Art. -Nr.: HY-149669

PH14

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PH14 is a dual PI3K/HDAC inhibitor with IC₅₀ values of 20.3 nM and 24.5 nM for PI3Kα and HDAC3, respectively. PH14 has antiproliferative activity and also induces apoptosis in Jeko-1 cells. PH14 can be used in cancer research, such as lymphoma.

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Reinheit: 99.29%
CAS. Nr.: 3053430-96-6
Formel: C₃₄H₃₉N₉O₅
Molecular Weight:653.73

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

PH14 Chemical Structure

CAS. Nr.: 3053430-96-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

PI3Kα

20.3 nM (IC₅₀)

HDAC3

24.5 nM (IC₅₀)

Alle PI3K Isoform-spezifische Produkte anzeigen :

Alle HDAC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	0.9 μM Compound: PH14	Antiproliferative activity against human HL-60 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis Antiproliferative activity against human HL-60 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis	[PMID: 37948955]
JeKo-1	IC₅₀	0.5 μM Compound: PH14	Antiproliferative activity against human JeKo-1 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis Antiproliferative activity against human JeKo-1 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis	[PMID: 37948955]
L02	IC₅₀	>100 μM Compound: PH14	Cytotoxicity against human HL7702 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis Cytotoxicity against human HL7702 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis	[PMID: 37948955]
MDA-MB-231	IC₅₀	1.5 μM Compound: PH14	Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis	[PMID: 37948955]
MM1.S	IC₅₀	2.9 μM Compound: PH14	Antiproliferative activity against human MM1.S cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis Antiproliferative activity against human MM1.S cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis	[PMID: 37948955]

Chemical Information

CAS. Nr. 3053430-96-6
Appearance Solid
Molecular Weight 653.73
Formel C₃₄H₃₉N₉O₅
Color White to pink
SMILES

COC1=NC(N2CCOCC2)=NC(C3=CC=C(NC(NC4=CC=C(C(NCCCCCC(NC5=CC=CC=C5N)=O)=O)C=C4)=O)C=C3)=N1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (76.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5297 mL

7.6484 mL

15.2968 mL

5 mM

0.3059 mL

1.5297 mL

3.0594 mL

10 mM

0.1530 mL

0.7648 mL

1.5297 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Deng J, et al. Discovery of benzamide-based PI3K/HDAC dual inhibitors with marked pro-apoptosis activity in lymphoma cells. Eur J Med Chem. 2023 Nov 3;262:115915. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.5297 mL	7.6484 mL	15.2968 mL	38.2421 mL
	5 mM	0.3059 mL	1.5297 mL	3.0594 mL	7.6484 mL
	10 mM	0.1530 mL	0.7648 mL	1.5297 mL	3.8242 mL
	15 mM	0.1020 mL	0.5099 mL	1.0198 mL	2.5495 mL
	20 mM	0.0765 mL	0.3824 mL	0.7648 mL	1.9121 mL
	25 mM	0.0612 mL	0.3059 mL	0.6119 mL	1.5297 mL
	30 mM	0.0510 mL	0.2549 mL	0.5099 mL	1.2747 mL
	40 mM	0.0382 mL	0.1912 mL	0.3824 mL	0.9561 mL
	50 mM	0.0306 mL	0.1530 mL	0.3059 mL	0.7648 mL
	60 mM	0.0255 mL	0.1275 mL	0.2549 mL	0.6374 mL

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PH14

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Kinase Inhibitor Library

PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Glycolysis Compound Library

Cytoskeleton Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Glucose Metabolism Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Osteogenesis Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Cell Death Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

Anti-Brain Cancer Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Posttranslational Modification Library

High-Efficiency Gene Editing Compound Library

Lactylation Compound Library

Alle PI3K Isoform-spezifische Produkte anzeigen

Alle HDAC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

PH14 Related Classifications

HY-149669 Related Classifications