641	RAN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16834	Ran Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23276	Ran Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RAN	MGD	MGI:1333112
Canis familiaris	RAN	VGNC	VGNC:59442
Rattus norvegicus	RAN	RGD	RGD:620367
Felis catus	RAN	VGNC	VGNC:80475
Others	RAN	NCBI